Epidemiology of allergic rhinitis and associated risk factors in Asia
AbstractThis review article aims to present the epidemiology and associated risk factors of allergic rhinitis (AR) in Asia. AR-related literature published on Asia was systematically reviewed and the associated risk factors were investigated.The prevalence of AR in Asia varied considerably depending on the geographical location, study design and population involved. Several risk factors were observed to have strong association with disease presentation across multiple studies. Among these, family income, family size, daily personal computer usage time, personal and parental education attainment, and stress level have shown...
Source: World Allergy Organization Journal - August 6, 2018 Category: Allergy & Immunology Source Type: research

Prevalence of food allergy in Vietnam: comparison of web-based with traditional paper-based survey
ConclusionsThe consistency of the WBS results with the PBS indicates a promising application of online surveys as an economic and validated model for future epidemiological studies, specifically in developing countries. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 23, 2018 Category: Allergy & Immunology Source Type: research

Geolocation with respect to personal privacy for the Allergy Diary app - a MASK study
Discussionk-anonymity is an acceptable method for the anonymization of MASK data and results can be used for other databases. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 16, 2018 Category: Allergy & Immunology Source Type: research

Management of chronic spontaneous urticaria: a worldwide perspective
ConclusionsPhysicians ’ characteristics (e.g. age, clinical experience, and specialty) and country specifics and regional features (e.g. availability of drugs for CSU treatment) importantly influence adherence to urticaria guidelines and CSU patient care and should be addressed in more detail in future research. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 4, 2018 Category: Allergy & Immunology Source Type: research

Type 2 immunity in asthma
AbstractType 2-immunity represents the typical adaptive response to allergen exposure in atopic individuals. It mainly involves Th2 cells and immunoglobulin E, as the main orchestrators of type 2-inflammation. Recently, it has been highlighted that allergens may be responsible for a Th2 response beside specific IgE activation and that a number of other environmental stimuli, such as viruses and pollutants, can trigger the same pattern of inflammation beyond atopy. Emerging data sustain a substantial role of the so-called epithelial dysfunction in asthma pathogenesis, both from anatomic and functional point of view. Further...
Source: World Allergy Organization Journal - June 26, 2018 Category: Allergy & Immunology Source Type: research

Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood – a longitudinal analysis of long-term follow-up of a randomized controlled trial
ConclusionMaternal supplementation with 900  mg of ω-3 LCPUFA did not change the progression of IgE-mediated allergic disease symptoms or sensitization throughout childhood from 1 to 6 years.Trial registrationAustralian New Zealand Clinical Trials Registry (ACTRN); DOMInO trialACTRN12605000569606, early childhood allergy follow upACTRN12610000735055 and 6-year allergy follow upACTRN12615000498594. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research

Debates in Allergy Medicine: Does oral immunotherapy  shorten the duration of milk and egg allergy? The pro argument
AbstractThe development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default immune response in the gut. A food allergy occurs when this process fails and a pathologic Th2 response is activated. Oral food immunotherapy (OIT) aims to restore immune tolerance in food-allergic individuals. The stimulation of Tregs production seems to represent a crucial step in inducing long-term tolerance, but other mechanisms (e.g., the suppression of mast cell and basophil reactivity, changes in aller...
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research

Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument
AbstractOral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow ’s milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy. While it has been shown that children who tolerate baked forms of egg and milk are more likely to deve...
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research

Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood – a longitudinal analysis of long-term follow-up of a randomized controlled trial
ConclusionMaternal supplementation with 900  mg of ω-3 LCPUFA did not change the progression of IgE-mediated allergic disease symptoms or sensitization throughout childhood from 1 to 6 years.Trial registrationAustralian New Zealand Clinical Trials Registry (ACTRN); DOMInO trialACTRN12605000569606, early childhood allergy follow upACTRN12610000735055 and 6-year allergy follow upACTRN12615000498594. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research