Informational feedback accelerates learning in multi-alternative perceptual judgements of orientation
This study shows that training with more informational feedback (RF) is more effective, though not necessary, in these challenging n-alternative tasks, a result that has implications for developing training paradigms in realistic tasks.PMID:37742454 | DOI:10.1016/j.visres.2023.108318 (Source: Vision Research)
Source: Vision Research - September 24, 2023 Category: Opthalmology Authors: Jiajuan Liu Zhong-Lin Lu Barbara Dosher Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Gene therapy and therapeutic editing with outer or inner retina animal models
Vision Res. 2023 Sep 15;213:108316. doi: 10.1016/j.visres.2023.108316. Online ahead of print.NO ABSTRACTPMID:37717278 | DOI:10.1016/j.visres.2023.108316 (Source: Vision Research)
Source: Vision Research - September 17, 2023 Category: Opthalmology Authors: Wolfgang Baehr Stephen H Tsang Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Deer management influences perception of avian plumage in temperate deciduous forests
Vision Res. 2023 Sep 11;213:108312. doi: 10.1016/j.visres.2023.108312. Online ahead of print.ABSTRACTMany animals use visual signals to communicate; birds use colorful plumage to attract mates and repel intruders. Visual signal conspicuousness is influenced by the lighting environment, which can be altered by human-induced changes. For example, deer-management efforts can affect vegetation structure and light availability. Whether these changes alter animal communication is still unknown. We investigated the effect of deer management on forest light and the contrast of understory birds against the forest background. We mod...
Source: Vision Research - September 13, 2023 Category: Opthalmology Authors: Timothy J Boycott Morgan G Sherrard Megan D Gall Kelly L Ronald Source Type: research
Deer management influences perception of avian plumage in temperate deciduous forests
Vision Res. 2023 Sep 11;213:108312. doi: 10.1016/j.visres.2023.108312. Online ahead of print.ABSTRACTMany animals use visual signals to communicate; birds use colorful plumage to attract mates and repel intruders. Visual signal conspicuousness is influenced by the lighting environment, which can be altered by human-induced changes. For example, deer-management efforts can affect vegetation structure and light availability. Whether these changes alter animal communication is still unknown. We investigated the effect of deer management on forest light and the contrast of understory birds against the forest background. We mod...
Source: Vision Research - September 13, 2023 Category: Opthalmology Authors: Timothy J Boycott Morgan G Sherrard Megan D Gall Kelly L Ronald Source Type: research
Attentional priming in Go No-Go search tasks
Vision Res. 2023 Sep 7;213:108313. doi: 10.1016/j.visres.2023.108313. Online ahead of print.ABSTRACTGo/No-Go responses in visual search yield different estimates of the operation of visual attention than more standard present versus absent tasks. Such minor methodological tweaks have a surprisingly large effect on measures that have, for the last half-century or so, formed the backbone of prominent theories of visual attention. Secondly, priming effects in visual search have a dominating influence on visual search, accounting for effects that have been attributed to top-down guidance in standard theories. Priming effects i...
Source: Vision Research - September 9, 2023 Category: Opthalmology Authors: Árni Kristjánsson T ómas Kristjánsson Source Type: research
Attentional priming in Go No-Go search tasks
Vision Res. 2023 Sep 7;213:108313. doi: 10.1016/j.visres.2023.108313. Online ahead of print.ABSTRACTGo/No-Go responses in visual search yield different estimates of the operation of visual attention than more standard present versus absent tasks. Such minor methodological tweaks have a surprisingly large effect on measures that have, for the last half-century or so, formed the backbone of prominent theories of visual attention. Secondly, priming effects in visual search have a dominating influence on visual search, accounting for effects that have been attributed to top-down guidance in standard theories. Priming effects i...
Source: Vision Research - September 9, 2023 Category: Opthalmology Authors: Árni Kristjánsson T ómas Kristjánsson Source Type: research
