Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex
Virus Res. 2024 Mar 13:199356. doi: 10.1016/j.virusres.2024.199356. Online ahead of print.ABSTRACTCoronaviruses contain one of the largest genomes among the RNA viruses, coding for 14-16 non-structural proteins (nsp) that are involved in proteolytic processing, genome replication and transcription, and four structural proteins that build the core of the mature virion. Due to conservation across coronaviruses, nsps form a group of promising drug targets as their inhibition directly affects viral replication and, therefore, progression of infection. A minimal but fully functional replication and transcription complex was sho...
Source: Virus Research - March 15, 2024 Category: Virology Authors: Maria Kuzikov Jeanette Reinshagen Krzysztof Wycisk Angela Corona Francesca Esposito Paolo Malune Candida Manelfi Daniela Iaconis Andrea Beccari Enzo Tramontano Marcin Nowotny Bj örn Windshügel Philip Gribbon Andrea Zaliani Source Type: research
Phylogeographic Dynamics of H9N2 Avian Influenza Viruses in Tunisia
Virus Res. 2024 Mar 9:199348. doi: 10.1016/j.virusres.2024.199348. Online ahead of print.ABSTRACTAvian influenza virus subtype H9N2 is endemic in commercial poultry in Tunisia. This subtype affects poultry and wild birds in Tunisia and poses a potential zoonotic risk. Tunisian H9N2 strains carry, in their hemagglutinins, the human-like marker 226L that is most influential in avian-to-human viral transmission. For a better understanding of how ecological aspects of the H9N2 virus and its circulation in poultry, migratory birds and environment shapes the spread of the dissemination of H9N2 in Tunisia, herein, we investigate ...
Source: Virus Research - March 11, 2024 Category: Virology Authors: Imen Larbi Arbi Marwa Oussama Souai Halima Tougorti Gary David Butcher Jihene Nsiri Chaima Badr Imen El Behi Jihene Lachhab Abdeljelil Ghram Source Type: research
Phylogeographic Dynamics of H9N2 Avian Influenza Viruses in Tunisia
Virus Res. 2024 Mar 9:199348. doi: 10.1016/j.virusres.2024.199348. Online ahead of print.ABSTRACTAvian influenza virus subtype H9N2 is endemic in commercial poultry in Tunisia. This subtype affects poultry and wild birds in Tunisia and poses a potential zoonotic risk. Tunisian H9N2 strains carry, in their hemagglutinins, the human-like marker 226L that is most influential in avian-to-human viral transmission. For a better understanding of how ecological aspects of the H9N2 virus and its circulation in poultry, migratory birds and environment shapes the spread of the dissemination of H9N2 in Tunisia, herein, we investigate ...
Source: Virus Research - March 11, 2024 Category: Virology Authors: Imen Larbi Arbi Marwa Oussama Souai Halima Tougorti Gary David Butcher Jihene Nsiri Chaima Badr Imen El Behi Jihene Lachhab Abdeljelil Ghram Source Type: research
Phylogeographic Dynamics of H9N2 Avian Influenza Viruses in Tunisia
Virus Res. 2024 Mar 9:199348. doi: 10.1016/j.virusres.2024.199348. Online ahead of print.ABSTRACTAvian influenza virus subtype H9N2 is endemic in commercial poultry in Tunisia. This subtype affects poultry and wild birds in Tunisia and poses a potential zoonotic risk. Tunisian H9N2 strains carry, in their hemagglutinins, the human-like marker 226L that is most influential in avian-to-human viral transmission. For a better understanding of how ecological aspects of the H9N2 virus and its circulation in poultry, migratory birds and environment shapes the spread of the dissemination of H9N2 in Tunisia, herein, we investigate ...
Source: Virus Research - March 11, 2024 Category: Virology Authors: Imen Larbi Arbi Marwa Oussama Souai Halima Tougorti Gary David Butcher Jihene Nsiri Chaima Badr Imen El Behi Jihene Lachhab Abdeljelil Ghram Source Type: research
Phylogeographic Dynamics of H9N2 Avian Influenza Viruses in Tunisia
Virus Res. 2024 Mar 9:199348. doi: 10.1016/j.virusres.2024.199348. Online ahead of print.ABSTRACTAvian influenza virus subtype H9N2 is endemic in commercial poultry in Tunisia. This subtype affects poultry and wild birds in Tunisia and poses a potential zoonotic risk. Tunisian H9N2 strains carry, in their hemagglutinins, the human-like marker 226L that is most influential in avian-to-human viral transmission. For a better understanding of how ecological aspects of the H9N2 virus and its circulation in poultry, migratory birds and environment shapes the spread of the dissemination of H9N2 in Tunisia, herein, we investigate ...
Source: Virus Research - March 11, 2024 Category: Virology Authors: Imen Larbi Arbi Marwa Oussama Souai Halima Tougorti Gary David Butcher Jihene Nsiri Chaima Badr Imen El Behi Jihene Lachhab Abdeljelil Ghram Source Type: research
Regulation mechanism of EBV-encoded EBER1 and LMP2A on YAP1 and the impact of YAP1 on the EBV infection status in EBV-associated gastric carcinoma
This study aims to explore the role and regulatory mechanism of Yes-associated protein 1 (YAP1) in the development of Epstein-Barr virus-associated gastric cancer (EBVaGC). Here we showed that EBV can upregulate the expression and activity of YAP1 protein through its encoded latent products EBV-encoded small RNA 1 (EBER1) and latent membrane protein 2A (LMP2A), enhancing the malignant characteristics of EBVaGC cells. In addition, we also showed that overexpression of YAP1 induced the expression of EBV encoding latent and lytic phase genes and proteins in the epithelial cell line AGS-EBV infected with EBV, and increased the...
Source: Virus Research - March 10, 2024 Category: Virology Authors: Yujie Sun Duo Shi Jiting Sun Yan Zhang Wen Liu Bing Luo Source Type: research
Regulation mechanism of EBV-encoded EBER1 and LMP2A on YAP1 and the impact of YAP1 on the EBV infection status in EBV-associated gastric carcinoma
This study aims to explore the role and regulatory mechanism of Yes-associated protein 1 (YAP1) in the development of Epstein-Barr virus-associated gastric cancer (EBVaGC). Here we showed that EBV can upregulate the expression and activity of YAP1 protein through its encoded latent products EBV-encoded small RNA 1 (EBER1) and latent membrane protein 2A (LMP2A), enhancing the malignant characteristics of EBVaGC cells. In addition, we also showed that overexpression of YAP1 induced the expression of EBV encoding latent and lytic phase genes and proteins in the epithelial cell line AGS-EBV infected with EBV, and increased the...
Source: Virus Research - March 10, 2024 Category: Virology Authors: Yujie Sun Duo Shi Jiting Sun Yan Zhang Wen Liu Bing Luo Source Type: research
Molecular and biological characterization of a novel partitivirus from Talaromyces pinophilus
Virus Res. 2024 Mar 5:199351. doi: 10.1016/j.virusres.2024.199351. Online ahead of print.ABSTRACTTalaromyces spp. have a worldwide distribution, are ecologically diverse and have been isolated from numerous different substrates. Talaromyces spp. are considered biotechnologically important due to their ability to produce a range of enzymes and pigments. Talaromyces pinophilus, belonging to genus Talaromyces and family Trichocomaceae, is known for producing several important bioactive metabolites. Here we report the isolation and characterisation of a partitivirus from T. pinophilus which we have nominated Talaromyces pinoph...
Source: Virus Research - March 7, 2024 Category: Virology Authors: Sidra Hassan Urayama Syun-Ichi Saba Shabeer Tahseen Ali Kiran Chien-Fu Wu Hiromitsu Moriyama Robert H A Coutts Ioly Kotta Loizou Atif Jamal Source Type: research
Molecular and biological characterization of a novel partitivirus from Talaromyces pinophilus
Virus Res. 2024 Mar 5:199351. doi: 10.1016/j.virusres.2024.199351. Online ahead of print.ABSTRACTTalaromyces spp. have a worldwide distribution, are ecologically diverse and have been isolated from numerous different substrates. Talaromyces spp. are considered biotechnologically important due to their ability to produce a range of enzymes and pigments. Talaromyces pinophilus, belonging to genus Talaromyces and family Trichocomaceae, is known for producing several important bioactive metabolites. Here we report the isolation and characterisation of a partitivirus from T. pinophilus which we have nominated Talaromyces pinoph...
Source: Virus Research - March 7, 2024 Category: Virology Authors: Sidra Hassan Urayama Syun-Ichi Saba Shabeer Tahseen Ali Kiran Chien-Fu Wu Hiromitsu Moriyama Robert H A Coutts Ioly Kotta Loizou Atif Jamal Source Type: research
Molecular and biological characterization of a novel partitivirus from Talaromyces pinophilus
Virus Res. 2024 Mar 5:199351. doi: 10.1016/j.virusres.2024.199351. Online ahead of print.ABSTRACTTalaromyces spp. have a worldwide distribution, are ecologically diverse and have been isolated from numerous different substrates. Talaromyces spp. are considered biotechnologically important due to their ability to produce a range of enzymes and pigments. Talaromyces pinophilus, belonging to genus Talaromyces and family Trichocomaceae, is known for producing several important bioactive metabolites. Here we report the isolation and characterisation of a partitivirus from T. pinophilus which we have nominated Talaromyces pinoph...
Source: Virus Research - March 7, 2024 Category: Virology Authors: Sidra Hassan Urayama Syun-Ichi Saba Shabeer Tahseen Ali Kiran Chien-Fu Wu Hiromitsu Moriyama Robert H A Coutts Ioly Kotta Loizou Atif Jamal Source Type: research
Role of long non-coding RNA DLY6E in regulating TMUV infection
Virus Res. 2024 Mar 4;343:199350. doi: 10.1016/j.virusres.2024.199350. Online ahead of print.ABSTRACTLong non-coding RNA (lncRNA) is a type of RNA with a length greater than 200 nt and lacking coding ability. In recent years, a considerable number of lncRNAs have been found to have important functions. The lncRNA plays an important role in growth and development, body metabolism, immune function, and regulation of viral replication. A lncRNA, MSTRG8505.2, was screened and named lncRNA DLY6E, which was a new duck-derived lncRNA. The lncRNADLY6E in this study has a complex secondary structure, specifically distributed in the...
Source: Virus Research - March 4, 2024 Category: Virology Authors: Siming Zhu Xin Chen Dalin He Meijuan Zhang Xinhong Man Yi Tang Youxiang Diao Source Type: research
Role of long non-coding RNA DLY6E in regulating TMUV infection
Virus Res. 2024 Mar 4;343:199350. doi: 10.1016/j.virusres.2024.199350. Online ahead of print.ABSTRACTLong non-coding RNA (lncRNA) is a type of RNA with a length greater than 200 nt and lacking coding ability. In recent years, a considerable number of lncRNAs have been found to have important functions. The lncRNA plays an important role in growth and development, body metabolism, immune function, and regulation of viral replication. A lncRNA, MSTRG8505.2, was screened and named lncRNA DLY6E, which was a new duck-derived lncRNA. The lncRNADLY6E in this study has a complex secondary structure, specifically distributed in the...
Source: Virus Research - March 4, 2024 Category: Virology Authors: Siming Zhu Xin Chen Dalin He Meijuan Zhang Xinhong Man Yi Tang Youxiang Diao Source Type: research
Role of long non-coding RNA DLY6E in regulating TMUV infection
Virus Res. 2024 Mar 2:199350. doi: 10.1016/j.virusres.2024.199350. Online ahead of print.ABSTRACTLong non-coding RNA (lncRNA) is a type of RNA with a length greater than 200 nt and lacking coding ability. In recent years, a considerable number of lncRNAs have been found to have important functions. The lncRNA plays an important role in growth and development, body metabolism, immune function, and regulation of viral replication. A lncRNA, MSTRG8505.2, was screened and named lncRNA DLY6E, which was a new duck-derived lncRNA. The lncRNADLY6E in this study has a complex secondary structure, specifically distributed in the hea...
Source: Virus Research - March 4, 2024 Category: Virology Authors: Siming Zhu Xin Chen Dalin He Meijuan Zhang Xinhong Man Yi Tang Youxiang Diao Source Type: research
Interleukin-1 β promotes human metapneumovirus replication via activating the cGAS-STING pathway
CONCLUSION: This study found that IL-1β could promote hMPV replication through the cGAS-STING pathway, which has the potential to serve as a candidate to fight against hMPV infection, targeting IL-1β may be an effective new strategy to restrain virus replication.PMID:38431054 | DOI:10.1016/j.virusres.2024.199344 (Source: Virus Research)
Source: Virus Research - March 2, 2024 Category: Virology Authors: Guojin Wu Yueyan Zhang Linlin Niu Yuan Hu Yuting Yang Yao Zhao Source Type: research
Do bed bugs transmit human viruses, or do humans spread bed bugs and their viruses? A worldwide survey of the bed bug RNA virosphere
Virus Res. 2024 Feb 29:199349. doi: 10.1016/j.virusres.2024.199349. Online ahead of print.ABSTRACTBED BUGS (HEMIPTERA: : Cimicidae) are a globally distributed hematophagous pest that routinely feed on humans. Unlike many blood-sucking arthropods, they have never been linked to pathogen transmission in a natural setting, and despite increasing interest in their role as disease vectors, little is known about the viruses that bed bugs naturally harbor. Here, we present a global-scale survey of the bed bug RNA virosphere. We sequenced the metatranscriptomes of 22 individual bed bugs (Cimex lectularius and Cimex hemipterus) fro...
Source: Virus Research - March 2, 2024 Category: Virology Authors: Hunter K Walt Jonas G King Johnathan M Sheele Florencia Meyer Jose E Pietri Federico G Hoffmann Source Type: research
