Revisiting a pollen-transmitted ilarvirus previously associated with angular mosaic of grapevine
We report the characterization of a novel tri-segmented RNA virus infecting Mercurialis annua, a common crop weed and model species in plant science. The virus, named "Mercurialis latent virus" (MeLaV) was first identified in a mixed infection with the recently described Mercurialis orthotospovirus 1 (MerV1) on symptomatic plants grown in glasshouses in Lausanne (Switzerland). Both viruses were found to be transmitted by Thrips tabaci, which presumably help the inoculation of infected pollen in the case of MeLaV. Complete genome sequencing of the latter revealed a typical ilarviral architecture and close phylogenetic relat...
Source: Virus Research - March 20, 2024 Category: Virology Authors: Mathieu Mahillon Justine Brodard Ruben Schoen Marleen Botermans Nathalie Dubuis Rapha ël Groux John R Pannell Arnaud G Blouin Olivier Schumpp Source Type: research
Can inflammatory plasma proteins predict Long COVID or Fatigue severity after SARS-CoV-2 infection?
CONCLUSIONS: This study demonstrates that certain immune response plasma proteins might play an important role in the pathophysiology of Long COVID and severity of fatigue after SARS-CoV-2 infection.PMID:38508399 | DOI:10.1016/j.virusres.2024.199363 (Source: Virus Research)
Source: Virus Research - March 20, 2024 Category: Virology Authors: Timo Schmitz Dennis Freuer Yvonne Go ßlau Tobias Dominik Warm Alexander Hyhlik-D ürr Jakob Linseisen Christa Meisinger Inge Kirchberger Source Type: research
Genetic Loci Regulate Sarbecovirus Pathogenesis: A Comparison across Mice and Humans
Virus Res. 2024 Mar 18:199357. doi: 10.1016/j.virusres.2024.199357. Online ahead of print.ABSTRACTCoronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, Middle East Respiratory CoV (MERS-CoV) in 2012, and SARS-CoV-2 in 2019. Although poorly characterized, natural genetic variation in human and other mammals modulate virus pathogenesis, as reflected by the spectrum of clinical outcomes ranging from asymptomatic infections to lethal disease. Using multiple human epidemic and zoonotic Sarbecoviruses, coupled wi...
Source: Virus Research - March 20, 2024 Category: Virology Authors: Alexandra Sch äfer Lisa E Gralinski Sarah R Leist Brea K Hampton Michael A Mooney Kara L Jensen Rachel L Graham Sudhakar Agnihothram Sophia Jeng Steven Chamberlin Timothy A Bell D Trevor Scobey Colton L Linnertz Laura A VanBlargan Larissa B Thackray Pabl Source Type: research
An evolutionary theory on virus mutation in COVID-19
Virus Res. 2024 Mar 18:199358. doi: 10.1016/j.virusres.2024.199358. Online ahead of print.ABSTRACTWith the rapid evolution of SARS-CoV-2, the emergence of new strains is an intriguing question. This paper presents an evolutionary theory to analyze the mutations of the virus and identify the conditions that lead to the generation of new strains. We represent the virus variants using a 4-letter sequence based on amino acid mutations on the spike protein and employ an n-distance algorithm to derive a variant phylogenetic tree. We show that the theoretically-derived tree aligns with experimental data on virus evolution. Additi...
Source: Virus Research - March 20, 2024 Category: Virology Authors: Liaofu Luo Jun Lv Source Type: research
Revisiting a pollen-transmitted ilarvirus previously associated with angular mosaic of grapevine
We report the characterization of a novel tri-segmented RNA virus infecting Mercurialis annua, a common crop weed and model species in plant science. The virus, named "Mercurialis latent virus" (MeLaV) was first identified in a mixed infection with the recently described Mercurialis orthotospovirus 1 (MerV1) on symptomatic plants grown in glasshouses in Lausanne (Switzerland). Both viruses were found to be transmitted by Thrips tabaci, which presumably help the inoculation of infected pollen in the case of MeLaV. Complete genome sequencing of the latter revealed a typical ilarviral architecture and close phylogenetic relat...
Source: Virus Research - March 20, 2024 Category: Virology Authors: Mathieu Mahillon Justine Brodard Ruben Schoen Marleen Botermans Nathalie Dubuis Rapha ël Groux John R Pannell Arnaud G Blouin Olivier Schumpp Source Type: research
Can inflammatory plasma proteins predict Long COVID or Fatigue severity after SARS-CoV-2 infection?
CONCLUSIONS: This study demonstrates that certain immune response plasma proteins might play an important role in the pathophysiology of Long COVID and severity of fatigue after SARS-CoV-2 infection.PMID:38508399 | DOI:10.1016/j.virusres.2024.199363 (Source: Virus Research)
Source: Virus Research - March 20, 2024 Category: Virology Authors: Timo Schmitz Dennis Freuer Yvonne Go ßlau Tobias Dominik Warm Alexander Hyhlik-D ürr Jakob Linseisen Christa Meisinger Inge Kirchberger Source Type: research
Genetic Loci Regulate Sarbecovirus Pathogenesis: A Comparison across Mice and Humans
Virus Res. 2024 Mar 18:199357. doi: 10.1016/j.virusres.2024.199357. Online ahead of print.ABSTRACTCoronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, Middle East Respiratory CoV (MERS-CoV) in 2012, and SARS-CoV-2 in 2019. Although poorly characterized, natural genetic variation in human and other mammals modulate virus pathogenesis, as reflected by the spectrum of clinical outcomes ranging from asymptomatic infections to lethal disease. Using multiple human epidemic and zoonotic Sarbecoviruses, coupled wi...
Source: Virus Research - March 20, 2024 Category: Virology Authors: Alexandra Sch äfer Lisa E Gralinski Sarah R Leist Brea K Hampton Michael A Mooney Kara L Jensen Rachel L Graham Sudhakar Agnihothram Sophia Jeng Steven Chamberlin Timothy A Bell D Trevor Scobey Colton L Linnertz Laura A VanBlargan Larissa B Thackray Pabl Source Type: research
An evolutionary theory on virus mutation in COVID-19
Virus Res. 2024 Mar 18:199358. doi: 10.1016/j.virusres.2024.199358. Online ahead of print.ABSTRACTWith the rapid evolution of SARS-CoV-2, the emergence of new strains is an intriguing question. This paper presents an evolutionary theory to analyze the mutations of the virus and identify the conditions that lead to the generation of new strains. We represent the virus variants using a 4-letter sequence based on amino acid mutations on the spike protein and employ an n-distance algorithm to derive a variant phylogenetic tree. We show that the theoretically-derived tree aligns with experimental data on virus evolution. Additi...
Source: Virus Research - March 20, 2024 Category: Virology Authors: Liaofu Luo Jun Lv Source Type: research
Revisiting a pollen-transmitted ilarvirus previously associated with angular mosaic of grapevine
We report the characterization of a novel tri-segmented RNA virus infecting Mercurialis annua, a common crop weed and model species in plant science. The virus, named "Mercurialis latent virus" (MeLaV) was first identified in a mixed infection with the recently described Mercurialis orthotospovirus 1 (MerV1) on symptomatic plants grown in glasshouses in Lausanne (Switzerland). Both viruses were found to be transmitted by Thrips tabaci, which presumably help the inoculation of infected pollen in the case of MeLaV. Complete genome sequencing of the latter revealed a typical ilarviral architecture and close phylogenetic relat...
Source: Virus Research - March 20, 2024 Category: Virology Authors: Mathieu Mahillon Justine Brodard Ruben Schoen Marleen Botermans Nathalie Dubuis Rapha ël Groux John R Pannell Arnaud G Blouin Olivier Schumpp Source Type: research
Structural impact of a new spike Y170W mutation detected in early emerging SARS-CoV-2 Omicron variants in France
Virus Res. 2024 Mar 16;343:199354. doi: 10.1016/j.virusres.2024.199354. Online ahead of print.ABSTRACTTo assess the genetic characteristics of the early emerging SARS-CoV-2 Omicron variant strains, we retrospectively analyzed a collection of 150 nasopharyngeal samples taken from a series of outpatient cases tested positive by a referenced qRT-PCR assay during the reported period of Omicron variant emergence in December 2021, in northeastern region of France. Next Generation Sequencing (NGS) analysis of SARS-CoV-2 spike sequences revealed that only 3 (2 %) of these detected strains were Omicron variants, while 147 (98 %) we...
Source: Virus Research - March 16, 2024 Category: Virology Authors: Marie Glenet Anne-Laure Lebreil Yohan N'Guyen Ittah Meyer St éphanie Baud Laurent Andreoletti Source Type: research
Structural impact of a new spike Y170W mutation detected in early emerging SARS-CoV-2 Omicron variants in France
Virus Res. 2024 Mar 16;343:199354. doi: 10.1016/j.virusres.2024.199354. Online ahead of print.ABSTRACTTo assess the genetic characteristics of the early emerging SARS-CoV-2 Omicron variant strains, we retrospectively analyzed a collection of 150 nasopharyngeal samples taken from a series of outpatient cases tested positive by a referenced qRT-PCR assay during the reported period of Omicron variant emergence in December 2021, in northeastern region of France. Next Generation Sequencing (NGS) analysis of SARS-CoV-2 spike sequences revealed that only 3 (2 %) of these detected strains were Omicron variants, while 147 (98 %) we...
Source: Virus Research - March 16, 2024 Category: Virology Authors: Marie Glenet Anne-Laure Lebreil Yohan N'Guyen Ittah Meyer St éphanie Baud Laurent Andreoletti Source Type: research
Structural impact of a new spike Y170W mutation detected in early emerging SARS-CoV-2 Omicron variants in France
Virus Res. 2024 Mar 16;343:199354. doi: 10.1016/j.virusres.2024.199354. Online ahead of print.ABSTRACTTo assess the genetic characteristics of the early emerging SARS-CoV-2 Omicron variant strains, we retrospectively analyzed a collection of 150 nasopharyngeal samples taken from a series of outpatient cases tested positive by a referenced qRT-PCR assay during the reported period of Omicron variant emergence in December 2021, in northeastern region of France. Next Generation Sequencing (NGS) analysis of SARS-CoV-2 spike sequences revealed that only 3 (2 %) of these detected strains were Omicron variants, while 147 (98 %) we...
Source: Virus Research - March 16, 2024 Category: Virology Authors: Marie Glenet Anne-Laure Lebreil Yohan N'Guyen Ittah Meyer St éphanie Baud Laurent Andreoletti Source Type: research
Structural impact of a new spike Y170W mutation detected in early emerging SARS-CoV-2 Omicron variants in France
Virus Res. 2024 Mar 14:199354. doi: 10.1016/j.virusres.2024.199354. Online ahead of print.ABSTRACTTo assess the genetic characteristics of the early emerging SARS-CoV-2 Omicron variant strains, we retrospectively analyzed a collection of 150 nasopharyngeal samples taken from a series of outpatient cases tested positive by a referenced qRT-PCR assay during the reported period of Omicron variant emergence in December 2021, in northeastern region of France. Next Generation Sequencing (NGS) analysis of SARS-CoV-2 spike sequences revealed that only 3 (2%) of these detected strains were Omicron variants, while 147 (98%) were ide...
Source: Virus Research - March 16, 2024 Category: Virology Authors: Marie Glenet Anne-Laure Lebreil Yohan N'Guyen Ittah Meyer Stephanie Baud Laurent Andreoletti Source Type: research
Selective pressure mediated by influenza virus M1 < sub > 58-66 < /sub > epitope-specific CD8 < sup > + < /sup > T cells promotes accumulation of extra-epitopic amino acid substitutions associated with viral resistance to these T cells
Virus Res. 2024 Mar 15;343:199355. doi: 10.1016/j.virusres.2024.199355. Online ahead of print.ABSTRACTInfluenza viruses are notorious for their capacity to evade host immunity. Not only can they evade recognition by virus-neutralizing antibodies, there is also evidence that they accumulate mutations in epitopes recognized by virus-specific CD8+T cells. In addition, we have shown previously that human influenza A viruses were less well recognized than avian influenza viruses by CD8+T cells directed to the highly conserved, HLA-A*02:01 restricted M158-66 epitope located in the Matrix 1 (M1) protein. Amino acid differences at...
Source: Virus Research - March 15, 2024 Category: Virology Authors: Janina M Jansen Robert Meineke Antonia Molle Carolien E van de Sandt Giulietta Saletti Guus F Rimmelzwaan Source Type: research
Dynamic of SARS-CoV-2 variants circulation in Tunisian pediatric population, during successive waves, from March 2020 to September 2022
This study describes the SARS-CoV-2 strains circulating in Tunisian pediatric population during successive waves. A total of 447 complete sequences were obtained from individuals aged from 13 days to 18 years, between March 2020 and September 2022: 369 sequences generated during this study and 78 ones, available in GISAID, previously obtained from Tunisian pediatric patients. These sequences were compared with 354 and 274 ones obtained from Tunisian adults and a global dataset, respectively. The variant circulation dynamics of predominant variants were investigated during the study period using maximum-likelihood phylogene...
Source: Virus Research - March 15, 2024 Category: Virology Authors: Haifa Khemiri Iolanda Mangone Mariem Gdoura Khawla Mefteh Anissa Chouikha Wasfi Fares Alessio Lorusso Massimo Ancora Adriano Di Pasquale Cesare Camm à Samar Ben Halima Henda Krichen Hanen Smaoui Ilhem Boutiba Ben Boubaker Olfa Bahri Henda Touzi Amel Sadr Source Type: research
