Duck Hepatitis A virus: full-length genome-based phylogenetic and phylogeographic view during 1986-2020
Virus Res. 2023 Aug 30:199216. doi: 10.1016/j.virusres.2023.199216. Online ahead of print.ABSTRACTDuck hepatitis A virus (DHAV) is one of key pathogens for duck viral hepatitis, especially in Asian duck industry. Currently, two main genotypes (DHAV-1 and -3) exist. To explore insightfully the evolutionary character, we assessed the available 141 full-length genome sequences of DHAV isolated in 1986-2020 globally and divided DHAV-1 and DHAV-3 into further seven (DHAV-1 a-g) and five (DHAV-3 a-e) sub-clades, respectively. Phylogenetic and phylogeographic network analyses indicated great genetic diversity of DHAV identified i...
Source: Virus Research - September 1, 2023 Category: Virology Authors: Caiting Yang Pir Tariq Shah Amina Nawal Bahoussi Changxin Wu Li Wang Li Xing Source Type: research

An investigation of excipients for a stable Orf viral vector formulation
In this study, the non-supplemented ORFV itself showed a very high stability at storage temperatures up to 28°C, with a linear titer loss of 0.10 log infectious particles per day at 4°C over a period of five weeks. To prolong this inherent stability, thirty additives, i.e., detergents, sugars, proteins, salts, and buffers as well as amino acids, were tested for their time- and temperature-dependent influence on the ORFV infectivity. A stabilizing effect on the infectivity was identified for the addition of all tested proteins, i.e., gelatine, bovine serum albumin, and recombinant human serum albumin (rHSA), of several su...
Source: Virus Research - September 1, 2023 Category: Virology Authors: Friederike Eilts Yasmina M J Harsy Keven Lothert Felix Pagallies Ralf Amann Michael W Wolff Source Type: research

Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice
CONCLUSIONS: This is the first study to demonstrate that HMPV VLP was successfully prepared in the baculovirus expression system. HMPV VLP could induce specific humoral and cellular immune responses as well as protective efficacy, and aluminium hydroxide may be an effective adjuvant in mice.PMID:37657510 | DOI:10.1016/j.virusres.2023.199215 (Source: Virus Research)
Source: Virus Research - September 1, 2023 Category: Virology Authors: Fenlian Ma Aijun Chen Yaoli Hong Hanchun Gao Qian Zhang Wenzhe Hou Lishu Zheng Source Type: research

Long non-coding RNAs ANRIL, THRIL, and NEAT1 as potential circulating biomarkers of SARS-CoV-2 infection and disease severity
In conclusion, the expression levels of the lncRNAs ANRIL and THRIL are correlated with the severity of COVID-19 and can be regarded as circulating biomarkers for disease progression.PMID:37657511 | DOI:10.1016/j.virusres.2023.199214 (Source: Virus Research)
Source: Virus Research - September 1, 2023 Category: Virology Authors: Zeynab Rahni Seyed Masoud Hosseini Shabnam Shahrokh Mahsa Saeedi Niasar Shahrzad Shoraka Hamed Mirjalali Ehsan Nazemalhosseini-Mojarad Mohammad Rostami-Nejad Habib Malekpour Mohammad Reza Zali Seyed Reza Mohebbi Source Type: research

Duck Hepatitis A virus: full-length genome-based phylogenetic and phylogeographic view during 1986-2020
Virus Res. 2023 Aug 30:199216. doi: 10.1016/j.virusres.2023.199216. Online ahead of print.ABSTRACTDuck hepatitis A virus (DHAV) is one of key pathogens for duck viral hepatitis, especially in Asian duck industry. Currently, two main genotypes (DHAV-1 and -3) exist. To explore insightfully the evolutionary character, we assessed the available 141 full-length genome sequences of DHAV isolated in 1986-2020 globally and divided DHAV-1 and DHAV-3 into further seven (DHAV-1 a-g) and five (DHAV-3 a-e) sub-clades, respectively. Phylogenetic and phylogeographic network analyses indicated great genetic diversity of DHAV identified i...
Source: Virus Research - September 1, 2023 Category: Virology Authors: Caiting Yang Pir Tariq Shah Amina Nawal Bahoussi Changxin Wu Li Wang Li Xing Source Type: research