Ostreid herpesvirus 1 latent infection and reactivation in adult Pacific oysters, Crassostrea gigas
Virus Res. 2023 Oct 13:199245. doi: 10.1016/j.virusres.2023.199245. Online ahead of print.ABSTRACTOstreid herpesvirus 1 (OsHV-1) is one of the most economically important pathogens of Pacific oysters. Understanding the pathogenesis of this virus is critical to developing tools to control outbreaks on shellfish farms. OsHV-1 is genetically related to vertebrate herpesviruses, which have a lytic and a latent stage, with the latent stage capable of being reactivated to the lytic stage. Here, OsHV-1 latency in Pacific oysters was investigated in experimentally and naturally infected oysters. Lytic infection in one-year-old oys...
Source: Virus Research - October 15, 2023 Category: Virology Authors: Konstantin Divilov Xisheng Wang Alexandra E Swisher Peyton C Yeoman Maxwell Rintoul Gary B Fleener Blaine Schoolfield Chris Langdon Ling Jin Source Type: research
Ostreid herpesvirus 1 latent infection and reactivation in adult Pacific oysters, Crassostrea gigas
Virus Res. 2023 Oct 13:199245. doi: 10.1016/j.virusres.2023.199245. Online ahead of print.ABSTRACTOstreid herpesvirus 1 (OsHV-1) is one of the most economically important pathogens of Pacific oysters. Understanding the pathogenesis of this virus is critical to developing tools to control outbreaks on shellfish farms. OsHV-1 is genetically related to vertebrate herpesviruses, which have a lytic and a latent stage, with the latent stage capable of being reactivated to the lytic stage. Here, OsHV-1 latency in Pacific oysters was investigated in experimentally and naturally infected oysters. Lytic infection in one-year-old oys...
Source: Virus Research - October 15, 2023 Category: Virology Authors: Konstantin Divilov Xisheng Wang Alexandra E Swisher Peyton C Yeoman Maxwell Rintoul Gary B Fleener Blaine Schoolfield Chris Langdon Ling Jin Source Type: research
Suppression of dengue virus replication by the French maritime pine extract Pycnogenol ®
Virus Res. 2023 Oct 11:199244. doi: 10.1016/j.virusres.2023.199244. Online ahead of print.ABSTRACTDengue virus (DENV) is mainly found in the tropics and infects approximately 400 million people annually. However, no clinically available therapeutic agents specific to dengue have been developed. Here, we examined the potential antiviral effects of the French maritime pine extract Pycnogenol® (PYC) against DENV because we previously found that the extract exerts antiviral effects on hepatitis C virus, which belongs to the Flavivirus family. First, we examined the efficacy of PYC against DENV1, 2, 3, and 4 serotypes and dete...
Source: Virus Research - October 13, 2023 Category: Virology Authors: Kazi Anowar Hossain Rupaly Akhter Md Haroon Or Rashid Lipi Akter Masashi Utsunomiya Bouchra Kitab NgweTun Mm Takayuki Hishiki Michinori Kohara Kouichi Morita Kyoko Tsukiyama-Kohara Source Type: research
Illuminating HTLV 1-induced Adult T-cell Leukemia/Lymphoma transcriptomic signature: a systems virology approach
CONCLUSIONS: In this study, we performed a deep bioinformatic examination on a limited set of genes with high probabilities of involvement in the pathogenesis of ATLL. Our results highlighted signaling pathways and genes with potential key roles in disease formation and resistance against current treatment strategies. Further studies are required to test the possible benefits of highlighted genes as biomarkers and targets of treatment.PMID:37832654 | DOI:10.1016/j.virusres.2023.199237 (Source: Virus Research)
Source: Virus Research - October 13, 2023 Category: Virology Authors: Mohammad-Moien Forghani-Ramandi Behnam Mostafavi Atefeh Bahavar Maryam Dehghankar Zeinab Siami Sayed-Hamidreza Mozhgani Source Type: research
HMGB1 Release Induced by EV71 Infection Exacerbates Blood-Brain Barrier Disruption via VE-cadherin Phosphorylation
CONCLUSION: The inflammatory mediator HMGB1 released by EV71 exacerbated BBB disruption by enhancing VE-cadherin phosphorylation, which in turn aggravated EV71-induced neuroinflammation.PMID:37832655 | DOI:10.1016/j.virusres.2023.199240 (Source: Virus Research)
Source: Virus Research - October 13, 2023 Category: Virology Authors: Qiao You Jing Wu Ye Liu Fang Zhang Na Jiang Xiaoyan Tian Yurong Cai Enhui Yang Ruining Lyu Nan Zheng Deyan Chen Zhiwei Wu Source Type: research
Suppression of dengue virus replication by the French maritime pine extract Pycnogenol ®
Virus Res. 2023 Oct 11:199244. doi: 10.1016/j.virusres.2023.199244. Online ahead of print.ABSTRACTDengue virus (DENV) is mainly found in the tropics and infects approximately 400 million people annually. However, no clinically available therapeutic agents specific to dengue have been developed. Here, we examined the potential antiviral effects of the French maritime pine extract Pycnogenol® (PYC) against DENV because we previously found that the extract exerts antiviral effects on hepatitis C virus, which belongs to the Flavivirus family. First, we examined the efficacy of PYC against DENV1, 2, 3, and 4 serotypes and dete...
Source: Virus Research - October 13, 2023 Category: Virology Authors: Kazi Anowar Hossain Rupaly Akhter Md Haroon Or Rashid Lipi Akter Masashi Utsunomiya Bouchra Kitab NgweTun Mm Takayuki Hishiki Michinori Kohara Kouichi Morita Kyoko Tsukiyama-Kohara Source Type: research
Illuminating HTLV 1-induced Adult T-cell Leukemia/Lymphoma transcriptomic signature: a systems virology approach
CONCLUSIONS: In this study, we performed a deep bioinformatic examination on a limited set of genes with high probabilities of involvement in the pathogenesis of ATLL. Our results highlighted signaling pathways and genes with potential key roles in disease formation and resistance against current treatment strategies. Further studies are required to test the possible benefits of highlighted genes as biomarkers and targets of treatment.PMID:37832654 | DOI:10.1016/j.virusres.2023.199237 (Source: Virus Research)
Source: Virus Research - October 13, 2023 Category: Virology Authors: Mohammad-Moien Forghani-Ramandi Behnam Mostafavi Atefeh Bahavar Maryam Dehghankar Zeinab Siami Sayed-Hamidreza Mozhgani Source Type: research
HMGB1 Release Induced by EV71 Infection Exacerbates Blood-Brain Barrier Disruption via VE-cadherin Phosphorylation
CONCLUSION: The inflammatory mediator HMGB1 released by EV71 exacerbated BBB disruption by enhancing VE-cadherin phosphorylation, which in turn aggravated EV71-induced neuroinflammation.PMID:37832655 | DOI:10.1016/j.virusres.2023.199240 (Source: Virus Research)
Source: Virus Research - October 13, 2023 Category: Virology Authors: Qiao You Jing Wu Ye Liu Fang Zhang Na Jiang Xiaoyan Tian Yurong Cai Enhui Yang Ruining Lyu Nan Zheng Deyan Chen Zhiwei Wu Source Type: research
Rhein suppresses African swine fever virus replication in vitro via activating the caspase-dependent mitochondrial apoptosis pathway
In this study, we confirmed that rhein inhibits ASFV replication significantly in a dose-dependent manner in vitro. Moreover, rhein could alter the susceptibility of PAMs to ASFV and promoted the production of superoxide in the mitochondria, which induced the loss of mitochondrial membrane potential, leading to the activation of caspase-9, caspase-3, and apoptosis. Mito-TEMPO, a mitochondria-targeted antioxidant, blocked rhein-induced mitochondrial superoxide generation and loss of mitochondrial membrane potential, prevented caspase-9 and caspase-3 activation, alleviated apoptosis, and suppressed the anti-ASFV activity of ...
Source: Virus Research - October 12, 2023 Category: Virology Authors: Zebu Song Yang Chen Hao Chang Yanchen Guo Qi Gao Zhi Wei Lang Gong Guihong Zhang ZeZhong Zheng Source Type: research
Unbranched rod-like RNA is required for RNA editing of hepatitis delta virus genotype 2 and genotype 4
Virus Res. 2023 Oct 10:199239. doi: 10.1016/j.virusres.2023.199239. Online ahead of print.ABSTRACTRNA editing of the hepatitis delta virus (HDV) is essential for generating the large delta antigen, which is crucial for virion assembly. In HDV genotype 1 (HDV-1), editing occurs within the context of the unbranched rod-like structure characteristic of HDV RNA, while RNA editing in HDV-3 requires a branched double-hairpin structure. The regulation of RNA editing in HDV-2 and HDV-4 remains uncertain. Based on predictions of the unbranched rod-like RNA structures of HDV-2 and HDV-4, the editing site occurs as an A.C mismatch pa...
Source: Virus Research - October 12, 2023 Category: Virology Authors: Chao-Wei Hsu Hsueh-Ying Hsu Chien-Hung Chen Mei Chao Source Type: research
Rhein suppresses African swine fever virus replication in vitro via activating the caspase-dependent mitochondrial apoptosis pathway
In this study, we confirmed that rhein inhibits ASFV replication significantly in a dose-dependent manner in vitro. Moreover, rhein could alter the susceptibility of PAMs to ASFV and promoted the production of superoxide in the mitochondria, which induced the loss of mitochondrial membrane potential, leading to the activation of caspase-9, caspase-3, and apoptosis. Mito-TEMPO, a mitochondria-targeted antioxidant, blocked rhein-induced mitochondrial superoxide generation and loss of mitochondrial membrane potential, prevented caspase-9 and caspase-3 activation, alleviated apoptosis, and suppressed the anti-ASFV activity of ...
Source: Virus Research - October 12, 2023 Category: Virology Authors: Zebu Song Yang Chen Hao Chang Yanchen Guo Qi Gao Zhi Wei Lang Gong Guihong Zhang ZeZhong Zheng Source Type: research
Unbranched rod-like RNA is required for RNA editing of hepatitis delta virus genotype 2 and genotype 4
Virus Res. 2023 Oct 10:199239. doi: 10.1016/j.virusres.2023.199239. Online ahead of print.ABSTRACTRNA editing of the hepatitis delta virus (HDV) is essential for generating the large delta antigen, which is crucial for virion assembly. In HDV genotype 1 (HDV-1), editing occurs within the context of the unbranched rod-like structure characteristic of HDV RNA, while RNA editing in HDV-3 requires a branched double-hairpin structure. The regulation of RNA editing in HDV-2 and HDV-4 remains uncertain. Based on predictions of the unbranched rod-like RNA structures of HDV-2 and HDV-4, the editing site occurs as an A.C mismatch pa...
Source: Virus Research - October 12, 2023 Category: Virology Authors: Chao-Wei Hsu Hsueh-Ying Hsu Chien-Hung Chen Mei Chao Source Type: research
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level
Virus Res. 2023 Oct 4:199234. doi: 10.1016/j.virusres.2023.199234. Online ahead of print.ABSTRACTDengue virus (DENV) is one of the most prevalent arthropod-borne diseases. It may cause dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), while no effective vaccines and drugs are available. Our study demonstrated that conessine exhibits broad antiviral activity against several enveloped viruses, including DENV, vesicular stomatitis virus, and herpes simplex virus. In addition, conessine has no direct destructive effect on the integrity or infectivity of virions. Both pre-treatment and post-treatment with conessin...
Source: Virus Research - October 6, 2023 Category: Virology Authors: Shili Zhou Jie Li Xiaomei Ling Shirui Dong Zhen Zhang Ming Li Source Type: research
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level
Virus Res. 2023 Oct 4:199234. doi: 10.1016/j.virusres.2023.199234. Online ahead of print.ABSTRACTDengue virus (DENV) is one of the most prevalent arthropod-borne diseases. It may cause dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), while no effective vaccines and drugs are available. Our study demonstrated that conessine exhibits broad antiviral activity against several enveloped viruses, including DENV, vesicular stomatitis virus, and herpes simplex virus. In addition, conessine has no direct destructive effect on the integrity or infectivity of virions. Both pre-treatment and post-treatment with conessin...
Source: Virus Research - October 6, 2023 Category: Virology Authors: Shili Zhou Jie Li Xiaomei Ling Shirui Dong Zhen Zhang Ming Li Source Type: research
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level
Virus Res. 2023 Oct 4:199234. doi: 10.1016/j.virusres.2023.199234. Online ahead of print.ABSTRACTDengue virus (DENV) is one of the most prevalent arthropod-borne diseases. It may cause dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), while no effective vaccines and drugs are available. Our study demonstrated that conessine exhibits broad antiviral activity against several enveloped viruses, including DENV, vesicular stomatitis virus, and herpes simplex virus. In addition, conessine has no direct destructive effect on the integrity or infectivity of virions. Both pre-treatment and post-treatment with conessin...
Source: Virus Research - October 6, 2023 Category: Virology Authors: Shili Zhou Jie Li Xiaomei Ling Shirui Dong Zhen Zhang Ming Li Source Type: research
