N < sup > pro < /sup > of classical swine fever virus enhances HMGB1 acetylation and its degradation by lysosomes to evade from HMGB1-mediated antiviral immunity
Virus Res. 2023 Nov 23;339:199280. doi: 10.1016/j.virusres.2023.199280. Online ahead of print.ABSTRACTClassical swine fever virus (CSFV) can dampen the host innate immunity by destabilizing IRF3 upon its binding with viral Npro. High mobility group box 1 (HMGB1), a non-histone nuclear protein, has diverse functions, including inflammation, innate immunity, etc., which are closely related to its cellular localization. We investigated potential mutual interactions between CSFV and HMGB1 and their effects on virus replication. We found that HMGB1 at the protein level, but not at mRNA level, was markedly reduced in CSFV-infect...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Xiao Han Hankun Xu Yifan Weng Rong Chen Jidong Xu Tong Cao Renjie Sun Ying Shan Fang He Weihuan Fang Xiaoliang Li Source Type: research
DUSP1 mRNA modulation during porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-infection regulates viruses replication
Virus Res. 2023 Nov 21:199282. doi: 10.1016/j.virusres.2023.199282. Online ahead of print.ABSTRACTThe effects of porcine circovirus type 2b (PCV2b) and porcine reproductive and respiratory syndrome virus (PRRSV) co-infection in epithelial cells of the swine respiratory tract is unknown. In the present study, the newborn pig trachea cell line NPTr-CD163, which is permissive to both viruses, was persistently infected with PCV2b and then with PRRSV. The viral replication, cell viability, cytokines' mRNA expression, and modulation of cellular genes expression were evaluated in infected cells. In NPTr-CD163 co-infection model, ...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Yaima Burgher Pulgaron Chantale Provost Fernando Alvarez Europa Meza Marie-Jeanne Pesant Christopher A Price Carl A Gagnon Source Type: research
Protection of laying chickens against the Canadian DMV/1639 infectious bronchitis virus infection through priming with heterologous live vaccine and boosting with heterologous or homologous inactivated vaccine
Virus Res. 2023 Nov 25;339:199281. doi: 10.1016/j.virusres.2023.199281. Online ahead of print.ABSTRACTThe emergence of the Canadian Delmarva (DMV)/1639 infectious bronchitis virus (IBV) type strains was associated with egg production disorders in Eastern Canadian layer operations. While developing vaccines for novel IBV variants is not typically a reasonable approach, the consideration of an autogenous vaccine becomes more appealing, particularly when the new variant presents significant economic challenges. The current study aimed to compare the efficacies of two vaccination programs that included heterologous live primin...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Mohamed S H Hassan Ahmed Ali Motamed Elsayed Mahmoud Danah Altakrouni Shahnas M Najimudeen Mohamed Faizal Abdul-Careem Source Type: research
N < sup > pro < /sup > of classical swine fever virus enhances HMGB1 acetylation and its degradation by lysosomes to evade from HMGB1-mediated antiviral immunity
Virus Res. 2023 Nov 23;339:199280. doi: 10.1016/j.virusres.2023.199280. Online ahead of print.ABSTRACTClassical swine fever virus (CSFV) can dampen the host innate immunity by destabilizing IRF3 upon its binding with viral Npro. High mobility group box 1 (HMGB1), a non-histone nuclear protein, has diverse functions, including inflammation, innate immunity, etc., which are closely related to its cellular localization. We investigated potential mutual interactions between CSFV and HMGB1 and their effects on virus replication. We found that HMGB1 at the protein level, but not at mRNA level, was markedly reduced in CSFV-infect...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Xiao Han Hankun Xu Yifan Weng Rong Chen Jidong Xu Tong Cao Renjie Sun Ying Shan Fang He Weihuan Fang Xiaoliang Li Source Type: research
DUSP1 mRNA modulation during porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-infection regulates viruses replication
Virus Res. 2023 Nov 21:199282. doi: 10.1016/j.virusres.2023.199282. Online ahead of print.ABSTRACTThe effects of porcine circovirus type 2b (PCV2b) and porcine reproductive and respiratory syndrome virus (PRRSV) co-infection in epithelial cells of the swine respiratory tract is unknown. In the present study, the newborn pig trachea cell line NPTr-CD163, which is permissive to both viruses, was persistently infected with PCV2b and then with PRRSV. The viral replication, cell viability, cytokines' mRNA expression, and modulation of cellular genes expression were evaluated in infected cells. In NPTr-CD163 co-infection model, ...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Yaima Burgher Pulgaron Chantale Provost Fernando Alvarez Europa Meza Marie-Jeanne Pesant Christopher A Price Carl A Gagnon Source Type: research
Protection of laying chickens against the Canadian DMV/1639 infectious bronchitis virus infection through priming with heterologous live vaccine and boosting with heterologous or homologous inactivated vaccine
Virus Res. 2023 Nov 21:199281. doi: 10.1016/j.virusres.2023.199281. Online ahead of print.ABSTRACTThe emergence of the Canadian DMV/1639 infectious bronchitis virus (IBV) type strains was associated with egg production disorders in Eastern Canadian layer operations. While developing vaccines for novel IBV variants is not typically a reasonable approach, the consideration of an autogenous vaccine becomes more appealing, particularly when the new variant presents significant economic challenges. The current study aimed to compare the efficacies of two vaccination programs that included heterologous live priming by Massachuse...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Mohamed S H Hassan Ahmed Ali Motamed Elsayed Mahmoud Danah Altakrouni Shahnas M Najimudeen Mohamed Faizal Abdul-Careem Source Type: research
N < sup > pro < /sup > of Classical swine fever virus enhances HMGB1 acetylation and its degradation by lysosomes to evade from HMGB1-mediated antiviral immunity
Virus Res. 2023 Nov 21:199280. doi: 10.1016/j.virusres.2023.199280. Online ahead of print.ABSTRACTClassical swine fever virus (CSFV) can dampen the host innate immunity by destabilizing IRF3 upon its binding with viral Npro. High mobility group box 1 (HMGB1), a non-histone nuclear protein, has diverse functions, including inflammation, innate immunity, etc., which are closely related to its cellular localization. We investigated potential mutual interactions between CSFV and HMGB1 and their effects on virus replication. We found that HMGB1 at the protein level, but not at mRNA level, was markedly reduced in CSFV-infected o...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Xiao Han Hankun Xu Yifan Weng Rong Chen Jidong Xu Tong Cao Renjie Sun Ying Shan Fang He Weihuan Fang Xiaoliang Li Source Type: research
DUSP1 mRNA modulation during porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-infection regulates viruses replication
Virus Res. 2023 Nov 21:199282. doi: 10.1016/j.virusres.2023.199282. Online ahead of print.ABSTRACTThe effects of porcine circovirus type 2b (PCV2b) and porcine reproductive and respiratory syndrome virus (PRRSV) co-infection in epithelial cells of the swine respiratory tract is unknown. In the present study, the newborn pig trachea cell line NPTr-CD163, which is permissive to both viruses, was persistently infected with PCV2b and then with PRRSV. The viral replication, cell viability, cytokines' mRNA expression, and modulation of cellular genes expression were evaluated in infected cells. In NPTr-CD163 co-infection model, ...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Yaima Burgher Pulgaron Chantale Provost Fernando Alvarez Europa Meza Marie-Jeanne Pesant Christopher A Price Carl A Gagnon Source Type: research
Protection of laying chickens against the Canadian DMV/1639 infectious bronchitis virus infection through priming with heterologous live vaccine and boosting with heterologous or homologous inactivated vaccine
Virus Res. 2023 Nov 21:199281. doi: 10.1016/j.virusres.2023.199281. Online ahead of print.ABSTRACTThe emergence of the Canadian DMV/1639 infectious bronchitis virus (IBV) type strains was associated with egg production disorders in Eastern Canadian layer operations. While developing vaccines for novel IBV variants is not typically a reasonable approach, the consideration of an autogenous vaccine becomes more appealing, particularly when the new variant presents significant economic challenges. The current study aimed to compare the efficacies of two vaccination programs that included heterologous live priming by Massachuse...
Source: Virus Research - November 23, 2023 Category: Virology Authors: Mohamed S H Hassan Ahmed Ali Motamed Elsayed Mahmoud Danah Altakrouni Shahnas M Najimudeen Mohamed Faizal Abdul-Careem Source Type: research
Isolation and characterization of a novel temperate bacteriophage infecting Aeromonas hydrophila isolated from a Macrobrachium rosenbergii larvae pond
In conclusion, this study increased our knowledge about a new temperate phage of A. hydrophila with strong lytic ability.PMID:37992971 | DOI:10.1016/j.virusres.2023.199279 (Source: Virus Research)
Source: Virus Research - November 22, 2023 Category: Virology Authors: Sunjian Lyu Fulei Xiong Tianpeng Qi Weifeng Shen Qi Guo Mingming Han Li Liu Weishao Bu Julin Yuan Bao Lou Source Type: research
Abnormalities in red blood cell production and pathogenesis of anemia in the progression of rock bream iridovirus (RBIV)
In this study, the viral replication patterns, blood characteristics and anemia-related factors were evaluated in rock bream post RBIV infection. The virus-infected RBCs of rock bream demonstrated similarities in the expression levels of hemoglobins (HGB) (α and β), cytokine-dependent hematopoietic cell linker (CLNK) and hematopoietic transcription factor GATA (GATA), with significantly decreasing levels from 4 days post infection (dpi) to 17 (dpi), when the viral replication was at its peak. This suggests that the expression of blood-related genes is inadequate for HGB synthesis and RBC production, thereby causing anemi...
Source: Virus Research - November 20, 2023 Category: Virology Authors: Soo-Jin Kim Jayeon Cheon Mi Young Cho Sung-Ju Jung Myung-Hwa Jung Source Type: research
Abnormalities in red blood cell production and pathogenesis of anemia in the progression of rock bream iridovirus (RBIV)
In this study, the viral replication patterns, blood characteristics and anemia-related factors were evaluated in rock bream post RBIV infection. The virus-infected RBCs of rock bream demonstrated similarities in the expression levels of hemoglobins (HGB) (α and β), cytokine-dependent hematopoietic cell linker (CLNK) and hematopoietic transcription factor GATA (GATA), with significantly decreasing levels from 4 days post infection (dpi) to 17 (dpi), when the viral replication was at its peak. This suggests that the expression of blood-related genes is inadequate for HGB synthesis and RBC production, thereby causing anemi...
Source: Virus Research - November 20, 2023 Category: Virology Authors: Soo-Jin Kim Jayeon Cheon Mi Young Cho Sung-Ju Jung Myung-Hwa Jung Source Type: research
Abnormalities in red blood cell production and pathogenesis of anemia in the progression of rock bream iridovirus (RBIV)
In this study, the viral replication patterns, blood characteristics and anemia-related factors were evaluated in rock bream post RBIV infection. The virus-infected RBCs of rock bream demonstrated similarities in the expression levels of hemoglobins (HGB) (α and β), cytokine-dependent hematopoietic cell linker (CLNK) and hematopoietic transcription factor GATA (GATA), with significantly decreasing levels from 4 days post infection (dpi) to 17 (dpi), when the viral replication was at its peak. This suggests that the expression of blood-related genes is inadequate for HGB synthesis and RBC production, thereby causing anemi...
Source: Virus Research - November 20, 2023 Category: Virology Authors: Soo-Jin Kim Jayeon Cheon Mi Young Cho Sung-Ju Jung Myung-Hwa Jung Source Type: research
5' Copyback Defective Viral Genomes are Major Component in Clinical and Non-clinical Influenza Samples
Virus Res. 2023 Nov 17:199274. doi: 10.1016/j.virusres.2023.199274. Online ahead of print.ABSTRACTClinical samples from people with influenza disease have been analyzed to assess the presence and abundance of Defective Viral Genomes (DVGs), but these have not been assessed using the same bioinformatic pipeline. The type of DVG most described for influenza infections (deletion DVGs) differs from the most commonly described DVGs from non-segmented negative stranded viruses (5' copyback). This could be attributed to either differences between viruses or the tools used to detect and characterize DVGs. Here we analyze several N...
Source: Virus Research - November 19, 2023 Category: Virology Authors: Xing Li Zhiping Ye Ewan P Plant Source Type: research
Appelmans protocol - a directed in vitro evolution enables induction and recombination of prophages with expanded host range
Virus Res. 2023 Nov 17:199272. doi: 10.1016/j.virusres.2023.199272. Online ahead of print.ABSTRACTInfections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) present significant healthcare challenges due to limited treatment options. Bacteriophage (phage) therapy offers potential as an alternative treatment. However, the high host specificity of phages poses challenges for their therapeutic application. To broaden the phage spectrum, laboratory-based phage training using the Appelmans protocol was employed in this study. As a result, the protocol successfully expanded the host range of a phage cocktail targeti...
Source: Virus Research - November 19, 2023 Category: Virology Authors: Thao Nguyen Vu Justin Ryan Clark Eris Jang Roshan D'Souza Le Phuong Nguyen Naina Adren Pinto Seongjun Yoo Ricardo Enrique Abadie Saenz Anthony William Maresso Dongeun Yong Source Type: research
