Non-cutaneous syncytial myoepitheliomas are identical to cutaneous counterparts: a clinicopathologic study of 24 tumors occurring at diverse locations
ConclusionSyncytial myoepithelioma is a rare but recognizable morphologic variant of myoepithelioma which may have a predilection for skin but also occurs in diverse non-cutaneous sites. Our series provides evidence supporting a reappraisal of the term “cutaneous syncytial myoepithelioma,” as 25% of patients in our series presented with non-cutaneous tumors; thus, we propose the term “syncytial myoepithelioma” to aid pathologist recognition and avoidance of potentially confusing terminology when referring to non-cutaneous examples. The beh avior of syncytial myoepithelioma, whether it arises in cutaneous or non-cut...
Source: Virchows Archiv - August 7, 2023 Category: Pathology Source Type: research
Coinciding kappa AL amyloidosis and kappa light chain deposition disease in the lung
(Source: Virchows Archiv)
Source: Virchows Archiv - August 3, 2023 Category: Pathology Source Type: research
Aggressive B-cell non-Hodgkin lymphomas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology
AbstractAggressive B-cell non-Hodgkin lymphomas are a heterogeneous group of diseases and our concepts are evolving as we learn more about their clinical, pathologic, molecular genetic features. Session IV of the 2020 EAHP Workshop covered aggressive, predominantly high-grade B-cell lymphomas, many that were difficult to classify. In this manuscript, we summarize the features of the submitted cases and highlight differential diagnostic difficulties. We specifically review issues related to high-grade B-cell lymphomas (HGBCLs) withMYC andBCL2 and/orBCL6 rearrangements including TdT expression in these cases, HGBCL, not othe...
Source: Virchows Archiv - August 2, 2023 Category: Pathology Source Type: research
Mediastinal large B cell lymphoma and surrounding gray areas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology
AbstractSession 3 of the 2021 European Association for Haematopathology/Society for Hematopathology Workshop focused on mediastinal large B cell lymphomas and surrounding gray areas. One half of the session was dedicated to primary mediastinal large B cell lymphoma (PMBL) and included cases with classic clinicopathologic features, as well as cases with either morphologic or immunophenotypic variation, and PMBL-like cases with primary extramediastinal disease. The role of additional immunophenotyping and/or molecular testing to aid in the diagnosis of PMBL was discussed. The second half of the session focused on mediastinal...
Source: Virchows Archiv - August 2, 2023 Category: Pathology Source Type: research
The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology
AbstractSession 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. Next, unusual cases with combined growth patterns and evolution of morphological features over time were presented to explore the clinicopathological impact of pr...
Source: Virchows Archiv - August 2, 2023 Category: Pathology Source Type: research
In this issue
(Source: Virchows Archiv)
Source: Virchows Archiv - August 1, 2023 Category: Pathology Source Type: research
Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics —a report of the 2022 EA4HP/SH lymphoma workshop
AbstractFollicular helper T-cell lymphomas (TFH lymphomas) were discussed in session V of the lymphoma workshop of the European Association for Haematopathology (EA4HP)/Society for Hematopathology (SH) 2022 meeting in Florence, Italy. The session focused on the morphologic spectrum of TFH lymphoma, including its three subtypes: angioimmunoblastic-type (AITL), follicular-type, and not otherwise specified (NOS). The submitted cases encompassed classic examples of TFH lymphoma and unusual cases such as those with early or indolent presentations, associated B-cell proliferations, or Hodgkin/Reed –Sternberg-like cells. The re...
Source: Virchows Archiv - July 27, 2023 Category: Pathology Source Type: research
Automated quantification of stromal tumour infiltrating lymphocytes is associated with prognosis in breast cancer
In this study, we validated a deep-learning breast cancer sTIL scoring model (smsTIL) based on the segmentation of tumour cells, benign ductal cells, lymphocytes, plasma cells, necrosis, and ‘other’ cells in whole slide images (WSI). Focusing on HER2 + and TNBC patient samples, we assessed the concordance between sTIL visual scoring and the smsTIL in 130 WSI. Furthermore, we analysed 175 WSI to correlate smsTIL with clinical data and patient outcomes. We found a high correlation between sTIL values scored visua lly and semi-automatically (R = 0.76;P = 2.2e-16). Patients with higher smsTIL had better overall...
Source: Virchows Archiv - July 27, 2023 Category: Pathology Source Type: research
PRAME immunohistochemistry in soft tissue tumors and mimics: a study of 350 cases highlighting its imperfect specificity but potentially useful diagnostic applications
AbstractPreferentially expressed antigen in melanoma (PRAME) immunohistochemistry is currently used in pathology for the assessment of melanocytic neoplasms; however, knowledge of its expression patterns in soft tissue tumors is limited. PRAME immunohistochemistry (clone QR005) was assessed on whole tissue sections of 350 soft-tissue tumors and mimics (> 50 histotypes). PRAME immunoreactivity was evaluated as follows: 0 “negative” (0% positive cells); 1+ (1–25% positive cells); 2+ (26–50% positive cells); 3+ (51–75% positive cells), and 4+ “diffuse” (> 75% positive cells). PRAME was expressed in 111 les...
Source: Virchows Archiv - July 21, 2023 Category: Pathology Source Type: research
Novel NONO::TFE3 fusion and ALK co-expression identified in a subset of cutaneous microcystic/reticular schwannoma
AbstractMicrocystic/reticular schwannoma (MRS) is a benign variant of schwannoma with a predilection for the gastrointestinal tract and skin. To date, genetic characterization of this tumor is limited. Prompted by the identification ofTFE3::NONO fusion and ALK overexpression in an index case of MRS, a cohort of tumors was collected from institutional and consultation archives of two institutions. Next-generation sequencing (NGS),TFE3 fluorescence in situ hybridization (FISH), and TFE3 and ALK immunohistochemistry were performed, while clinicopathologic variables were documented. Eighteen MRS cases were identified (35 to 85...
Source: Virchows Archiv - July 19, 2023 Category: Pathology Source Type: research
Prognostic value and clinicopathological roles of the tumor immune microenvironment in salivary duct carcinoma
We examined the immunohistochemical expression of CD8, FOXP3, PD1, PD-L1, CTLA4, LAG3, and mismatch repair (MMR) proteins, tumor-infiltrating lymphocytes (TILs), and microsatellite instability (MSI) status in 175 cases of SDC. The associations between these TIME-related markers and the clinicopathological factors and prognosis were evaluated. An elevated expression of CD8, FOXP3, PD1, CTLA4, and LAG3 was associated with more aggressive histological features and an advanced N and/or M classification, elevated Ki-67 index, and poor prognosis. Furthermore, cases with a high PD-L1 expression exhibited more aggressive histologi...
Source: Virchows Archiv - July 19, 2023 Category: Pathology Source Type: research
Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2 cases
AbstractThree main uterine leiomyoma molecular subtypes include tumors withMED12 mutation, molecular aberrations leading to HMGA2 overexpression, and biallelic loss of FH. These aberrations are mutually exclusive and can be found in approximately 80 –90% of uterine leiomyoma, in which they seem to be a driver event. Approximately 10% of uterine leiomyoma, however, does not belong to any of these categories. Uterine leiomyoma with HMGA2 overexpression is the most common subtype in cellular and second most common category of usual leiomyoma. In some of these tumors, rearrangement ofHMGA2 gene is present. The most common fu...
Source: Virchows Archiv - July 19, 2023 Category: Pathology Source Type: research
Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) – low TIL density may predict poorer long-term prognosis in T1 laryngeal cancer
In conclusion, in patients treated for T1 glottic LSCC, low stromal TIL density was associated with local recurrences and new primary tumors of the larynx. High PD-L1 expression with low stromal TIL density may be associated with worse survival in T1 glottic LSCC. (Source: Virchows Archiv)
Source: Virchows Archiv - July 18, 2023 Category: Pathology Source Type: research
MYCN amplification, TERT rearrangements and ATRX mutations in neuroblastoma: clinicopathological correlates- an Indian perspective
ConclusionsOur results provide data indicating poor clinical outcome in NB carryingMYCN amplification andTERT-mRNA upregulation. (Source: Virchows Archiv)
Source: Virchows Archiv - July 17, 2023 Category: Pathology Source Type: research
Evaluation of high-risk human papillomavirus in sinonasal papillomas and squamous cell carcinomas
AbstractThe sinonasal tract is considered a second hotspot for human papillomavirus (HPV)-related tumors in the head and neck, with HPV being identified in up to 62% of squamous cell carcinomas (SCCs) and 38% of papillomas. There is limited data from geographical regions with low prevalence of high-risk (HR)-HPV on the association of HR-HPV in sinonasal neoplasms and on utility of p16 as a surrogate marker. p16 immunohistochemistry, HR-HPV mRNA ISH and quantitative real-time PCR (qPCR) were performed on a retrospective cohort of sinonasal papillomas and SCCs.KRAS mutation analysis was done in oncocytic papillomas. p16 ...
Source: Virchows Archiv - July 15, 2023 Category: Pathology Source Type: research
