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Elevated circulating Th2 but not group 2 innate lymphoid cell responses characterize canine atopic dermatitis
Publication date: Available online 24 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Simon P. Früh, Mridusmita Saikia, Jeremy Eule, Christina A. Mazulis, Julia E. Miller, Joby M. Cowulich, Oyebola O. Oyesola, Lauren M. Webb, Seth A. Peng, Rebecca L. Cubitt, Charles G. Danko, William H. Miller, Elia D. Tait WojnoAbstractAtopic dermatitis (AD) is an allergic skin disease that causes significant morbidity and affects multiple species. AD is highly prevalent in companion dogs and the clinical management of the disease remains challenging. An improved understanding of the immunologic and genetic pathwa...
Source: Veterinary Immunology and Immunopathology - January 25, 2020 Category: Veterinary Research Source Type: research

Title: Identification of Canine IgG and its subclasses, IgG1, IgG2, IgG3 and IgG4, by Immunofixation and Commercially Available Antisera
Publication date: Available online 23 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Dillon Donaghy, A Russell MooreAbstractImmunofixation is a diagnostic and research tool used for characterizing the electrophoretic location of immunoglobulin fractions in serum and urine. Commercially available polyclonal antisera which discriminate two IgG subclasses (IgG1 and IgG2) are available and commonly used. More recently, four IgG subclasses have been defined in the dog based on cDNA data. Archived serum from 16 dogs with naturally occurring monoclonal or biclonal gammopathies were characterized using rou...
Source: Veterinary Immunology and Immunopathology - January 24, 2020 Category: Veterinary Research Source Type: research

Contribution of astrocytes and macrophage migration inhibitory factor to immune-mediated canine encephalitis caused by the distemper virus
Publication date: Available online 20 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Tatianna F.S. De Nardo, Paulo H.L. Bertolo, Priscila A. Bernardes, Danísio P. Munari, Gisele F. Machado, Luciana S. Jardim, Pamela R.R. Moreira, Mayara C. Rosolem, Rosemeri O. VasconcelosABSTRACTMacrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that is produced by many cell types in situations of homeostasis or disease. One of its functions is to act as a proinflammatory molecule. In humans, several studies have shown that MIF levels become elevated in the serum, urine, cerebrospinal fluid and...
Source: Veterinary Immunology and Immunopathology - January 20, 2020 Category: Veterinary Research Source Type: research

Cytokine tear film profile determination in eyes of healthy dogs and those with inflammatory periocular and skin disorders
Publication date: Available online 16 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): P.S. Martinez, C.M. Pucheu, C.C. Liu, R.T. CarterAbstractAlterations in serum cytokine levels and profiles have been reported in association with a variety of disease conditions (e.g., allergic, immune-mediated, etc.) in both humans and animals. In comparison to serum cytokine measurements, tear cytokine measurements might be expected to more accurately reflect the inflammatory milieu associated with periocular disease. The purpose of this study was to use a multiplexed assay to compare the cytokine profile of tear...
Source: Veterinary Immunology and Immunopathology - January 17, 2020 Category: Veterinary Research Source Type: research

Effect of the complete replacement of dietary fish meal by soybean meal on histopathology and immune response of the hindgut in grass carp (Ctenopharyngodon idellus)
In conclusion, grass carp SBMIE is regulated by the adjustment of SBM-based diet intake, and the changes of the above-mentioned genes expression suggest that these genes may be involved in SBMIE. (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - January 9, 2020 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: January 2020Source: Veterinary Immunology and Immunopathology, Volume 219Author(s): (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - January 4, 2020 Category: Veterinary Research Source Type: research

Genotype-associated differences in bursal recovery after infectious bursal disease virus (IBDV) inoculation
This study suggests, that the impact of T-cell immunity on the recovery process after IBDV infection may need to be considered further for the development of new breeding programs for disease resistant chicken lines. (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - December 20, 2019 Category: Veterinary Research Source Type: research

Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits
Publication date: Available online 18 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): M. Bjelka, K. NovákAbstractThe bovine genes TLR1, TLR2 and TLR6, which encode Toll-like receptors, key components of the innate immune system, were screened for polymorphisms in Czech Red Pied (Czech Simmental) cattle, and the different variants present in the population were tested for association with reproductive and fitness traits. Diversity was investigated in a group of 164 bulls using hybrid resequencing of pooled amplicons with PacBio technology and of pooled genomic DNA using HiSeq X-Ten technology. The ...
Source: Veterinary Immunology and Immunopathology - December 19, 2019 Category: Veterinary Research Source Type: research

Anti-inflammatory effects of a p38 MAP kinase inhibitor, doramapimod, against bacterial cell wall toxins in equine whole blood
Publication date: Available online 17 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Jennifer R. Bauquier, Brett S. Tennent-Brown, Elizabeth Tudor, Simon R. BaileyAbstractDoramapimod (BIRB-796-BS), is an anti-inflammatory compound, acting through p38 MAPK inhibition, but its anti-inflammatory effects have not previously been studied in the horse. Whole blood aliquots from healthy horses diluted 1:1 with cell culture medium were incubated for 21 hours with 1 µg/ml of lipopolysaccharide (LPS), lipoteichoic acid (LTA) or peptidoglycan (PGN) in the presence of increasing concentrations of doramap...
Source: Veterinary Immunology and Immunopathology - December 19, 2019 Category: Veterinary Research Source Type: research

Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma
Publication date: Available online 16 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Erin Cletzer, Shawna Klahn, Nikolaos Dervisis, Tanya LeRoithAbstractDysregulation of the Janus Kinase (JAK) – Signal Transducer and Activator of Transcription (STAT) cellular signaling pathway has been associated with the development and progression of multiple human cancers. STAT3 has been reported to be present and constitutively active in a number of veterinary cancers, and few studies have reported mutations or activation of JAK1 or JAK2. Archived tissue samples from 54 client-owned dogs with histologically-...
Source: Veterinary Immunology and Immunopathology - December 17, 2019 Category: Veterinary Research Source Type: research

Evaluation of protective efficacy of inactivated Mycoplasma synoviae vaccine with different adjuvants
Publication date: Available online 12 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Xiaowei Gong, Qiwei Chen, Naola Ferguson-Noel, Laszlo Stipkovits, Susan Szathmary, Yongsheng Liu, Fuying ZhengAbstractMycoplasma synoviae (MS) is a poultry pathogen with a reported distribution throughout the world. Vaccination is utilized as an important component of MS control programs for MS infection. The aim of this study was to evaluate protection efficacy of an inactivated MS vaccine (MS bacterin) with different adjuvants in broilers against a Chinese field isolate (CHN-BZJ2-2015). Vaccination with adjuvant...
Source: Veterinary Immunology and Immunopathology - December 14, 2019 Category: Veterinary Research Source Type: research

A Novel Bovine CXCL15 Gene in The GRO Chemokine Gene Cluster
The objectives of this study are to annotate the gene sequence and compare the gene transcription levels among different bovine tissues based on our published microarray data. The gene transcribing the EST contains a 90-amino acid protein sequence. The results of bioinformatic analyses using comparative genetics, multiple sequence alignments, phylogenetic analysis and promoter sequence analysis indicated that this gene is a novel ELR + CXCL gene orthologous to mouse CXCL15. The gene is highly conserved in ruminants and exists in many mammals but not in chickens, primates or pigs. Phylogenetic analysis and gene structur...
Source: Veterinary Immunology and Immunopathology - December 11, 2019 Category: Veterinary Research Source Type: research

Transcriptomic profile of chicken Bone Marrow-Derive Dendritic cells in response to H9N2 avian influenza A virus
Publication date: Available online 9 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Qingtao Liu, Jing Yang, Xinmei Huang, Yuzhuo Liu, Kaikai Han, Dongmin Zhao, Lijiao Zhang, Yin LiAbstractAvian influenza subtype H9N2 infection is a mild but highly contagious disease that is associated with a decrease in the efficacy of vaccine interventions, and an increase in susceptibility to secondary infections in poultry. However, the immune evasion mechanism of H9N2 avian influenza viruses (AIVs) in chickens is poorly understood. Dendritic cells (DCs) are immune cells of major importance, involved in innate ...
Source: Veterinary Immunology and Immunopathology - December 10, 2019 Category: Veterinary Research Source Type: research

Multivariate analysis of the immune response to different rabies vaccines
This study showed that the immune fingerprint approach can be used to screen vaccine formulations. It provides additional information compared to classical vaccination and infectious challenge efficacy study. (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - December 9, 2019 Category: Veterinary Research Source Type: research

Different doses of tannin reflect a double-edged impact on broiler chicken immunity
Publication date: Available online 9 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Amany Ramah, Masahiro Yasuda, Yuki Ohashi, Marimu Urakawa, Tetsuo Kida, Tenya Yanagita, Ryoko Uemura, Hatem H. Bakery, Nabila M. Abdelaleem, Elham A. El-ShewyAbstractTannin is one of the most common phytochemical secondary phenolic metabolites, which is widely distributed in various plant production systems. Dietary intake of tannin can exert different actions on the immune system. The aim of this study was to evaluate the influence of different concentrations on broiler chicken immunity. Three groups (n = 10 i...
Source: Veterinary Immunology and Immunopathology - December 9, 2019 Category: Veterinary Research Source Type: research