Editorial Board
Publication date: April 2020Source: Veterinary Immunology and Immunopathology, Volume 222Author(s): (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - March 25, 2020 Category: Veterinary Research Source Type: research

CellTrace Violet™ inhibits equine lymphocyte proliferation
Publication date: Available online 18 March 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): J. Lacy Kamm, Natalie A. Parlane, Christopher B. Riley, Erica K. Gee, Joanna M. Roberts, C. Wayne McIlwraith (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - March 19, 2020 Category: Veterinary Research Source Type: research

Phenotypic characterization of equine monocyte-derived dendritic cells generated ex vivo utilizing commercially available serum-free medium
Publication date: Available online 17 March 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Brina S. Lopez, David J. Hurley, Shyla Giancola, Steeve Giguère, M. Julia. B. Felippe, Kelsey A. Hart (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - March 18, 2020 Category: Veterinary Research Source Type: research

Immunopathological characterization of red focal changes in Atlantic salmon (Salmo salar) white muscle
Publication date: Available online 12 March 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Håvard Bjørgen, Subramani Kumar, Gjermund Gunnes, Charles McL. Press, Espen Rimstad, Erling Olaf Koppang (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - March 13, 2020 Category: Veterinary Research Source Type: research

T cell epitope content comparison (EpiCC) analysis demonstrates a bivalent PCV2 vaccine has greater T cell epitope overlap with field strains than monovalent PCV2 vaccines
Publication date: Available online 6 March 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Meggan Bandrick, Andres H. Gutierrez, Prerak Desai, Gonzalo Rincon, William D. Martin, Frances E. Terry, Anne S. De Groot, Dennis L. Foss (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - March 7, 2020 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: March 2020Source: Veterinary Immunology and Immunopathology, Volume 221Author(s): (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - March 3, 2020 Category: Veterinary Research Source Type: research

Associations between circulating levels of natural antibodies, total serum immunoglobulins, and polymorphonuclear leukocyte function in early postpartum dairy cows
Publication date: Available online 26 February 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): T.H. Silva, M.L. Celestino, P.R. Menta, R.C. Neves, M.A. Ballou, V.S. Machado (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - February 27, 2020 Category: Veterinary Research Source Type: research

Measuring CMI responses using the PrimeFlow RNA assay: A new method of evaluating BVDV vaccination response in cattle
This study also demonstrated a decrease in the frequency and amount of BVDV in PBMCs, harvested from vaccinated calves and exposed to BVDV in vitro. Collectively data from this study highlights the association between an increase in IFN-γ and a decreased infection rate of isolated PBMC’s, based on the frequency and amount of BVDV positive cells following in vitro exposure. This new method combines not only the ability to evaluate cellular responses, but also the ability to understand potential antiviral properties associated with cellular responses. This is the first assay to describe and simultaneously measure CMI resp...
Source: Veterinary Immunology and Immunopathology - February 16, 2020 Category: Veterinary Research Source Type: research

Measuring CMI responses using the PrimeFlow RNA assay; a new method of evaluating BVDV vaccination response in cattle
This study also demonstrated a decrease in the frequency and amount of BVDV in PBMCs, harvested from vaccinated calves and exposed to BVDV in vitro. Collectively data from this study highlights the association between an increase in IFN-γ and a decreased infection rate of isolated PBMC’s, based on the frequency and amount of BVDV positive cells following in vitro exposure. This new method combines not only the ability to evaluate cellular responses, but also the ability to understand potential antiviral properties associated with cellular responses. This is the first assay to describe and simultaneously measure CMI resp...
Source: Veterinary Immunology and Immunopathology - February 12, 2020 Category: Veterinary Research Source Type: research

Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle
This study demonstrates the optimisation of this commercially available assay for systemic immune phenotyping in cattle. The early immune response in Holstein-Friesian bull calves (n = 10) was assessed by haematology, flow cytometry and cytokine expression profiling after 24 hour ex-vivo PAMP (LPS, poly (I:C) and Zymosan) stimulation in TruCulture® tubes. A comparative analysis was also performed with a traditional whole blood stimulation assay and cell viability using both systems was also evaluated. Results: Supernatant collected from TruCulture® tubes showed a significant increase in IL-1β and IL-8 expression c...
Source: Veterinary Immunology and Immunopathology - February 12, 2020 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: February 2020Source: Veterinary Immunology and Immunopathology, Volume 220Author(s): (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - February 5, 2020 Category: Veterinary Research Source Type: research

Memory B cells and tuberculosis
Publication date: Available online 2 February 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Konstantin P. Lyashchenko, H. Martin Vordermeier, W. Ray WatersAbstractImmunological memory is a central feature of adaptive immunity. Memory B cells are generated upon stimulation with antigen presented by follicular dendritic cells in the peripheral lymphoid tissues. This process typically involves class-switch recombination and somatic hypermutation and it can be dependent or independent on germinal centers or T cell help. The mature B cell memory pool is generally characterized by remarkable heterogeneity of fu...
Source: Veterinary Immunology and Immunopathology - February 4, 2020 Category: Veterinary Research Source Type: research

Identification of canine IgG and its subclasses, IgG1, IgG2, IgG3 and IgG4, by immunofixation and commercially available antisera
Publication date: March 2020Source: Veterinary Immunology and Immunopathology, Volume 221Author(s): Dillon Donaghy, A Russell MooreAbstractImmunofixation is a diagnostic and research tool used for characterizing the electrophoretic location of immunoglobulin fractions in serum and urine. Commercially available polyclonal antisera which discriminate two IgG subclasses (IgG1 and IgG2) are available and commonly used. More recently, four IgG subclasses have been defined in the dog based on cDNA data. Archived serum from 16 dogs with naturally occurring monoclonal or biclonal gammopathies were characterized using routine serum...
Source: Veterinary Immunology and Immunopathology - January 29, 2020 Category: Veterinary Research Source Type: research

Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population
Publication date: Available online 26 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Melissa H. Siard-Altman, Patricia A. Harris, Amber D. Moffett-Krotky, Joanne L. Ireland, Alejandra Betancourt, Virginia D. Barker, Kellie E. McMurry, Stephanie E. Reedy, Amanda A. AdamsAbstractSimilarly to aged humans, senior horses (≥20 years) exhibit chronic low-grade inflammation systemically, known as inflamm-aging. Inflamm-aging in the senior horse has been characterized by increased circulating inflammatory cytokines as well as increased inflammatory cytokine production by lymphocytes and monocytes in respo...
Source: Veterinary Immunology and Immunopathology - January 27, 2020 Category: Veterinary Research Source Type: research

Vincristine, carboplatin and cisplatin increase oxidative burst induced by paf in canine neutrophils
Publication date: Available online 24 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Nathalia Mendez, Pablo Alarcon, Catalina Millán, Rafael A. Burgos, Francisco J. Morera, Javier OjedaAbstractMyelosupression resulting from chemotherapy has been widely described in veterinary medicine; however, there is limited information relating to alterations in neutrophil function after chemotherapy in dogs with cancer. The aim of this study was to determine the non-proliferative effects of vincristine, carboplatin, and cisplatin on canine neutrophils by evaluating activation of oxidative and non-oxidative re...
Source: Veterinary Immunology and Immunopathology - January 25, 2020 Category: Veterinary Research Source Type: research