Characterisation of the pruritus responses and pruritic behaviours in an interleukin 31-induced canine model of pruritus
CONCLUSIONS AND CLINICAL RELEVANCE: In conclusion, intravenous IL-31 reproducibly induces itch responses in dogs. Future evaluations of the canine IL-31 pruritic model should assess total pruritic behaviours in seconds rather than using a biased 'YES/NO' behaviour per 1 min scoring system.PMID:38149639 | DOI:10.1111/vde.13231 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 27, 2023 Category: Veterinary Research Authors: Jason Pearson Tara Denley Amanda Blubaugh Sujung Jun Kim Jonathan E Fogle Renato Leon Caleb Goss Frane Banovic Source Type: research
Characterisation of the pruritus responses and pruritic behaviours in an interleukin 31-induced canine model of pruritus
CONCLUSIONS AND CLINICAL RELEVANCE: In conclusion, intravenous IL-31 reproducibly induces itch responses in dogs. Future evaluations of the canine IL-31 pruritic model should assess total pruritic behaviours in seconds rather than using a biased 'YES/NO' behaviour per 1 min scoring system.PMID:38149639 | DOI:10.1111/vde.13231 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 27, 2023 Category: Veterinary Research Authors: Jason Pearson Tara Denley Amanda Blubaugh Sujung Jun Kim Jonathan E Fogle Renato Leon Caleb Goss Frane Banovic Source Type: research
Characterisation of the pruritus responses and pruritic behaviours in an interleukin 31-induced canine model of pruritus
CONCLUSIONS AND CLINICAL RELEVANCE: In conclusion, intravenous IL-31 reproducibly induces itch responses in dogs. Future evaluations of the canine IL-31 pruritic model should assess total pruritic behaviours in seconds rather than using a biased 'YES/NO' behaviour per 1 min scoring system.PMID:38149639 | DOI:10.1111/vde.13231 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 27, 2023 Category: Veterinary Research Authors: Jason Pearson Tara Denley Amanda Blubaugh Sujung Jun Kim Jonathan E Fogle Renato Leon Caleb Goss Frane Banovic Source Type: research
Abstracts of the scientific communications presented at the 34th European Veterinary Dermatology Congress Organized by ESVD-ECVD, Gothenburg, Sweden, 31 August-2 September 2023
Vet Dermatol. 2023 Dec 18. doi: 10.1111/vde.13222. Online ahead of print.NO ABSTRACTPMID:38111011 | DOI:10.1111/vde.13222 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Source Type: research
Diascopy and histopathological evaluation of nonblanching erythematous dermatoses in dogs
CONCLUSIONS AND CLINICAL RELEVANCE: Negative diascopy was associated with haemorrhage and vascular pathological findings in the majority of cases, yet not all. Haemorrhage was identified histologically in all diseases previously reported as nonblanching as well as in a few additional diseases.PMID:38111018 | DOI:10.1111/vde.13230 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Stephanie Forbes Sonya Bettenay Nadine M Meertens Brett E Wildermuth Kerstin Wildermuth Ralf S Mueller Source Type: research
Cutaneous anaphylactoid reaction to polyoxyethylene hydrogenated castor oil in dogs
CONCLUSIONS AND CLINICAL RELEVANCE: The threshold concentration can serve as a consideration for developing safe new drug formulations and for clinical decision-making around using drugs containing PEG derivatives. IDT is useful to predict the risk of adverse effects. Antihistamines could demonstrate a prophylactic effect.PMID:38111025 | DOI:10.1111/vde.13228 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Yukina Sugiyama Shinpei Kawarai Shinichi Ansai Pradeep Bist Soman N Abraham Takuya Maruo Source Type: research
Tumour necrosis factor- α induces C-C motif chemokine ligand 5 production in canine keratinocytes
CONCLUSIONS AND CLINICAL RELEVANCE: TNF-α may be involved in skin inflammation in dogs by promoting CCL5 production in keratinocytes. Furthermore, the synergistic effect of TNF-α and IFN-γ suggests that the local Th1-type milieu may aggravate skin inflammation. Further studies are required to elucidate the role of TNF-α-induced CCL5 production of keratinocytes in the pathogenesis of cAD.PMID:38111073 | DOI:10.1111/vde.13227 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Kaho Takahashi Taiga Okazawa Tomoaki Shingaki Keiko Furuya Junpei Kimura Keitaro Ohmori Source Type: research
Abstracts of the scientific communications presented at the 34th European Veterinary Dermatology Congress Organized by ESVD-ECVD, Gothenburg, Sweden, 31 August-2 September 2023
Vet Dermatol. 2023 Dec 18. doi: 10.1111/vde.13222. Online ahead of print.NO ABSTRACTPMID:38111011 | DOI:10.1111/vde.13222 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Source Type: research
Diascopy and histopathological evaluation of nonblanching erythematous dermatoses in dogs
CONCLUSIONS AND CLINICAL RELEVANCE: Negative diascopy was associated with haemorrhage and vascular pathological findings in the majority of cases, yet not all. Haemorrhage was identified histologically in all diseases previously reported as nonblanching as well as in a few additional diseases.PMID:38111018 | DOI:10.1111/vde.13230 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Stephanie Forbes Sonya Bettenay Nadine M Meertens Brett E Wildermuth Kerstin Wildermuth Ralf S Mueller Source Type: research
Cutaneous anaphylactoid reaction to polyoxyethylene hydrogenated castor oil in dogs
CONCLUSIONS AND CLINICAL RELEVANCE: The threshold concentration can serve as a consideration for developing safe new drug formulations and for clinical decision-making around using drugs containing PEG derivatives. IDT is useful to predict the risk of adverse effects. Antihistamines could demonstrate a prophylactic effect.PMID:38111025 | DOI:10.1111/vde.13228 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Yukina Sugiyama Shinpei Kawarai Shinichi Ansai Pradeep Bist Soman N Abraham Takuya Maruo Source Type: research
Tumour necrosis factor- α induces C-C motif chemokine ligand 5 production in canine keratinocytes
CONCLUSIONS AND CLINICAL RELEVANCE: TNF-α may be involved in skin inflammation in dogs by promoting CCL5 production in keratinocytes. Furthermore, the synergistic effect of TNF-α and IFN-γ suggests that the local Th1-type milieu may aggravate skin inflammation. Further studies are required to elucidate the role of TNF-α-induced CCL5 production of keratinocytes in the pathogenesis of cAD.PMID:38111073 | DOI:10.1111/vde.13227 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Kaho Takahashi Taiga Okazawa Tomoaki Shingaki Keiko Furuya Junpei Kimura Keitaro Ohmori Source Type: research
Abstracts of the scientific communications presented at the 34th European Veterinary Dermatology Congress Organized by ESVD-ECVD, Gothenburg, Sweden, 31 August-2 September 2023
Vet Dermatol. 2023 Dec 18. doi: 10.1111/vde.13222. Online ahead of print.NO ABSTRACTPMID:38111011 | DOI:10.1111/vde.13222 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Source Type: research
Diascopy and histopathological evaluation of nonblanching erythematous dermatoses in dogs
CONCLUSIONS AND CLINICAL RELEVANCE: Negative diascopy was associated with haemorrhage and vascular pathological findings in the majority of cases, yet not all. Haemorrhage was identified histologically in all diseases previously reported as nonblanching as well as in a few additional diseases.PMID:38111018 | DOI:10.1111/vde.13230 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Stephanie Forbes Sonya Bettenay Nadine M Meertens Brett E Wildermuth Kerstin Wildermuth Ralf S Mueller Source Type: research
Cutaneous anaphylactoid reaction to polyoxyethylene hydrogenated castor oil in dogs
CONCLUSIONS AND CLINICAL RELEVANCE: The threshold concentration can serve as a consideration for developing safe new drug formulations and for clinical decision-making around using drugs containing PEG derivatives. IDT is useful to predict the risk of adverse effects. Antihistamines could demonstrate a prophylactic effect.PMID:38111025 | DOI:10.1111/vde.13228 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Yukina Sugiyama Shinpei Kawarai Shinichi Ansai Pradeep Bist Soman N Abraham Takuya Maruo Source Type: research
Tumour necrosis factor- α induces C-C motif chemokine ligand 5 production in canine keratinocytes
CONCLUSIONS AND CLINICAL RELEVANCE: TNF-α may be involved in skin inflammation in dogs by promoting CCL5 production in keratinocytes. Furthermore, the synergistic effect of TNF-α and IFN-γ suggests that the local Th1-type milieu may aggravate skin inflammation. Further studies are required to elucidate the role of TNF-α-induced CCL5 production of keratinocytes in the pathogenesis of cAD.PMID:38111073 | DOI:10.1111/vde.13227 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - December 19, 2023 Category: Veterinary Research Authors: Kaho Takahashi Taiga Okazawa Tomoaki Shingaki Keiko Furuya Junpei Kimura Keitaro Ohmori Source Type: research
