Tackling Challenges in Assessing the Economic Value of Tumor-Agnostic Therapies: A Cost-Effectiveness Analysis of Pembrolizumab as a Case Study
Assessing the value of tumor-agnostic therapies (TAD) is challenging given the potential variability in treatment effects, trials with small sample sizes, different standards-of-care (SoC), and lack of comparative data from single-arm basket trials. Our study developed and applied novel methods to assess the value of pembrolizumab compared to SoC to inform coverage decisions. (Source: Value in Health)
Source: Value in Health - March 26, 2024 Category: International Medicine & Public Health Authors: Yilin Chen, Peter Martin, Lurdes Y.T. Inoue, Anirban Basu, Josh J. Carlson Source Type: research
Do QALYs discriminate against the elderly? An empirical analysis of published cost effectiveness analyses
Critics of quality-adjusted life years (QALYs) argue that it discriminates against older individuals. However, little empirical evidence has been produced to inform this debate. To compare published cost effectiveness analyses (CEAs) on patients aged ≥65 years and those aged (Source: Value in Health)
Source: Value in Health - March 26, 2024 Category: International Medicine & Public Health Authors: Feng Xie, Ting Zhou, Brittany Humphries, Peter J. Neumann Source Type: research
Methods for including adverse events in economic evaluations: suggestions for improvement.
Inclusion of relevant effectiveness and safety outcomes in economic evaluation of health technologies is required to aid efficient healthcare decisions. Our objective was to identify the key issues related to the inclusion of adverse events (AEs) in economic evaluation and explore perspectives for good practice recommendations to handle these issues. (Source: Value in Health)
Source: Value in Health - March 26, 2024 Category: International Medicine & Public Health Authors: Salah Ghabri, Dalia Dawoud, Michael Drummond Tags: Methodology Source Type: research
Challenges of Incorporating Life Cycle Drug Pricing in Cost-Effectiveness Models: A Review of Methods and Modeling Suggestions
To conduct a review of existing methods used to incorporate life cycle drug pricing (LCDP) in cost-effectiveness analyses (CEAs), identify common methodological challenges, and suggest modeling approaches for prospectively implementing LCDP in CEA. (Source: Value in Health)
Source: Value in Health - March 19, 2024 Category: International Medicine & Public Health Authors: Mathilde Puls, James Horscroft, Benjamin Kearns, Daniel Gladwell, Edward Church, Kasper Johannesen, Bill Malcolm, John Borrill Tags: Systematic Literature Review Source Type: research
Cost-effectiveness of 2 Models of Pessary Care for Pelvic Organ Prolapse: Findings From the TOPSY Randomized Controlled Trial
This study aimed to to investigate the cost-effectiveness of pessary self-management (SM) when compared with clinic-based care (CBC). A decision analytic model was developed to extend the economic evaluation. (Source: Value in Health)
Source: Value in Health - March 14, 2024 Category: International Medicine & Public Health Authors: Sarkis Manoukian, Helen Mason, Suzanne Hagen, Rohna Kearney, Kirsteen Goodman, Catherine Best, Andrew Elders, Lynn Melone, Lucy Dwyer, Melanie Dembinsky, Aethele Khunda, Karen Lesley Guerrero, Doreen McClurg, John Norrie, Ranee Thakar, Carol Bugge Tags: Economic Evaluation Source Type: research
Cost-effectiveness of two models of pessary care for pelvic organ prolapse: Findings from the TOPSY randomised controlled trial.
Pelvic organ prolapse is the descent of one or more reproductive organs from their normal position, causing associated negative symptoms. One conservative treatment option is pessary management. The aim of this study was to investigate the cost-effectiveness of pessary self-management (SM) when compared to clinic-based care (CBC). A decision-analytic model was developed to extend the economic evaluation. (Source: Value in Health)
Source: Value in Health - March 14, 2024 Category: International Medicine & Public Health Authors: Sarkis Manoukian, Helen Mason, Suzanne Hagen, Rohna Kearney, Kirsteen Goodman, Catherine Best, Andrew Elders, Lynn Melone, Lucy Dwyer, Melanie Dembinsky, Aethele Khunda, Karen Lesley Guerrero, Doreen McClurg, John Norrie, Ranee Thakar, Carol Bugge Source Type: research
The Measurement Properties of the EQ Health and Well-being and EQ Health and Well-Being Short Form in Italian Population: A Comparative Study With EQ-5D-5L
The EQ Health and Well-being, EQ-HWB (25-item) and the EQ-HWB-S (9-item), are new generic measures of health and well-being. The purpose of this study was to examine the measurement properties of the EQ-HWB and EQ-HWB-S measures in relation to the EQ-5D-5L among the Italian general population. (Source: Value in Health)
Source: Value in Health - March 13, 2024 Category: International Medicine & Public Health Authors: Maja Kuhari ć, A. Simon Pickard, Clara Mukuria, Aureliano Paolo Finch Tags: Patient-Reported Outcomes Source Type: research
Comparison of EQ Health and Well-Being Long and Short With Other Preference-Based Measures Among United States Informal Caregivers
This study aimed to evaluate the psychometric properties and construct validity of the EQ-HWB/EQ-HWB-S in a US caregiver population. (Source: Value in Health)
Source: Value in Health - March 13, 2024 Category: International Medicine & Public Health Authors: Maja Kuharic, Brendan Mulhern, Lisa K. Sharp, Robin S. Turpin, A. Simon Pickard Tags: Patient-Reported Outcomes Source Type: research
Comparison of EQ Health and Well-Being Long and Short (EQ-HWB/EQ-HWB-S) with Other Preference-Based Measures Among United States Informal Caregivers
This study aimed to evaluate the psychometric properties and construct validity of the EQ-HWB/EQ-HWB-S in a US caregiver population. (Source: Value in Health)
Source: Value in Health - March 13, 2024 Category: International Medicine & Public Health Authors: Maja Kuharic, Brendan Mulhern, Lisa K. Sharp, Robin S. Turpin, A. Simon Pickard Source Type: research
Hepatitis C Elimination in Rwanda: Progress, Feasibility, and Economic Evaluation
In 2018, Rwanda launched a national program to eliminate the hepatitis C virus (HCV). We aim to assess the impact of the program to date and identify strategies to achieve the World Health Organization's HCV elimination goals by 2030. (Source: Value in Health)
Source: Value in Health - March 13, 2024 Category: International Medicine & Public Health Authors: Huaiyang Zhong, Alec Aaron, Lindsey Hiebert, Janvier Serumondo, Yueran Zhuo, Madeline Adee, Gallican N. Rwibasira, John W. Ward, Jagpreet Chhatwal Source Type: research
Psychometric properties of General Oral Health Assessment Index across ages: COSMIN Systematic Review
To systematically review the psychometric properties of the Geriatric Oral Health Assessment Index (GOHAI) across age groups using the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) methodology. (Source: Value in Health)
Source: Value in Health - March 13, 2024 Category: International Medicine & Public Health Authors: Judit Oszl ánszky, László Gulácsi, Márta Péntek, Péter Hermann, Zsombor Zrubka Tags: Systematic Literature Review Source Type: research
The measurement properties of the EQ Health and Wellbeing (EQ-HWB) and EQ Health and Wellbeing Short form (EQ-HWB-S) in Italian Population: A Comparative Study with EQ-5D-5L
The EQ Health and Wellbeing, EQ-HWB (25-item) and the EQ-HWB-S (9-item), are new generic measures of health and wellbeing. The purpose of this study was to examine the measurement properties of the EQ-HWB and EQ-HWB-S measures in relation to the EQ-5D-5L among the Italian general population. (Source: Value in Health)
Source: Value in Health - March 13, 2024 Category: International Medicine & Public Health Authors: Maja Kuhari ć, A. Simon Pickard, Clara Mukuria, Aureliano Paolo Finch Source Type: research
Logical Inconsistencies with Expected Utility Theory May Align Better with Patient Preferences —A Response to Paulden et al.
(Source: Value in Health)
Source: Value in Health - March 12, 2024 Category: International Medicine & Public Health Authors: Anirban Basu Tags: Letter to the Editor Source Type: research
Costs and Productivity Benefits of the Department of Veterans Affairs Maintaining Internal Systems and Strengthening Integrated Outside Networks Act Scribes Trial
To improve access, the VA Maintaining Internal Systems and Strengthening Integrated Outside Networks (MISSION) Act of 2018 mandated a 2-year study of medical scribes in Veterans Health Administration specialty clinics and emergency departments. Medical scribes are employed in clinical settings with the goals of increasing provider productivity and satisfaction by minimizing physicians ’ documentation burden. Our objective is to quantify the economic outcomes of the MISSION Act scribes trial. (Source: Value in Health)
Source: Value in Health - March 8, 2024 Category: International Medicine & Public Health Authors: Paul R. Shafer, Sivagaminathan Palani, Iman Saeed, Aaron Legler, Kyle Barr, Kristina Carvalho, Steven D. Pizer Tags: Economic Evaluation Source Type: research
It is time to reconsider the 3% discount rate
This article seeks to identify an appropriate rate for high-income countries because it can influence projected cost-effectiveness and hence resource allocation recommendations. (Source: Value in Health)
Source: Value in Health - March 8, 2024 Category: International Medicine & Public Health Authors: Joshua T. Cohen Tags: Methodology Source Type: research
