Author Reply: “Emulating Trials and Quantifying Bias: The Convergence of HTA Agency RWE Guidances”
We are grateful to the authors for their letter about our article on emulation of target trials (TTs) with real-world data to inform health technology assessment (HTA).1 We offer the following response and encourage further debate around this important topic. (Source: Value in Health)
Source: Value in Health - December 18, 2023 Category: International Medicine & Public Health Authors: Silvia Moler-Zapata, Andrew Hutchings, Stephen O ’Neill, Richard J. Silverwood, Richard Grieve Tags: Letter to the Editor Source Type: research
Author ’s reply: “Emulating trials and quantifying bias: the convergence of HTA agency RWE guidances”
(Source: Value in Health)
Source: Value in Health - December 18, 2023 Category: International Medicine & Public Health Authors: Silvia Moler-Zapata, Andrew Hutchings, Stephen O ’Neill, Richard J. Silverwood, Richard Grieve Tags: Letter to the Editor Source Type: research
Influence of Self-Reported Health Impairments on German EQ-5D-5L Values
Value Health. 2023;26(11):1636 –1644. (Source: Value in Health)
Source: Value in Health - December 18, 2023 Category: International Medicine & Public Health Authors: Svenja Elkenkamp, Kristina Ludwig, Wolfgang Greiner Tags: Erratum Source Type: research
Logical Inconsistencies in the Health Years in Total and Equal Value of Life-Years Gained
This study aimed to assess whether recently proposed alternatives to the quality-adjusted life-year (QALY), intended to address concerns about discrimination, are suitable for informing resource allocation decisions. (Source: Value in Health)
Source: Value in Health - December 2, 2023 Category: International Medicine & Public Health Authors: Mike Paulden, Chris Sampson, James F. O ’Mahony, Eldon Spackman, Christopher McCabe, Jeff Round, Tristan Snowsill Tags: Methodology Source Type: research
Logical Inconsistencies in the Health Years in Total and Equal Value of Life Years Gained
To assess whether recently-proposed alternatives to the quality-adjusted life year (QALY), intended to address concerns about discrimination, are suitable for informing resource allocation decisions. (Source: Value in Health)
Source: Value in Health - December 2, 2023 Category: International Medicine & Public Health Authors: Mike Paulden, Chris Sampson, James F. O ’Mahony, Eldon Spackman, Christopher McCabe, Jeff Round, Tristan Snowsill Tags: Methodology Source Type: research
Economic Burden and Service Utilization of Children With Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
This study aims to systematically synthesize the literature on service utilization and costs for children with ADHD. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: Mitchell Dodds, Sithara Wanni Arachchige Dona, Lisa Gold, David Coghill, Ha N.D. Le Tags: Systematic Literature Review Source Type: research
P1 Automating Economic Modelling: A Case Study of AI's Potential With Large Language Models
The potential to integrate large language models (LLMs) such as GPT-4 in script extraction and generation could revolutionise the creation and deployment of economic models. The aim of this study was to assess the validity of a partitioned survival model produced by GPT-4 against a published model, comparing treatments for advanced or metastatic non-small cell lung cancer (NSCLC) for patients who had disease progression after platinum-based treatment and had not received prior immunotherapy (CTLA4 or PD-[L]1 inhibitors). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: T. Reason, W. Rawlinson, B. Malcolm, S. Klijn, J. Langham, A. Gimblett Tags: Innovations in Modeling for Health Technology Assessment Source Type: research
P2 NICE's Pathways Pilot: Incorporating Disease-Specific Reference Models Into Health Technology Assessment in England
Like other health technology assessment (HTA) bodies, NICE is seeing an increasing number of technologies being appraised in the same disease area, creating complex pathways with multiple sequential decisions and multi-comparator decision spaces. HTA bodies need to adapt their methods to meet the challenges of providing robust, useful, and timely guidance with ever increasing demand. NICE is developing refined appraisal processes that are proportionate to different needs. Pathways is one approach, built around a core model that spans a disease pathway and multiple technologies. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Brooke, L. Dunning, E. Bell, I. Watson, D. Dawoud, J. Bouvy Source Type: research
P3 Open-Source Model Framework for Health-Economic Evaluation of Early Treatment in Alzheimer's Disease
Recent drug developments in Alzheimer's disease (AD) have increased attention for decision-analytic models to assess their value. Transparency and credibility of decision-models are key for their results to be used by decision-makers. Relatively short-term trial evidence requires assumptions on long-term treatment effect, which drives uncertainty. We aim to develop an open-source AD decision-model framework for the health-economic evaluation of emerging AD treatments. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: R. Handels, A. Wimo, A. Skoldunger, A. Tate, B. Winblad, D. Silvertand, L. Nguyen, L. J önsson, S. Grimm, S. Aye, W. Herring Source Type: research
P4 Testing SimPy, a Library for Patient-Level Simulations in Python: An Application to Resource Management in Healthcare Systems
The NICE Decision Support Unit presented a Technical Support Document report to carry out patient-level simulations for cost-effectiveness modeling in R, VBA and Simul8. We tested the SimPy Python library and discuss its use. In the light of the bottlenecks which emerged after the COVID-19 pandemic, we applied SimPy to a real-world scenario of an ophthalmic clinic. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: F. Felizzi Source Type: research
P9 Impact of Organized Colorectal Cancer Screening on Age-Specific Population Incidences: Evidence from a Natural Experiment in Sweden
Colorectal cancer (CRC) incurs a significant burden of disease globally. Organized CRC screening programs have been widely implemented for early detection and prevention. To understand the public health impact of these programs, quantitative evidence on changes in age-specific population incidences is fundamental. We aimed to provide such evidence by exploiting a natural experiment in Sweden, where two out of the 21 regions (comprising nearly 20% of the Swedish population) have offered organized screening since 2008. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: G. Chauca Strand, U. Str ömberg, A. Forsberg, C. Bonander Tags: The Impact of Cancer Screening Programs on Population Health Outcomes Source Type: research
P10 Impact of the COVID-19 Pandemic on Cancer Screenings in Portugal and Years of Life Lost Due to Delayed Diagnoses
This study aimed to evaluate the impact of the COVID-19 pandemic on cancer screening programs carried out by the Portuguese National Health Service (NHS), and to estimate the consequences on cancer morbidity and mortality. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: D. Mendes, D. Figueiredo, C. Alves, A. Penedones, B. Costa, F. Batel Marques Source Type: research
P11 Real-World Evidence of Total Colonoscopy for Colorectal Cancer Screening Based on Test Performance RCTs
Total colonoscopy (TCS) has been anticipated as a new method for colorectal cancer screening. Although randomized control studies (RCTs) are ongoing, there has yet to be a conclusive result. We evaluated the effectiveness of TCS screening following the stepwise approach developed by the World Endoscopic Evaluation (WEO). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: C. Hamashima, T. Terasaw, S. Hosono, T. Katayama, S. Sasaki, K. Abe, K. Hoshi, T. Tadano Source Type: research
P12 Screen-Detected Breast Cancers Have Improved 5-Year Disease Free Interval Compared to Interval and Non-Screen-Related Breast Cancer, Taking Lead Time into Account
We investigated the association between method of breast cancer detection and disease free interval (DFI), corrected for lead-time. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Eijkelboom, L. de Munck, J.D.M. Otten, M.J.M. Broeders, S. Siesling Source Type: research
P5 An Update on Calcitonin Gene-Related Peptide Monoclonal Antibodies Reimbursed Under a Managed Access Protocol in Ireland
This study provides a summary of the number of applications for CGRP MABs submitted and an overview of the utilisation of CGRP MABs on the High Tech Arrangement. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: K. Finnigan, A. Smith, S. Clarke, M. Barry, C. Gorry Tags: The Impact of Cost-Containment Initiatives from across the Globe Source Type: research
