When You Hear Hoofbeats, Sometimes Think of Zebras
Theodore Woodward, MD, a professor at the University of Maryland, is credited with telling his medical interns in the 1940s, “When you hear hoofbeats behind you, don’t expect to see a zebra.”1 By 1960, it was widely quoted throughout the medical profession. The phrase delivered the message that, “Common things occur commonly,” and has been part of medical dogma for decades.2 (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 21, 2023 Category: Urology & Nephrology Authors: Kevin R. Loughlin Tags: Foreword Source Type: research
The Progession Landscape of Diagnostic and Treatment Options for Kidney Cancer
The management approaches for kidney cancer have undergone a dramatic transformation over the past 20 years. While recent developments in systemic therapeutic options for advanced disease have received a great deal of attention, in truth it is but one of a multitude of notable breakthroughs in the care of patients with kidney cancer, all of which have served to improve patient outcomes. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 21, 2023 Category: Urology & Nephrology Authors: Steven L. Chang, Michael L. Blute Tags: Preface Source Type: research
Renal Cancer: Old and New Paradigms
UROLOGIC CLINICS OF NORTH AMERICA (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 21, 2023 Category: Urology & Nephrology Authors: Steven L. Chang, Michael L. Blute Source Type: research
Copyright
ELSEVIER (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 21, 2023 Category: Urology & Nephrology Source Type: research
Contributors
KEVIN R. LOUGHLIN, MD, MBA (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 21, 2023 Category: Urology & Nephrology Source Type: research
Contents
Kevin R. Loughlin (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 21, 2023 Category: Urology & Nephrology Source Type: research
Forthcoming Issues
Pediatric Urology (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 21, 2023 Category: Urology & Nephrology Source Type: research
Evolution in the Pathologic Classification of Renal Neoplasia
The pathologic classification of renal tumors is a dynamic and complex process, which has evolved to a “histomolecular” driven system. Despite advances in molecular characterization, most renal tumors can be diagnosed by morphology with or without using a limited set of immunohistochemical stains. If access to molecular resources and specific immunohistochemical markers is limited, pathologists m ay face difficulties in following an optimal algorithm to classify renal tumors. In this article, we detail the historical evolution of renal tumor classification, including a synopsis of major changes introduced by the curren...
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Reza Alaghehbandan, Steven C. Campbell, Jesse K. McKenney Source Type: research
The Changing Role of Renal Mass Biopsy
The incidence and prevalence of small renal masses (SRMs) continues to rise and with increased detection comes increases in surgical management, although the probability of an SRM being benign is upward of 30%. An extirpative treatment first diagnose-later strategy persists and clinical tools for risk stratification such as renal mass biopsy remain severely underutilized. The overtreatment of SRMs has multiple detrimental effects including surgical complications, psychosocial stress, financial loss, and reduced renal function leading to downstream effects such as the need for dialysis and cardiovascular disease. (Source: U...
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Sohrab Naushad Ali, Zachary Tano, Jaime Landman Source Type: research
Cystic Renal Masses
This article provides a contemporary overview of historical and emerging clinical paradigms in the diagnosis and management of this distinct clinical entity. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Majed Alrumayyan, Lucshman Raveendran, Keith A. Lawson, Antonio Finelli Source Type: research
Long-Term Renal Function Following Renal Cancer Surgery
Knowledge of functional recovery after partial (PN) and radical nephrectomy for renal cancer has advanced considerably, with PN now established as the reference standard for most localized renal masses. However, it is still unclear whether PN provides an overall survival benefit in patients with a normal contralateral kidney. While early studies seemingly demonstrated the importance of minimizing warm-ischemia time during PN, multiple new investigations over the last 10 years have proven that parenchymal mass lost is the most important predictor of new baseline renal function. Minimizing loss of parenchymal mass during res...
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Andrew M. Wood, Tarik Benidir, Rebecca A. Campbell, Nityam Rathi, Robert Abouassaly, Christopher J. Weight, Steven C. Campbell Source Type: research
The Great Masquerader ’s New Wardrobe in the Modern Era
This article will provide a review of the causes of these symptoms. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Kevin R. Loughlin Source Type: research
Radiation Therapy in the Treatment of Localized and Advanced Renal Cancer
Renal cell carcinoma (RCC) has historically been considered resistant to radiotherapy. However, advances in the field of radiation oncology have led to safe delivery of higher radiation doses through the use of stereotactic body radiotherapy (SBRT) that have shown significant activity against RCC. SBRT has now been shown to be a highly effective modality for management of localized RCC for nonsurgical candidates. Increasing evidence also points to a role for SBRT in the management of oligometastatic RCC as a means for not only providing palliation but prolonging time to progression and potentially improving survival. (Sour...
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Kendrick Yim, Jonathan E. Leeman Source Type: research
Biomarkers for the Detection and Surveillance of Renal Cancer
Renal cell carcinoma (RCC) is a heterogeneous disease characterized by a broad spectrum of disorders in terms of genetics, molecular and clinical characteristics. There is an urgent need for noninvasive tools to stratify and select patients for treatment accurately. In this review, we analyze serum, urinary, and imaging biomarkers that have the potential to detect malignant tumors in patients with RCC. We discuss the characteristics of these numerous biomarkers and their ability to be used routinely in clinical practice. The development of biomarkers continues to evolve with promising prospects. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Jos é Ignacio Nolazco, Simon John Christoph Soerensen, Benjamin I. Chung Source Type: research
The Changing Landscape of Immunotherapy for Advanced Renal Cancer
The management of advanced renal cell carcinoma has advanced tremendously over the past decade, but most patients still do not receive durable clinical benefit from current therapies. Renal cellcarcinoma is an immunogenic tumor, historically with conventional cytokine therapies, such as interleukin-2 and interferon- α, and contemporarily with the introduction of immune checkpoint inhibitors. Now the central therapeutic strategy in renal cell carcinoma is combination therapies including immunecheckpoint inhibitors. In this Review, we look back on the historical changes in systemic therapy for advanced renal cel l carcinoma...
Source: Urologic Clinics of North America - February 20, 2023 Category: Urology & Nephrology Authors: Soki Kashima, David A. Braun Source Type: research
