Retraction Note to: Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Downregulation of miR-185 and upregulation of miR-218 expression may be potential diagnostic and prognostic biomarkers of human chondrosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Urinary parameters predictive and electrolyte disturbances of cisplatin-induced acute renal associated with cancer as a critical target of the chemotherapeutic agent in patients with solid tumors
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Tissue expression levels of miR-29b and miR-422a in children, adolescents, and young adults ’ age groups and their association with prediction of poor prognosis in human osteosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Downregulation of microRNA-217 and microRNA-646 acts as potential predictor biomarkers in progression, metastasis, and unfavorable prognosis of human osteosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Canine transmissible venereal tumor and seminoma: a cytohistopathology and chemotherapy study of tumors in the growth phase and during regression after chemotherapy
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Clinical significance and expression of the PRSS3 and Wiskott –Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Improving the diagnosis, treatment, and biology patterns of feline mammary intraepithelial lesions: a potential model for human breast masses with evidence from epidemiologic and cytohistopathologic studies
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Downregulation of miR-148b as biomarker for early detection of hepatocellular carcinoma and may serve as a prognostic marker
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
Identification of miRNAs as non-invasive biomarkers for early diagnosis of lung cancers
AbstractCurrent clinical diagnostic methods lack the specificity in detecting lung cancer patients. The issue is particularly critical for stage I and II patients. Considerable evidence showed microRNA plays a very important role in lung carcinogenesis. Here, we identified a panel of 41 miRNAs significantly elevated in patients with lung cancer, of which eight miRNAs were further validated in an independent sample cohort. Classification analysis using the panel of eight miRNAs generated a discriminatory power of 93.3 % sensitivity and 93.8 % specificity in separating non-small-cell lung cancer (NSCLC) patients from norm...
Source: Tumor Biology - November 2, 2016 Category: Cancer & Oncology Source Type: research
MiR-212/132 is epigenetically downregulated by SOX4/EZH2-H3K27me3 feedback loop in ovarian cancer cells
In this study, we investigated the regulative effects of miR-212 and miR-132 on SOX4 expression in ovarian cancer cells and also studied whether there is a feedback regulation between miR-212/miR-132 and SOX4 via an epigenetic mechanism. The results showed that both EZH2 and SOX4 overexpressions significantly repressed miR-212 and miR-132 expressions in SKOV3 and OV2008 cells. Immunoprecipitation assay showed that there are interactions among SOX4, EZH2, and H3K27me3, and ChIP assay confirmed significant enrichment of EZH2 and H3K27me3 in the promoter region of miR-212/132. Both pri-miR-212 and pri-miR-132 expressions decr...
Source: Tumor Biology - November 2, 2016 Category: Cancer & Oncology Source Type: research
The E6-TAp63 β-Dicer feedback loop involves in miR-375 downregulation and epithelial-to-mesenchymal transition in HR-HPV+ cervical cancer cells
In this study, we found that miR-375 overexpression restored TAp63β expression. TAp63β overexpression significantly enhanced transcription and translation of Dicer, which furth er led to increased mature miR-375 levels. Therefore, we infer that there is an E6-TAp63β-Dicer feedback loop involved in miR-375 dysregulation in cervical cancer. Besides, we observed that enforced TAp63β expression significantly reduced the mesenchymal markers including N-cadherin, Vimentin, Sna il, and Slug but increased the epithelial marker E-cadherin in both Hela and SiHa cells. The wound healing assay also confirmed that TAp63β overexpre...
Source: Tumor Biology - November 2, 2016 Category: Cancer & Oncology Source Type: research
Establishment of a miRNA-mRNA regulatory network in metastatic renal cell carcinoma and screening of potential therapeutic targets
This study aimed to screen effective diagnosis or treatment biomarkers for renal cell carcinoma, especially for metastatic renal cell carcinoma (mRCC) based on microRNA (miRNA) and messenger RNA (mRNA) genechip, and their regulatory network. The differential expressions of miRNAs and mRNAs were examined by miRNA and mRNA gene-chip analyses, respectively, in patients with either localized renal cell carcinoma (lRCC) or mRCC, and a miRNA-mRNA regulatory network was established. Subsequently, the regulation of selected mRNAs by miRNAs was validated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and ...
Source: Tumor Biology - November 1, 2016 Category: Cancer & Oncology Source Type: research
