RETRACTED ARTICLE: The expression of mitochondrial complexes I and III correlates with prognosis or diagnosis in retinoblastoma: immunohistochemical and histopathological parameters
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research
IL-17A produced by peritoneal macrophages promote the accumulation and function of granulocytic myeloid-derived suppressor cells in the development of colitis-associated cancer
In this study, we found the level of IL-17 was increased in pathogenic colon site during the early stage of CAC model. Further experiments showed the increased IL-17 was probably secreted by peritoneal macrophages when exposed to dextran sulfate sodium (DSS). In vitro, we found that IL-17 could enhance survival and suppressive function of granulocytic (G)-MDSCs, the subset associated with inflammation. With the development of CAC, the proportions of MDSCs and Th17 cells were continuously increased by the high level of IL-17 produced by macrophages. However, the increase of MDSCs was earlier and acuter than that of Th17 cel...
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research
Effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition
This study examined the effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition. Different CoCl2 concentrations were used to treat A549 cells and establish a CoCl2-induced hypoxic model of A549 cells. MTT and clone formation assays were used to determine the effects of different concentrations of CoCl2 on the growth and proliferation of A549 cells treated by different doses of X-ray irradiation. The siRNA-expressing vector was transfected by liposomes and for silencing ofTUSC3. Flow cytometry was used to measure ce...
Source: Tumor Biology - November 29, 2016 Category: Cancer & Oncology Source Type: research
LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes
In conclusion, the data demonstrated that high HOTAIR expression acted as a competitive endogenous RNA to promote cisplatin resistance in gastric cancer. Further study will evaluate HOTAIR expression as a biomarker to predict treatment response of cisplatin and explore inhibition of HOTAIR expression as a novel strategy for anti-cisplatin resistance in human gastric cancer. (Source: Tumor Biology)
Source: Tumor Biology - November 29, 2016 Category: Cancer & Oncology Source Type: research
FAT4 functions as a tumor suppressor in triple-negative breast cancer
AbstractTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is often associated with biologic behavior with frequent distant metastasis. FAT tumor suppressor homolog 4 (FAT4), a cadherin-related protein, is involved in a variety of biological processes as a tumor suppressor; however, the role of FAT4 in TNBC is still unclear. The aim of our study was to identify the role of FAT4 in TNBC and examine the underlying molecular mechanisms. The expression of FAT4 was evaluated by immunohistochemistry, western blotting, and qRT-PCR in a series of TNBC tissues. The effects of FAT4 on the ability of ...
Source: Tumor Biology - November 27, 2016 Category: Cancer & Oncology Source Type: research
Regulation of autophagy by Ca 2+
AbstractAutophagy is an evolutionarily conserved lysosomal catabolic process used as an internal engine in response to nutrient starvation or metabolic stress. A number of protein complexes and an intricate network of stress signaling cascades impinge on the regulation of autophagy; the mammalian target of rapamycin serves as a canonical player. Ca2+, as a major intracellular second messenger, regulates multiple physiological and pathological functions. Although significant information is already well-established about the role of Ca2+ in apoptosis, its role in autophagy has been recently determined and is poorly understoo...
Source: Tumor Biology - November 17, 2016 Category: Cancer & Oncology Source Type: research
Integrated analysis identified an intestinal-like and a diffuse-like gene sets that predict gastric cancer outcome
AbstractThe two major histological types of gastric cancer, intestinal and diffuse subtypes, have distinct epidemiological and pathophysiological features and were also suggested to be of diverse clinical outcomes. Although the gene expression spectrum of gastric cancer subtypes has been reported by previous studies, its linkage with gastric cancer clinical features and outcomes remains elusive. We investigated large-sample online gastric cancer datasets for seeking genes correlated with the clinical diversities between gastric cancer intestinal and diffuse subtypes. Genes differently expressed between the two subtypes wer...
Source: Tumor Biology - November 16, 2016 Category: Cancer & Oncology Source Type: research
Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation
AbstractBCCIP was originally identified as a BRCA2- and CDKN1A- (Cip1/waf1/p21) interacting protein, also known as BCCIP. It has been reported to express in various types of cancers, including colorectal cancer (CRC), astrocytic brain tumors, and glioblastomas. However, the relationship between BCCIP expression and clinicopathological features of hepatocellular carcinoma (HCC) remains to be determined. Herein, we demonstrated that BCCIP was downregulated in clinical HCC tissues; its level was inversely correlated with multiple clinicopathological factors, such as tumor grade, tumor size, and Ki67 expression. Cox regression...
Source: Tumor Biology - November 9, 2016 Category: Cancer & Oncology Source Type: research
A novel model for identification of prognostic indicator for clinical outcome of squamous cell lung carcinoma
AbstractSquamous cell carcinoma of the lung (SCCL) is the most common and aggressive lung tumor with poor clinical outcome. Identification and development of potential genes in prognostic process could be beneficial for clinical management. Sequencing data of 300 SCCL samples at level 3 were downloaded from The Cancer Genome Atlas (TCGA) data portal. Single-factor survival analysis was performed by the Kaplan-Meier method. Functional annotation was conducted on the high-frequency genes filtered out by 1000 times of the least absolute shrinkage and selectionator operator regression analysis. Meanwhile, multi-factor survival...
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research
MicroRNA-92 promotes invasion and chemoresistance by targeting GSK3 β and activating Wnt signaling in bladder cancer cells
In conclusion, our study demonstrated that upregulation of miR-92 is closel y related with malignant progression of bladder cancer and miR-92 promotes proliferation, invasion, and Wnt/c-myc/MMP7 signaling by targeting GSK3β. (Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Overexpression of interleukins IL-17 and IL-8 with poor prognosis in colorectal cancer induces metastasis
(Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Evaluation of gene expression level of CDC5L and MACC1 in poor prognosis and progression of osteosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma
(Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research
Retraction Note to: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study
(Source: Tumor Biology)
Source: Tumor Biology - November 7, 2016 Category: Cancer & Oncology Source Type: research
Potential role of Wnt/ β-catenin signaling in blastic transformation of chronic myeloid leukemia: cross talk between β-catenin and BCR-ABL
In conclusion, our data indicate a close relationship between β-catenin and BCR-ABL/PI3K/AKT in blastic phase CML. β-Catenin inhibition may be of therapeutic value by targeting LSCs in combination with a tyrosine kinase inhibitor, which may delay blas tic transformation of CML. (Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research
