Highly immunogenic prime –boost DNA vaccination protects chickens against challenge with homologous and heterologous H5N1 virus
Publication date: 2014 Source:Trials in Vaccinology, Volume 3 Author(s): Anna Stachyra, Anna Góra-Sochacka, Róża Sawicka, Katarzyna Florys, Violetta Sączyńska, Monika Olszewska, Anna Pikuła, Krzysztof Śmietanka, Zenon Minta, Bogusław Szewczyk, Włodzimierz Zagórski, Agnieszka Sirko Highly pathogenic avian influenza viruses (HPAIVs) cause huge economic losses in the poultry industry because of high mortality rate in infected flocks and trade restrictions. Protective antibodies, directed mainly against hemagglutinin (HA), are the primary means of protection against influenza outbreaks...
Source: Trials in Vaccinology - July 20, 2016 Category: Infectious Diseases Source Type: research

Engineered exosomes boost the HCV NS3-specific CD8+ T lymphocyte immunity in humans
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Simona Anticoli, Emiliana Falcone, Anna Ruggieri, Maurizio Federico At the present, no anti-Hepatitis C virus (HCV) HCV vaccine is available, and many patients failed the treatment with new class of HCV inhibitors. In HCV infection, both experimental and clinic evidences indicate that a strong CTL-immune response could have significant therapeutic effects. We developed an innovative anti-HCV CD8+ T immunogen based on the uploading in engineered exosomes of full-length HCV-NS3 protein. HCV NS3 exosomes appeared immunogenic when injected in mice, ...
Source: Trials in Vaccinology - May 17, 2016 Category: Infectious Diseases Source Type: research

Altered adjuvant of foot-and-mouth disease vaccine improves immune response and protection from virus challenge
In this study, we produced vaccines for O, A, and Asia1 serotypes by mixing oil adjuvants, Emulsigen-D (ED), ISA 201, and ISA 206 with and without an aluminum hydroxide (AL) gel and measured their immunogenicity and safety to obtain information regarding critical differences (survival or weight loss) of vaccine quality in mice; the goal of this test was to overcome the difficulties associated with experiments large or medium-sized animals. The groups immunized with the vaccines containing only the oil adjuvants (ED, ISA 201, and ISA 206) had similar or higher levels of neutralizing antibodies and structural protein antibod...
Source: Trials in Vaccinology - May 10, 2016 Category: Infectious Diseases Source Type: research

A post hoc assessment of duration of protection in CAPiTA (Community Acquired Pneumonia immunization Trial in Adults)
Conclusions The results of this post hoc analysis of the persistence of PCV13 VE in adults ⩾65years, indicate that PCV13 was protective over the 5-year duration of the study, with no waning of efficacy observed. ClinicalTrials.gov identifier NCT00744263 (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - May 4, 2016 Category: Infectious Diseases Source Type: research

Immunogenicity and protection conferred by a recombinant Mycobacterium marinum vaccine against Buruli ulcer
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Bryan E. Hart, Laura P. Hale, Sunhee Lee Mycobacterium ulcerans (MU) infection causes the disfiguring necrotic skin disease, Buruli ulcer (BU). While vaccination with Mycobacterium bovis BCG provides nominal antigenic cross-reactivity for induction of immunity against experimental MU infection, a mycobacterial species with greater genetic homology to Mycobacterium ulcerans may serve as a richer source of cross-protective immunogens and lack the pathological features of MU-based vaccines. Mycobacterium marinum, a highly homologous genetic relative...
Source: Trials in Vaccinology - May 4, 2016 Category: Infectious Diseases Source Type: research

Impact of the rotavirus vaccine in Valladolid, Spain: An interrupted time series analysis
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Alberto Pérez-Rubio, Francisco Javier Luquero, Maria Rosario Bachiller Luque, Paz de la Torre Pardo, José María Eiros Bouza Rotavirus vaccines (RV) have decreased the infant morbidity and mortality in countries that included RV in their national schedule. Rotavirus vaccination is recommended by the Spanish Society of Pediatrics; however, Spain, as most countries in Europe, has authorized commercialization but not included RV in its national vaccination program. We assessed the impact of RV on the rotavirus hospitalization r...
Source: Trials in Vaccinology - May 4, 2016 Category: Infectious Diseases Source Type: research

B-cell epitope mapping for the design of vaccines and effective diagnostics
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Tarek A. Ahmad, Amrou E. Eweida, Salah A. Sheweita The increasing resistance of many microbial strains to antibiotics, delayed laboratory results, and side effects of many chemotherapeutics has raised the need to search for sensitive diagnostics and new prophylactic strategies especially prevention by vaccination. Understanding the epitope/antibody interaction is the key to constructing potent vaccines and effective diagnostics. B-cell epitope mapping is a promising approach to identifying the main antigenic determinants of microorganisms, in spe...
Source: Trials in Vaccinology - May 4, 2016 Category: Infectious Diseases Source Type: research

Stress effect on humoral and cell mediated immune response: Indispensable part of corticosterone and cytokine in neutrophil function
Conclusion This result further concludes that prior immunization of SRBC in animal’s act as a vaccination, which helps to prevent noise stress induced impairment in immune system. Orally administered I. tinctoria prevented noise altered immune system. These results also concluded that I. tinctoria supplementation could act as an immunomodulators and suggesting its therapeutic efficacy as an antistressor. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - April 28, 2016 Category: Infectious Diseases Source Type: research

Development of immunization trials against Acinetobacter baumannii
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Tarek A. Ahmad, Dina M. Tawfik, Salah A. Sheweita, Medhat Haroun, Laila H. El-Sayed Acinetobacter baumannii has recently crossed all lines once considered harmless, pushing its way as a nosocomial pathogen. It had acquired resistance to almost all available chemotherapies and mainly targets intensive care residents; causing pneumonia and major outbreaks with high mortality rates. This urged the need for preventive methods, which include infection control, non-specific immune-therapy, passive, and active immunization in order to offer vulnerable...
Source: Trials in Vaccinology - April 20, 2016 Category: Infectious Diseases Source Type: research

Immunogenicity and safety of a quadrivalent influenza vaccine in children and adolescents in Taiwan: A phase III open-label trial
In conclusion, this study showed that the 2013–2014 Northern Hemisphere formulation of the intramuscular IIV4 was immunogenic and well tolerated by children and adolescents 9–17years of age. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - March 3, 2016 Category: Infectious Diseases Source Type: research

Development of immunization trials against Eimeria spp.
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Tarek A. Ahmad, Bassant A. El-Sayed, Laila H. El-Sayed Coccidiosis is a major intestinal disease affecting economically valuable livestock animals such as chickens and turkeys. Economic losses are associated with decreased productivity in afflicted animals. The different Eimeria spp. are the main etiologic agents for that virulent disease. The usefulness of prophylactic and therapeutic anticoccidial compounds has decreased in recent years due to the emergence of drug resistance in Eimeria, together with their possible toxic effect to the human co...
Source: Trials in Vaccinology - February 20, 2016 Category: Infectious Diseases Source Type: research

Commercial bacterins did not induce detectable levels of antibodies in mice against Mycoplasma hyopneumoniae antigens strongly recognized by swine immune system
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Andressa Fisch, Silvana Beutinger Marchioro, Charles Klazer Gomes, Vanessa Galli, Natasha Rodrigues de Oliveira, Simone Simionatto, Odir Antônio Dellagostin, Marcelo Mendonça, Ângela Nunes Moreira, Fabricio Rochedo Conceição Enzootic Pneumonia (EP) caused by Mycoplasma hyopneumoniae results in major economic losses to the swine industry. Hence, the identification of factors that provide protection against EP could help to develop effective vaccines. One such factor that provides partial protection are bacte...
Source: Trials in Vaccinology - February 5, 2016 Category: Infectious Diseases Source Type: research

Efficacy and safety of a new intradermal PCV2 vaccine in pigs
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): M. Sno, E. Cox, H. Holtslag, T. Nell, S. Pel, R. Segers, V. Fachinger, M. Witvliet The safety and efficacy of a new intradermal one dose vaccine containing Porcine Circovirus type 2 (PCV2) antigen – Porcilis® PCV ID – was evaluated in laboratory studies and under field conditions. In addition, the concurrent use with an intradermal Mycoplasma hyopneumoniae vaccine – Porcilis® M Hyo ID ONCE – was evaluated. Vaccination with Porcilis® PCV ID resulted in small transient local reactions in a high percentage of...
Source: Trials in Vaccinology - January 22, 2016 Category: Infectious Diseases Source Type: research

Immunogenic multistage recombinant protein vaccine confers partial protection against experimental toxoplasmosis mimicking natural infection in murine model
In this study, we generated a BAG1 and GRA1 multistage vaccine that induced strong immune response in which the protection was not at anticipated level. In addition, the murine model was orally challenged with tissue cysts to mimic natural route of infection. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - December 10, 2015 Category: Infectious Diseases Source Type: research

An assessment, in mice, of the safety of the childhood immunization vaccines sourced from three south-eastern states of Nigeria
Conclusion The vaccines were generally safe and non-toxic. The cold-chain systems in the States studied were efficient and had not compromised the safety of the vaccines. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - November 27, 2015 Category: Infectious Diseases Source Type: research

Immunogenicity in dogs and protection against visceral leishmaniasis induced by a 14kDa Leishmania infantum recombinant polypeptide
Publication date: 2016 Source:Trials in Vaccinology, Volume 5 Author(s): Claudia Abeijon, Nada Daifalla, Greice Krautz-Peterson, Stefano Pizzirani, Gillian Beamer, Neuza M. Frazatti-Gallina, Isaias Raw, Antonio Campos-Neto In areas were human visceral leishmaniasis (VL) is endemic, the domestic dog is the main parasite reservoir in the infectious cycle of Leishmania infantum. Development of prophylactic strategies to lower the parasite burden in dogs would reduce sand fly transmission thus lowering the incidence of zoonotic VL. Here we demonstrate that vaccination of dogs with a recombinant 14kDa polypeptide of L...
Source: Trials in Vaccinology - November 25, 2015 Category: Infectious Diseases Source Type: research

Decay of Sabin inactivated poliovirus vaccine (IPV)-boosted poliovirus antibodies
Conclusion The decay of poliovirus antibodies over a 21–22-month period was similar regardless of the type of booster vaccine used, suggesting the scientific data of Salk IPV long-term persistence and decay may be broadly applicable to Sabin IPV. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - August 25, 2015 Category: Infectious Diseases Source Type: research

ISCOM-based equine influenza vaccine: Duration of immunity and randomised clinical trials to assess an accelerated schedule of immunisation and efficacy
Publication date: 2015 Source:Trials in Vaccinology, Volume 4 Author(s): R. Paillot, S. Fraser, L. Prowse-Davis, N. Rash, F. Montesso, N. Slootmans, A. Thomas, B. Besognet, T. Meinert, E. Ons, J. Salt The widespread use of equine influenza (EI) vaccines plays an important role in the prevention and control of EI outbreaks. Vaccine strain updates, optimisation of immunisation schedules, and frequent evaluation of vaccine efficacy are necessary to maintain an acceptable level of protection and overall disease control. Results from three independent vaccine studies are reported here. Study 1: duration of immunity...
Source: Trials in Vaccinology - July 30, 2015 Category: Infectious Diseases Source Type: research

Immunomodulatory role of outer membrane vesicles of Shigella in mouse model
Publication date: 2015 Source:Trials in Vaccinology, Volume 4 Author(s): Soma Mitra, Ritam Sinha, Dhrubajyoti Nag, Hemanta Koley In our previous studies, we discussed the protective efficacy of the two types of vaccine formulation namely SOMVs (single-serotype outer membrane vesicles) and MOMVs (multi-serotype outer membrane vesicles). Here, we compared the immunogenic roles of these two types of formulations and also studied general immunomodulation by Shigella OMVs in adult BALB/c mice. The production of various pro-inflammatory (TNF-α, IL-1β, IL-6, IL-12, IL-18, IFN-γ) and anti-inflammatory (IL-4 ...
Source: Trials in Vaccinology - July 24, 2015 Category: Infectious Diseases Source Type: research

Examination of serological memory in rabbits injected with Bacillus anthracis protective antigen adsorbed to Alhydrogel
Publication date: 2015 Source:Trials in Vaccinology, Volume 4 Author(s): Stephen F. Little, Wendy M. Webster Serological memory after inoculation of protective antigen (PA) combined with Alhydrogel adjuvant (PA/Alhydrogel) was examined in New Zealand white rabbits, an animal model for anthrax. A threshold dose of 0.1μg of PA/Alhydrogel was identified which resulted in an ELISA titer 2weeks after a primary immunization of only 0.168μg anti-PA IgG per ml and a toxin-neutralizing antibody titer (TNA ED50) of 1.8 (n =40). A significant increase in anti-PA IgG and TNA ED50 titers were measured (p <0.0001) 2week...
Source: Trials in Vaccinology - July 16, 2015 Category: Infectious Diseases Source Type: research

Efficacy and safety of a combined Porcine Circovirus and Mycoplasma hyopneumoniae vaccine in finishing pigs
Publication date: 2015 Source:Trials in Vaccinology, Volume 4 Author(s): Maarten Witvliet , Hans Holtslag , Tom Nell , Ruud Segers , Vicky Fachinger The safety and protective efficacy of a new one dose combination vaccine containing Porcine Circovirus type 2 (PCV2) and M. hyopneumoniae antigens – Porcilis® PCV M Hyo - was evaluated in laboratory studies and under field conditions. Vaccination resulted in a moderate temperature increase on the day of vaccination and mild systemic and local reactions were found in only a low percentage of the vaccinated pigs. The local reactions observed were small (max. 2 cm) an...
Source: Trials in Vaccinology - June 25, 2015 Category: Infectious Diseases Source Type: research

Simultaneous immunization of cattle with foot-and-mouth disease (FMD) and live anthrax vaccines do not interfere with FMD booster responses
In this study we evaluated if the simultaneous application of a Bacillus anthracis live vaccine with a commercial tetravalent oil-based FMD vaccine (FMD-vac) used in Argentina, modifies the antibody booster responses against FMD virus (FMDV) in cattle. Two groups of 16 heifers with comparable liquid phase blocking ELISA (LPBE) titers were immunized with the FMD-vac alone or simultaneously with a commercial attenuated bovine anthrax Sterne strain vaccine (ABV). Serum samples were obtained at 0, 25, 60 and 90days post vaccination (dpv) and specific antibodies against two FMDV vaccine strains were assessed by LPBE, avidity an...
Source: Trials in Vaccinology - June 5, 2015 Category: Infectious Diseases Source Type: research

Development and field application of a new combined vaccine against Peste des Petits Ruminants and Sheep Pox
Publication date: 2015 Source:Trials in Vaccinology, Volume 4 Author(s): F. Fakri , F. Ghzal , S. Daouam , A. Elarkam , L. Douieb , Y. Zouheir , K. Tadlaoui , O. Fassi-Fihri A combined vaccine against Peste des Petits Ruminants (PPR) and Sheep/Goat Pox (SGP) was developed and applied in the field, using a new association of vaccine strains: PPR Nigeria 75 strain with a titre of 104.1 TCID50 and Sheep Pox Romania strain with a titre of 104.0 TCID50. Safety and efficacy were evaluated on goats and sheep in comparison with monovalent PPR and SGP vaccines. Goats were challenged by PPR virulent strain and sheep by SP virulent...
Source: Trials in Vaccinology - April 28, 2015 Category: Infectious Diseases Source Type: research

Improved protection in guinea pigs after vaccination with a recombinant BCG expressing MPT64 on its surface
Publication date: 2015 Source:Trials in Vaccinology, Volume 4 Author(s): Simon O. Clark , Giovanni Delogu , Emma Rayner , Michela Sali , Ann Williams , Riccardo Manganelli The lack of an efficient vaccine against tuberculosis is still one of the major problems threatening global human health. In previous work we showed that expression of the protective antigen MPT64 on the surface of Mycobacterium bovis BCG, the only approved vaccine against tuberculosis, strongly improved its immunogenicity and protective potential in mice. In this work we demonstrate that the same recombinant strain is able to induce better protection ...
Source: Trials in Vaccinology - April 28, 2015 Category: Infectious Diseases Source Type: research

Immunization of horses with a polyvalent live-attenuated African horse sickness vaccine: Serological response and disease occurrence under field conditions
Publication date: 2015 Source:Trials in Vaccinology, Volume 4 Author(s): Umberto Molini , Giuseppe Marucchella , Adrianatus Maseke , Gaetano Federico Ronchi , Mauro Di Ventura , Romolo Salini , Massimo Scacchia , Attilio Pini African horse sickness (AHS) is a non-contagious, insect-borne disease of equids caused by a RNA virus (AHSV), which belongs to the genus Orbivirus, family Reoviridae. The disease is endemic in sub-Saharan and western Africa, where prevention strictly depends upon vaccination. The present paper aims at evaluating the serological response and the occurrence of AHS in horses bred under field condition...
Source: Trials in Vaccinology - April 28, 2015 Category: Infectious Diseases Source Type: research

Immunogenicity and safety of a tetravalent dengue vaccine during a five-year follow-up period
In conclusion, TDV appears to have good safety and persistence of antibodies over five years. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - April 11, 2015 Category: Infectious Diseases Source Type: research

The efficacy of a multivalent calicivirus, herpesvirus and parvovirus vaccine and a rabies vaccine is not affected when administered in combination
In conclusion, the data show that combining these two separate vaccines in one administration has limited impact on their ability to generate serological responses, and that these responses are still of a magnitude previously demonstrated to be protective. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - February 25, 2015 Category: Infectious Diseases Source Type: research

Sociodemographic influences on immunization of children with chronic neurological disorders in Enugu, Nigeria
Conclusion Children with obvious neurological deficits whose mothers have low educational attainment are at risk of low immunization coverage. It is recommended that healthcare workers should assess the immunization status of children with CND at every opportunity. Female education and empowerment should be encouraged as a means of enhancing the immunization coverage of these children. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - January 15, 2015 Category: Infectious Diseases Source Type: research

Adjuvant immunotherapy of feline injection-site sarcomas with the recombinant canarypox virus expressing feline interleukine-2 evaluated in a controlled monocentric clinical trial when used in association with surgery and brachytherapy
The objective of this randomised, controlled, parallel-group monocentric clinical trial was to assess the efficacy (at low and high dose) and the safety (at high dose) of a recombinant canarypox virus (ALVAC®) expressing feline interleukin 2 (IL-2). ALVAC IL-2 was administered to cats as an adjunct treatment of feline fibrosarcoma in complement to surgery and brachytherapy (reference treatment). Seventy-one cats with a first occurrence of feline fibrosarcoma were referred to the Veterinary Oncology Centre for post-surgical radiotherapy. They were randomly assigned to three treatment groups: reference treatment group (2...
Source: Trials in Vaccinology - December 6, 2014 Category: Infectious Diseases Source Type: research

An integrated multi-study analysis of serum HAI antibody responses to Ann Arbor strain live attenuated influenza vaccine in children and adults
This study characterizes HAI titers for LAIV. Serum HAI data were pooled from 40 LAIV clinical trials enrolling subjects aged 2–49years. Using pre- and postvaccination titers, geometric mean fold rises (GMFRs) and seroresponse rates (⩾4-fold rise) were determined by age and baseline serostatus (seronegative ⩽8, seropositive >8). Responses were generally evaluated after 2 doses for those 2–8years of age and after 1 dose for those 9–49years of age. Data were available for 6909 children and 3444 adults. A total of 20 different LAIV formulations were used, representing 6 H1N1 strains, 9 H3N2 strain...
Source: Trials in Vaccinology - December 4, 2014 Category: Infectious Diseases Source Type: research

Trivalent inactivated subunit influenza vaccine Influvac®: 30-year experience of safety and immunogenicity
Conclusions This review of the 30-year clinical experience with Influvac® found that the overall benefit-to-risk ratio is positive for all age groups from 6months upwards. The currently available evidence from the many clinical trials that have been performed confirms that Influvac® remains an effective and safe vaccine for preventing seasonal influenza. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Rotavirus gastroenteritis in Latin America: A hospital-based study in children under 3years of age
This study confirms the high disease burden of rotavirus gastroenteritis among children in Latin America, which might be reduced by the use of effective vaccines. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity
Conclusions The candidate TB vaccine, MVA85A has been safely administered to over 100 healthy adults in the UK. Intradermal vaccination with MVA85A induced a transient, superficial reaction local to the injection site and mild short-lived viral symptoms. The local and systemic AE profile of MVA85A vaccination was comparable to published data of other intradermal vaccines and live viral vaccines respectively. Local reaction sizes and body temperature measurements did not correlate with the adaptive cellular immune response to MVA85A. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Optimizing the efficiency of therapeutic HIV vaccine trials: A case for CTN 173
Conclusions Randomized controlled trials such as CTN 173, with well-defined surrogate endpoints and frequent immunologic and virologic monitoring, are necessary to streamline the approach to effective vaccine discovery and to ensure patient safety. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Clinical development, registration, and introduction of human rotavirus vaccine: The Latin American experience
Publication date: 2012 Source:Trials in Vaccinology, Volume 1 Author(s): Irene Perez Schael , Miguel O’Ryan , Xavier Sáez-Llorens , Alexandre C. Linhares , F.R. Velázquez , Romulo E. Colindres , Thomas Breuer , Eduardo Ortega-Barria Rotavirus (RV) is the leading cause of severe gastroenteritis (GE) among infants and young children worldwide, accounting for 453,000 deaths in children aged <5years. In Latin America rotavirus causes an estimated 15,000 deaths annually and accounts for 20–70% of acute gastroenteritis cases requiring hospitalization. This results in an estimated annual cost of...
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Rotavirus serotype distribution in northern Brazil trends over a 27 year period pre and post national vaccine introduction
Publication date: 2012 Source:Trials in Vaccinology, Volume 1 Author(s): Alessilva Oliveira , Joana D’Arc P. Mascarenhas , Luana S. Soares , Sylvia F.S. Guerra , Yvone B. Gabbay , Nervo Sánchez , Romulo E. Colindres , Maria Cleonice A. Justino , Alexandre C. Linhares In Brazil, a rotavirus vaccine was included in the public sector in March 2006. In order to identify a possible effect of vaccination on rotavirus strains we evaluated the distribution of serotypes/genotypes in northern Brazil during pre (1981–2005) and early post (2006–2008) national rotavirus vaccine introduction periods. Of 1286 r...
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Welcome Editorial to Trials in Vaccinology
Publication date: 2012 Source:Trials in Vaccinology, Volume 1 Author(s): Ray Spier (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Publisher’s Note – Launching Trials in Vaccinology
Publication date: 2012 Source:Trials in Vaccinology, Volume 1 (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

A neonatal oral Mycobacterium tuberculosis-SIV prime/intramuscular MVA-SIV boost combination vaccine induces both SIV and Mtb-specific immune responses in infant macaques
Publication date: 2013 Source:Trials in Vaccinology, Volume 2 Author(s): Kara Jensen , Myra Grace dela Pena , Robert L. Wilson , Uma Devi K. Ranganathan , William R. Jacobs Jr. , Glenn Fennelly , Michelle Larsen , Koen K.A. Van Rompay , Pamela A. Kozlowski , Kristina Abel Mother-to-child-transmission of HIV by breast-feeding remains a major obstacle in the eradication of HIV infection. Compared to adults, HIV-infected infants have more rapid disease and show higher susceptibility to co-infections like tuberculosis (TB). Although the Bacille Calmette–Guérin vaccine can be administered at birth to protect agai...
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Effectiveness, tolerability and patient satisfaction of paediatric live-attenuated influenza immunization (LAIV) in routine-care in Germany: A case-control-study
Conclusion In routine administration in Germany, LAIV was highly effective and well-tolerated, resulting in good patient satisfaction. Nasal LAIV offers a suitable way to increase paediatric influenza immunization coverage. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease in people aged 65years and over in the North East of England, April 2006–July 2012
Publication date: 2013 Source:Trials in Vaccinology, Volume 2 Author(s): L.B. Wright , G.J. Hughes , K.E. Chapman , R. Gorton , D. Wilson The 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for all aged ⩾65years in the UK to help reduce the burden of invasive pneumococcal disease (IPD). A total of 728 IPD cases aged ⩾65years were diagnosed between 1 April 2006 and 31 July 2012 in the North East of England. Crude vaccine effectiveness (VE) estimates for PPV23 were calculated using the indirect-cohort method using a stratified analysis. VE for persons aged ⩾65years was 28.5% (95% confidence inter...
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

A randomized controlled study to assess the immunogenicity and tolerability of a 2012 trivalent seasonal inactivated influenza vaccine administered via a disposable syringe jet injector device versus a traditional pre-filled syringe and needle
This study suggests that subject to confirmation of non-inferiority in an appropriately powered study, the Stratis DSJI is a viable alternative strategy for the administration of seasonal influenza vaccines with particular appeal for individuals with needle phobia. Australia New Zealand Clinical Trials Register: ACTRN12612000709842. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Pneumococcal vaccine responses in elderly patients with multiple myeloma, Waldenstrom’s macroglobulinemia, and monoclonal gammopathy of undetermined significance
Conclusion Our findings confirm that B cell malignancies and disorders among elderly patients are associated with suboptimal responses to pneumococcal vaccination. Single-dose PCV7 was not shown to be superior to PPV. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Hospital-based surveillance study of rotavirus gastroenteritis in children under 5years of age in Lebanon
Conclusion RVGE hospitalizations are prevalent in children under 5years of age in Lebanon. This baseline data might be useful for decision makers when initiating measures, such as vaccination, to prevent the disease. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Implementation of the quadrivalent vaccine against HPV in the Municipality of Campos dos Goytacazes, Brazil – A combination of strategies to increase immunization coverage and early reduction of genital warts
Conclusion A hybrid strategy for HPV proved to be effective in vaccinating adolescents in this municipality. HPV vaccine was safe and effective in reducing genital warts, as demonstrated by international studies. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Clinical evaluation to confirm the manufacturing consistency of three lots of an adjuvanted glycoprotein D genital herpes vaccine in healthy seronegative pre-teen and adolescent girls: A phase III multi-center double-blind randomized trial
Conclusions This study demonstrated the lot-to-lot consistency of three commercial scale production lots of herpes simplex candidate vaccine. The vaccine was immunogenic and had a clinically acceptable safety profile when administered in HSV type 1 and HSV-2 seronegative girls aged 10–17years. The study was registered at clinicaltrials.gov (identifier NCT00224471). (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Efficacy of vaccination of 3-week-old piglets with Circovac® against porcine circovirus diseases (PCVD)
Publication date: 2013 Source:Trials in Vaccinology, Volume 2 Author(s): Bernhard Heißenberger , Christiane Weissenbacher-Lang , Isabel Hennig-Pauka , Mathias Ritzmann , Andrea Ladinig In this controlled, blinded and randomised study, Circovac®, an inactivated PCV2 vaccine was used for active immunisation of 3-week-old piglets (0.5ml, i.m., one-shot). In a PCVD affected farm, a total of 1105 piglets from three consecutive farrowing batches were included. The vaccine efficacy was assessed by clinical parameters such as mortality, underweight pigs and improvement of average daily weight gain (ADWG) during the fat...
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Analysis of recombinant, multivalent dengue virus containing envelope (E) proteins from serotypes-1, -3 and -4 and expressed in baculovirus
This study indicates that recombinant E protein expressed in a baculovirus system can induce humoral and cellular immune responses. (Source: Trials in Vaccinology)
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Neem leaf glycoprotein optimizes effector and regulatory functions within tumor microenvironment to intervene therapeutically the growth of B16 melanoma in C57BL/6 mice
Publication date: Available online 6 December 2013 Source:Trials in Vaccinology Author(s): Subhasis Barik , Saptak Banerjee , Madhurima Sarkar , Avishek Bhuniya , Soumyabrata Roy , Anamika Bose , Rathindranath Baral Therapy with neem leaf glycoprotein (NLGP) inhibits murine B16-melanoma in vivo and improves survivability. Studies on tumor-microenvironment (TME) from NLGP treated mice (NLGP-TME) suggests that anti-tumor effect is directly associated with enhanced CD8+T cell activity, dominance of type 1 cytokines/chemokine network with downregulation of suppressive cellular functions. NLGP-TME educated CD8+T cells showed ...
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research

Non-specific immunity of BCG vaccine: A perspective of BCG immunotherapy
Publication date: 2014 Source:Trials in Vaccinology, Volume 3 Author(s): Najeeha Talat Iqbal , Rabia Hussain BCG is a widely used vaccine worldwide for neonates including Pakistan. BCG has more than 90% coverage through the EPI program which was introduced in 1965 in Pakistan. BCG has limited efficacy against the transmissible form of pulmonary tuberculosis in high TB endemic countries. However, BCG vaccination continues in these countries because BCG confers protection against the disseminated form of TB in children. BCG has also shown some protection against leprosy and certain forms of cancers. One reason for such non...
Source: Trials in Vaccinology - October 12, 2014 Category: Infectious Diseases Source Type: research