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Publication date: April 2020Source: Trends in Pharmacological Sciences, Volume 41, Issue 4Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - March 13, 2020 Category: Drugs & Pharmacology Source Type: research
Combining Allosteric and Orthosteric Drugs to Overcome Drug Resistance
Publication date: Available online 12 March 2020Source: Trends in Pharmacological SciencesAuthor(s): Duan Ni, Yun Li, Yuran Qiu, Jun Pu, Shaoyong Lu, Jian Zhang (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - March 12, 2020 Category: Drugs & Pharmacology Source Type: research
Pharmacology on Target
Publication date: Available online 28 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Agnieszka T. Kawashima, Alexandra C. Newton (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 29, 2020 Category: Drugs & Pharmacology Source Type: research
Dawn of a New RAMPage
Publication date: Available online 27 February 2020Source: Trends in Pharmacological SciencesAuthor(s): D. Stephen Serafin, Natalie R. Harris, Natalie R. Nielsen, Duncan I. Mackie, Kathleen M. Caron (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 28, 2020 Category: Drugs & Pharmacology Source Type: research
Polyunsaturated Fatty Acid Deuteration against Neurodegeneration
Publication date: Available online 26 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Mikhail S. Shchepinov (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 28, 2020 Category: Drugs & Pharmacology Source Type: research
Charting the Fragmented Landscape of Drug Synergy
Publication date: Available online 26 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Christian T. Meyer, David J. Wooten, Carlos F. Lopez, Vito Quaranta (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 28, 2020 Category: Drugs & Pharmacology Source Type: research
Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration
Publication date: Available online 24 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Raul Krauss, Todd Bosanac, Rajesh Devraj, Thomas Engber, Robert O. Hughes (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 25, 2020 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: March 2020Source: Trends in Pharmacological Sciences, Volume 41, Issue 3Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 20, 2020 Category: Drugs & Pharmacology Source Type: research
Introducing the New Advisory Board Members in Trends in Pharmacological Sciences
Publication date: March 2020Source: Trends in Pharmacological Sciences, Volume 41, Issue 3Author(s): Kusumika Mukherjee (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 20, 2020 Category: Drugs & Pharmacology Source Type: research
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Publication date: March 2020Source: Trends in Pharmacological Sciences, Volume 41, Issue 3Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 20, 2020 Category: Drugs & Pharmacology Source Type: research
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Publication date: February 2020Source: Trends in Pharmacological Sciences, Volume 41, Issue 2Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 13, 2020 Category: Drugs & Pharmacology Source Type: research
Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs
Publication date: Available online 5 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Sofie Martens, Sam Hofmans, Wim Declercq, Koen Augustyns, Peter VandenabeeleThe scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates prosurvival signaling and inflammatory gene expression, while its kinase activity mediates both apoptosis and necroptosis; the latter involving RIPK3 kinase activity. The mutual transition between the scaffold and kinase functions of RIPK1 is regulated by (de)ubiquitylation and (de)phosphorylation. RIPK1-mediated cell death leads to disruption of epithelial barrier...
Source: Trends in Pharmacological Sciences - February 6, 2020 Category: Drugs & Pharmacology Source Type: research
DELs Inside Cells
Publication date: Available online 4 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Animesh Roy, Thomas KodadekDNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 5, 2020 Category: Drugs & Pharmacology Source Type: research
Context-Dependent Pharmacological Effects of Metformin on the Immune System
Publication date: Available online 5 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Fabrizio Marcucci, Elisabetta Romeo, Carmelo A. Caserta, Cristiano Rumio, François LefoulonMetformin is used for the treatment of type 2 diabetes mellitus and has shown therapeutic effects in preclinical models of other pathologies, such as cancer and autoimmune diseases. The antitumor activity of metformin is due, in part, to immunostimulatory effects. In the context of other pathologies, such as autoimmune or inflammatory diseases, metformin has immunosuppressive effects. There is evidence that the immunostimulatory ef...
Source: Trends in Pharmacological Sciences - February 5, 2020 Category: Drugs & Pharmacology Source Type: research
Epimimetics: Novel Therapeutics Targeting Epigenetic Mediators and Modulators
Publication date: Available online 30 January 2020Source: Trends in Pharmacological SciencesAuthor(s): Anthony J. HannanEpigenetic alterations have been associated with a wide range of diseases. Furthermore, many therapeutic interventions modelling environmental exposures appear to involve epigenetic mechanisms. Recent progress has been made in developing drugs targeting specific epigenetic components. Here, I propose developing ‘epimimetics’, novel drugs that mimic or enhance therapeutic effects of epigenetic modifications. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - February 1, 2020 Category: Drugs & Pharmacology Source Type: research
