Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations
Publication date: Available online 28 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Kathleen M. Broughton, Mark A. SussmanAbility to promote completion of mitotic cycling of adult mammalian cardiomyocytes remains an intractable and vexing challenge, despite being one of the most sought after ‘holy grails’ of cardiovascular research. While some of the struggle is attributable to adult cardiomyocytes themselves that are notoriously post-mitotic, another contributory factor rests with difficulty in definitive tracking of adult cardiomyocyte cell cycle and lack of rigorous measures to track pr...
Source: Trends in Endocrinology and Metabolism - June 29, 2019 Category: Endocrinology Source Type: research

Microbiota and Thyroid Interaction in Health and Disease
Publication date: Available online 27 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Eleonore Fröhlich, Richard WahlThe microbiota has been identified as an important factor in health and in a variety of diseases. An altered microbiota composition increases the prevalence of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). Microbes influence thyroid hormone levels by regulating iodine uptake, degradation, and enterohepatic cycling. In addition, there is a pronounced influence of minerals on interactions between host and microbiota, particularly selenium, iron, and zinc. In manife...
Source: Trends in Endocrinology and Metabolism - June 29, 2019 Category: Endocrinology Source Type: research

Reactive Carbonyl Species: Diabetic Complication in the Heart and Lungs
Publication date: Available online 25 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Cheng-ju Tian, Zhong ZhenAbnormal chemical reactions in hyperglycemia alter normal metabolic processes in diabetes, which is a key process in the production of reactive carbonyls species (RCS). Increasing the concentration of RCS may result in carbonyl/oxidative stress in both the diabetic heart and lung. Ryanodine receptors (RyRs) not only play a key role in heart contraction, including rhythmic contraction and relaxation of the heart, but they are also important for controlling the airway smooth muscle. RCS modifies ...
Source: Trends in Endocrinology and Metabolism - June 26, 2019 Category: Endocrinology Source Type: research

Going Back to the Biology of FGF21: New Insights
Publication date: Available online 24 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jo E. Lewis, Francis J.P. Ebling, Ricardo J. Samms, Kostas TsintzasFibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues. In preclinical models of obesity and type 2 diabetes, treatment with FGF21 improves glucose homeostasis and promotes weight loss, and, as a result, FGF21 has attracted considerable attention as a therapeutic agent for the treatment of metabolic syndrome in humans. An impro...
Source: Trends in Endocrinology and Metabolism - June 25, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: July 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 7Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - June 19, 2019 Category: Endocrinology Source Type: research

Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia–Reperfusion Injury
Publication date: July 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 7Author(s): Naila Rabbani, Paul J. ThornalleyHexokinase-2 (HK2) was recently found to produce increased metabolic flux through glycolysis in hyperglycemia without concurrent transcriptional or other functional regulation. Rather, stabilization to proteolysis by increased glucose substrate binding produced unscheduled increased glucose metabolism in response to high cytosolic glucose concentration. This produces abnormal increases in glycolytic intermediates or glycolytic overload, driving cell dysfunction and vulnerability to the ...
Source: Trends in Endocrinology and Metabolism - June 19, 2019 Category: Endocrinology Source Type: research

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Publication date: July 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 7Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - June 19, 2019 Category: Endocrinology Source Type: research

Gluconeogenic Enzymes in β-Cells: Pharmacological Targets for Improving Insulin Secretion
Publication date: Available online 15 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Francisco Westermeier, Todd Holyoak, Joel L. Asenjo, Rodrigo Gatica, Francisco Nualart, Ian Burbulis, Romina BertinatPancreatic β-cells express the gluconeogenic enzymes glucose 6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FBP), and phosphoenolpyruvate (PEP) carboxykinase (PCK), which modulate glucose-stimulated insulin secretion (GSIS) through their ability to reverse otherwise irreversible glycolytic steps. Here, we review current knowledge about the expression and regulation of these enzymes in the cont...
Source: Trends in Endocrinology and Metabolism - June 17, 2019 Category: Endocrinology Source Type: research

Platelets as Potent Signaling Entities in Type 2 Diabetes Mellitus
Publication date: Available online 10 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Etheresia PretoriusType 2 diabetes mellitus (T2DM) is a multifactorial disease with a dysregulated circulating inflammatory molecule tendency. T2DM is closely associated with systemic inflammation, endothelial dysfunction, cardiovascular risk, and increased clotting susceptibility. Platelets have fundamental roles in the development and propagation of inflammation and cardiovascular risk. They signal through membrane receptors, resulting in (hyper)activation and release of inflammatory molecules from platelet compartme...
Source: Trends in Endocrinology and Metabolism - June 11, 2019 Category: Endocrinology Source Type: research

Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology
Publication date: Available online 10 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Francisco J. Schopfer, Nicholas K.H. KhooIn addition to supporting cellular energetic demands and providing building blocks for lipid synthesis, fatty acids (FAs) are precursors of potent signaling molecules. In particular, the presence of conjugated double bonds on the fatty-acyl chain provides a preferential target for nitration generating nitro-FAs (NO2-FAs). The formation of NO2-FAs is a nonenzymatic process that requires reactive nitrogen species and occurs locally at the site of inflammation or during gastric aci...
Source: Trends in Endocrinology and Metabolism - June 11, 2019 Category: Endocrinology Source Type: research

Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines
Publication date: Available online 31 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Helena Teede, Marie Misso, Eliza C. Tassone, Didier Dewailly, Ernest Hy Ng, Ricardo Azziz, Robert J. Norman, Marianne Andersen, Stephen Franks, Kathleen Hoeger, Samantha Hutchison, Sharon Oberfield, Duru Shah, Femke Hohmann, Sasha Ottey, Preeti Dabadghao, Joop S.E. LavenPolycystic ovary syndrome (PCOS) affects 8–13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an altern...
Source: Trends in Endocrinology and Metabolism - June 1, 2019 Category: Endocrinology Source Type: research

Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism
Publication date: Available online 30 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Amandine Verlande, Selma MasriThe circadian clock is a biological mechanism that dictates an array of rhythmic physiological processes. Virtually all cells contain a functional clock whose disruption results in altered timekeeping and detrimental systemic effects, including cancer. Recent advances have connected genetic disruption of the clock with multiple transcriptional and signaling networks controlling tumor initiation and progression. An additional feature of this circadian control relies on cellular metabolism, b...
Source: Trends in Endocrinology and Metabolism - May 31, 2019 Category: Endocrinology Source Type: research

Adipose Progenitor Cells Contribute to Lipid Spillover during Obesity
Publication date: Available online 29 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Nabil Rabhi, Stephen R. FarmerA recent study (Girousse et al. Cell Rep. 2019;27:323–333) shows that CXCR4+ adipose progenitors (APCs) contribute to lipid spillover during high-fat feeding through their release from subcutaneous fat depots (ScATs) and migration to skeletal muscle where they differentiate into adipocytes. Pharmacological antagonism of CXCR4, which prevents the CXCL12-dependent retention of APCs in ScAT, mimics the effects of overfeeding. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 31, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: June 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 6Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 31, 2019 Category: Endocrinology Source Type: research

Subscription and Copyright Information
Publication date: June 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 6Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 31, 2019 Category: Endocrinology Source Type: research

Distinct Roles of the NAD+-Sirt1 and FAD-LSD1 Pathways in Metabolic Response and Tissue Development
Publication date: Available online 28 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Mitsuyoshi Nakao, Kotaro Anan, Hirotaka Araki, Shinjiro HinoVarious nutritional signals are transduced by two epigenetic pathways: NAD-dependent sirtuin Sirt1 (NAD+-Sirt1) deacetylase and flavin adenine dinucleotide–dependent lysine-specific demethylase 1 (FAD-LSD1). These pathways are controlled by dietary vitamins and nutrient-responsive hormones such as glucocorticoids and insulin, resulting in endocrine–metabolism–epigenome cooperation in adipocyte and skeletal muscle development. (Source: Trends i...
Source: Trends in Endocrinology and Metabolism - May 29, 2019 Category: Endocrinology Source Type: research

A Century of Diabetes Technology: Signals, Models, and Artificial Pancreas Control
Publication date: Available online 28 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Boris KovatchevArguably, diabetes mellitus is one of the best-quantified human conditions: elaborate in silico models describe the action of the human metabolic system; real-time signals such as continuous glucose monitoring are readily available; insulin delivery is being automated; and control algorithms are capable of optimizing blood glucose fluctuation in patients’ natural environments. The transition of the artificial pancreas (AP) to everyday clinical use is happening now, and is contingent upon seamless co...
Source: Trends in Endocrinology and Metabolism - May 29, 2019 Category: Endocrinology Source Type: research

The Whys and Hows of Calculating Total Cellular ATP Production Rate
Publication date: Available online 27 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Megan E. Handel, Martin D. Brand, Shona A. MookerjeeQuantifying total cellular ATP production rate has become easier with recent technology and is essential to understanding energy metabolism in cells and tissues. We review fundamental concepts for determining total cellular ATP production rate from measurements of oxygen consumption and acidification rates and discuss their application to answering biological questions. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 27, 2019 Category: Endocrinology Source Type: research

Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity
Publication date: Available online 20 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Margherita T. Cantorna, Connie J. Rogers, Juhi AroraInflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation of the gastrointestinal tract and an immune-mediated attack against the commensal microbiota. Vitamin D is an essential vitamin that not only promotes calcium and phosphate absorption but also regulates immune function. The active form of vitamin D [1,25(OH)2D] has been shown to suppress symptoms of IBD by inhibiting T cell responses. Host protection from gastrointestinal infection dep...
Source: Trends in Endocrinology and Metabolism - May 22, 2019 Category: Endocrinology Source Type: research

Promises of Nanotherapeutics in Obesity
Publication date: Available online 21 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Garrett I. Ash, Dongin Kim, Mahua ChoudhuryThe application of nanotechnology to medicine promises a wide range of new tools and possibilities, from earlier diagnostics and improved imaging, to better, more efficient, and more targeted therapies. This emerging field could help address obesity, with advances in drug delivery, nutraceuticals, and genetic and epigenetic therapeutics. Its application to obesity is still largely in the development phase. Here, we review the novel angle of nanotech applied to human consumable ...
Source: Trends in Endocrinology and Metabolism - May 22, 2019 Category: Endocrinology Source Type: research

Host–Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols
Publication date: Available online 7 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): F.F. Anhê, B.S.Y. Choi, J.R.B. Dyck, J.D. Schertzer, A. MarettePolyphenols are nonessential phytonutrients abundantly found in fruits and vegetables. A wealth of data from preclinical models and clinical trials consistently supports cardiometabolic benefits associated with dietary polyphenols in murine models and humans. Furthermore, a growing number of studies have shown that specific classes of polyphenols, such as proanthocyanidins (PACs) and ellagitannins, as well as the stilbenoid resveratrol, can alleviate se...
Source: Trends in Endocrinology and Metabolism - May 8, 2019 Category: Endocrinology Source Type: research

Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics
Publication date: Available online 6 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Max Friesen, Chad A. CowanInsulin resistance (IR) is a rapidly growing pandemic. It poses an enormous health burden given its comorbidity with obesity, type 2 diabetes (T2D), and other metabolic and cardiovascular diseases (CVDs). Adipose tissue has been established as a key regulator of whole-body metabolic homeostasis, with interest growing rapidly. Emerging evidence suggests that adipocytes play an important role in these afflictions and contribute to IR. Genome-wide association studies (GWAS) have begun to illuminate...
Source: Trends in Endocrinology and Metabolism - May 7, 2019 Category: Endocrinology Source Type: research

The First Hormone: Adrenaline
Publication date: Available online 4 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Yi RaoIt is not often that three misconceptions are associated with one molecule for more than a century. This is the case with adrenaline. The aim here is to clarify that adrenaline was the first hormone, with the discovery of its activity and chemical purification being prior to secretin. Adrenaline is the correct name given by Jōkichi Takamine, epinephrine being its inactive benzoyl derivative. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 5, 2019 Category: Endocrinology Source Type: research

Hormetic Effects of Phytochemicals on Health and Longevity
Publication date: Available online 3 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jan Martel, David M. Ojcius, Yun-Fei Ko, Po-Yuan Ke, Cheng-Yeu Wu, Hsin-Hsin Peng, John D. YoungCaloric restriction, intermittent fasting, and exercise activate defensive cellular responses such as autophagy, DNA repair, and the induction of antioxidant enzymes. These processes improve health and longevity by protecting cells and organs against damage, mutations, and reactive oxygen species. Consuming a diet rich in vegetables, fruits, and mushrooms can also improve health and longevity. Phytochemicals such as alkaloids,...
Source: Trends in Endocrinology and Metabolism - May 5, 2019 Category: Endocrinology Source Type: research

Let’s Enter the Wonderful World of Immunometabolites
Publication date: Available online 3 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Kyra E. de Goede, Karl J. Harber, Jan Van den BosscheOver the past decade, cancer metabolism research taught us that metabolites are much more than intermediate or end products of metabolism. As such, the name ‘oncometabolite’ emerged. Immunometabolism research has developed tremendously over the past few years and, in analogy to the cancer metabolism field, the term ‘immunometabolite’ has been used for different metabolites and purposes. Here, we propose a definition for the term ‘immunomet...
Source: Trends in Endocrinology and Metabolism - May 5, 2019 Category: Endocrinology Source Type: research

Clocking In, Working Out: Circadian Regulation of Exercise Physiology
Publication date: Available online 2 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Drew Duglan, Katja A. LamiaResearch over the past century indicates that the daily timing of physical activity impacts on both immediate performance and long-term training efficacy. Recently, several molecular connections between circadian clocks and exercise physiology have been identified. Circadian clocks are protein-based oscillators that enable anticipation of daily environmental cycles. Cell-autonomous clocks are present in almost all cells of the body, and their timing is set by a variety of internal and external ...
Source: Trends in Endocrinology and Metabolism - May 2, 2019 Category: Endocrinology Source Type: research

Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells
Publication date: Available online 27 April 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Elyssa Bernfeld, David A. FosterCancer cells consume glutamine, a nonessential amino acid (NEAA), at exceedingly high rates to fulfill their energetic and biosynthetic requirements for proliferation. Glutamine plays distinct roles from essential amino acids in cell cycle progression and in the activation of mammalian target of rapamycin (mTOR). Furthermore, the need of cancer cells for glutamine can be exploited therapeutically – especially those driven by KRas. In this review we explore several distinct cellula...
Source: Trends in Endocrinology and Metabolism - April 29, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: May 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 5Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - April 17, 2019 Category: Endocrinology Source Type: research

Subscr. info + Copyrights
Publication date: May 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 5Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - April 17, 2019 Category: Endocrinology Source Type: research

Eating Rewards the Gears of the Clock
Publication date: Available online 29 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jorge MendozaEating behavior is regulated by metabolic and hedonic brain networks, which interact with each other to balance the physiological regulation of hunger and satiety. The daily balance of this regulation is controlled by the central circadian clock. Importantly, metabolic and reward properties of food impact the functioning of circadian clocks, altering the oscillatory activity of the molecular clockwork and circadian rhythms. However, when feeding (metabolic or reward) is timed, the whole circadian system i...
Source: Trends in Endocrinology and Metabolism - March 31, 2019 Category: Endocrinology Source Type: research

Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts
Publication date: Available online 30 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Christian Herder, Michael Roden, Dan ZieglerThe most prevalent chronic complications of diabetes are diabetic neuropathies, among which distal sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) are the best studied. Their major clinical sequelae such as foot ulcers, neuropathic pain, and orthostatic hypotension are associated with lower quality of life and increased risk of mortality. Here we discuss the recent insights into DSPN and CAN focusing on two prospective cohorts; that is, the G...
Source: Trends in Endocrinology and Metabolism - March 31, 2019 Category: Endocrinology Source Type: research

Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage
Publication date: Available online 27 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Mahmoud H. Elbatreek, Mayra P. Pachado, Antonio Cuadrado, Karin Jandeleit-Dahm, Harald H.H.W. SchmidtReactive oxygen species (ROS) have been mainly viewed as unwanted by-products of cellular metabolism, oxidative stress, a sign of a cellular redox imbalance, and potential disease mechanisms, such as in diabetes mellitus (DM). Antioxidant therapies, however, have failed to provide clinical benefit. This paradox can be explained by recent discoveries that ROS have mainly essential signaling and metabolic functions and e...
Source: Trends in Endocrinology and Metabolism - March 28, 2019 Category: Endocrinology Source Type: research

Common Fatty Markers in Diseases with Dysregulated Lipogenesis
Publication date: Available online 26 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): David Balgoma, Curt Pettersson, Mikael HedelandRecent studies have reported the upregulation of a subgroup of triacylglycerides as markers of different diseases with dysregulated lipogenesis, which means that these markers are not selective. This observation has a deep impact on their use as diagnostic tools in clinical practice (e.g., markers of risk of type 2 diabetes). (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - March 28, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: April 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 4Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - March 15, 2019 Category: Endocrinology Source Type: research

Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth
Publication date: Available online 5 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Tessa A.C. Garrud, Dino A. GiussaniAnte- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspr...
Source: Trends in Endocrinology and Metabolism - March 6, 2019 Category: Endocrinology Source Type: research

Calcium Signaling As a Therapeutic Target for Liver Steatosis
Publication date: Available online 5 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Eunüs S. Ali, Nikolai PetrovskyHepatic steatosis, the first step in nonalcoholic fatty liver disease (NAFLD), can arise from various pathophysiological conditions. While lipid metabolism in the liver is normally balanced such that there is no excessive lipid accumulation, when this homeostasis is disrupted lipid droplets (LDs) accumulate in hepatocytes resulting in cellular toxicity. The mechanisms underlying this accumulation and the subsequent hepatocellular damage are multifactorial and poorly understood, with ...
Source: Trends in Endocrinology and Metabolism - March 6, 2019 Category: Endocrinology Source Type: research

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723–735, 2018)
Publication date: Available online 2 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Marc N. Wein, Marc Foretz, David E. Fisher, Ramnik J. Xavier, Henry M. Kronenberg (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - March 4, 2019 Category: Endocrinology Source Type: research

ACMSD: A Novel Target for Modulating NAD+ Homeostasis
Publication date: Available online 21 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jun YoshinoNAD+ has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD+ metabolism and overexpression of human ACMSD leads to niacin dependency for NAD+ biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD+ deficiency. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - February 22, 2019 Category: Endocrinology Source Type: research

Mathematical Modelling of Endocrine Systems
Publication date: Available online 21 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Eder Zavala, Kyle C.A. Wedgwood, Margaritis Voliotis, Joël Tabak, Francesca Spiga, Stafford L. Lightman, Krasimira Tsaneva-AtanasovaHormone rhythms are ubiquitous and essential to sustain normal physiological functions. Combined mathematical modelling and experimental approaches have shown that these rhythms result from regulatory processes occurring at multiple levels of organisation and require continuous dynamic equilibration, particularly in response to stimuli. We review how such an interdisciplinary appr...
Source: Trends in Endocrinology and Metabolism - February 22, 2019 Category: Endocrinology Source Type: research

NR Supplementation During Lactation: Benefiting Mother and Child
Publication date: Available online 21 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Dengbao Yang, Yihong WanAbnormal nicotinamide adenine dinucleotide (NAD+) metabolism causes a wide spectrum of diseases. A recent study (Cell Rep. 2019;26:969–983) shows that postpartum NAD+ homeostasis is depressed. By restoring NAD+ homeostasis, maternal nicotinamide riboside (NR) supplementation during lactation enhances postpartum weight loss, as well as juvenile development and adult neurogenesis in the offspring. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - February 21, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: March 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 3Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - February 20, 2019 Category: Endocrinology Source Type: research

‘Et Tu, Leptin?’
Publication date: Available online 18 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Diego Perez-TilveLeptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome. Yet, new evidence demonstrates an unexpected causal role for leptin in obesity-associated hyperglycemia. Like the betrayal of Julius Caesar by Brutus, insulin did not see that coming from leptin. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - February 20, 2019 Category: Endocrinology Source Type: research

Veiled Potential of Secretagogin in Diabetes: Correlation or Coincidence?
Publication date: Available online 13 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Anand Kumar Sharma, Radhika Khandelwal, Yogendra SharmaSecretagogin (SCGN) is a calcium sensor protein enriched in neuroendocrine cells in general and pancreatic β-cells in particular. SCGN regulates insulin secretion through several Ca2+-dependent interactions. Recent studies implicate SCGN in the β-cell physiology and extracellular insulin function, making it an intriguing candidate in diabetes research. Here, we propose a conjoining theme of diversified SCGN function in diabetes pathology. In our opini...
Source: Trends in Endocrinology and Metabolism - February 14, 2019 Category: Endocrinology Source Type: research

Antipsychotics Promote Metabolic Disorders Disrupting Cellular Lipid Metabolism and Trafficking
Publication date: Available online 1 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Chiara Vantaggiato, Elena Panzeri, Andrea Citterio, Genny Orso, Marco PozziAntipsychotics frequently cause obesity and related metabolic disorders that current psychopharmacological/endocrinological theories do not explain consistently. An integrative/alternative theory implies metabolic alterations happening at the cellular level. Many observations in vitro and in vivo, and pivotal observations in humans, point towards chemical properties of antipsychotics, independent of receptor binding characteristics. Being amp...
Source: Trends in Endocrinology and Metabolism - February 2, 2019 Category: Endocrinology Source Type: research

Anticatabolic Effects of Ketone Bodies in Skeletal Muscle
Publication date: Available online 31 January 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Andrew P. Koutnik, Dominic P. D’Agostino, Brendan EganThe ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of β-hydroxybutyrate have recently been demonstrated in human skeletal muscle under inflammatory insult, thereby expanding upon the wide-ranging therapeutic applications of nutritional ketosis. (Source: Trends i...
Source: Trends in Endocrinology and Metabolism - February 1, 2019 Category: Endocrinology Source Type: research

Spatial Technologies in Obesity Research: Current Applications and Future Promise
Publication date: Available online 1 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Peng Jia, Hong Xue, Li Yin, Alfred Stein, Minqi Wang, Youfa WangGeographic Information Systems (GIS), Global Positioning Systems (GPS), and remote sensing (RS) are revolutionizing obesity-related research. The primary applications of GIS have included visualizing obesity outcomes and risk factors, constructing obesogenic environmental indicators, and detecting geographical patterns of obesity prevalence and obesogenic environmental features. GPS was mainly used to delineate individual activity space and combined wit...
Source: Trends in Endocrinology and Metabolism - February 1, 2019 Category: Endocrinology Source Type: research

Implications and Future Perspectives of AGEs in PCOS Pathophysiology
Publication date: Available online 1 February 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Zaher Merhi, Eleni A. Kandaraki, Evanthia Diamanti-KandarakisHuman, animal, and in vitro studies provide evidence that advanced glycation end-products (AGEs) may contribute to the pathogenesis of polycystic ovary syndrome (PCOS) and its metabolic and reproductive consequences. AGEs are able to induce, via activation of key intracellular signaling pathways, the generation of oxidative stress and proinflammatory cytokines, thus contributing to the adverse health impact of PCOS. This review presents the implications of...
Source: Trends in Endocrinology and Metabolism - February 1, 2019 Category: Endocrinology Source Type: research

Metabolic Disease Epidemics: Emerging Challenges in Regenerative Medicine
Publication date: Available online 29 January 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Raquel Costa-Almeida, Rui L. Reis, Manuela E. GomesThe interplay between cell/tissue damage caused by metabolic dysfunction and regenerative potential remains elusive. The tissue engineering and regenerative medicine (TERM) field is now facing a worldwide epidemic of obesity. This Forum article uncovers prospective questions to be addressed in TERM toward the development of effective regenerative therapies adjusted to these new demands. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - January 29, 2019 Category: Endocrinology Source Type: research

Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance
Publication date: Available online 25 January 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Isin Cakir, Eduardo A. NillniOverweight and obesity pose significant health problems globally, and are causatively linked to metabolic dysregulation. The hypothalamus integrates neural, nutritional, and hormonal cues to regulate homeostasis, including circadian rhythm, body temperature, thirst, food intake, energy expenditure, and glucose metabolism. Hypothalamic neuropeptides play a fundamental role in these processes. Studies during the past two decades suggest a role of central endoplasmic reticulum (ER) stress i...
Source: Trends in Endocrinology and Metabolism - January 26, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: February 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 2Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - January 23, 2019 Category: Endocrinology Source Type: research