High-sensitive Troponin: A new tool for clinical decision-making in valvular heart disease?
Given the demographic changes in the western hemisphere, heart disease epidemiology is undergoing a substantial change. During the next decades, we will face an enormous rise of valvular heart disease (VHD) patients with a need for treatment [1]. In particular, the fraction of typical age-associated VHDs such as aortic stenosis and mitral regurgitation will continue to increase. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - February 6, 2017 Category: Cardiology Authors: Johanne Frank, Norbert Frey, Derk Frank Source Type: research

Lifestyle and life-long lasting cardiovascular health
Cardiovascular diseases (CVD) represent the leading cause of mortality worldwide [1]. Their incidence is determined by lifestyle-related risk factors, whose impact start early in life. Both genetic and lifestyle factors contribute to individual-level CVD risk. In a recent combined analysis of four studies, genetic and lifestyle factors were independently associated with an increased risk of coronary artery disease; in participants at high genetic risk, a favorable lifestyle was associated with a 50% risk reduction than was an unhealthy lifestyle [2]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - February 6, 2017 Category: Cardiology Authors: Luis A. Moreno Source Type: research

Role of electrophysiological evaluation for the best device choice to prevent sudden cardiac death in patients with Myotonic Dystrophy Type 1 and Emery Dreifuss Muscular Dystrophy
Dear Editor, (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - February 4, 2017 Category: Cardiology Authors: Vincenzo Russo, Luisa Politano, Gerardo Nigro Source Type: research

Myocardial fibrosis predicts ventricular tachyarrhythmias
Myocardial fibrosis is a common pattern in the setting of different heart diseases, and promotes ventricular tachyarrhythmias by creating a vulnerable substrate for reentrant activity and by favoring the emergence of triggers. Currently, late gadolinium enhancement (LGE) cardiac magnetic resonance is considered the reference method for the noninvasive assessment of ventricular fibrosis. Several studies and meta-analyses have shown that ventricular fibrosis detected by LGE is a powerful predictor of ventricular tachyarrhythmic events in ischemic, non-ischemic dilated cardiomyopathy and hypertrophic cardiomyopathy patients. ...
Source: Trends in Cardiovascular Medicine - January 31, 2017 Category: Cardiology Authors: Marcello Disertori, Michela Mas è, Flavia Ravelli Source Type: research

Editorial commentary: Nomograms in pediatric cardiology: where are we?
In this issue of Trends in Cardiovascular Medicine, Cantinotti et al. [1] describe in a comprehensive review the current limitations of pediatric echocardiography nomograms and highlight the new advances made for functional data. The rationale for this review article is justified, even for those in pediatric cardiology, as the concept of nomograms and Z scores are often unfamiliar and methodological pitfalls are not fully understood. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 30, 2017 Category: Cardiology Authors: Israel Valverde Source Type: research

Nomograms in pediatric cardiology: where are we?
In this issue of Trends in Cardiovascular Medicine, Cantinotti et al. [1] describe in a comprehensive review the current limitations of pediatric echocardiography nomograms and highlight the new advances made for functional data. The rationale for this review article is justified, even for those in pediatric cardiology, as the concept of nomograms and Z scores are often unfamiliar and methodological pitfalls are not fully understood. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 29, 2017 Category: Cardiology Authors: Israel Valverde Source Type: research

The cardiovascular safety trials of DPP-4 inhibitors, GLP-1 agonists, and SGLT2 inhibitors
In this paper, we review the results of large, double-blind, placebo-controlled randomized trials mandated by the US Food and Drug Administration to examine the cardiovascular safety of newly-approved antihyperglycemic agents in patients with type 2 diabetes. The cardiovascular effects of dipeptidyl peptidase-4 (DPP-4) inhibitors remain controversial: while these drugs did not reduce or increase the risk of primary, pre-specified composite cardiovascular outcomes, one DPP-4 inhibitor (saxagliptin) increased the risk of hospitalization for heart failure in the overall population; another (alogliptin) demonstrated inconsiste...
Source: Trends in Cardiovascular Medicine - January 27, 2017 Category: Cardiology Authors: Matthew H. Secrest, Jacob A. Udell, Kristian B. Filion Source Type: research

Editorial commentary: Guidelines for the treatment of chronic heart failure
Today, the treatment of cardiovascular diseases has become complex but in many cases providing both symptom relief and life-prolongation. Treatment of chronic heart failure (CHF) is a syndrome where the success of treating patients with CHF has become dramatically improved over the last 25 years. However, with the advancing complexity of both diagnosing and treating CHF, there is a need for help and advice for most physicians and other healthcare professionals from specialists with particular experience in this context. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 25, 2017 Category: Cardiology Authors: Karl Swedberg Source Type: research

Editorial commentary: Wolff-Parkinson-White pattern and syndrome: Where do we stand in 2017?
Much has been learned about the Wolff-Parkinson-White Syndrome since first described in the early 1900s. Studies have described the prevalence of this condition, the pathologic and electrophysiologic basis of this condition, the link between WPW Syndrome – paroxysmal supraventricular tachycardia – atrial fibrillation – and sudden cardiac death, and also the technique and outcomes of catheter ablation of WPW syndrome. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 25, 2017 Category: Cardiology Authors: Hugh Calkins Source Type: research

Editorial commentary: Atrial fibrillation ablation with cryoenergy: It ׳s “Cool”; it׳s “Non-inferior”; Is it better?
A comparison between radiofrequency ablation and cryoballoon ablation for pulmonary vein isolation is presented by Reissmann et al. in the current issue of the journal [1]. This is of particular interest given the recent multi-center, randomized trial comparing the two techniques head-to-head ( “Fire and Ice” [2]) and the ongoing discussion in the EP community. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 25, 2017 Category: Cardiology Authors: Fredrik Holmqvist, James P. Daubert Source Type: research

Wolff-Parkinson-White Pattern and Syndrome: Where Do We Stand in 2017?
Much has been learned about the Wolff-Parkinson-White Syndrome since first described in the early 1900s. Studies have described the prevalence of this condition, the pathologic and electrophysiologic basis of this condition, the link between WPW Syndrome – paroxysmal supraventricular tachycardia – atrial fibrillation – and sudden cardiac death, and also the technique and outcomes of catheter ablation of WPW syndrome. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 24, 2017 Category: Cardiology Authors: Hugh Calkins Source Type: research

Atrial Fibrillation Ablation with Cryoenergy: It's “Cool”; it's “Non-inferior”; Is it Better?
A comparison between radiofrequency ablation and cryoballoon ablation for pulmonary vein isolation is presented by Reissmann et al. in the current issue of the journal [1]. This is of particular interest given the recent multi-center, randomized trial comparing the two techniques head-to-head ( “Fire and Ice”[2]) and the ongoing discussion in the EP community. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 24, 2017 Category: Cardiology Authors: Fredrik Holmqvist, James P. Daubert Source Type: research

Guidelines for the treatment of chronic heart failure
KS has received honoraria for consultancies from Astrazeneca, Amgen, Novartis and Servier (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 24, 2017 Category: Cardiology Authors: Karl Swedberg Source Type: research

Pediatric Echocardiographic Nomograms: What Has Been Done and What Still Needs to be Done
Nomograms are essential tools for quantification in pediatric echocardiography. In the last few years, multiple sources highlight that nomograms employed for decades presented significant numerical and methodological limitations. As a result, widely different ranges of normality were generated, thus creating confusion in estimation of several cardiac diseases. New nomograms have recently been generated, overcoming some of the gaps of previous research: wider sample sizes (including neonates/infants), solid statistical/methodological plan, and availability of new data (chamber dimensions, many functional parameters). (Sourc...
Source: Trends in Cardiovascular Medicine - January 18, 2017 Category: Cardiology Authors: Massimiliano Cantinotti, Shelby Kutty, Eliana Franchi, Marco Paterni, Marco Scalese, Giorgio Iervasi, Martin Koestenberger Source Type: research

Ed Board
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 18, 2017 Category: Cardiology Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 18, 2017 Category: Cardiology Source Type: research

High sensitivity troponin and valvular heart disease
Blood-based biomarkers have been extensively studied in a range of cardiovascular diseases and have established utility in routine clinical care, most notably in the diagnosis of acute coronary syndrome (e.g., troponin) and the management of heart failure (e.g., brain-natriuretic peptide). The role of biomarkers is less well established in the management of valvular heart disease (VHD), in which the optimal timing of surgical intervention is often challenging. One promising biomarker that has been the subject of a number of recent VHD research studies is high sensitivity troponin (hs-cTn). (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 15, 2017 Category: Cardiology Authors: Cian P. McCarthy, Eoin Donnellan, Dermot Phelan, Brian P. Griffin, Maurice E. Sarano, John W. McEvoy Source Type: research

Heart failure guidelines: What ’s new?
Heart Failure is a global epidemic, affecting approximately 5 million adults in the U.S.A. The cornerstone of contemporary pharmacological therapy targets the over activated renin-angiotensin-aldosterone and sympathetic autonomic systems. The 2016 focused pharmacologic update on the current Heart Failure Guidelines introduces the use of two newly approved regimens valsartan/sacubitril and ivabradine. Over the last two decades, guideline directed medical therapy has accomplished significant improvement in survival rates among heart failure patients; however these novel compounds were reported to exert additional mortality a...
Source: Trends in Cardiovascular Medicine - January 10, 2017 Category: Cardiology Authors: Lampros Papadimitriou, Carine E. Hamo, Javed Butler Source Type: research

Editorial commentary: “Discovery of a Murine Model of clinical pulmonary arterial hypertension: Mission impossible?” by Dai and Zhao
Pulmonary hypertension (PH) is defined as a mean pulmonary arterial pressure of ≥25mmHg at rest, which is determined by right heart catheterization [1]. The condition is further characterized by a progressive increase of pulmonary vascular resistance leading to right ventricular failure and death [2]. The clinical classification of PH categorizes multiple clinical conditions into five groups according to clinical presentation/etiology, histologic findings, hemodynamic characteristics and treatment strategy. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 10, 2017 Category: Cardiology Authors: Gerald J. Maarman Source Type: research

Editorial to “Discovery of a Murine Model of clinical pulmonary arterial hypertension: Mission impossible?” by Dai and Zhao
Pulmonary hypertension (PH) is defined as a mean pulmonary arterial pressure of ≥25mmHg at rest, which is determined by right heart catheterization [1]. The condition is further characterized by a progressive increase of pulmonary vascular resistance leading to right ventricular failure and death [2]. The clinical classification of PH categorizes multiple clinical conditions into five groups according to clinical presentation/etiology, histologic findings, hemodynamic characteristics and treatment strategy. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 9, 2017 Category: Cardiology Authors: Gerald J. Maarman Tags: Editorial Source Type: research

Editorial to: “Discovery of a Murine Model of Clinical Pulmonary Arterial Hypertension: Mission Impossible?” by Dai and Zhao
Pulmonary hypertension (PH) is defined as a mean pulmonary arterial pressure of ≥25mmHg at rest, which is determined by right heart catheterization [1]. The condition is further characterized by a progressive increase of pulmonary vascular resistance leading to right ventricular failure and premature death [2]. Clinical classification of PH categorizes multiple clinical condi tions into five groups according to clinical presentation/etiology, histologic findings, hemodynamic characteristics and treatment strategy. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 9, 2017 Category: Cardiology Authors: Gerald J. Maarman Source Type: research

Heart failure guidelines: What's new?
Heart Failure is a global epidemic, affecting approximately 5 million adults in the U.S.A. The cornerstone of contemporary pharmacological therapy targets the over activated renin-angiotensin-aldosterone and sympathetic autonomic systems. The 2016 focused pharmacologic update on the current Heart Failure Guidelines introduces the use of two newly approved regimens valsartan/sacubitril and ivabradine. Over the last two decades, guideline directed medical therapy has accomplished significant improvement in survival rates among heart failure patients; however these novel compounds were reported to exert additional mortality a...
Source: Trends in Cardiovascular Medicine - January 9, 2017 Category: Cardiology Authors: Lampros Papadimitriou, Carine E. Hamo, Javed Butler Source Type: research

Editorial commentary: Sleep disordered breathing and cardiovascular outcomes: Is it time to change our thinking?
In this issue, Cowie summarizes the results of recent randomized controlled trials (RCT) on the effects of treatment of obstructive or central respiratory events during sleep on cardiovascular outcomes [1]. Unexpected results, such as those reported by recent studies, challenge our current way of thinking, and may help to better design future studies. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 5, 2017 Category: Cardiology Authors: Maria R. Bonsignore Source Type: research

Sleep disordered breathing and cardiovascular outcomes: is it time to change our thinking?
In this issue, Cowie summarizes the results of recent randomized controlled trials (RCT) on the effects of treatment of obstructive or central respiratory events during sleep on cardiovascular outcomes [1]. Unexpected results, such as those reported by recent studies, challenge our current way of thinking, and may help to better design future studies. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - January 4, 2017 Category: Cardiology Authors: Maria R. Bonsignore Source Type: research

Dietary Strategies for Cardiovascular Health
Cardiovascular disease is developed across a lifetime accumulation of risk. Numerous independent and synergistic cardiovascular risk factors can be induced by unhealthy dietary patterns. Epidemiological, mechanistic, clinical, and translational research point to refined sugars, processed and fatty meats, synthetic oils, and sodium as major dietary risk factors. The purpose of this review is to integrate these learnings into key principles for dietary frameworks aimed at improving overall cardiovascular health. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 30, 2016 Category: Cardiology Authors: Brad P. Dieter, Katherine R. Tuttle Source Type: research

Editorial commentary: L5: An LDL fraction in which pathogenic activity of LDL is concentrated
After the establishment of LDL as a risk factor for cardiovascular disease (CVD), researchers have been seeking the real nature of pathological LDL. L5, a good candidate to be it, is coming. In this issue of this journal, Akyol S et al. reviewed recent progress of the study of L5, a subfraction of LDL, in the pathogenesis of atherothrombotic diseases [1]. Here, I am summarizing points of the L5 study. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 22, 2016 Category: Cardiology Authors: Tatsuya Sawamura, Yoshiko Fujita, Sayaka Horiuchi, Akemi Kakino Source Type: research

L5: an LDL fraction in which pathogenic activity of LDL is concentrated
After the establishment of LDL as a risk factor for cardiovascular disease (CVD), researchers have been seeking the real nature of pathological LDL. L5, a good candidate to be it, is coming. In this issue of this journal, Akyol S et al. reviewed recent progress of the study of L5, a subfraction of LDL, in the pathogenesis of atherothrombotic diseases [1]. Here, I am summarizing points of the L5 study. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 21, 2016 Category: Cardiology Authors: Tatsuya Sawamura, Yoshiko Fujita, Sayaka Horiuchi, Akemi Kakino Source Type: research

Editorial commentary: Towards improved understanding of atrial fibrillation in South Asians
Recent worldwide epidemiological data have confirmed a rising burden of atrial fibrillation (AF) incidence, prevalence as well as its associated morbidity and mortality between 1990 and 2010 [1]. The same upward trend was seen in South Asia, which constitutes India, Bangladesh, Pakistan, Sri Lanka and Nepal, although the overall burden of AF in the South Asian region was lower than in developed countries [1]. This is despite higher prevalence of risk factors such as hypertension, diabetes, smoking, reduced physical activity, dyslipidemia and poorer diet quality in the South Asian population [2]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 21, 2016 Category: Cardiology Authors: Rajiv Mahajan, Dennis H. Lau Source Type: research

Towards Improved Understanding of Atrial Fibrillation in South Asians
Recent worldwide epidemiological data have confirmed a rising burden of atrial fibrillation (AF) incidence, prevalence as well as its associated morbidity and mortality between 1990 and 2010 [1]. The same upward trend was seen in South Asia, which constitutes India, Bangladesh, Pakistan, Sri Lanka and Nepal, although the overall burden of AF in the South Asian region was lower than in developed countries [1]. This is despite higher prevalence of risk factors such as hypertension, diabetes, smoking, reduced physical activity, dyslipidemia and poorer diet quality in the South Asian population [2]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 20, 2016 Category: Cardiology Authors: Rajiv Mahajan, Dennis H Lau Source Type: research

Sleep apnea: state of the art
Many patient with, or at risk of, cardiovascular disease have sleep disordered breathing (SDB), which can be either obstructive (with intermittent collapse of the upper airway) or central (episodic loss of respiratory drive). SDB is associated with sleep disturbance, hypoxaemia, haemodynamic changes, and sympathetic activation. Such patients have a worse prognosis than those without SDB. Mask-based therapies of positive airway pressure targeted at SDB can improve measures of sleep quality and partially normalize the sleep and respiratory physiology, but recent randomized trials of cardiovascular outcomes in SDB have either...
Source: Trends in Cardiovascular Medicine - December 18, 2016 Category: Cardiology Authors: Martin R Cowie Source Type: research

Ed Board
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 16, 2016 Category: Cardiology Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 16, 2016 Category: Cardiology Source Type: research

Discovery of a Murine Model of Clinical PAH: Mission Impossible?
Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH. (Source: Tre...
Source: Trends in Cardiovascular Medicine - December 14, 2016 Category: Cardiology Authors: Zhiyu Dai, You-Yang Zhao Source Type: research

Cryoballoon Ablation Versus Radiofrequency Ablation For Atrial Fibrillation
Atrial fibrillation (AF) is the most prevalent arrhythmia. Its incidence increases with age and AF is associated with an increased risk of stroke, heart failure and mortality [1 –3]. The management of AF aims either at rate or rhythm control. Asymptomatic patients can be managed by rate control [4–6], whereas rhythm control is intended in symptomatic patients [7]. Either antiarrhythmic drugs (AAD) or catheter-based ablation (CA) can be applied when aiming at rhythm cont rol. However, CA is superior to AAD in maintaining sinus rhythm (SR) [8–13] and provides an effective treatment option, particularly for ...
Source: Trends in Cardiovascular Medicine - December 13, 2016 Category: Cardiology Authors: Bruno Reissmann, Andreas Metzner, Karl-Heinz Kuck Source Type: research

Long Term Risk of Wolff-Parkinson-White Pattern and Syndrome
For years, conventional wisdom has held that patients with asymptomatic ventricular pre-excitation (asymptomatic WPW or WPW pattern) were at low risk for adverse outcomes. This assumption has been challenged more recently in a number of observational/natural history studies as well as in prospective trials in which patients were more aggressively studied via invasive electrophysiology study (EPS) and more aggressively treated, in some cases, with pre-emptive catheter ablation, despite the lack of symptoms. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - December 2, 2016 Category: Cardiology Authors: Susan S. Kim, Bradley P. Knight Source Type: research

Why are South Asians seemingly protected against the development of atrial fibrillation? A review of current evidence
This article summarizes current evidence surrounding the development of AF and its relationship to ethnicity, offers potential reasons for this disparity and identifies future areas of research. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 23, 2016 Category: Cardiology Authors: James O ’Neill, Muzahir H Tayebjee Source Type: research

The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications
Cardiovascular disease (CVD) is a health problem of great concern to both the public and medical authorities. Low-density lipoprotein (LDL) has been reported to play an important role in both the development and progression of CVD, but studies are underway to determine how LDL exerts its effects. In recent years, it has been found that LDL has several subfractions, each of which affects endothelial function differently; L5, the most electronegative fraction, has been shown to be unique in that it induces an atherogenic response. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 18, 2016 Category: Cardiology Authors: Sumeyya Akyol, Jonathan Lu, Omer Akyol, Fatih Akcay, Ferah Armutcu, Liang-Yin Ke, Chu-Huang Chen Source Type: research

Editorial Commentary: Clinical gene therapy trials for heart failure: Did they fail?
I have not failed. I ׳ve just found 10,000 ways that won׳t work. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 15, 2016 Category: Cardiology Authors: Shin Watanabe, Kiyotake Ishikawa Source Type: research

Clinical Gene Therapy Trials for Heart Failure: Did They Fail?
I have not failed. I've just found 10,000 ways that won't work. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 15, 2016 Category: Cardiology Authors: Shin Watanabe, Kiyotake Ishikawa Source Type: research

Gene Therapy for Heart Failure
Novel strategies are needed to treat the growing population of heart failure patients. While new drug and device based therapies have improved outcomes over the past several decades, heart failure patients continue to experience amongst the lowest quality of life of any chronic disease, high likelihood of being hospitalized and marked reduction in survival. Better understanding of many of the basic mechanisms involved in the development of heart failure has helped identify abnormalities that could potentially be targeted by gene transfer. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 4, 2016 Category: Cardiology Authors: Barry Greenberg Source Type: research

My APPROACH to the patient with arrhythmogenic right ventricular cardiomyopathy (ARVC)
Clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) is challenging owing to the broad range of phenotypic manifestations, reduced genetic penetrance, and age-related progression characterizing the disease. There is no single “gold-standard” test for ARVC, and diagnosis relies on a scoring system of “major” and “minor” criteria based on the demonstration of a combination of defects in ventricular morphology and function, depolarization/repolarization ECG abnormalities, myocardial tissue histological changes, arrhythmias, and family history. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - November 1, 2016 Category: Cardiology Authors: Angeliki Asimaki Source Type: research

Ed Board
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - October 11, 2016 Category: Cardiology Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - October 11, 2016 Category: Cardiology Source Type: research

Editorial commentary: Genetic testing in the absence of phenotype: When genetic testing may cause harm
Newly developed diagnostic tests are often embraced with great enthusiasm. Such advances create excitement for both practitioners and patients, providing hope that challenging medical conditions may be accurately diagnosed and henceforth optimally managed. This is the aim of all health care providers, to provide insightful explanation for ones suffering and to offer some means of disease-specific management. Among the great medical advances of the last 25 years, perhaps none have cross pollinated so many disciplines of medicine as the advent of clinical genetic testing, owing to the rapid successes in gene discovery resear...
Source: Trends in Cardiovascular Medicine - October 9, 2016 Category: Cardiology Authors: Michael H. Gollob, MD Source Type: research

Genetic Testing in the Absence of Phenotype: When Genetic Testing May Cause Harm
Newly developed diagnostic tests are often embraced with great enthusiasm. Such advances create excitement for both practitioners and patients, providing hope that challenging medical conditions may be accurately diagnosed and henceforth optimally managed. This is the aim of all health care providers, to provide insightful explanation for ones suffering and to offer some means of disease-specific management. Among the great medical advances of the last 25 years, perhaps none have cross pollinated so many disciplines of medicine as the advent of clinical genetic testing, owing to the rapid successes in gene discovery resear...
Source: Trends in Cardiovascular Medicine - October 9, 2016 Category: Cardiology Authors: Michael H. Gollob Source Type: research

Editorial commentary: Simulation training in cardiovascular medicine: Problematic, utopian or necessary?
Searching PubMed -all fields- for the string “simulation training”, we find that there is an unabated increase in publications in this field over the last two decades: from less than 200 papers in the late ’90s to more than 1600 in 2015. These papers are published in different journals in a variety of medical disciplines: from anesthesio logy to obstetrics and gynecology, from emergency medicine to ophthalmology, from laparoscopic surgery to nursing. The context in which these studies are conducted is quite different. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - October 6, 2016 Category: Cardiology Authors: Roberto De Ponti, MD, FHRS Tags: Editorial Commentary Source Type: research

Simulation training in cardiovascular medicine: problematic, utopian or necessary?
Searching PubMed -all fields- for the string “simulation training”, we find that there is an unabated increase in publications in this field over the last two decades: from less than 200 papers in the late ’90s to more than 1,600 in 2015. These papers are published in different journals in a variety of medical disciplines: from anesthesi ology to obstetrics and gynecology, from emergency medicine to ophthalmology, from laparoscopic surgery to nursing. The context in which these studies are conducted is quite different. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - October 6, 2016 Category: Cardiology Authors: Roberto De Ponti Source Type: research

My APPROACH to the depressed patient after a myocardial infarction
Depression following a myocardial infarction (MI) is known to increase the risk of complications, hospitalizations, and death. Therefore, screening for depression following an MI is strongly encouraged. All post-MI patients should be administered a validated depression questionnaire, such as the Patient Health Questionnaire (PHQ)-9. The American Heart Association (AHA) recommends a two-step depression screening method, consisting of the PHQ-2 followed by the PHQ-9, if indicated. Identifying the severity of depressive symptoms is important for determining the optimal treatment plan. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - October 5, 2016 Category: Cardiology Authors: Heidi T. May Source Type: research

MY APPROACH to Managing Statin-Associated Muscle Symptoms
Our clinic specializes in managing patients with statin-associated side effects and particularly muscle symptoms, or “SAMS.” The term SAMS is preferred over “statin myalgia” because it has been difficult to prove that statins cause mild muscle symptoms. I believe that statins do cause SAMS, although probably in fewer patients than we think. For example, in our double-blind, placebo-controlled STOMP study, 9.4% of 203 participants receiving 80mg of atorvastatin daily for 6 months developed reproducible muscle complaints as did 4.6% of 217 participants on placebo. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - October 5, 2016 Category: Cardiology Authors: Paul D. Thompson Source Type: research