Clinical Aspects of Inherited J-Wave Syndromes
Presence of J-point elevation with rapidly ascending ST segment in the anterior leads of the 12-lead electrocardiogram has been generally considered a benign phenomenon. The concept of benign nature of J-waves has changed as data emerged on variants of J-waves that were associated with the increased risk of sudden cardiac death. Two specific inherited arrhythmia syndromes, such as Brugada syndrome and early repolarization syndrome, have been recognized that carry an increased risk for ventricular fibrillation. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - September 5, 2014 Category: Cardiology Authors: Heikki V. Huikuri, M. Juhani Junttila Source Type: research

My Approach to Treatment of the Congenital Long QT Syndromes
. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - September 5, 2014 Category: Cardiology Authors: Michael J. Ackerman Source Type: research

Warfarin pharmacogenetics
The cytochrome P450 (CYP) 2C9 and vitamin K epoxide reductase complex 1 (VKORC1) genotypes have been strongly and consistently associated with warfarin dose requirements, and dosing algorithms incorporating genetic and clinical information have been shown to be predictive of stable warfarin dose. However, clinical trials evaluating genotype-guided warfarin dosing produced mixed results, calling into question the utility of this approach. Recent trials used surrogate markers as endpoints rather than clinical endpoints, further complicating translation of the data to clinical practice. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - September 5, 2014 Category: Cardiology Authors: Julie A. Johnson, Larisa H. Cavallari Source Type: research

New Cholesterol Guidelines and Primary Prevention in Women
Cardiovascular disease (CVD) remains the leading cause of death for women in the United States. The role of primary prevention of CVD is a necessary focus of healthcare, given the overall prevalence of CVD and its risk factors in women. In 2013, the American College of Cardiology and the American Heart Association released new guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk (ASCVD) in adults that were based on results of randomized-controlled trials. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - September 3, 2014 Category: Cardiology Authors: Martha Gulati, C. Noel Bairey Merz Source Type: research

Aspirin in the Primary Prevention of Cardiovascular Disease: Current Knowledge and Future Research Needs
The totality of evidence on aspirin in the primary prevention of cardiovascular disease is incomplete, whereas it is far more robust and clear in secondary prevention. Thus, any consideration of the benefits and risks of aspirin in primary prevention should be viewed in the context of the data in secondary prevention. [1] Further, all the data on aspirin should be viewed in the context of the contributions of different types of evidence in the conclusion of a valid statistical association from analytic studies designed a priori to test a hypothesis as well as a judgment of causality based on the totality of evidence. (Sour...
Source: Trends in Cardiovascular Medicine - September 1, 2014 Category: Cardiology Authors: Charles H. Hennekens, James E Dalen Source Type: research

State of the art: Cardiac transplantation
Recent advances in the management of heart transplant recipients have resulted in improved survival, particularly in the early post-transplant period. Although graft rejection, infection, malignancy, and allograft vasculopathy remain important challenges to the long-term management of heart transplant recipients, active research in these fields continues to advance our understanding and improve outcomes. This review will provide an overview of modern heart transplantation, summarize our current understanding of best practices for the management of heart transplant recipients, and describe recent advances in the field and a...
Source: Trends in Cardiovascular Medicine - August 26, 2014 Category: Cardiology Authors: Margot K. Davis, Sharon A. Hunt Source Type: research

Current trends in U.S. cardiology practice
Over the last six years, the practice of cardiology in the U.S. has experienced a substantial transition from independent practice to practices integrated within hospital systems. This change has been driven by major economic factors that have largely been determined by the federal government. Meanwhile, cardiologists׳ salaries and the demand for new cardiologists have remained stable. Best practices have embraced this new partnership with hospital systems to improve quality, cost, and access to cardiovascular care. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 26, 2014 Category: Cardiology Authors: Suzette Jaskie, George Rodgers Source Type: research

MY APPROACH to Heart Failure With Preserved Ejection Fraction
Barry A. Borlaug, MD (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 19, 2014 Category: Cardiology Authors: Barry A. Borlaug Tags: MY APPROACH Source Type: research

MY APPROACH to Treating Heart Failure With Reduced Ejection Fraction
Barry H. Greenberg, MD (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 19, 2014 Category: Cardiology Authors: Barry H. Greenberg Tags: MY APPROACH Source Type: research

Evaluation of the stable coronary artery disease patient: Anatomy trumps physiology
The past decade has been associated with profound progress in both the assessment and treatment of stable ischemic heart disease (SIHD) patients. The many randomized clinical trials, observational studies, and post hoc analyses continue to elucidate the role of coronary anatomy and ischemic burden in treating our patients in routine clinical practice, with the preponderance of the current scientific evidence base suggesting that coronary anatomy does indeed trump physiology in predicting future coronary events in SIHD patients. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 14, 2014 Category: Cardiology Authors: Karan P. Desai, Mandeep S. Sidhu, William E. Boden Source Type: research

The interplay between cell death signaling pathways in the heart
To date, one of the most intriguing and compelling concepts to impact contemporary cell biology is the notion that cell fate is “programmed” or genetically controlled. Indeed, the regulation of cell fate is crucial for embryonic development, and tissue homeostasis. Given the importance of removing damaged or irreversibly injured cells from the body, it is not surprising that defects in the regulatory mechanisms that govern cell death and/or survival more generally have been implicated in a number of human pathologies including cancer, neurodegenerative diseases, and cardiac failure. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 13, 2014 Category: Cardiology Authors: Agnieszka K. Biala, Lorrie A. Kirshenbaum Source Type: research

Adiponectin and insulin cross talk: The microvascular connection
Adiponectin exerts both vasodilatory and insulin-sensitizing actions and its levels are decreased in insulin-resistant humans and animals. The mechanisms underlying adiponectin׳s insulin-sensitizing effect have been extensively investigated but remain largely unclear. Muscle microvasculature critically regulates muscle insulin action by modulating insulin delivery to the microvessels nurturing the muscle cells and the trans-endothelial insulin transport. We have recently reported that adiponectin exerts its insulin-sensitizing effect via recruiting muscle microvasculature, expanding the endothelial surface area, and incre...
Source: Trends in Cardiovascular Medicine - August 7, 2014 Category: Cardiology Authors: Lina Zhao, Zhuo Fu, Zhenqi Liu Source Type: research

Novel drug-eluting stents for coronary revascularization
Over the past decades, there has been significant evolution in coronary stents used in percutaneous coronary intervention. The current novel drug-eluting stents available in the United States represent significant advancements compared to angioplasty, bare-metal stents, and the first generation of drug-eluting stents (DES). The Xience everolimus-eluting stents, Promus everolimus-eluting stents, and Resolute zotarolimus-eluting stents currently demonstrate the optimal balance of safety and efficacy. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 2, 2014 Category: Cardiology Authors: Bill D. Gogas, Michael McDaniel, Habib Samady, Spencer B. King Source Type: research

miR-22 in cardiac remodeling and disease
Regulation of gene expression during cardiac development and remodeling is very complicated, involving epigenetic, transcriptional, post-transcriptional, and translational regulation. Our understanding of the molecular mechanisms underlying cardiac remodeling is still far from complete. MicroRNAs are a class of small non-coding RNAs that have been shown to play critical roles in gene regulation in cardiovascular biology and disease. microRNA-22 (miR-22) is an evolutionally conserved miRNA that is highly expressed in the heart. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 2, 2014 Category: Cardiology Authors: Zhan-Peng Huang, Da-Zhi Wang Source Type: research

Novel Drug-Eluting Stents For Coronary Revascularization
Over the past decades, there has been significant evolution in coronary stents used in percutaneous coronary intervention. The current novel drug eluting stents available in the United States represent significant advancements compared to angioplasty, bare metal stents, and the first generation of drug-eluting stents (DES). The Xience everolimus-eluting stents, Promus everolimus-eluting stents, and Resolute Zotarolimus-eluting stents currently demonstrate the optimal balance of safety and efficacy. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 2, 2014 Category: Cardiology Authors: Bill D. Gogas, Michael McDaniel, Habib Samady, Spencer B. King Source Type: research

miR-22 in cardiac remodeling and disease
Regulation of gene expression during cardiac development and remodeling is very complicated, involving epigenetic, transcriptional, post-transcriptional and translational regulation. Our understanding of the molecular mechanisms underlying cardiac remodeling is still far from complete. MicroRNAs are a class of small non-coding RNAs that have been shown to play critical roles in gene regulation in cardiovascular biology and disease. microRNA-22 (miR-22) is an evolutionally conserved miRNA that is highly expressed in the heart. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 2, 2014 Category: Cardiology Authors: Zhan-Peng Huang, Da-Zhi Wang Source Type: research

An update on cardio-oncology
Over the past decades, there have been great advancements in the survival outcome of patients with cancer. As a consequence, treatment regimens are being extended to patient populations that would not have qualified in the past based on comorbidities and age. Furthermore, the anti-cancer regimens, which have been and are being used, can cause considerable morbidity and even mortality. In fact, new drugs such as tyrosine kinase inhibitors have yielded unanticipated side effects in frequency and severity. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 21, 2014 Category: Cardiology Authors: Joerg Herrmann, Amir Lerman Source Type: research

An Update on Cardio-Oncology
Over the past decades there have been great advancements in the survival outcome of patients with cancer. As a consequence, treatment regimens are being extended to patient populations, which would not have qualified in the past based on co-morbidities and age. Furthermore, the anti-cancer regimens, which have been and are being used, can cause considerable morbidity and even mortality. In fact, new drugs such as tyrosine kinase inhibitors have yielded unanticipated side effects in frequency and severity. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 21, 2014 Category: Cardiology Authors: Joerg Herrmann, Amir Lerman Source Type: research

Ablation of ventricular arrhythmias
Ventricular arrhythmias (VAs) commonly occur in patients with structural heart disease and may present as ventricular premature depolarizations (VPDs), monomorphic ventricular tachycardia (VT), or polymorphic VT/ventricular fibrillation. Idiopathic VAs can also occur in patients with normal hearts. This review explores the etiology, clinical presentation, and management strategies for different types of VAs. Medical and invasive treatment strategies are discussed, and different approaches to catheter ablation are outlined. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 11, 2014 Category: Cardiology Authors: Mouhannad M. Sadek, Francis E. Marchlinski Source Type: research

Ablation of Ventricular Arrhythmias
Ventricular arrhythmias (VAs) commonly occur in patients with structural heart disease, and may present as ventricular premature depolarizations (VPDs), monomorphic ventricular tachycardia (VT), or polymorphic VT/ ventricular fibrillation. Idiopathic VAs can also occur in patients with normal hearts. This review explores the etiology, clinical presentation and management strategies for different types of VAs. Medical and invasive treatment strategies are discussed, and different approaches to catheter ablation are outlined. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 11, 2014 Category: Cardiology Authors: Mouhannad M. Sadek, Francis E. Marchlinski Source Type: research

Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia: Risk factor and potential therapeutic target?
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited heart rhythm disorder characterized by the occurrence of potentially life-threatening polymorphic ventricular tachyarrhythmias in conditions of physical or emotional stress. The underlying cause is a dysregulation in intracellular Ca handling due to mutations in the sarcoplasmic reticulum Ca release unit. Recent experimental work suggests that sinus bradycardia, which is sometimes observed in CPVT patients, may be another primary defect caused by CPVT mutations. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 9, 2014 Category: Cardiology Authors: Michela Faggioni, Christian van der Werf, Bjorn C. Knollmann Source Type: research

MY APPROACH to clinical management of hypertrophic cardiomyopathy
My initial approach to a patient with hypertrophic cardiomyopathy (HCM) involves the assessment of several clinical issues: (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 9, 2014 Category: Cardiology Authors: Martin S. Maron Tags: MY APPROACH Source Type: research

MY APPROACH to evaluation of patients prior to high-risk PCI with left ventricular support devices
With the aging population and more extensive and complex coronary disease seen in the elderly population, there are times when interventional cardiologists are asked to perform high-risk percutaneous coronary intervention (PCI) among patients who have previously been considered for coronary artery bypass grafting, but where this strategy is not felt to be the best approach for the patient based on the heart team׳s review of the information. Performing high-risk PCI is fairly complex and straddles the area between bypass surgery and more routine medium- or low-risk PCI. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 9, 2014 Category: Cardiology Authors: E. Magnus Ohman Tags: MY APPROACH Source Type: research

Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia – risk factor and potential therapeutic target?
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 9, 2014 Category: Cardiology Authors: Michela Faggioni, Christian van der Werf, Bjorn Knollmann Source Type: research

MY APPROACH to Clinical Management of Hypertrophic Cardiomyopathy
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 9, 2014 Category: Cardiology Authors: Martin S. Maron Source Type: research

MY APPROACH to Evaluation of Patients Prior to High-Risk PCI With Left Ventricular Support Devices
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 9, 2014 Category: Cardiology Authors: E. Magnus Ohman Source Type: research

What can ancient mummies teach us about atherosclerosis?
Ancient mummies have captivated a wide variety of audiences for centuries. In order to better understand the evolution and causative features of atherosclerosis, the Horus group is applying modern scientific methods to study ancient mummies. We have used CT scanning to detect calcification in arteries as an indication of the presence of atherosclerosis, and are correlating these results with cultural and lifestyle features of various populations of ancient people as represented by their ancient mummified remains. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 3, 2014 Category: Cardiology Authors: Samuel Wann, Gregory S. Thomas Source Type: research

What Can Ancient Mummies Teach Us About Atherosclerosis?
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 3, 2014 Category: Cardiology Authors: Samuel Wann, Gregory S. Thomas Source Type: research

Introduction to MY APPROACH
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 1, 2014 Category: Cardiology Source Type: research

Cover 1
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 1, 2014 Category: Cardiology Source Type: research

Table of Contents
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 1, 2014 Category: Cardiology Source Type: research

TCM Editorial Policy
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 1, 2014 Category: Cardiology Source Type: research

Editorial board page
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - July 1, 2014 Category: Cardiology Source Type: research

Role of protease-activated receptors (PARs) for the innate immune response of the heart
Protease-activated receptors (PARs) are a family of G-protein-coupled receptors with a unique activation mechanism via cleavage by the serine proteases of the coagulation cascade, immune cell-released proteases, and proteases from pathogens. Pathogens, such as viruses and bacteria, cause myocarditis and heart failure and PAR1 was shown to positively regulate the anti-viral innate immune response via interferon β during virus-induced myocarditis. In contrast, PAR2 negatively regulated the innate immune response and inhibited the interferon β expression. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 26, 2014 Category: Cardiology Authors: Alice Weithauser, Ursula Rauch Source Type: research

Role of protease-activated Receptors (PARs)for the innate immune response of the heart
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 26, 2014 Category: Cardiology Authors: Alice Weithauser, Ursula Rauch Source Type: research

Chelation therapy and cardiovascular disease: Connecting Scientific Silos to Benefit Cardiac Patients
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 11, 2014 Category: Cardiology Authors: Julio G. Peguero, Ivan Arenas, Gervasio A. Lamas Source Type: research

An emerging role for the miR-26 family in cardiovascular disease
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 11, 2014 Category: Cardiology Authors: Basak Icli, Pranav Dorbala, Mark W. Feinberg Source Type: research

Mechanical Closure Devices for Atrial Fibrillation
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 7, 2014 Category: Cardiology Authors: Matthew J. Price, David R. Holmes Source Type: research

Pin1: A molecular Orchestrator in the heart
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 4, 2014 Category: Cardiology Authors: Nirmala Hariharan, Mark A. Sussman Source Type: research

MY APPROACH to Asymptomatic Mitral Regurgitation
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 4, 2014 Category: Cardiology Authors: Rick A Nishimura Source Type: research

MY APPROACH to the use of NOACs for stroke prevention in Patients with atrial fibrillation
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 4, 2014 Category: Cardiology Authors: Gregory Y.H. Lip Source Type: research

The value of cardiac genetic testing
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 2, 2014 Category: Cardiology Authors: Jodie Ingles, Christopher Semsarian Source Type: research

Renal Denervation for Refractory Ventricular Arrhythmias
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 29, 2014 Category: Cardiology Authors: Jason S. Bradfield, Marmar Vaseghi, Kalyanam Shivkumar Source Type: research

WITHDRAWN: Ceramic materials for porcelain veneers: Part II. effect of material, shade, and thickness on translucency
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 27, 2014 Category: Cardiology Authors: Karine T.L. Barizon, Cathia Bergeron, Marcos A. Vargas, Fang Qian, Deborah S. Cobb, David G. Gratton, Saulo Geraldeli Source Type: research

My Approach to Detecting Atrial Fibrillation
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 26, 2014 Category: Cardiology Authors: Rod Passman Source Type: research

The ten advances that have defined modern cardiology
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 21, 2014 Category: Cardiology Authors: Eugene Braunwald Source Type: research

Introduction to MY APPROACH
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 12, 2014 Category: Cardiology Authors: C. Richard Conti Source Type: research

WITHDRAWN: The Ten Advances that Have Defined Modern Cardiology
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 12, 2014 Category: Cardiology Authors: Eugene Braunwald Source Type: research

My Approach to Evaluating Chest Pain in the ER
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 12, 2014 Category: Cardiology Authors: C. Richard Conti Source Type: research

Cover 1
(Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 1, 2014 Category: Cardiology Source Type: research