Editorial commentary: QTdrugs: From electrocardiographic intervals to prevention of sudden cardiac death
I am pleased to comment on the article of Woosley et al. [1] published in this issue of TCM. The QT interval represents both the ventricular depolarization (QRS complex) and repolarization (ST segment and T wave). When depolarization is normal (QRS complexes of normal duration), we used it as a surrogate to measure electrical recovery of ventricular myocardium [2]. QT interval varies inversely with heart rate and therefore the clinical parameter we used is the corrected QT interval or QTc; usually using the formula described by Henry Cuthbert Bazett from Oxford in 1920 [3] and modified to its actual form in 1947 by Taran a...
Source: Trends in Cardiovascular Medicine - August 23, 2017 Category: Cardiology Authors: Manlio F. M árquez Source Type: research
QTdrugs: From electrocardiographic intervals to prevention of sudden cardiac death
I am pleased to comment on the article of Woosley et al. [1] published in this issue of TCM. The QT interval represents both the ventricular depolarization (QRS complex) and repolarization (ST segment and T wave). When depolarization is normal (QRS complexes of normal duration), we used it as a surrogate to measure electrical recovery of ventricular myocardium [2]. QT interval varies inversely with heart rate and therefore the clinical parameter we used is the corrected QT interval or QTc; usually using the formula described by Henry Cuthbert Bazett from Oxford in 1920 [3] and modified to its actual form in 1947 by Taran a...
Source: Trends in Cardiovascular Medicine - August 23, 2017 Category: Cardiology Authors: Manlio F Marquez Source Type: research
Editorial commentary: Leadless pacemaker: A pacemaker revolution or a simply new alternative solution?
A review concerning leadless pacemaker (LPM) performance and complications is presented by Lee et al. [1] in the current issue of the journal. This is of particular interest given the recent published studies and registries in this field and the ongoing discussion in the EP community [2 –6]. So far, permanent endovenous cardiac pacing was the main effective treatment for symptomatic bradycardia, yet the conventional transvenous pacemaker (PM) used to achieve it carries complications associated with its pacing lead and pocket [7,8]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 22, 2017 Category: Cardiology Authors: Antoine Da Costa Source Type: research
Leadless Pacemaker: A Pacemaker Revolution or a Simply New Alternative Solution?
A review concerning leadless pacemaker (LPM) performance and complications is presented by Justin Z. Lee et al. in the current issue of the journal [1]. This is of particular interest given the recent published studies and registries in this field and the ongoing discussion in the EP community [2 –6]. So far, permanent endovenous cardiac pacing was the main effective treatment for symptomatic bradycardia, yet the conventional transvenous pacemaker (PM) used to achieve it carries complications associated with its pacing lead and pocket [7,8]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 22, 2017 Category: Cardiology Authors: Antoine Da Costa Tags: Editorial commentary Source Type: research
Editorial commentary: Modulation of the QT interval by gender and age
Bazett noted in 1920 that women have a longer QT interval than men, an observation confirmed by multiple subsequent studies. In the last several decades we have learned much more about the effect of gender and age on the QT interval, as well as the role of sex hormones in modulating cardiac myocyte behavior, and the interaction between age, gender, and long QT syndrome mutations. In the current issue of “Trends in Cardiovascular Medicine,” Vink et al. [1] provide an in-depth review of the effects of gender and age on the QT interval in normal subjects and in patients with long QT syndrome. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 19, 2017 Category: Cardiology Authors: Elizabeth S. Kaufman Source Type: research
Editorial commentary: Death after acute myocardial infarction, possible to predict?
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in the United States and across the globe. Given the extensive number of people affected each year [1], attempts to predict which patients are at elevated risk of adverse outcomes have been a mainstay of clinical care for decades. As aptly noted by Castro-Dominguez and co-authors in the current edition of Trends in Cardiovascular Medicine, the primary aim of such predictions is to inform prognosis and guide treatment decisions [2]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 19, 2017 Category: Cardiology Authors: Krzysztof Drzymalski, Joshua Schulman-Marcus Source Type: research
Editorial commentary: Is it still important to evaluate patients with ischemic cardiomyopathy for viable dysfunctional myocardium prior to myocardial revascularization?
In this issue of Trends in Cardiovascular Medicine, Kalra et al. [1] provide a state-of-the-art summary of the contemporary approaches available to evaluate myocardial viability and address the increasingly controversial question as to whether it is still clinically relevant in the management of patients with ischemic cardiomyopathy. The historical view and answer to this question would be a resounding yes! The presence of viable dysfunctional myocardium in patients with severely depressed left ventricular function has been used to identify a subgroup of patients that had left ventricular dysfunction on the basis of chroni...
Source: Trends in Cardiovascular Medicine - August 19, 2017 Category: Cardiology Authors: John M. Canty Source Type: research
Death after Acute Myocardial Infarction, Possible to Predict?
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in the United States and across the globe. Given the extensive number of people affected each year [1], attempts to predict which patients are at elevated risk of adverse outcomes have been a mainstay of clinical care for decades. As aptly noted by Castro-Dominguez and co-authors in the current edition of Trends in Cardiovascular Medicine, the primary aim of such predictions is to inform prognosis and guide treatment decisions [2]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 19, 2017 Category: Cardiology Authors: Krzysztof Drzymalski, Joshua Schulman-Marcus Source Type: research
Modulation of the QT interval by Gender and Age
Bazett noted in 1920 that women have a longer QT interval than men, an observation confirmed by multiple subsequent studies. In the last several decades we have learned much more about the effect of gender and age on the QT interval, as well as the role of sex hormones in modulating cardiac myocyte behavior, and the interaction between age, gender, and long QT syndrome mutations. In the current issue of “Trends in Cardiovascular Medicine”, Vink et al. provide an in-depth review of the effects of gender and age on the QT interval in normal subjects and in patients with long QT syndrome [1]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 19, 2017 Category: Cardiology Authors: Elizabeth S. Kaufman Source Type: research
Is it Still Important to Evaluate Patients with Ischemic Cardiomyopathy for Viable Dysfunctional Myocardium Prior to Myocardial Revascularization?
In this issue of Trends in Cardiovascular Medicine, Kalra and colleagues [1] provide a state of the art summary of the contemporary approaches available to evaluate myocardial viability and address the increasingly controversial question as to whether it is still clinically relevant in the management of patients with ischemic cardiomyopathy. The historical view and answer to this question would be a resounding yes! The presence of viable dysfunctional myocardium in patients with severely depressed left ventricular function has been used to identify a subgroup of patients that had left ventricular dysfunction on the basis o...
Source: Trends in Cardiovascular Medicine - August 19, 2017 Category: Cardiology Authors: John M. Canty Source Type: research
Current Status of MitraClip for Patients with Mitral and Tricuspid Regurgitation
Mitral valve regurgitation (MR) affects approximately 4 million people in the United States alone, increasing in prevalence with age. Approved by the Food and Drug Administration (FDA) in October 2013, percutaneous edge-to-edge transcatheter mitral valve repair (also known as the MitraClip system) has been used in over 40,000 patients globally. Additionally, there is keen interest and early exploration into the use of MitraClip for treatment of severe symptomatic tricuspid regurgitation, another undertreated disease with significant morbidity and mortality. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 18, 2017 Category: Cardiology Authors: Sidakpal S. Panaich, Mackram F. Eleid Source Type: research
Biology and clinical relevance of noncoding sno/scaRNAs
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small Cajal body-associated RNAs (scaRNAs) are a subset of the snoRNA family and collect in the Cajal body where they perform their canonical function to biochemically modify spliceosomal RNAs prior to maturation. Failure of sno/scaRNAs have been implicated in pathology such as congenital heart anomalies, neuromuscular disorders, and various malignancies. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 11, 2017 Category: Cardiology Authors: Thuy Cao, Sheeja Rajasingh, Saheli Samanta, Buddhadeb Dawn, Douglas C. Bittel, Johnson Rajasingh Source Type: research
Biology and clinical relevance of non-coding sno/scaRNAs
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small Cajal body associated RNAs (scaRNAs) are a subset of the snoRNA family and collect in the Cajal body where they perform their canonical function to biochemically modify spliceosomal RNAs prior to maturation. Failure of sno/scaRNAs have been implicated in pathology such as congenital heart anomalies, neuromuscular disorders, and various malignancies. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 11, 2017 Category: Cardiology Authors: Thuy Cao, Sheeja Rajasingh, Saheli Samanta, Buddhadeb Dawn, Douglas C. Bittel, Johnson Rajasingh Source Type: research
Long-term outlook for transcatheter aortic valve replacement
Transcatheter aortic valve replacement (TAVR) revolutionized the treatment of severe symptomatic aortic stenosis (AS). TAVR is increasingly offered for lower-risk patients. The role and place of TAVR in the future treatment of AS is not clear yet. In this review, we discuss the long-term outlook for TAVR, its challenges and its relationship to conventional surgical aortic valve replacement. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 10, 2017 Category: Cardiology Authors: Andras P. Durko, Ruben L. Osnabrugge, A. Pieter Kappetein Source Type: research
Long term outlook for transcatheter aortic valve replacement
Transcatheter aortic valve replacement (TAVR) revolutionized the treatment of severe symptomatic aortic stenosis (AS). TAVR is increasingly offered for lower-risk patients. The role and place of TAVR in the future treatment of AS is not clear yet. In this review, we discuss the long term outlook for TAVR, its challenges and its relationship to conventional surgical aortic valve replacement. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - August 10, 2017 Category: Cardiology Authors: Andras P. Durko, Ruben L. Osnabrugge, A. Pieter Kappetein Source Type: research
