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(Source: Transplantation Reviews)
Source: Transplantation Reviews - April 1, 2017 Category: Transplant Surgery Source Type: research
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(Source: Transplantation Reviews)
Source: Transplantation Reviews - April 1, 2017 Category: Transplant Surgery Source Type: research
Management Of Biliary Anastomotic Strictures After Liver Transplantation
Biliary strictures constitute 40% to 60% of the biliary complications after liver transplantation. They are more common after living donor related liver transplantation (LDLT) than orthotopic liver transplantation (OLT). Balloon dilation followed by multiple plastic stent insertion leads to a mean resolution rate of 84% in the treatment of ASs after OLT. Endoscopic treatment of ASs after LDLT is more difficult because of the small size of the ASs, their multiple number and peripheral location. Balloon dilation followed by multiple plastic stent insertion had a mean resolution rate of 53%. (Source: Transplantation Reviews)
Source: Transplantation Reviews - March 29, 2017 Category: Transplant Surgery Authors: Aydin Seref Koksal, Ahmet Tarik Eminler, Erkan Parlak, Ahmet Gurakar Source Type: research
Handle with care: A systematic review on frailty in cardiac care and its usefulness in heart transplantation
There is growing consensus that frailty, a state of vulnerability and a decline in functioning across multiple physiological body systems, is a valuable criterion to guide clinicians' risk prediction for poor outcomes in adult transplant candidates. In its 2016 listing criteria for heart transplantation the International Society for Heart Lung Transplantation recommends frailty assessment. We aimed to summarize the usefulness of frailty assessment in heart transplant candidates or recipients reported throughout the literature. (Source: Transplantation Reviews)
Source: Transplantation Reviews - March 29, 2017 Category: Transplant Surgery Authors: Oliver Mauthner, Veerle Claes, Mieke Deschodt, Sunita R. Jha, Sandra Engberg, Peter S. Macdonald, Phillip J. Newton, Sabina De Geest Source Type: research
The use of kinase inhibitors in solid organ transplantation
Despite the efficacy of current immunosuppression regimes used in solid organ transplantation, graft dysfunction, graft lost and antibody-mediated rejection, continue to be problematic. As a result; clear attraction in exploiting key potential targets controlled by kinase phosphorylation have led to a number of studies exploring the use of these drugs in transplantation.AimIn this review, we consider the role of tyrosine kinase as a target in transplantation and summarise the relevant studies on kinase inhibitors that have been reported to date. (Source: Transplantation Reviews)
Source: Transplantation Reviews - March 25, 2017 Category: Transplant Surgery Authors: S Dholakia, JE Fildes, PJ Friend Source Type: research
Cutaneous Fungal Infections in Solid Organ Transplant Recipients
Although there is an abundance of information on cutaneous malignancies in transplant recipients, information on cutaneous infections in solid organ transplant recipients is underrepresented in dermatologic and transplant literature. Our paper provides a comprehensive review of fungal cutaneous infections within the solid organ transplant population. We compiled literature specific to the solid organ transplant population, reviewing cutaneous manifestations owing to fungal infections. Furthermore, we discuss the diagnosis and treatment of such infections. (Source: Transplantation Reviews)
Source: Transplantation Reviews - March 11, 2017 Category: Transplant Surgery Authors: Muneeb Ilyas, Amit Sharma Source Type: research
Optimizing everolimus exposure when combined with calcineurin inhibitors in solid organ transplantation
The mammalian target of rapamycin (mTOR) inhibitor everolimus is a narrow therapeutic index drug for which optimal exposure levels are essential. The consistent pharmacokinetic profile of everolimus allows trough concentration (C0) measurement to be an appropriate and reliable index for therapeutic drug monitoring (TDM). Exposure-response analyses of data from early fixed-dose trials demonstrated that rates of biopsy-proven acute rejection (BPAR) are significantly higher if everolimus C0 declines below 3 ng/mL, an observation confirmed in subsequent concentration-controlled trials. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 25, 2017 Category: Transplant Surgery Authors: Teun van Gelder, Lutz Fischer, Fuad Shihab, Maria Shipkova Source Type: research
Neurological disorders in liver transplant candidates: pathophysiology and clinical assessment
Compromised liver function, as a consequence of acute liver insufficiency or severe chronic liver disease may be associated with various neurological syndromes, which involve both central and peripheral nervous system. Acute and severe hyperammoniemia inducing cellular metabolic alterations, prolonged state of “neuroinflammation”, activation of brain microglia, accumulation of manganese and ammonia, and systemic inflammation are the main causative factors of brain damage in liver failure. The most widely recognized neurological complications of serious hepatocellular failure include hepatic encephalop athy, diffuse cer...
Source: Transplantation Reviews - February 24, 2017 Category: Transplant Surgery Authors: Paolo Feltracco, Annachiara Cagnin, Cristiana Carollo, Stefania Barbieri, Carlo Ori Source Type: research
Antithymocyte globulins in renal transplantation —from lymphocyte depletion to lymphocyte activation: The doubled-edged sword
Compelling data suggest that lymphocyte depletion following T cell depleting therapy may induce prolonged CD4 T cell lymphopenia and trigger lymphocyte activation in some patients. These profound and non-reversible immune changes in T cell pool subsets are the consequence of both impaired thymic renewal and peripheral homeostatic proliferation. Chronic viral challenges by CMV play a major role in these immune alterations. Even when the consequences of CD4 T cell lymphopenia have been now well described, recent studies shed new light on the clinical consequences of immune activation. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 17, 2017 Category: Transplant Surgery Authors: Jamal Bamoulid, Thomas Cr épin, Cécile Courivaud, Jean-Michel Rebibou, Philippe Saas, Didier Ducloux Source Type: research
Antithymocyte globulins in renal transplantation - from lymphocyte depletion to lymphocyte activation: the doubled-edged sword
Compelling data suggest that lymphocyte depletion following T cell depleting therapy may induce prolonged CD4 T cell lymphopenia and trigger lymphocyte activation in some patients. These profound and non-reversible immune changes in T cell pool subsets are the consequence of both impaired thymic renewal and peripheral homeostatic proliferation. Chronic viral challenges by CMV play a major role in these immune alterations. Even when the consequences of CD4 T cell lymphopenia have been now well described, recent studies shed new light on the clinical consequences of immune activation. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 16, 2017 Category: Transplant Surgery Authors: Jamal Bamoulid, Thomas Cr épin, Cécile Courivaud, Jean-Michel Rebibou, Philippe Saas, Didier Ducloux Source Type: research
Sex Differences in Transplantation
Sex plays a role in the incidence and progression of a wide variety of diseases and conditions related to transplantation. Additionally, a growing body of clinical and experimental evidence suggests that sex can impact the pharmacokinetics and pharmacodynamics of several commonly used immunosuppressive and anti-infective drugs in transplant recipients. A better understanding of these sex differences will facilitate advances in individualizing treatment for patients and improve outcomes of solid organ transplantation. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 16, 2017 Category: Transplant Surgery Authors: Jeremiah D. Momper, Michael L. Misel, Dianne B. McKay Source Type: research
Current Understanding and Management of Splenic Steal Syndrome After Liver Transplant: A Systematic Review
Splenic steal syndrome (SSS) is a condition that can occur after orthotopic liver transplant (OLT). However, limited information is available about this condition. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 16, 2017 Category: Transplant Surgery Authors: Chaolun Li, Baljendra Kapoor, Eunice Moon, Cristiano Quintini, Weiping Wang Source Type: research
Supplemental Oxygen During Hypothermic Kidney Preservation: A Systematic Review
We reviewed the evidence for ex-vivo Supplemental Oxygen during Hypothermic preservation (SOH) for deceased donor kidneys. Bibliographic databases were searched for human and animal studies of SOH in kidney transplantation reporting on patient or animal survival rate, discard rate, technical complications or renal function outcomes. We make special reference to a specific subgroup: supplemental oxygen applied during cold perfusion, referred to as Hypothermic Oxygenated Perfusion (HOP). Four human and 25 animal studies were identified. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 16, 2017 Category: Transplant Surgery Authors: JM O'Callaghan, KT Pall, LHM Pengel, Consortium for Organ preservation in Europe (COPE) Source Type: research
The clinical course of IgA Nephropathy after Kidney Transplantation and its management
Immunoglobulin (Ig) A nephropathy is one of the most common primary glomerulonephritides worldwide causing end stage renal disease in up to 20 –40% of affected patients, nearly two decades post diagnosis. Kidney transplantation is the treatment of choice for patients with renal failure, secondary to glomerular diseases. However, IgA nephropathy has a strong tendency to recur in the graft, and although initially thought to be a benign con dition, several reports of graft loss, due to recurrent IgA nephropathy, there have been over the last three decades. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 1, 2017 Category: Transplant Surgery Authors: Sophia Lionaki, Konstantinos Panagiotellis, Christine Melexopoulou, John N Boletis Tags: Review article Source Type: research
Bridging Locoregional Therapy: Longitudinal Trends and Outcomes in Patients with Hepatocellular Carcinoma
The purpose of this article is to analyze longitudinal trends in locoregional therapy (LRT) use and review locoregional therapy's role in the management of hepatocellular carcinoma prior to orthotropic liver transplantation Porrett et al. (2006) . LRT has a role in both bridge to transplantation and downstaging of patients not initially meeting Milan or UCSF Criteria. Due to the lack of randomized controlled trials, no specific bridging LRT modality is recommended over another for treating patients on the waiting list, however each modality has unique and patient-specific advantages. (Source: Transplantation Reviews)
Source: Transplantation Reviews - February 1, 2017 Category: Transplant Surgery Authors: Hayley C. Oligane, Orrie N. Close, Minzhi Xing, Hyun S. Kim Source Type: research
