Transcriptomic profile of human iPSC-derived podocyte-like cells exposed to a panel of xenobiotics
Toxicol In Vitro. 2024 Mar 4:105804. doi: 10.1016/j.tiv.2024.105804. Online ahead of print.ABSTRACTPodocytes play a critical role in the formation and maintenance of the glomerular filtration barrier and injury to these cells can lead to a breakdown of the glomerular barrier causing permanent damage leading to progressive chronic kidney disease. Matured podocytes have little proliferative potential, which makes them critical cells from a health perspective, but also challenging cells to maintain in vitro. Differentiating podocyte-like cells from induced pluripotent stem cells (iPSC) cells provides a novel and continuous so...
Source: Toxicology in Vitro - March 6, 2024 Category: Toxicology Authors: Cormac Murphy Paul Jennings Anja Wilmes Source Type: research
Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
CONCLUSION: Lovastatin impairs cellular proliferation but enhances HA production in human FLSs.PMID:38432573 | DOI:10.1016/j.tiv.2024.105806 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 3, 2024 Category: Toxicology Authors: Wen-Tien Wu Chen-Chie Wang Dai-Hua Lu Kuan-Jung Lu Yu-Chia Chang Kai-Chiang Yang Source Type: research
Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
CONCLUSION: Lovastatin impairs cellular proliferation but enhances HA production in human FLSs.PMID:38432573 | DOI:10.1016/j.tiv.2024.105806 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 3, 2024 Category: Toxicology Authors: Wen-Tien Wu Chen-Chie Wang Dai-Hua Lu Kuan-Jung Lu Yu-Chia Chang Kai-Chiang Yang Source Type: research
Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
CONCLUSION: Lovastatin impairs cellular proliferation but enhances HA production in human FLSs.PMID:38432573 | DOI:10.1016/j.tiv.2024.105806 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 3, 2024 Category: Toxicology Authors: Wen-Tien Wu Chen-Chie Wang Dai-Hua Lu Kuan-Jung Lu Yu-Chia Chang Kai-Chiang Yang Source Type: research
Characterization of palmitic acid toxicity induced insulin resistance in HepG2 cells
CONCLUSION: Thus, our data clearly demonstrate that both these mechanisms work simultaneously and more importantly, identified a threshold of HepG2 cells, which when crossed led to the pathological state of IR in response to PA.PMID:38431059 | DOI:10.1016/j.tiv.2024.105802 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 2, 2024 Category: Toxicology Authors: Sajad Malik Shrirang Inamdar Jhankar Acharya Pranay Goel Saroj Ghaskadbi Source Type: research
Using cell culture systems from the Persian Gulf Arabian yellowfin sea bream, Acanthopagrus arabicus, to assess the effects of dexamethasone on gonad and brain aromatase activity and steroid production
In conclusion, results highlight that DEX is able to change the activity of aromatase, and disrupt the biosynthesis of estrogens and thus affect reproduction in fish.PMID:38431060 | DOI:10.1016/j.tiv.2024.105803 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 2, 2024 Category: Toxicology Authors: Zahra Balasem Negin Salamat Hoda Mojiri-Forushani Source Type: research
Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis
CONCLUSION: Circ_0003356 is identified as a potential biomarker of the prognosis of human gastric cancer, and circ_0003356/miR-556-5p/FKBP5 axis could be a promising target in gastric cancer treatment.PMID:38401744 | DOI:10.1016/j.tiv.2024.105787 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Chuanhui Lu Jing Wu Xiaoguang Li Wei Huang Yongmu Fang Ying Huang Source Type: research
In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22;97:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thro...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research
Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis
CONCLUSION: Circ_0003356 is identified as a potential biomarker of the prognosis of human gastric cancer, and circ_0003356/miR-556-5p/FKBP5 axis could be a promising target in gastric cancer treatment.PMID:38401744 | DOI:10.1016/j.tiv.2024.105787 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Chuanhui Lu Jing Wu Xiaoguang Li Wei Huang Yongmu Fang Ying Huang Source Type: research
In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research
Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis
CONCLUSION: Circ_0003356 is identified as a potential biomarker of the prognosis of human gastric cancer, and circ_0003356/miR-556-5p/FKBP5 axis could be a promising target in gastric cancer treatment.PMID:38401744 | DOI:10.1016/j.tiv.2024.105787 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Chuanhui Lu Jing Wu Xiaoguang Li Wei Huang Yongmu Fang Ying Huang Source Type: research
In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research
Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis
CONCLUSION: Circ_0003356 is identified as a potential biomarker of the prognosis of human gastric cancer, and circ_0003356/miR-556-5p/FKBP5 axis could be a promising target in gastric cancer treatment.PMID:38401744 | DOI:10.1016/j.tiv.2024.105787 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Chuanhui Lu Jing Wu Xiaoguang Li Wei Huang Yongmu Fang Ying Huang Source Type: research
In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research
Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis
CONCLUSION: Circ_0003356 is identified as a potential biomarker of the prognosis of human gastric cancer, and circ_0003356/miR-556-5p/FKBP5 axis could be a promising target in gastric cancer treatment.PMID:38401744 | DOI:10.1016/j.tiv.2024.105787 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Chuanhui Lu Jing Wu Xiaoguang Li Wei Huang Yongmu Fang Ying Huang Source Type: research
