Hemocompatibility studies in nanotoxicology: Hemolysis or eryptosis? (A review)
Toxicol In Vitro. 2024 Apr 4;98:105814. doi: 10.1016/j.tiv.2024.105814. Online ahead of print.ABSTRACTHemocompatibility evaluation is an important step in nanotoxicological studies. It is generally accepted that nanomaterials promote lysis of erythrocytes, blood clotting, alter phagocytosis, and upregulate pro-inflammatory cytokines. However, there are no standardized guidelines for testing nanomaterials hemocompatibility despite the fact that nanomaterials enter the bloodstream and interact with blood cells. In this review, the current knowledge on the ability of nanomaterials to induce distinct cell death modalities of e...
Source: Toxicology in Vitro - April 6, 2024 Category: Toxicology Authors: Anton Tkachenko Source Type: research
Hemocompatibility studies in nanotoxicology: Hemolysis or eryptosis? (A review)
Toxicol In Vitro. 2024 Apr 4:105814. doi: 10.1016/j.tiv.2024.105814. Online ahead of print.ABSTRACTHemocompatibility evaluation is an important step in nanotoxicological studies. It is generally accepted that nanomaterials promote lysis of erythrocytes, blood clotting, alter phagocytosis and upregulate pro-inflammatory cytokines. However, there are no standardized guidelines for testing nanomaterials hemocompatibility despite the fact that nanomaterials enter the bloodstream and interact with blood cells. In this review, the current knowledge on the ability of nanomaterials to induce distinct cell death modalities of eryth...
Source: Toxicology in Vitro - April 6, 2024 Category: Toxicology Authors: Anton Tkachenko Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption
Toxicol In Vitro. 2024 Mar 24;97:105813. doi: 10.1016/j.tiv.2024.105813. Online ahead of print.ABSTRACTThe aims of the current study included characterizing the intestinal transport mechanism of polystyrene microplastics (MPs) with different charges and sizes in the intestinal epithelial cell model and determining the inhibitory effect of green tea extracts (GTEs) on the intestinal absorption of MPs in Caco-2 cells. The smaller sizes, which included diameters of 0.2 μm, of amine-modified MPs compared to either larger size (1 μm diameter, or carboxylate-MPs (0.2 and 1 μm diameter) significantly lowered the cell viability...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Woo-Hyun Kim Dong-Ho Lee Jeong-Eun Kim Hyun Woo Jeong Jin-Oh Chung JongHwa Roh WanGi Kim Xiaoting Fu Soon-Mi Shim Source Type: research
