Time to treat the climate and nature crisis as one indivisible global health emergency
Over 200 health journals call on the United Nations (UN), political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency. The world is currently responding to the climate crisis and the nature crisis as if they were separate challenges. This is a dangerous mistake. The 28th Conference of the Parties (COP) on climate change is about to be held in Dubai while the 16th COP on biodiversity is due to be held in T...
Source: Thorax - December 15, 2023 Category: Respiratory Medicine Authors: Zielinski, C., on behalf of the authorship group listed below Tags: Open access, Thorax Editorial Source Type: research
Journal club
Does a brand-name inhaler provide better efficacy compared with its generic counterpart? The clinical equivalence between generic and brand-name inhalers has yet to be determined. Moreover, there is a lack of comprehensive studies on specific populations affected by these products. To bridge this knowledge gap, Feldman et al1 conducted a cohort study focusing on adults aged 40 and above diagnosed with chronic obstructive pulmonary disease (COPD). The research aimed to compare the effectiveness and safety of fluticasone-salmeterol inhalers (a combination therapy consisting of inhaled corticosteroids and long acting bronchod...
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Ee, W. W. Tags: Thorax Journal club Source Type: research
Readmission following hospital admission for community-acquired pneumonia in England
Conclusion
Pneumonia is the most common condition treated on readmission following hospitalisation with CAP and carries a higher mortality than both the index admission or readmission due to other diagnoses. Strategies to reduce readmissions due to pneumonia are required. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Lawrence, H., McKeever, T. M., Lim, W. S., On behalf of the British Thoracic Society Tags: Thorax Respiratory infection Source Type: research
Examining the effect of the COVID-19 pandemic on community virus prevalence and healthcare utilisation reveals that peaks in asthma, COPD and respiratory tract infection occur with the re-emergence of rhino/enterovirus
Conclusions
The prevalence of nearly all non-COVID-19 respiratory viruses decreased during the pandemic and was associated with marked reductions in ED visits and hospitalisations. The re-emergence of rhino/enterovirus was associated with increased healthcare utilisation. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Ho, T., Shahzad, A., Jones, A., Raghavan, N., Loeb, M., Johnston, N. Tags: Open access, Thorax, COVID-19 Respiratory epidemiology Source Type: research
Core outcome set for pulmonary rehabilitation of patients with COPD: results of a modified Delphi survey
Conclusion
A COS for PR of people with COPD is now available and can be used by different stakeholders to improve consistency and comparability of studies, benchmark PR and improve the quality of care provided. Future research should establish the core measures and investigate the uptake of this COS. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Souto-Miranda, S., Saraiva, I., Spruit, M. A., Marques, A. Tags: Thorax Rehabilitation Source Type: research
Lung function tracking in children with perinatally acquired HIV following early antiretroviral therapy initiation
Conclusion
Our study indicates that early ART initiation can mitigate the loss of lung function in CHIV with lasting benefit through childhood; however, there remains concern of small airway disease. CHEU does not appear to disrupt childhood lung function trajectory. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Gie, A., Davies, C., Vaida, F., Morrison, J., Maree, D., Otwombe, K., Browne, S. H., van der Zalm, M. M., Cotton, M. F., Innes, S., Goussard, P. Tags: Open access, Thorax Paediatric lung disease Source Type: research
Risk factors for poorer respiratory outcomes in adolescents and young adults born preterm
Conclusions
Even after accounting for the neonatal course, a respiratory admission during childhood remained significantly associated with reduced peak lung function in the preterm-born cohort, with the largest difference seen in those with BPD. A respiratory admission during childhood should, therefore, be considered a risk factor for long-term respiratory morbidity in those born preterm, especially for individuals with BPD. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Smith, E. F., Hemy, N. R., Hall, G. L., Wilson, A. C., Murray, C. P., Simpson, S. J. Tags: Open access, Thorax Paediatric lung disease Source Type: research
Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard
Conclusion
More preterm infants are surviving with worse respiratory outcomes, particularly severe BPD requiring postdischarge respiratory support. Ultimately, these survivors will develop chronic respiratory diseases requiring greater healthcare resources. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Kwok, T. C., Poulter, C., Algarni, S., Szatkowski, L., Sharkey, D. Tags: Open access, Thorax Paediatric lung disease Source Type: research
Early experience of a new national lung allocation scheme in the UK based on clinical urgency
Conclusion
The UKLAS scheme prioritises the critically ill and improves transplantation odds. The true impact on waiting-list mortality and post-transplant survival requires further follow-up. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Al-Adhami, A., Al-Aloul, M., Rushton, S., Thompson, R. D., Carby, M., Lordan, J., Clark, S., Spencer, H., Tsui, S., Parmar, J. Tags: Editor's choice, Thorax Lung transplantation Source Type: research
Novel electromagnetic navigation bronchoscopy system for the diagnosis of peripheral pulmonary nodules: a prospective, multicentre study
Conclusion
This novel ENB system can be used in combination with different bronchoscopes, ancillary techniques and sampling instruments with a high diagnostic yield and safety profile for the diagnosis of PPNs, of which the combination of thin bronchoscope, rEBUS and GS was the most common method in clinical practice.
Trial registration number
NCT03716284. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Li, Y., Chen, W., Xie, F., Huang, R., Liu, X., Xiao, Y., Cao, L., Hu, Y., Ke, M., Wu, S., Sun, J. Tags: Open access, Thorax Lung cancer Source Type: research
Phenotyping by persistent inflammation in systemic sclerosis associated interstitial lung disease: a EUSTAR database analysis
Conclusions
Phenotyping by persistent inflammation provides valuable prognostic information, independent of demographics, disease duration, cutaneous subtype, treatment and SSc-ILD severity. The findings from this study support early immunosuppressive treatment in patients with SSc-ILD with persistent inflammation. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Guler, S., Sarbu, A.-C., Stalder, O., Allanore, Y., Bernardino, V., Distler, J., Gabrielli, A., Hoffmann-Vold, A.-M., Matucci-Cerinic, M., Müller-Ladner, U., Ortiz-Santamaria, V., Rednic, S., Riccieri, V., Smith, V., Ullman, S., Walker, U. A., Gei Tags: Thorax Interstitial lung disease Source Type: research
Fragmentation of care between intensive and primary care settings and opportunities for improvement
Conclusion
This study identified gaps in care between ICU discharge and reintegration with primary care from the lived experience of patients, caregivers, intensivists and GPs. These data provide foci for future interventional research to improve the integration of care for this vulnerable and underserved cohort. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Leggett, N., Emery, K., Rollinson, T. C., Deane, A., French, C., Manski Nankervis, J.-A., Eastwood, G., Miles, B., Merolli, M., Ali Abdelhamid, Y., Haines, K. J. Tags: Thorax Critical care Source Type: research
Recent trends in asthma diagnosis, preschool wheeze diagnosis and asthma exacerbations in English children and adolescents: a SABINA Jr study
Conclusion
Paediatric asthma incidence decreased in the UK since 2008, particularly in 1–5-year-olds; this was accompanied by a decline in asthma prevalence. Preschool wheeze incidence also decreased in this age group. However, exacerbation rates have been increasing. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Kallis, C., Maslova, E., Morgan, A. D., Sinha, I., Roberts, G., van der Valk, R. J. P., Quint, J. K., Tran, T. N. Tags: Open access, Thorax Asthma Source Type: research
Atopic and non-atopic effects of fish oil supplementation during pregnancy
Conclusions
n-3 LCPUFA supplementation in pregnancy showed protective effects on non-atopic asthma and infections. Protective effects on atopic asthma depended on maternal FADS genotype and n-3 LCPUFA levels. This indicates that the fatty acid pathway is involved in multiple mechanisms affecting the risk of asthma subtypes and infections.
Trial registration number
NCT00798226. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Bisgaard, H., Mikkelsen, M., Rasmussen, M. A., Sevelsted, A., Schoos, A.-M. M., Brustad, N., Eliasen, A. U., Thorsen, J., Chawes, B., Gürdeniz, G., Morin, A., Stark, K., Stokholm, J., Ober, C., Pedersen, C. E. T., Bonnelykke, K. Tags: Thorax Asthma Source Type: research
Outcomes of systemic sclerosis associated interstitial lung disease patients with a persistent inflammatory phenotype based on serial CRP measurements
Interstitial lung disease (ILD) is a serious complication of systemic sclerosis (SSc) with a variable clinical trajectory.1 Both clinical and biological factors can provide prognostic information on the risk of progression of ILD; however, prognostic biomarkers do not consistently predict outcomes in patients receiving different treatments for SSc-ILD.2 In the present issue of Thorax, Guler et al demonstrate that persistent elevation in C reactive protein (CRP) is associated with an increased risk of mortality in 1171 patients with SSc-ILD.3 Notably, in this observational study, treatment with immunosuppressive therapy (de...
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Volkmann, E. R., Tashkin, D. P. Tags: Thorax Editorial Source Type: research
