Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD: a randomised controlled trial
Conclusions
A comprehensive program by using the Kaia app following PR maintained PA and improved symptoms in patients with COPD at 6 months. The app might be an important accessory tool for enhanced COPD care.
Trial registration number
DRKS00017275. (Source: Thorax)
Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Spielmanns, M., Gloeckl, R., Jarosch, I., Leitl, D., Schneeberger, T., Boeselt, T., Huber, S., Kaur-Bollinger, P., Ulm, B., Mueller, C., Bjoerklund, J., Spielmanns, S., Windisch, W., Pekacka-Egli, A.-M., Koczulla, A. R. Tags: Open access, Thorax Chronic obstructive pulmonary disease Source Type: research
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma
Conclusions
Multiple novel SNPs associated with ICS response were identified in older adult asthmatics. Several SNPs annotated to genes previously associated with asthma and other airway or allergic diseases, including PTCHD4. (Source: Thorax)
Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Wang, A. L., Lahousse, L., Dahlin, A., Edris, A., McGeachie, M., Lutz, S. M., Sordillo, J. E., Brusselle, G., Lasky-Su, J., Weiss, S. T., Iribarren, C., Lu, M. X., Tantisira, K. G., Wu, A. C. Tags: Thorax Asthma Source Type: research
ICS/formoterol maintenance and reliever therapy: how far beyond asthma?
In moderate and severe asthma, the use of inhaled corticosteroid (ICS)/formoterol maintenance and reliever therapy (MART) reduces the risk of severe exacerbation by about one-third compared with the equivalent dose of ICS/long-acting beta2-agonist (LABA) maintenance plus short-acting beta2-agonist (SABA) reliever therapy.1 This efficacy has not only been demonstrated in populations with tightly defined asthma,1 but also in a high-risk ‘real-world’ population with asthma, which included smokers, and did not require the demonstration of bronchodilator responsiveness.2 The broad population of patients with asthma ...
Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Beasley, R., Bruce, P., Hatter, L. Tags: Thorax Editorial Source Type: research
Elucidating minimal important difference in childhood interstitial lung diseases
Rare paediatric lung diseases have been a challenge over years for paediatric pulmonologists. There has been growing attention to rare lung diseases in paediatrics in recent years. Especially, childhood interstitial lung disease (chILD) became an area of special interest since comprehensive classification systems1 and clinical network2 have been steadily developed. chILD is an umbrella term representing a highly heterogenous group of rare diseases comprising more than 200 different lung conditions.2 The incidence in Europe is 0.5–1 case in 100 000.3 In the UK and Ireland, the prevalence is estimated as 0.36 cases per...
Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Jerkic, S.-P., Schulze, J. Tags: Thorax Editorial Source Type: research
Should we retain smaller growing nodules in lung cancer screening programmes for surveillance?
The UK National Screening Committee recently approved a national programme for lung cancer screening (LCS) by low-dose CT (LDCT).1 Measures that will reduce burden on downstream clinical care in the National Health Service (NHS) are therefore greatly welcomed. This need is further amplified in the postpandemic era where services are already stretched and waiting times are higher than ever.2 In the current issue of Thorax, Creamer et al present results from the SUMMIT study’s prospective LCS nodule management algorithm that aims to do exactly that.3 Their protocol differs from other LCS protocols in that they increase...
Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Ruparel, M. Tags: Thorax Editorial Source Type: research
Journal club
Providing safety netting advice for lung cancer symptoms in primary care: patients preferred active advice Lung cancer (LC) symptoms are often initially non-specific and have poor discriminatory value. The initial consultation for these symptoms may be to reassure patients but it is important to use safety netting strategies to ensure reconsultation in event that symptoms fail to resolve. However, the quality of safety netting has not been researched so far. A qualitative interview study by Black et al (BMC 2022;23:179) involved interview of 20 patients who recently saw their GP with respiratory symptoms which could potent...
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Tyagi, R. Tags: Thorax Journal club Source Type: research
Spontaneous intrapulmonary haemorrhage in vascular Ehlers-Danlos syndrome
A 17-year-old male patient presented with a 2-year history of intermittent self-resolving left or right pleuritic chest pain, radiating to the back and with variable duration from several minutes to days. He was a non-smoker and had no known medical or family history. Physical examination was remarkable for hypermobility of small joints (figure 1A) and translucent skin with visible veins (figure 1B). Two chest CT scans, separated by 2 years, revealed waxing and waning bilateral multiple nodules and cavities with surrounding ground glass opacity (figure 1C–F). Absence of aortic and arterial aneurysms was revealed by t...
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Wang, P., Meng, Z., Feng, R., Shi, J., Xu, W. Tags: Images in Thorax, Thorax Source Type: research
Unresectable undifferentiated sarcoma of the pulmonary artery
Case A 70-year-old female patient with known Parkinson’s disease and arterial hypertension presented with a progressive exertional dyspnoea over the last couple of months. She also suffered from night sweats and weight loss of 5 kg which the patient claimed to be intentional. Angina, syncope, cough, fever and haemoptysis were denied. Chest X-ray was performed and a right paratracheal mass was observed. Therefore, a CT thorax was indicated and showed a 12.6x6.5 cm right central mass with infiltration of the pulmonary artery. Furthermore, intrapulmonary artery opacity was detected and initially interpreted as a saddle ...
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Shalabi, A., Graeter, T., Velandia, C., Kuon, J., Ehab, A. Tags: Images in Thorax, Thorax Source Type: research
Longitudinal follow-up of postacute COVID-19 syndrome: DLCO, quality-of-life and MRI pulmonary gas-exchange abnormalities
129Xe MRI red blood cell to alveolar tissue plasma ratio (RBC:TP) abnormalities have been observed in ever-hospitalised and never-hospitalised people with postacute COVID-19 syndrome (PACS). But, it is not known if such abnormalities resolve when symptoms and quality-of-life scores improve. We evaluated 21 participants with PACS, 7±4 months (baseline) and 14±4 months (follow-up) postinfection. Significantly improved diffusing capacity of the lung for carbon monoxide (DLCO, =14%pred ;95%CI 7 to 21, p<0.001), postexertional dyspnoea (=–0.7; 95%CI=–0.2 to –1.2, p=0.019), St George’s Re...
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Matheson, A. M., McIntosh, M. J., Kooner, H. K., Abdelrazek, M., Albert, M. S., Dhaliwal, I., Nicholson, J. M., Ouriadov, A., Svenningsen, S., Parraga, G. Tags: Open access, Thorax, COVID-19 Brief communication Source Type: research
Cytoreductive surgery with hyperthermic intrathoracic chemotherapy for malignant pleural mesothelioma: a systematic review
Conclusion
Surgery with hyperthermic intrathoracic chemotherapy offers a safe and effective therapy with an improvement in disease-free interval and overall survival, particularly when hyperthermic intrathoracic chemotherapy is administered at a higher dose.
PROSPERO registration number
CRD42019129002. (Source: Thorax)
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Dawson, A. G., Kutywayo, K., Mohammed, S. B., Fennell, D. A., Nakas, A. Tags: Thorax Thoracic surgery Source Type: research
Cigarette smoking is a secondary cause of folliculin loss
Conclusions
Our study demonstrates that CS exposure is a secondary cause of FLCN deficiency due to the enhanced proteolysis, which promoted airway epithelial cell death. (Source: Thorax)
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Li, X., Lai, Y., Lane, Z., Strollo, H., Tanimura, K., Sembrat, J. C., Zou, C., Myerburg, M. M., Rojas, M., Shapiro, S., Jiang, Y., Nyunoya, T. Tags: Open access, Thorax Smoking Source Type: research
CT pectoralis muscle area is associated with DXA lean mass and correlates with emphysema progression in a tobacco-exposed cohort
Conclusions
PMA is an accessible measure of muscle mass and may serve as a useful clinical surrogate for assessing skeletal muscle loss in smokers. Decreased PMA correlated with emphysema progression but not lung function decline, suggesting a difference in the pathophysiology driving emphysema, airflow obstruction and comorbidity risk. (Source: Thorax)
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: O'Brien, M. E., Zou, R. H., Hyre, N., Leader, J. K., Fuhrman, C. R., Sciurba, F. C., Nouraie, M., Bon, J. Tags: Thorax Skeletal muscle Source Type: research
Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis
Conclusions
These findings demonstrate a previously uncharacterised role of a key chromatin modulator in lymphocyte survival that may shed light on devising therapeutic modalities to lessen the severity of septic immunosuppression. (Source: Thorax)
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Lai, Y., Li, X., Li, T., Li, X., Nyunoya, T., Chen, K., Kitsios, G., Nouraie, M., Zhang, Y., McVerry, B. J., Lee, J. S., Mallmapalli, R. K., Zou, C. Tags: Open access, Thorax Respiratory infection Source Type: research
Differentiation of malignant from benign pleural effusions based on artificial intelligence
Conclusions
We applied a deep learning model to the segmentation of pleural effusions, and the model showed encouraging performance in the differential diagnosis of BPE and MPE. (Source: Thorax)
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Wang, S., Tan, X., Li, P., Fan, Q., Xia, H., Tian, S., Pan, F., Zhan, N., Yu, R., Zhang, L., Duan, Y., Xu, J., Ma, Y., Chen, W., Li, Y., Zhao, Z., Liu, C., Bao, Q., Yang, L., Jin, Y. Tags: Open access, Thorax Pleural disease Source Type: research
Derivation and validation of a simple multidimensional index incorporating exercise capacity parameters for survival prediction in idiopathic pulmonary fibrosis
Conclusion
A simple point-based baseline-risk prediction model incorporating exercise capacity predictors into the original GAP index may improve prognostication in patients with IPF. (Source: Thorax)
Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Chandel, A., Pastre, J., Valery, S., King, C. S., Nathan, S. D. Tags: Open access, Thorax Interstitial lung disease Source Type: research
