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Normothermic thyroid storm: an unusual presentation
Thyroid storm is a rare life-threatening emergency due to thyrotoxicosis. A 30-year-old female presented with restlessness, tachycardia and vomiting but with normothermia which is an unusual presentation. There is the need for clinicians to be aware of atypical clinical features that can make the diagnosis of thyroid storm difficult. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - August 2, 2016 Category: Endocrinology Authors: Sabir, A. A., Sada, K., Yusuf, B. O., Aliyu, I. Tags: Letter to the Editor Source Type: research

{beta}-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells
Thorough research on the capacity of human islet transplantation to cure type 1 diabetes led to the achievement of 3- to 5-year-long insulin independence in nearly half of transplanted patients. Yet, translation of this technique to clinical routine is limited by organ shortage and the need for long-term immunosuppression, restricting its use to adults with unstable disease. The production of new bona fide β cells in vitro was thus investigated and finally achieved with human pluripotent stem cells (PSCs). Besides ethical concerns about the use of human embryos, studies are now evaluating the possibility of circumvent...
Source: Therapeutic Advances in Endocrinology and Metabolism - August 2, 2016 Category: Endocrinology Authors: Corritore, E., Lee, Y.-S., Sokal, E. M., Lysy, P. A. Tags: Reviews Source Type: research

Methimazole-induced insulin autoimmune syndrome
Conclusions: IAS is associated with methimazole use due to formation of autoantibodies to insulin after its interaction with Sulfhydryl (SH) group in methimazole. While IAS is a rare entity, it demands consideration in hypoglycemia in patients with autoimmune conditions. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - August 2, 2016 Category: Endocrinology Authors: Jain, N., Savani, M., Agarwal, M., Kadaria, D. Tags: Reviews Source Type: research

Treatment with insulin analogs, especially Glargine and Lispro, associates with better renal function and higher hemoglobin levels in Type 1 diabetic patients with impaired kidney function
Conclusions: Present results suggest that treatment of type 1 diabetic patients with normal and impaired renal function with insulin analogs, especially Glargine and Lispro, is associated with better kidney function, lower urinary albumin/creatinine ratio and lower hemoglobin concentration compared to therapy with human insulin. If confirmed by other studies, treatment with insulin analogs may be a further possibility in delaying progression of nephropathy and in preventing early hemoglobin decline. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - August 2, 2016 Category: Endocrinology Authors: Hasslacher, C., Kulozik, F., Lorenzo Bermejo, J. Tags: Original Research Source Type: research

Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study
Conclusion: These results suggest that daily vitamin D supplementation may ameliorate CVD risk factors including a decrease in 11β-HSD1 activity, as evidenced by the decrease in the cortisol/cortisone ratio, and improve exercise performance in healthy individuals. However, large scale studies are required to verify our findings. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - August 2, 2016 Category: Endocrinology Authors: Al-Dujaili, E. A. S., Munir, N., Iniesta, R. R. Tags: Original Research Source Type: research

Review of vancomycin-induced renal toxicity: an update
In recent times the use of larger doses of vancomycin aimed at curbing the increasing incidence of resistant strains of Staphylococcus aureus has led to a wider report of acute kidney injury (AKI). Apart from biological plausibility, causality is implied by the predictive association of AKI with larger doses, longer duration, and graded plasma concentrations of vancomycin. AKI is more likely to occur with the concurrent use of nephrotoxic agents, and in critically ill patients who are susceptible to poor renal perfusion. Although most vancomycin-induced AKI cases are mild and therefore reversible, their occurrence may be a...
Source: Therapeutic Advances in Endocrinology and Metabolism - June 1, 2016 Category: Endocrinology Authors: Bamgbola, O. Tags: Reviews Source Type: research

Osteoporosis in liver disease: pathogenesis and management
In this study we review the pathogenesis, diagnosis and treatment of specific liver disease entities and their relation to osteoporosis. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - June 1, 2016 Category: Endocrinology Authors: Handzlik-Orlik, G., Holecki, M., Wilczynski, K., Duława, J. Tags: Reviews Source Type: research

Metabolic consequences of modern immunosuppressive agents in solid organ transplantation
Among other factors, sophistication of immunosuppressive (IS) regimen accounts for the remarkable success attained in the short- and medium-term solid organ transplant (SOT) survival. The use of steroids, mycophenolate mofetil and calcineurin inhibitors (CNI) have led to annual renal graft survival rates exceeding 90% in the last six decades. On the other hand, attrition rates of the allograft beyond the first year have remained unchanged. In addition, there is a persistent high cardiovascular (CV) mortality rate among transplant recipients with functioning grafts. These shortcomings are in part due to the metabolic effect...
Source: Therapeutic Advances in Endocrinology and Metabolism - June 1, 2016 Category: Endocrinology Authors: Bamgbola, O. Tags: Reviews Source Type: research

Management of diabetes in Morocco: results of the International Diabetes Management Practices Study (IDMPS) - wave 5
Conclusions: The clinical burden of diabetes is high in Morocco and the majority of patients do not achieve the recommended glycaemia target, suggesting that there is a huge gap between evidence-based diabetic management and real-life practice. Better education of patients and improved compliance with international recommendations are necessary to deliver a better quality of diabetic care. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - June 1, 2016 Category: Endocrinology Authors: Chadli, A., El Aziz, S., El Ansari, N., Ajdi, F., Seqat, M., Latrech, H., Belmejdoub, G. Tags: Original Research Source Type: research

Seven years of follow up of trabecular bone score, bone mineral density, body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center
Conclusion: Long-term rhGH treatment in AGHD patients induces a large and sustained improvement in QoL. Metabolic effects are variable with an increase in LBM as well as in BMI and BFM. There is a positive effect on BMD based on the increase in LS BMD, which stabilizes during long-term therapy and is not associated with a similar increase in bone microarchitecture. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - June 1, 2016 Category: Endocrinology Authors: Allo Miguel, G., Serraclara Pla, A., Partida Munoz, M. L., Martinez Diaz-Guerra, G., Hawkins, F. Tags: Original Research Source Type: research

Glibenclamide-induced profound hypoglycaemic crisis: a case report
We present drug-induced hypoglycaemia in a 77-year-old Pakistani male who had hypertension, type II diabetes and renal parenchymal disease (grade I), presented to the emergency department complaining of a 1-day history of fever, loose motions and drowsiness. His fever was low grade, intermittent, and not associated with rigors and chills. He had four episodes of watery stools for 1 day, with no associated vomiting but with drowsiness. He was aphasic, unable to walk and did not recognize his family members. The patient was taken to his local doctor who found him to be hypoglycaemic, with a blood sugar of 45 mg/dl. He was ma...
Source: Therapeutic Advances in Endocrinology and Metabolism - March 30, 2016 Category: Endocrinology Authors: Hussain, A., Ali, I., Khan, A. U., Khan, T. M. Tags: Letter to the Editor Source Type: research

Clinically and pharmacologically relevant interactions of antidiabetic drugs
Patients with type 2 diabetes mellitus often require multifactorial pharmacological treatment due to different comorbidities. An increasing number of concomitantly taken medications elevate the risk of the patient experiencing adverse drug effects or drug interactions. Drug interactions can be divided into pharmacokinetic and pharmacodynamic interactions affecting cytochrome (CYP) enzymes, absorption properties, transporter activities and receptor affinities. Furthermore, nutrition, herbal supplements, patient’s age and gender are of clinical importance. Relevant drug interactions are predominantly related to sulfony...
Source: Therapeutic Advances in Endocrinology and Metabolism - March 30, 2016 Category: Endocrinology Authors: May, M., Schindler, C. Tags: Reviews Source Type: research

Chemerin as an independent predictor of cardiovascular event risk
Currently, coronary artery disease (CAD) is considered a major ailment in humans with widespread prevalence. CAD also accounts for high mortality rates around the world that involves several known risk factors. Chemerin is a novel adipokinine that is associated with inflammation and adipogenesis. Furthermore, experimental and clinical data indicate that localized as well as circulating chemerin expression and activation are elevated in numerous metabolic and inflammatory diseases including psoriasis, obesity, type 2 diabetes, metabolic syndrome and cardiovascular disease. Chemerin is accepted as being a strong marker becau...
Source: Therapeutic Advances in Endocrinology and Metabolism - March 30, 2016 Category: Endocrinology Authors: Inci, S., Aksan, G., Dogan, P. Tags: Reviews Source Type: research

Serum chemerin and high-sensitivity C reactive protein as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes
Conclusion: Both serum chemerin and hs-CRP could be considered as markers of subclinical atherosclerosis, and hence, may be utilized for the early detection of macrovascular disease, in Egyptian patients with type 2 diabetes. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - March 30, 2016 Category: Endocrinology Authors: Lachine, N. A., Elnekiedy, A. A., Megallaa, M. H., Khalil, G. I., Sadaka, M. A., Rohoma, K. H., Kassab, H. S. Tags: Original Research Source Type: research

Stimulation of incretin secreting cells
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide-1 (GLP-1) are secreted from enteroendocrine cells in the gut and regulate physiological and homeostatic functions related to glucose control, metabolism and food intake. This review provides a systematic summary of the molecular mechanisms underlying secretion from incretin cells, and an understanding of how they sense and interact with lumen and vascular factors and the enteric nervous system through transporters and G-protein coupled receptors (GPCRs) present on their surface to ultimately culminate in hormone release. Some...
Source: Therapeutic Advances in Endocrinology and Metabolism - February 1, 2016 Category: Endocrinology Authors: Pais, R., Gribble, F. M., Reimann, F. Tags: Reviews Source Type: research