Sunitinib-induced cardiac hypertrophy and the endothelin axis
Conclusion: Early metabolic changes predict sunitinib-induced cardiac remodeling. Endothelin blockade can prevent some but not all cardiotoxic side-effects of sunitinib, in particular left ventricle hypertrophy that appears to be induced by sunitinib through an endothelin-independent mechanism. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Joevin Sourdon, Caterina Facchin, Ana ï s Certain, Thomas Viel, Blaise Robin, Franck Lager, Carmen Marchiol, Daniel Balvay, Thulaciga Yoganathan, Judith Favier, Pierre-Louis Tharaux, Neeraj Dhaun, Gilles Renault, Bertrand Tavitian Tags: Research Paper Source Type: research
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17
Conclusion: This study illustrates the dynamics between PA cells and immune TME in promoting PA invasion via M2 polarization. CCL17 levels in the TME are related to the PA invasiveness and clinical prognosis, and the CCL17/CCR4/mTOCR1 axis may serve as potential therapeutic targets for Pas. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Anke Zhang, Yuanzhi Xu, Houshi Xu, Jie Ren, Tong Meng, Yunjia Ni, Qingwei Zhu, Wen-Bo Zhang, Yuan-Bo Pan, Jiali Jin, Yunke Bi, Zhe Bao Wu, Shaojian Lin, Meiqing Lou Tags: Research Paper Source Type: research
MERS-CoV and SARS-CoV-2 replication can be inhibited by targeting the interaction between the viral spike protein and the nucleocapsid protein
Conclusions: We suggest that the interaction between the S protein and the N protein can be targeted to design new therapeutics against emerging coronaviruses, including SARS-CoV-2. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Byoung Kwon Park, Jinsoo Kim, Sangkyu Park, Dongbum Kim, Minyoung Kim, Kyeongbin Baek, Joon-Yong Bae, Man-Seong Park, Won-Keun Kim, Younghee Lee, Hyung-Joo Kwon Tags: Research Paper Source Type: research
KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma
Conclusions: Collectively, we elucidated that upregulated KDM6B facilitates tumor metastasis in OS via modulating LDHA expression. Our findings deepen the recognition of OS metastasis mechanism and suggest that KDM6B might be a new potential therapeutic target for the treatment of OS (especially highly metastatic OS). (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yuhang Jiang, Fengfeng Li, Bowen Gao, Mengjun Ma, Meng Chen, Yanfeng Wu, Weidong Zhang, Yangbai Sun, Sanhong Liu, Huiyong Shen Tags: Research Paper Source Type: research
Molecular targets for anticancer therapies in companion animals and humans: what can we learn from each other?
Despite clinical successes in the treatment of some early stage cancers, it is undeniable that novel and innovative approaches are needed to aid in the fight against cancer. Targeted therapies offer the desirable feature of tumor specificity while sparing healthy tissues, thereby minimizing side effects. However, the success rate of translation of these therapies from the preclinical setting to the clinic is dramatically low, highlighting an important point of necessary improvement in the drug development process in the oncology field. The practice of a comparative oncology approach can address some of the current issues, ...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Irati Beltr á n Hern á ndez, Jannes Z. Kromhout, Erik Teske, Wim E. Hennink, Sebastiaan A. van Nimwegen, Sabrina Oliveira Tags: Review Source Type: research
The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer
Conclusion: Our characterization of the relationship between PRLR-SF signaling, the NEK9-Hippo pathway, PPP and nucleotide synthesis explains a mechanism for the correlation between PRLR-SF and metabolic reprogramming in PDAC progression. Strategies to alter this pathway might be developed for the treatment or prevention of pancreatic cancer. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Huizhen Nie, Pei-Qi Huang, Shu-Heng Jiang, Qin Yang, Li-Peng Hu, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing Li, Yi-Fan Zhang, Lei Zhu, Yan-Li Zhang, Yanqiu Yu, Gary Guishan Xiao, Yong-Wei Sun, Jianguang Ji, Zhi-Gang Zhang Tags: Research Paper Source Type: research
Engineering extracellular vesicles with platelet membranes fusion enhanced targeted therapeutic angiogenesis in a mouse model of myocardial ischemia reperfusion
Conclusions: This engineering strategy to modify pre-isolated EVs with platelet membranes by membrane fusion bestows EVs with the targeting ability of platelets and offers an exciting opportunity to design other targeted EVs fused with cell membranes from different sources for therapeutic angiogenesis. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Qiyu Li, Yanan Song, Qiaozi Wang, Jing Chen, Jinfeng Gao, Haipeng Tan, Su Li, Yuan Wu, Hongbo Yang, Hanwei Huang, Yang Yu, Yao Li, Ning Zhang, Zheyong Huang, Zhiqing Pang, Juying Qian, Junbo Ge Tags: Research Paper Source Type: research
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28
Conclusions: The present study demonstrates that CAFs promote breast cancer progression and metastasis via exosomal miR-500a-5p and indicate that inhibiting CAF-derived miR-500a-5p is an alternative modality for the treatment of breast cancer. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Bing Chen, Yuting Sang, Xiaojin Song, Dong Zhang, Lijuan Wang, Wenjing Zhao, Yiran Liang, Ning Zhang, Qifeng Yang Tags: Research Paper Source Type: research
Injectable conductive hydrogel can reduce pacing threshold and enhance efficacy of cardiac pacemaker
Conclusion: PAMB-G hydrogel reduces cardiac pacing threshold voltage, which is able to enhance pacemaker efficacy. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Zhao An, Jun Wu, Shu-Hong Li, Shanglin Chen, Fang-Lin Lu, Zhi-Yun Xu, Hsing-Wen Sung, Ren-Ke Li Tags: Research Paper Source Type: research
LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d: Erratum
(Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Haihai Liang, Zhenwei Pan, Xiaoguang Zhao, Li Liu, Jian Sun, Xiaomin Su, Chaoqian Xu, Yuhong Zhou, Dandan Zhao, Bozhi Xu, Xuelian Li, Baofeng Yang, Yanjie Lu, Hongli Shan Tags: Erratum Source Type: research
Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase: Erratum
(Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jiang-Kai Dong, Hui-Min Lei, Qian Liang, Ya-Bin Tang, Ye Zhou, Yang Wang, Shengzhe Zhang, Wen-Bin Li, Yunguang Tong, Guanglei Zhuang, Liang Zhang, Hong-Zhuan Chen, Liang Zhu, Ying Shen Tags: Erratum Source Type: research
Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis
Conclusions: Collectively, we suggest that DR4 downregulation is coupled to therapeutic efficacy of EGFR-targeted therapy and predicts improved prognosis, revealing a previously undiscovered connection between EGFR-targeted therapy and DR4 modulation. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Shuo Zhang, Zhen Chen, Puyu Shi, Songqing Fan, Yong He, Qiming Wang, Yixiang Li, Suresh S. Ramalingam, Taofeek K. Owonikoko, Shi-Yong Sun Tags: Research Paper Source Type: research
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation
Conclusions: Our study reveals that SIRT3 mediated-deacetylation of NLRC4 is pivotal for NLRC4 activation and the acetylation switch of NLRC4 may aid the clearance of S. typhimurium infection. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chenyang Guan, Xian Huang, Jinnan Yue, Hongrui Xiang, Samina Shaheen, Zhenyan Jiang, Yuexiao Tao, Jun Tu, Zhenshan Liu, Yufeng Yao, Wen Yang, Zhaoyuan Hou, Junling Liu, Xiao-Dong Yang, Qiang Zou, Bing Su, Zhiduo Liu, Jun Ni, Jinke Cheng, Xuefeng Wu Tags: Research Paper Source Type: research
Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets
Exosomes are nanosized lipid vesicles originating from the endosomal system that carry many macromolecules from their parental cells and play important roles in intercellular communication. The functions and underlying mechanisms of exosomes in atherosclerosis have recently been intensively studied. In this review, we briefly introduce exosome biology and then focus on advances in the roles of exosomes in atherosclerosis, specifically exosomal changes associated with atherosclerosis, their cellular origins and potential functional cargos, and their detailed impacts on recipient cells. We also discuss the potential of exoso...
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chen Wang, Zhelong Li, Yunnan Liu, Lijun Yuan Tags: Review Source Type: research
Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis
Conclusions: Our results suggest that ADSL is a novel oncogene in CRC, modulating mitochondrial function, metabolism and oxidative stress, thus promoting cell cycle progression, proliferation and migration. Our results also suggest that ADSL is a predictive biomarker of response to 6-mercaptopurine in the pre-clinical setting. (Source: Theranostics)
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Stephanie Taha-Mehlitz, Gaia Bianco, Mairene Coto-Llerena, Venkatesh Kancherla, Glenn R. Bantug, John Gallon, Caner Ercan, Federica Panebianco, Serenella Eppenberger-Castori, Marco von Strauss, Sebastian Staubli, Martin Bolli, Ralph Peterli, Matthias S. M Tags: Research Paper Source Type: research
