M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice
Conclusions: Our results showed, for the first time, that microglia regulate glial scar formation via small extracellular vesicles, indicating that M2 microglial small extracellular vesicles could represent a new therapeutic approach for stroke. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Zongwei Li, Yaying Song, Tingting He, Ruoxue Wen, Yongfang Li, Tingting Chen, Shuxian Huang, Yongting Wang, Yaohui Tang, FanXia Shen, Heng-Li Tian, Guo-Yuan Yang, Zhijun Zhang Tags: Research Paper Source Type: research
Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis
Conclusion: Cardiomyocyte-expressed LRP6 promoted the degradation of Wnt5a and Wnt11 by regulating CTSD and inhibited cardiac fibrosis under pressure overload. Our study demonstrated a novel role of LRP6 as an anti-fibrosis regulator. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xiang Wang, Yan Zou, Zhidan Chen, Yang Li, Le Pan, Ying Wang, Ming Liu, Chao Yin, Jian Wu, Chunjie Yang, Lei Zhang, Chenze Li, Zheyong Huang, Daowen Wang, Juying Qian, Junbo Ge, Yunzeng Zou, Hui Gong Tags: Research Paper Source Type: research
Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring
Conclusion: Prenatal PBM treatment exerts neuroprotective effects on neonatal HI rats. Underlying mechanisms for this neuroprotection may include preservation of mitochondrial function, reduction of inflammation, and decreased oxidative stress. Our findings support the possible use of PBM treatment in high-risk pregnancies to alleviate or prevent HI-induced brain injury in the perinatal period. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Luodan Yang, Yan Dong, Chongyun Wu, Hannah Youngblood, Yong Li, Xuemei Zong, Lei Li, Tongda Xu, Quanguang Zhang Tags: Research Paper Source Type: research
Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells
Conclusions: NHE1 plays a role in developing glioma immunosuppressive TME in part by dysregulating glucose metabolism of GAMs and emerges as a therapeutic target for improving glioma immunity. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Md Nabiul Hasan, Lanxin Luo, Dawei Ding, Shanshan Song, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Lesley M. Foley, Xiudong Guan, Gary Kohanbash, T. Kevin Hitchens, Maria G. Castro, Zhongling Zhang, Dandan Sun Tags: Research Paper Source Type: research
From biomarkers to therapeutic targets: the promise of PD-L1 in thyroid autoimmunity and cancer
The programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) immune checkpoint proteins hold promise as diagnostic, prognostic, and therapeutic targets for precision oncology. By restoring antitumor T cell surveillance, the high degree of effectiveness of the immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment. However, the majority of patients (65-80 %) treated with ICIs experience significant side effects, called immune-related adverse events (irAEs), resulting in autoimmune damage to various organs. Therefore, broadening the clinical applicability of these treatments to all cancer types re...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Gr é goire D'Andr é a, Sandra Lassalle, Nicolas Guevara, Baharia Mograbi, Paul Hofman Tags: Review Source Type: research
Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice
Conclusions: These results suggest that NLN and NEW are promising metastasis-inhibiting peptide therapeutics and targeting moieties for CD44v6-expressing metastases. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Fatima Khan, Smriti Gurung, Gowri Rangaswamy Gunassekaran, Sri Murugan Poongkavithai Vadevoo, Lianhua Chi, Uttapol Permpoon, Md. Enamul Haque, Yun-Ki Lee, Soo-Woong Lee, Soyoun Kim, Byungheon Lee Tags: Research Paper Source Type: research
Targeting transforming growth factor- β signaling for enhanced cancer chemotherapy
During the past decades, drugs targeting transforming growth factor-β (TGFβ) signaling have received tremendous attention for late-stage cancer treatment since TGFβ signaling has been recognized as a prime driver for tumor progression and metastasis. Nonetheless, in healthy and pre-malignant tissues, TGFβ functions as a potent tumor suppressor. Furthermore, TGFβ signaling plays a key role in normal development and homeostasis by regulating cell proliferation, differentiation, migration, apoptosis, and immune evasion, and by suppressing tumor-associated inflammation. Therefore, targeting TGFβ s...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang Tags: Review Source Type: research
Molecular stratification by BCL2A1 and AIM2 provides additional prognostic value in penile squamous cell carcinoma
Conclusions: BCL2A1 and AIM2 promote PSCC progression. Integrating BCL2A1 and AIM2 as novel molecular classifiers with pN stage provides additional information for the prognosis and treatment of PSCC patients. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xingliang Tan, Dong Chen, Shengjie Guo, Yanjun Wang, Yuantao Zou, Zhiming Wu, Fangjian Zhou, Zike Qin, Zhuowei Liu, Yun Cao, Chunhua Lin, Gangjun Yuan, Kai Yao Tags: Research Paper Source Type: research
Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer
Conclusion: Our results suggest that AA contributes to an unfavorable clinical outcome of OC by impacting the phenotype of tumor-associated macrophages. Besides critical AA-regulated signal transduction proteins identified in the present study, PLA2G2A might represent a potential prognostic tool and therapeutic target to interfere with OC progression. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Raimund Dietze, Mohamad K. Hammoud, Mar í a G ó mez-Serrano, Annika Unger, Tim Bieringer, Florian Finkernagel, Anna M. Sokol, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Viviane Ponath, Christian Preu ß er, Elke Pogge von Strandmann, Sabine M ü ller Tags: Research Paper Source Type: research
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR
Conclusion: Our work suggests that circDLC1, a downstream target of KIAA1429, is a promising prognostic marker for HCC patients, and the circDLC1-HuR-MMP1 axis may serve as a potential therapeutic target for HCC treatment. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Hailing Liu, Tian Lan, Hui Li, Lin Xu, Xing Chen, Haotian Liao, Xiangzheng Chen, Jinpeng Du, Yunshi Cai, Jinju Wang, Xuefeng Li, Jiwei Huang, Kefei Yuan, Yong Zeng Tags: Research Paper Source Type: research
Network- and systems-based re-engineering of dendritic cells with non-coding RNAs for cancer immunotherapy
Conclusions: Our approach enables the systematic analysis and identification of functional miRNA-gene interactions that can be experimentally tested for improving DC immunogenic potency. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xin Lai, Florian S. Dreyer, Martina Cantone, Martin Eberhardt, Kerstin F. Gerer, Tanushree Jaitly, Steffen Uebe, Christopher Lischer, Arif Ekici, J ü rgen Wittmann, Hans-Martin J ä ck, Niels Schaft, Jan D ö rrie, Julio Vera Tags: Research Paper Source Type: research
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells
Conclusion: Our results indicate that breast cancer cell-derived exosomes play an important role in promoting breast cancer bone metastasis, which is associated with the formation of pre-metastatic niche via transferring miR-21 to osteoclasts. The data from patient samples further reflect the significance of miR-21 as a potential target for clinical diagnosis and treatment of breast cancer bone metastasis. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xinxin Yuan, Niansong Qian, Shukuan Ling, Yuheng Li, Weijia Sun, Jianwei Li, Ruikai Du, Guohui Zhong, Caizhi Liu, Guotao Yu, Dengchao Cao, Zizhong Liu, Yinbo Wang, Zhihong Qi, Yingpeng Yao, Fang Wang, Jingjing Liu, Shanshan Hao, Xiaoyan Jin, Yinlong Zhao, Tags: Research Paper Source Type: research
Tofacitinib restores the balance of γ δ Treg/ γ δ T17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome
Conclusions: Recovery of γδTreg/γδT17 cell balance was a novel mechanism by which TOF alleviated RA. Meanwhile, NLRP3 played a pivotal role in the process of TOF-mediated γδT17 cell activation. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xinyu Yang, Ning Zhan, Yang Jin, Hanzhi Ling, Chipeng Xiao, Zhen Xie, Hao Zhong, Xinxin Yu, Runhua Tang, Jinglan Ma, Jubo Guan, Guoyu Yin, Gan Wu, Liangjing Lu, Jianguang Wang Tags: Research Paper Source Type: research
Proteasome activator PA200 maintains stability of histone marks during transcription and aging
Conclusion: PA200 promotes the transcription-coupled degradation of the core histones, and plays an important role in maintaining the stability of histone marks during transcription and aging. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Tian-Xia Jiang, Shuang Ma, Xia Han, Zi-Yu Luo, Qian-Qian Zhu, Tomoki Chiba, Wei Xie, Kui Lin, Xiao-Bo Qiu Tags: Research Paper Source Type: research
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts
Conclusion: Our data demonstrated that upregulation of COL6A1 activated by H3K27 acetylation promoted the cell migration and invasion by suppressing STAT1 pathway in OS cells. Moreover, COL6A1 can be packaged into OS cell-derived exosomes and activate CAFs to promote OS metastasis. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Ying Zhang, Zhaoyong Liu, Xia Yang, Weiqing Lu, Yelong Chen, Youbin Lin, Jin Wang, Suxia Lin, Jing-Ping Yun Tags: Research Paper Source Type: research
