The 14-3-3 σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway
Conclusions: Our results indicate that 14-3-3σ plays a pivotal role in the anoikis resistance and metastasis of HCC cells, presumably by inhibiting EGFR degradation and regulating the activation of the EGFR-dependent ERK1/2 pathway. To our best knowledge, this is the first report of the role of 14-3-3σ in the anoikis resistance of HCC cells, offering new research directions for the treatment of metastatic cancer by targeting 14-3-3σ. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Jia Song, Yachong Liu, Furong Liu, Lu Zhang, Ganxun Li, Chaoyi Yuan, Chengpeng Yu, Xun Lu, Qiumeng Liu, Xiaoping Chen, Huifang Liang, Zeyang Ding, Bixiang Zhang Tags: Research Paper Source Type: research
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
Macrophages phagocytize pathogens to initiate innate immunity and products from the tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated macrophage (TAM)-mediated immune responses results in immune suppression. To reverse this immune disorder, the regulatory mechanism of TAMs in the TME needs to be clarified. Immune molecules (cytokines and chemokines) from TAMs and the TME have been widely accepted as mutual mediators of signal transduction in the past few decades. Recently, researchers have tried to seek the intrinsic mechanism of TAM phenotypic and functional changes through metabolic con...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Degao Chen, Xiaomei Zhang, Zhongjun Li, Bo Zhu Tags: Review Source Type: research
Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications
Type 2 diabetes mellitus (T2DM) is a complex multifactorial disease causing the development of a large range of cardiovascular (CV) complications. Lifestyle changes and pharmacological therapies only partially halt T2DM progression, and existing drugs are unable to completely suppress the increased CV risk of T2DM patients. Extracellular vesicles (EV)s are membrane-coated nanoparticles released by virtually all living cells and are emerging as novel mediators of T2DM and its CV complications. As a matter of fact, several preclinical models suggest a key involvement of EVs in the initiation and/or progression of insulin res...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Francesco Prattichizzo, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Fabiola Olivieri, Paola de Candia, Valeria De Nigris, Antonio Ceriello Tags: Review Source Type: research
The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction
Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world, and the inflammatory response plays a pivotal role in the progress of myocardial necrosis and ventricular remodeling, dysfunction and heart failure after AMI. Therapies aimed at modulating immune response after AMI on a molecular and cellular basis are urgently needed. Exosomes are a type of extracellular vesicles which contain a large amount of biologically active substances, like lipids, nucleic acids, proteins and so on. Emerging evidence suggests key roles of exosomes in immune regulation post AMI. A variety of immune cells pa...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yu-Yan Xiong, Zhao-Ting Gong, Rui-Jie Tang, Yue-Jin Yang Tags: Review Source Type: research
CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain
Conclusion: CXCL12-mediated monocyte recruitment into the perivascular space is critical for neuroinflammation and the resultant cognitive impairment in neuropathic pain. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Chun-Lin Mai, Zhi Tan, Ya-Nan Xu, Jing-Jun Zhang, Zhen-Hua Huang, Dong Wang, Hui Zhang, Wen-Shan Gui, Jun Zhang, Zhen-Jia Lin, Ying-Tong Meng, Xiao Wei, Ying-Tao Jie, Peter M. Grace, Long-Jun Wu, Li-Jun Zhou, Xian-Guo Liu Tags: Research Paper Source Type: research
Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism
Background: The host-parasite relationship is based on subtle interplay between parasite survival strategies and host defense mechanisms. It is well known that helminth infection, which afflicts more than one billion people globally, correlates with a decreased prevalence of obesity. Dissecting the underlying mechanisms can provide new targets for treating obesity from the host-parasite interaction perspective.Methods: C57BL/6 mice received a normal or high-fat diet (HFD) with or without Sjp40 (one main component of schistosome-derived soluble egg antigens) treatment. Both the loss and gain-of-function experiments by the i...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yangyue Ni, Zhipeng Xu, Chen Li, Yuxiao Zhu, Ran Liu, Fan Zhang, Hao Chang, Maining Li, Liang Sheng, Zhong Li, Min Hou, Lin Chen, Hong You, Donald P. McManus, Wei Hu, Yinong Duan, Yu Liu, Minjun Ji Tags: Research Paper Source Type: research
IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression
Conclusion: This investigation found that IGF2BP1 has a crucial role in the m6A-dependent regulatory mechanism for endometrial cancer. This study provides new insights into our understanding of disease progression and provides another potential route for understanding biological functions. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Lin Zhang, Yicong Wan, Zihan Zhang, Yi Jiang, Zhiyue Gu, Xiaoling Ma, Sipei Nie, Jing Yang, Jinghe Lang, Wenjun Cheng, Lan Zhu Tags: Research Paper Source Type: research
Putting the BRK on breast cancer: From molecular target to therapeutics
BReast tumor Kinase (BRK, also known as PTK6) is a non-receptor tyrosine kinase that is highly expressed in breast carcinomas while having low expression in the normal mammary gland, which hints at the oncogenic nature of this kinase in breast cancer. In the past twenty-six years since the discovery of BRK, an increasing number of studies have strived to understand the cellular roles of BRK in breast cancer. Since then, BRK has been found both in vitro and in vivo to activate a multitude of oncoproteins to promote cell proliferation, metastasis, and cancer development. The compelling evidence concerning the oncogenic roles...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Hui Li Ang, Yi Yuan, Xianning Lai, Tuan Zea Tan, Lingzhi Wang, Benjamin BoJun Huang, Vijay Pandey, Ruby Yun-Ju Huang, Peter E. Lobie, Boon Cher Goh, Gautam Sethi, Celestial T. Yap, Ching Wan Chan, Soo Chin Lee, Alan Prem Kumar Tags: Review Source Type: research
ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway
Conclusions: Our study demonstrates that activation of miR-126-3p production in ECs/SMCs and interactions between ECs and SMCs play an important role in reduction of vascular calcification by ERK1/2 inhibition. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Peng Zeng, Jie Yang, Lipei Liu, Xiaoxiao Yang, Zhi Yao, Chuanrui Ma, Haibo Zhu, Jiamin Su, Qian Zhao, Ke Feng, Shu Yang, Yan Zhu, Xiaoju Li, Wenguang Wang, Yajun Duan, Jihong Han, Yuanli Chen Tags: Research Paper Source Type: research
Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist
Conclusion: The OECs that reached the lesion site were activated by the release of pro-inflammatory cytokines from activated microglia in the lesion site and secreted IL-1Ra to reduce neuroinflammation. Intravenous transplantation of OECs has high therapeutic effectiveness for the treatment of SCI via the secretion of IL-1Ra to reduce neuroinflammation. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Lijian Zhang, Xiaoqing Zhuang, P ä ivi Kotitalo, Thomas Keller, Anna Krzyczmonik, Merja Haaparanta-Solin, Olof Solin, Sarita Forsback, Tove J. Gr ö nroos, Chunlei Han, Francisco R. L ó pez-Pic ó n, Hechun Xia Tags: Research Paper Source Type: research
Three-dimensional Imaging Coupled with Topological Quantification Uncovers Retinal Vascular Plexuses Undergoing Obliteration
Conclusion: Coupling 3-D LSFM with topological quantification uncovered the retinal vasculature undergoing hyperoxia-induced obliteration from the secondary (outer) plexus to the vertical sprouts. The use of clustering coefficients, Euler's number, and PCA provided new network insights into OIR-associated vascular obliteration, with translational significance for investigating therapeutic interventions to prevent visual impairment. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Chih-Chiang Chang, Alison Chu, Scott Meyer, Yichen Ding, Michel M. Sun, Parinaz Abiri, Kyung In Baek, Varun Gudapati, Xili Ding, Pierre Guihard, Kristina I. Bostrom, Song Li, Lynn K. Gordon, Jie J. Zheng, Tzung K. Hsiai Tags: Research Paper Source Type: research
Retraction of “ MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance ”
(Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Jinping Lu, Yuejin Li, Yuanzhong Wu, Shan Zhou, Chaojun Duan, Zigang Dong, Tiebang Kang, Faqing Tang Tags: Retraction Source Type: research
Apolipoprotein E, low-density lipoprotein receptor, and immune cells control blood-brain barrier penetration by AAV-PHP.eB in mice
Conclusions: Our findings demonstrate that the ApoE-LDLR pathway underlies the CNS tropism of AAV-PHP.eB and that the immune system contributes to the strain specificity of AAV-PHP.eB. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Bao-Shu Xie, Xin Wang, Yao-Hua Pan, Gan Jiang, Jun-Feng Feng, Yong Lin Tags: Research Paper Source Type: research
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis
Conclusion: Our study provides a valuable reference for modulating macrophage polarization and a promising strategy for the treatment of pulmonary fibrosis in clinical settings. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Ting Pan, Qing Zhou, Kang Miao, Lei Zhang, Guorao Wu, Jun Yu, Yongjian Xu, Weining Xiong, Yong Li, Yi Wang Tags: Research Paper Source Type: research
Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials
Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Young Joo Han, Keum Hwa Lee, Sojung Yoon, Seoung Wan Nam, Seohyun Ryu, Dawon Seong, Jae Seok Kim, Jun Young Lee, Jae Won Yang, Jinhee Lee, Ai Koyanagi, Sung Hwi Hong, Elena Dragioti, Joaquim Radua, Lee Smith, Hans Oh, Ramy Abou Ghayda, Andreas Kronbichler Tags: Review Source Type: research
