COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges
The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals. COVID-19 spreads between humans through respiratory droplets produced when an infected person coughs or sneezes. The COVID-19 outbreak originated in Wuhan, China at the end of 2019. As of 29 Sept 2020, over 235 countries, areas or territories across the globe reported a total of 33,441,919 confirmed cases, and 1,003,497 confirmed deaths due to COVID-19. Individuals of all ages are at risk for infection, but in most cases diseas...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Anup S. Pathania, Philip Prathipati, Bakrudeen AA. Abdul, Srinivas Chava, Santharam S. Katta, Subash C. Gupta, Pandu R. Gangula, Manoj K. Pandey, Donald L. Durden, Siddappa N. Byrareddy, Kishore B. Challagundla Tags: Review Source Type: research
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis
Conclusion: Our results suggested the metabolism of amino acids and carnitines are significantly altered in psoriasis, especially the metabolism of EAAs, BCAAs, and LC(C0), which may play key roles in the pathogenesis of psoriasis. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Chao Chen, Guixue Hou, Chunwei Zeng, Yan Ren, Xiang Chen, Cong Peng Tags: Research Paper Source Type: research
Implantation of regenerative complexes in traumatic brain injury canine models enhances the reconstruction of neural networks and motor function recovery
Conclusion: Implantation of this complex enhanced therapy in traumatic brain injury (TBI) through structural repair and functional recovery. These effects exhibit the translational prospects for the clinical application of this complex. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Jipeng Jiang, Chen Dai, Xiaoyin Liu, Lujia Dai, Ruixin Li, Ke Ma, Huiyou Xu, Fei Zhao, Zhiwen Zhang, Tao He, Xuegang Niu, Xuyi Chen, Sai Zhang Tags: Research Paper Source Type: research
Enhanced neprilysin-mediated degradation of hippocampal A β 42 with a somatostatin peptide that enters the brain
Conclusion: With intravenous injections of our BBB permeable SST peptide, we were able to significantly increase the levels neprilysin, an effect that was followed by a significant and selective degradation of membrane-bound Aβ42 in the hippocampus. Being that membrane-bound Aβ triggers neuronal toxicity and the hippocampus is the central brain area in the progression of AD, the study has illuminated a new potential treatment paradigm with a promising safety profile targeting only the disease affected areas. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Fadi Rofo, Canan Ugur Yilmaz, Nicole Metzendorf, Tobias Gustavsson, Chiara Beretta, Anna Erlandsson, Dag Sehlin, Stina Syv ä nen, Per Nilsson, Greta Hultqvist Tags: Research Paper Source Type: research
Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation
Conclusions: HBP-mediated O-GlcNAcylation positively regulates host antiviral response against HBV in vitro and in vivo. The findings reveal a link between HBP, O-GlcNAc modification, and innate antiviral immunity by targeting SAMHD1. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Jie Hu, Qingzhu Gao, Yang Yang, Jie Xia, Wanjun Zhang, Yao Chen, Zhi Zhou, Lei Chang, Yuan Hu, Hui Zhou, Li Liang, Xiaosong Li, Quanxin Long, Kai Wang, Ailong Huang, Ni Tang Tags: Research Paper Source Type: research
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance
Conclusions: Our study has provided a novel STAT3 inhibitor with significant anti-tumor activities in NSCLC and suggests that combination of STAT3 inhibitor such as W2014-S with gefitinib could serve as a promising strategy to overcome EGFR-TKIs acquired resistance in NSCLC patients. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Qiyao Zheng, Hui Dong, Jianshan Mo, Yi Zhang, Jie Huang, Shumin Ouyang, Shuo Shi, Kai Zhu, Xinming Qu, Wenhao Hu, Peiqing Liu, Yuanxiang Wang, Xiaolei Zhang Tags: Research Paper Source Type: research
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3
Conclusions: Our study demonstrated that ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Lijie Zhou, Zhengshuai Song, Junyi Hu, Lilong Liu, Yaxin Hou, Xiaoping Zhang, Xiong Yang, Ke Chen Tags: Research Paper Source Type: research
Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury
Conclusions: Our results indicated that PBA might be a new Nrf2 activator that covalently binds to two critical domains of Keap1, and shows cardioprotective activities against ischemia-reperfusion injury. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yuanyuan Cheng, Liangkai Cheng, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang, Zhongqiu Liu Tags: Research Paper Source Type: research
Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer
Conclusion: EV-delivered miR-181a-5p from patient's serum is a promising diagnostic biomarker for bone metastatic prostate cancer. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yanqing Wang, Yu-Xiang Fang, Baijun Dong, Xinxing Du, Jialin Wang, Xiao Wang, Wei-Qiang Gao, Wei Xue Tags: Research Paper Source Type: research
Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis
Conclusions: We have identified miR-199a-5p as one of the mechanisms employed by hUC-MSCs to alleviate lupus disease associated pathologies in MRL/lpr mice, which is attributable for promoting splenic CD4+ T cell senescence through Sirt1/p53 pathway. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Tao Cheng, Shuai Ding, Shanshan Liu, Yan Li, Lingyun Sun Tags: Research Paper Source Type: research
Collagenase IV and clusterin-modified polycaprolactone-polyethylene glycol nanoparticles for penetrating dense tumor tissues
Conclusion: Novel ColIV and CLU-modified PCL-PEG nanoparticles showed excellent cellular uptake, ECM penetration, antiphagocytosis, and antitumor effects both in vitro and in vivo. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Hao-Yan Huang, Li-Qing Chen, Wei Sun, Huan-Huan Du, Shunli Dong, Atef Mohammed Qasem Ahmed, Dingyun Cao, Jing-Hao Cui, Yi Zhang, Qing-Ri Cao Tags: Research Paper Source Type: research
LncRNA BCYRN1-induced autophagy enhances asparaginase resistance in extranodal NK/T-cell lymphoma
Conclusions: It was found that BCYRN1 was a valuable prognostic biomarker in ENKTCL. BCYRN1 could promote resistance to ASP by inducing autophagy, which could be reversed by inhibition of autophagy. Our findings highlight the feasibility of combining autophagy inhibition and ASP in the treatment of ENKTCL. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Liang Wang, Jing Yang, He-nan Wang, Rui-ying Fu, Xin-di Liu, Ying-shi Piao, Li-qiang Wei, Jing-wen Wang, Luo Zhang Tags: Research Paper Source Type: research
Extra-domain B of fibronectin as an alternative target for drug delivery and a cancer diagnostic and prognostic biomarker for malignant glioma
Conclusions: Taken together, these results show that EDB-FN can be an effective drug delivery target and biomarker for MG. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Phei Er Saw, Xiaoding Xu, Bo Ram Kang, Jungsul Lee, Yeo Song Lee, Chungyeul Kim, Hyungsin Kim, Shin-Hyuk Kang, Yoo Jin Na, Hong Joo Moon, Joo Han Kim, Youn-Kwan Park, Wonki Yoon, Jong Hyun Kim, Taek-Hyun Kwon, Chulhee Choi, Sangyong Jon, Kyuha Chong Tags: Research Paper Source Type: research
Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer
Conclusion: Our findings suggest that BCT could serve as a promising therapeutic candidate against CRPC and highlight the potential benefit of targeting AR-FL/AR-V7-HSP90 axis to overcome resistance caused by aberrant AR-FL/AR-V7 signaling. (Source: Theranostics)
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Sue Jin Moon, Byong Chang Jeong, Hwa Jin Kim, Joung Eun Lim, Hye-Jeong Kim, Ghee Young Kwon, Joshua A. Jackman, Jeong Hoon Kim Tags: Research Paper Source Type: research
Molecular machineries and physiological relevance of ER-mediated membrane contacts
Membrane contact sites (MCSs) are defined as regions where two organelles are closely apposed, and most MCSs associated with each other via protein-protein or protein-lipid interactions. A number of key molecular machinery systems participate in mediating substance exchange and signal transduction, both of which are essential processes in terms of cellular physiology and pathophysiology. The endoplasmic reticulum (ER) is the largest reticulum network within the cell and has extensive communication with other cellular organelles, including the plasma membrane (PM), mitochondria, Golgi, endosomes and lipid droplets (LDs). Th...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Shiyin Lin, Tian Meng, Haofeng Huang, Haixia Zhuang, Zhengjie He, Huan Yang, Du Feng Tags: Research Paper Source Type: research
