The Homeotic Protein SIX3 Suppresses Carcinogenesis and Metastasis through Recruiting the LSD1/NuRD(MTA3) Complex
Conclusion: Our study revealed an important mechanistic link between the loss of function of SIX3 and tumor progression, identified a molecular basis for the opposing actions of MTA1 and MTA3, and may provide new potential prognostic indicators and targets for cancer therapy. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yu Zheng, Yi Zeng, Rongfang Qiu, Ruiqiong Liu, Wei Huang, Yongqiang Hou, Shuang Wang, Shuai Leng, Dandan Feng, Yang Yang, Yan Wang Tags: Research Paper Source Type: research

O2-generating MnO2 nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia
Conclusion: This study not only demonstrated the great potential of HSA-MnO2-Ce6 NPs for bladder cancer photodynamic ablation but also provided a new therapeutic strategy to overcoming tumor hypoxia. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Tingsheng Lin, Xiaozhi Zhao, Sheng Zhao, Hang Yu, Wenmin Cao, Wei Chen, Hui Wei, Hongqian Guo Tags: Research Paper Source Type: research

Black Phosphorus and its Biomedical Applications
Black phosphorus (BP), also known as phosphorene, has attracted recent scientific attention since its first successful exfoliation in 2014 owing to its unique structure and properties. In particular, its exceptional attributes, such as the excellent optical and mechanical properties, electrical conductivity and electron-transfer capacity, contribute to its increasing demand as an alternative to graphene-based materials in biomedical applications. Although the outlook of this material seems promising, its practical applications are still highly challenging. In this review article, we discuss the unique properties of BP, whi...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jane Ru Choi, Kar Wey Yong, Jean Yu Choi, Azadeh Nilghaz, Yang Lin, Jie Xu, Xiaonan Lu Tags: Review Source Type: research

Targeting ALDH2 for Therapeutic Interventions in Chronic Pain-Related Myocardial Ischemic Susceptibility
Conclusion: Collectively, chronic pain-enhanced carbonyl stress promotes myocardial ischemic intolerance by SIRT1 carbonylative inactivation and impairment of LKB1-AMPK interaction. ALDH2 activation and prevention of protein carbonylation may be a potential therapeutic target for myocardial ischemic vulnerability in chronic pain patients. Our results newly provided overlapping cellular mechanisms of chronic pain and myocardial dysfunction interplay. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Chen Li, Wanqing Sun, Chunhu Gu, Zheng Yang, Nanhu Quan, Jingrun Yang, Zhaoling Shi, Lu Yu, Heng Ma Tags: Research Paper Source Type: research

Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy
Conclusion: A novel multifunctional theranostic nanoplatform based on OPCNs was designed and developed for dual-modal image-guided synergistic tumor photothermal radiotherapy. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jinghua Li, Xiangyang Zu, Gaofeng Liang, KeKe Zhang, Yuliang Liu, Ke Li, Zhong Luo, Kaiyong Cai Tags: Research Paper Source Type: research

Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
Chemotherapy is still a main option for cancer therapy, but its efficacy is often unsatisfying due to multidrug resistance (MDR). The tumor microenvironment is considered a dominant factor causing MDR. Stimuli-responsive nanomedicines exhibit many superiorities for reversal of MDR. As smart systems, stimuli-responsive nanomedicines are desirable for achieving site-specific accumulation and triggered drug release in response to slight changes in physicochemical properties in pathological conditions or to exogenous stimuli. In this review, we highlight the current progress of various nanomedicines with different stimuli-resp...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Lei Zhou, Hao Wang, Yaping Li Tags: Review Source Type: research

Nondestructive Analysis of Tumor-Associated Membrane Protein Integrating Imaging and Amplified Detection in situ Based on Dual-Labeled DNAzyme
Conclusion: The integrated system provides solid results for both imaging and quantification of TMPs, making it a competitive method over some traditional techniques for the analysis of TMPs, which offers potential application as a toolbox in the future. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Xiaoxia Chen, Jing Zhao, Tianshu Chen, Tao Gao, Xiaoli Zhu, Genxi Li Tags: Research Paper Source Type: research

PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells
Conclusion: These results identified a novel molecular pathway in glioma cells that may provide a potential innovative approach for tumor therapy. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Xiaobai Liu, Jian Zheng, Yixue Xue, Hai Yu, Wei Gong, Ping Wang, Zhen Li, Yunhui Liu Tags: Research Paper Source Type: research

MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance
Conclusions: Our results suggest that pairs of cooperating miRNAs could be used as potential RNA therapeutics to reduce E2F1-related chemoresistance. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Xin Lai, Shailendra K Gupta, Ulf Schmitz, Stephan Marquardt, Susanne Knoll, Alf Spitschak, Olaf Wolkenhauer, Brigitte M P ü tzer, Julio Vera Tags: Research Paper Source Type: research

68Ga-BBN-RGD PET/CT for GRPR and Integrin α v β 3 Imaging in Patients with Breast Cancer
This study was to assess a gastrin-releasing peptide receptor (GRPR) and integrin αvβ3 dual targeting tracer 68Ga-BBN-RGD for positron emission tomography (PET)/computed tomography (CT) imaging of breast cancer and metastasis. Materials and Methods: Twenty-two female patients were recruited either with suspected breast cancer on screening mammography (n = 16) or underwent breast cancer radical mastectomy (n = 6). All the 22 patients underwent PET/CT at 30-45 min after intravenous injection of 68Ga-BBN-RGD. Eleven out of 22 patients also accepted 68Ga-BBN PET/CT within 2 weeks for comparison. A final diagnosis wa...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jingjing Zhang, Feng Mao, Gang Niu, Li Peng, Lixin Lang, Fang Li, Hongyan Ying, Huanwen Wu, Boju Pan, Zhaohui Zhu, Xiaoyuan Chen Tags: Research Paper Source Type: research

Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery
Conclusion: Our study demonstrates the ability of leukosomes to target activated vasculature and exhibit superior accumulation in tumors and vascular lesions. The versatility of the phospholipid backbone within leukosomes permits the incorporation of various contrast agents. Furthermore, leukosomes can potentially be loaded with therapeutics possessing diverse physical properties and thus warrant further investigation toward the development of powerful theranostic agents. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jonathan O. Martinez, Roberto Molinaro, Kelly A. Hartman, Christian Boada, Roman Sukhovershin, Enrica De Rosa, Dickson Kirui, Shanrong Zhang, Michael Evangelopoulos, Angela M. Carter, James A. Bibb, John P. Cooke, Ennio Tasciotti Tags: Research Paper Source Type: research

Non-invasive monitoring of in vivo hydrogel degradation and cartilage regeneration by multiparametric MR imaging
Conclusion: This USPIO-labeled CNC/SF hydrogel system provides a new perspective on image-guided tissue engineering for cartilage regeneration. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Zelong Chen, Chenggong Yan, Shina Yan, Qin Liu, Meirong Hou, Yikai Xu, Rui Guo Tags: Research Paper Source Type: research

Delivery of Sonic Hedgehog Gene Repressed Irradiation-induced Cellular Senescence in Salivary Glands by Promoting DNA Repair and Reducing Oxidative Stress
Conclusion: Repressing cellular senescence contributes to the rescue of IR-induced hyposalivation by transient activation of Hh signaling, which is related to enhanced DNA repair and decreased oxidative stress in SMGs. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Bo Hai, Qingguo Zhao, Michael A. Deveau, Fei Liu Tags: Research Paper Source Type: research

Diagnosis of LVAD Thrombus using a High-Avidity Fibrin-Specific 99mTc Probe
Treatment of advanced heart failure with implantable LVADs is increasing, driven by profound unmet patient need despite potential serious complications: bleeding, infection, and thrombus. The experimental objective was to develop a sensitive imaging approach to assess early thrombus accumulation in LVADs under operational high flow and high shear rates.Methods: A monomeric bifunctional ligand with a fibrin-specific peptide, a short spacer, and 99mTc chelating amino acid sequence (F1A) was developed and compared to its tetrameric PEG analogue (F4A).Results: 99mTc attenuation by LVAD titanium (1 mm) was 23%. 99mTc-F1A affini...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Grace Cui, Walter J. Akers, Michael J. Scott, Michael Nassif, John S. Allen, Anne H. Schmieder, Krishna S. Paranandi, Akinobu Itoh, Dmitry D. Beyder, Samuel Achilefu, Gregory A. Ewald, Gregory M. Lanza Tags: Research Paper Source Type: research

LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d
Conclusion: Taken together, our study elucidated the role and mechanism of PFL in cardiac fibrosis, indicating the potential role of PFL inhibition as a novel therapy for cardiac fibrosis. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Haihai Liang, Zhenwei Pan, Xiaoguang Zhao, Li Liu, Jian Sun, Xiaomin Su, Chaoqian Xu, Yuhong Zhou, Dandan Zhao, Bozhi Xu, Xuelian Li, Baofeng Yang, Yanjie Lu, Hongli Shan Tags: Research Paper Source Type: research

Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Maxime Gauberti, Antoine P. Fournier, Fabian Docagne, Denis Vivien, Sara Martinez de Lizarrondo Tags: Review Source Type: research

Systematic Assessment of Strategies for Lung-targeted Delivery of MicroRNA Mimics
There is considerable interest in the use of synthetic miRNA mimics (or inhibitors) as potential therapeutic agents in pulmonary vascular disease; however, the optimal delivery method to achieve high efficiency, selective lung targeting has not been determined. Here, we sought to investigate the relative merits of different lung-targeted strategies for delivering miRNA mimics in rats.Methods: Tissue levels of a synthetic miRNA mimic, cel-miR-39-3p (0.5 nmol in 50 µL invivofectamine/PBS vehicle) were compared in male rats (n=3 rats/method) after delivery by commonly used lung-targeting strategies including intratrache...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Kenny Schlosser, Mohamad Taha, Duncan J. Stewart Tags: Research Paper Source Type: research

Indocyanine green-incorporating nanoparticles for cancer theranostics
Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal angiography, and defining cardiovascular and liver function for over 50 years. Recently, there has been an increasing interest in the incorporation of ICG into nanoparticles (NPs) for cancer theranostic applications. Various types of ICG-incorporated NPs have been developed and strategically functionalised to embrace multiple imaging and therapeutic techniques for cancer diagnosis and treatment. This review systematically summaries the biodistribution of various types of ICG-incorporated NPs for the first time, and discusses the pri...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Haolu Wang, Xinxing Li, Brian Wan-Chi Tse, Haotian Yang, Camilla A. Thorling, Yuxin Liu, Margaux Touraud, Jean Batiste Chouane, Xin Liu, Michael S. Roberts, Xiaowen Liang Tags: Review Source Type: research

Serum exosomes can restore cellular function in vitro and be used for diagnosis in dysferlinopathy
Conclusions: Our findings provide evidence that exosomes are efficient carriers of dysferlin and can be employed for the treatment and non-invasive diagnosis of dysferlinopathy. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Xue Dong, Xianjun Gao, Yi Dai, Ning Ran, HaiFang Yin Tags: Research Paper Source Type: research

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop
Conclusion: MiR-630 may be a potential biomarker for the prediction of TKI therapeutic response and outcome in patients with lung adenocarcinoma. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: De-Wei Wu, Yao-Chen Wang, Lee Wang, Chih Yi Chen, Huei Lee Tags: Research Paper Source Type: research

GRO- α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NF κ B signaling cascade
Conclusion: This study highlights the significance of GRO-α and IL-8 as the key chemokines in the peritoneal tumor microenvironment and suggests the utility of targeting their receptor CXCR2 as a potential target-based therapy for peritoneal metastases of ovarian cancer. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Mingo Ming-Ho Yung, Hermit Wai-Man Tang, Patty Chun-Hui Cai, Thomas Ho-Yin Leung, Siew-Fei Ngu, Karen Kar-Loen Chan, Dakang Xu, Huijuan Yang, Hextan Yuen-Sheung Ngan, David Wai Chan Tags: Research Paper Source Type: research

S6K1 phosphorylation-dependent degradation of Mxi1 by β -Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer
Conclusion: Our findings not only establish a crosstalk between the mTOR/S6K1 signaling pathway and Myc activation, but also suggest that targeting S6K1/Mxi1 pathway is a promising therapeutic strategy for the treatment of lung cancer. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yumei Huang, Kaishun Hu, Sheng Zhang, Xiaorong Dong, Zhongyuan Yin, Rui Meng, Yingchao Zhao, Xiaofang Dai, Tao Zhang, Kunyu Yang, Li Liu, Kai Huang, Shaojun Shi, Yu Zhang, Junjie Chen, Gang Wu, Shuangbing Xu Tags: Research Paper Source Type: research

Non-invasive Prenatal Diagnosis of Chromosomal Aneuploidies and Microdeletion Syndrome Using Fetal Nucleated Red Blood Cells Isolated by Nanostructure Microchips
Conclusion: Our method offers effective and accurate analysis of fNRBCs for comprehensive NIPT to monitor fetal cell development. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Chun Feng, Zhaobo He, Bo Cai, Jianhong Peng, Jieping Song, Xuechen Yu, Yue Sun, Jing Yuan, Xingzhong Zhao, Yuanzhen Zhang Tags: Research Paper Source Type: research

Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation
Conclusions: The current study showed that GLUT1 expression was inversely correlated with sensitivity of gastric cancer cells to pharmacological ascorbate and suggested that GLUT1 expression in gastric cancer may serve as a marker for sensitivity to pharmacological ascorbate. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yun-Xin Lu, Qi-Nian Wu, Dong-liang Chen, Le-Zong Chen, Zi-Xian Wang, Chao Ren, Hai-yu Mo, Ya Chen, Hui Sheng, Ying-Nan Wang, Yun Wang, Jia-Huan Lu, De-shen Wang, Zhao-lei Zeng, Feng Wang, Feng-Hua Wang, Yu-Hong Li, Huai-Qiang Ju, Rui-Hua Xu Tags: Research Paper Source Type: research

Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound
Conclusion: Our study provides a new strategy for the efficient ultrasound-triggered chemotherapy by nanocarriers with programmable LIFU capable of achieving the on-demand drug release. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yang Cao, Yuli Chen, Tao Yu, Yuan Guo, Fengqiu Liu, Yuanzhi Yao, Pan Li, Dong Wang, Zhigang Wang, Yu Chen, Haitao Ran Tags: Research Paper Source Type: research

Desmin- and vimentin-mediated hepatic stellate cell-targeting radiotracer 99mTc-GlcNAc-PEI for liver fibrosis imaging with SPECT
Conclusion: 99mTc-GlcNAc-PEI SPECT/CT was useful in assessing liver fibrosis and monitoring the treatment response. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Deliang Zhang, Rongqiang Zhuang, Zhide Guo, Mengna Gao, Lumei Huang, Linyi You, Pu Zhang, Jindian Li, Xinhui Su, Hua Wu, Xiaoyuan Chen, Xianzhong Zhang Tags: Research Paper Source Type: research

Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells
Hypoxia, a hallmark of malignant tumors, often correlates with increasing tumor aggressiveness and poor treatment outcomes. Due to a lack of vasculature, effective drug delivery to hypoxic tumor regions remains challenging. Signaling through the chemokine SDF-1α and its receptor CXCR4 plays a critical role in the homing of stem cells to ischemia for potential use as drug-delivery vehicles. To harness this mechanism for targeting tumor hypoxia, we developed polymeric nanoparticle-induced CXCR4-overexpressing human adipose-derived stem cells (hADSCs). Using glioblastoma multiforme (GBM) as a model tumor, we evaluated t...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Xinyi Jiang, Christine Wang, Sergio Fitch, Fan Yang Tags: Research Paper Source Type: research

Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis
Conclusion: The STP-guided intracellular drug delivery system using the necroptosis mechanism showed profound anti-osteosarcoma activity, especially eliminated lung metastasis in vivo. This drug formulation may have great potential for treatment of osteosarcoma. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Suoyuan Li, Tao Zhang, Weiguo Xu, Jianxun Ding, Fei Yin, Jing Xu, Wei Sun, Hongsheng Wang, Mengxiong Sun, Zhengdong Cai, Yingqi Hua Tags: Research Paper Source Type: research

Cancer-associated fibroblasts enhance tumor 18F-FDG uptake and contribute to the intratumor heterogeneity of PET-CT
Conclusion: CAFs promote tumor progression and increase SUVmax of 18F-FDG, suggesting CAFs lead to the intratumor heterogeneity of the SUV and the SUVmax is a prognostic marker for cancer patients. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Chengfang Shangguan, Guifang Gan, Jieying Zhang, Jinliang Wu, Ying Miao, Miao Zhang, Biao Li, Jun Mi Tags: Research Paper Source Type: research

Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors
Conclusion: The multiplex magneto-nanosensor assays enable longitudinal proteomic studies on mouse tumor models to understand tumor development and therapy mechanisms more precisely within a single biological object. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jung-Rok Lee, Iris Appelmann, Cornelius Miething, Tyler O. Shultz, Daniel Ruderman, Dokyoon Kim, Parag Mallick, Scott W. Lowe, Shan X. Wang Tags: Research Paper Source Type: research

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
Conclusions: Both MSCs-derived MPs and Exos exerted an anti-inflammatory role on T and B lymphocytes independently of MSCs priming. However, Exos were more efficient in suppressing inflammation in vivo. Our work is the first demonstration of the therapeutic potential of MSCs-derived EVs in inflammatory arthritis. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Dani è le No ë l Tags: Research Paper Source Type: research

Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis
Conclusions: These results open up a promising direction for further medical diagnostic techniques. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jun Li, Younghee Kwon, Kyung Soo Chung, Chang Su Lim, Dayoung Lee, Yongkang Yue, Jisoo Yoon, Gyoungmi Kim, Sang-Jip Nam, Youn Wook Chung, Hwan Myung Kim, Caixia Yin, Ji-Hwan Ryu, Juyoung Yoon Tags: Research Paper Source Type: research

Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells
Conclusion: We demonstrate that plasma-based thromboelastometry provides a reliable tool to detect pro-coagulant activity of therapeutic cells. Selecting TF-deficient BMSC is a novel strategy for improving cell therapy applicability by reducing cell dose-dependent IBMIR risk. The particularly strong pro-coagulant activity of UC and WAT preparations sounds an additional note of caution regarding uncritical systemic application of stromal cells, particularly from non-hematopoietic extravascular sources. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Str Tags: Research Paper Source Type: research

Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma
Conclusion: In vitro and in vivo data strongly indicate that the ANG-IMNPs were capable of selectively delivering dual photosensitizers to brain astrocytoma tumors for effective PDT/PTT in conjugation with a substantially improved median survival. The therapeutic efficacy of ANG-IMNPs demonstrated in this study suggests their potential in overcoming BBB and establishing an effective treatment against GBM. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yuan-Chung Tsai, Priya Vijayaraghavan, Wen-Hsuan Chiang, Hsin-Hung Chen, Te-I Liu, Ming-Yin Shen, Ayumu Omoto, Masao Kamimura, Kohei Soga, Hsin-Cheng Chiu Tags: Research Paper Source Type: research

D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria
Conclusion: These D-amino acid-modified AuNPs serve as a promising platform for rapid visual identification of pathogens in the clinic. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Xinglong Yang, Yan Dang, Jinli Lou, Huawu Shao, Xingyu Jiang Tags: Research Paper Source Type: research

Potential Red-Flag Identification of Colorectal Adenomas with Wide-Field Fluorescence Molecular Endoscopy
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial grow...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Elmire Hartmans, Jolien J.J. Tjalma, Matthijs D. Linssen, Pilar Beatriz Garcia Allende, Marjory Koller, Annelies Jorritsma-Smit, Mariana e Silva de Oliveira Nery, Sjoerd G. Elias, Arend Karrenbeld, Elisabeth G.E. de Vries, Jan H. Kleibeuker, Gooitzen M. v Tags: Research Paper Source Type: research

Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet
We examined urinary levels of metabolites in 103 participants of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial after nearly 30 days on a defined diet containing high sodium (targeting 150 mmol sodium intake per day) or low sodium (50 mmol per day). Targeted chromatography/mass spectrometry analysis was performed in 24 h urine samples for 47 amino metabolites and 10 metabolites related to the tricarboxylic acid cycle. The effect of an identified metabolite on blood pressure was examined in Dahl salt-sensitive rats.Results: Urinary metabolite levels improved the prediction of classification of blood pressur...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R. Lanza, Pengyuan Liu, Yong Liu, Purushottam W. Laud, Kristie Usa, Yongcheng He, Mingyu Liang Tags: Research Paper Source Type: research

Current Strategies for Brain Drug Delivery
The objective of this review is to provide a broad overview on current strategies for brain drug delivery and related subjects from the past five years. It is hoped that this review could inspire readers to discover possible approaches to deliver drugs into the brain. After an initial overview of the BBB structure and function in both healthy and pathological conditions, this review re-visits, according to recent publications, some questions that are controversial, such as whether nanoparticles by themselves could cross the BBB and whether drugs are specifically transferred to the brain by actively targeted nanoparticles. ...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Xiaowei Dong Tags: Review Source Type: research

XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells
Conclusion: Our study highlights the importance of IAPs in the maintenance of CSCs in NPC. Thus, XIAP is a promising therapeutic target in CSCs and suggests that NPC patients may benefit from a combination treatment of APG-1387 with conventional chemotherapy. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jiao Ji, Yan Yu, Zhi-Ling Li, Ming-Yuan Chen, Rong Deng, Xiang Huang, Guang-Feng Wang, Meng-Xia Zhang, Qi Yang, Senthilkumar Ravichandran, Gong-Kan Feng, Xue-Lian Xu, Chen-Lu Yang, Miao-Zhen Qiu, Lin Jiao, Dajun Yang, Xiao-Feng Zhu Tags: Research Paper Source Type: research

Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways
Conclusion: miR302-367 regulation of endothelial Cdc42 and Ccnd1 signal pathways for EC migration and proliferation advances our understanding of developmental angiogenesis, and meanwhile provides a rationale for future interventions of pathological angiogenesis that shares many common features of physiological angiogenesis. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jingjiang Pi, Jie Liu, Tao Zhuang, Lin Zhang, Huimin Sun, Xiaoli Chen, Qian Zhao, Yashu Kuang, Sheng Peng, Xiaohui Zhou, Zuoren Yu, Ting Tao, Brian Tomlinson, Paul Chan, Ying Tian, Huimin Fan, Zhongmin Liu, Xiangjian Zheng, Edward Morrisey, Yuzhen Zhang Tags: Research Paper Source Type: research

PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways
Conclusions: PRL-3 expression enhances the invasion and proliferation of glioma cells, highlighting this phosphatase as a novel prognostic candidate and an attractive target for future therapy in glioblastoma. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Nan Mu, Jintao Gu, Nannan Liu, Xiaochang Xue, Zhen Shu, Kuo Zhang, Tonglie Huang, Chu Chu, Wangqian Zhang, Li Gong, Huadong Zhao, Bo Jia, Dakuan Gao, Lei Shang, Wei Zhang, Qingdong Guo Tags: Research Paper Source Type: research

The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes
In conclusion, PTRF serves as a promising biomarker in both tumor samples and serum exosomes, thus facilitating the detection of glioma and potentially serving as a therapeutic target for glioblastoma multiforme. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Kai Huang, Chuan Fang, Kaikai Yi, Xing Liu, Hongzhao Qi, Yanli Tan, Junhu Zhou, Ying Li, Mingyang Liu, Yuqing Zhang, Jingxuan Yang, Jianning Zhang, Min Li, Chunsheng Kang Tags: Research Paper Source Type: research

Oxygen-generating Hybrid Polymeric Nanoparticles with Encapsulated Doxorubicin and Chlorin e6 for Trimodal Imaging-Guided Combined Chemo-Photodynamic Therapy
Conclusion: The designed CDM NPs are expected to provide an alternative way of improving antitumor efficacy by combined chemo-PDT further enhanced by oxygen generation, and would have broad applications in cancer theranostics. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: DanRong Hu, LiJuan Chen, Ying Qu, JinRong Peng, BingYang Chu, Kun Shi, Ying Hao, Lin Zhong, MengYao Wang, ZhiYong Qian Tags: Research Paper Source Type: research

Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1
Gene-based therapies represent a promising therapeutic paradigm for the treatment of HIV-1, as they have the potential to maintain sustained viral inhibition with reduced treatment interventions. Such an option may represent a long-term treatment alternative to highly active antiretroviral therapy.Methods: We previously described a therapeutic approach, referred to as transcriptional gene silencing (TGS), whereby small noncoding RNAs directly inhibit the transcriptional activity of HIV-1 by targeting sites within the viral promoter, specifically the 5' long terminal repeat (LTR). TGS differs from traditional RNA interferen...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jiehua Zhou, Daniel Lazar, Haitang Li, Xin Xia, Sangeetha Satheesan, Paige Charlins, Denis O'Mealy, Ramesh Akkina, Sheena Saayman, Marc S. Weinberg, John J. Rossi, Kevin V. Morris Tags: Research Paper Source Type: research

Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance Imaging-Guided Efficient Photothermal Ablation of Cancer
Conclusion: In this work, we reported a bioinspired strategy where melanin, a natural product in the human body, is encapsulated into PEGylated nanoliposomes for efficient theranostics with high biocompatibility. This work provides a new strategy for creating desirable theranostic agents with concurrent high biocompatibility and satisfactory theranostic performance through the use of materials that totally originate from biosystems. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Liang Zhang, Danli Sheng, Dong Wang, Yuanzhi Yao, Ke Yang, Zhigang Wang, Liming Deng, Yu Chen Tags: Research Paper Source Type: research

Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis
Conclusion: Our findings suggest that USC-Exos may represent a promising strategy for diabetic soft tissue wound healing by promoting angiogenesis via transferring DMBT1 protein. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Chun-Yuan Chen, Shan-Shan Rao, Lu Ren, Xiong-Ke Hu, Yi-Juan Tan, Yin Hu, Juan Luo, Yi-Wei Liu, Hao Yin, Jie Huang, Jia Cao, Zhen-Xing Wang, Zheng-Zhao Liu, Hao-Ming Liu, Si-Yuan Tang, Ran Xu, Hui Xie Tags: Research Paper Source Type: research

Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity
Conclusion: The efficiency and versatility of the multifunctional density microbeads approach provides new opportunities for personalized cancer diagnostics and treatments. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Qinqin Huang, Fu-Bing Wang, Chun-Hui Yuan, Zhaobo He, Lang Rao, Bo Cai, Bolei Chen, Susu Jiang, Zhiqiang Li, Jincao Chen, Wei Liu, Feng Guo, Zheng Ao, Shi Chen, Xing-Zhong Zhao Tags: Research Paper Source Type: research

Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content
Conclusion: We provide both the theoretical and experimental framework for a multi-scale EIT strategy to detect liver lipid content. Our preliminary studies pave the way to enhance the spatial resolution of EIT as a marker for fatty liver disease and metabolic syndrome. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yuan Luo, Parinaz Abiri, Shell Zhang, Chih-Chiang Chang, Amir H. Kaboodrangi, Rongsong Li, Ashish K. Sahib, Alex Bui, Rajesh Kumar, Mary Woo, Zhaoping Li, Ren é R. Sevag Packard, Yu-Chong Tai, Tzung K. Hsiai Tags: Research Paper Source Type: research

2D Superparamagnetic Tantalum Carbide Composite MXenes for Efficient Breast-Cancer Theranostics
Conclusion: This work not only significantly broadens the biomedical applications of MXene-based nanoplatforms (Ta4C3 MXene) by exploring their novel family members and further functionalization strategies (magnetic functionalization in this work), but also provides a novel and efficient theranostic nanoplatform for efficient breast-cancer theranostics. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Zhuang Liu, Han Lin, Menglong Zhao, Chen Dai, Shengjian Zhang, Weijun Peng, Yu Chen Tags: Research Paper Source Type: research

Porphyrin-grafted Lipid Microbubbles for the Enhanced Efficacy of Photodynamic Therapy in Prostate Cancer through Ultrasound-controlled In Situ Accumulation
Conclusions: This is the first preclinical investigation of MBs applied in PDT for PCa. PGL-MBs possess favorable CEUS imaging effects to enhance the localization of tumors. PGL-MBs with LFUS control PS accumulation at the tumor site to achieve highly effective PDT of PCa. This strategy carries enormous clinical potential for PCa management. (Source: Theranostics)
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Yujia You, Xiaolong Liang, Tinghui Yin, Min Chen, Chen Qiu, Chuang Gao, Xiaoyou Wang, Yongjiang Mao, Enze Qu, Zhifei Dai, Rongqin Zheng Tags: Research Paper Source Type: research