Numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation
The effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in previous researches. In fact, microcir... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 19, 2021 Category: Biomedical Science Authors: Fan He, Lu Hua and Tingting Guo Tags: Research Source Type: research

Required concentration index quantifies effective drug combinations against hepatitis C virus infection
Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-res... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 9, 2021 Category: Biomedical Science Authors: Yusuke Kakizoe, Yoshiki Koizumi, Yukino Ikoma, Hirofumi Ohashi, Takaji Wakita, Shingo Iwami and Koichi Watashi Tags: Research Source Type: research

Analysis and forecast of dengue incidence in urban Colombo, Sri Lanka
Understanding the dynamical behavior of dengue transmission is essential in designing control strategies. Mathematical models have become an important tool in describing the dynamics of a vector borne disease.... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 7, 2021 Category: Biomedical Science Authors: KKWH Erandi, SSN Perera and AC Mahasinghe Tags: Research Source Type: research

Statistical field theory of the transmission of nerve impulses
Stochastic processes leading voltage-gated ion channel dynamics on the nerve cell membrane are a sufficient condition to describe membrane conductance through statistical mechanics of disordered and complex sy... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 6, 2021 Category: Biomedical Science Authors: Gianluigi Zangari del Balzo Tags: Research Source Type: research

A numerical simulation of air flow in the human respiratory system for various environmental conditions
The functions of the nasal cavity are very important for maintaining the internal environment of the lungs since the inner walls of the nasal cavity control the temperature and saturation of the inhaled air wi... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 6, 2021 Category: Biomedical Science Authors: Alibek Issakhov, Yeldos Zhandaulet, Aizhan Abylkassymova and Assylbek Issakhov Tags: Research Source Type: research

Simulation-based assessment of model selection criteria during the application of benchmark dose method to quantal response data
To employ the benchmark dose (BMD) method in toxicological risk assessment, it is critical to understand how the BMD lower bound for reference dose calculation is selected following statistical fitting procedu... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - August 5, 2020 Category: Biomedical Science Authors: Keita Yoshii, Hiroshi Nishiura, Kaoru Inoue, Takayuki Yamaguchi and Akihiko Hirose Tags: Research Source Type: research

Ontological model of multi-agent Smart-system for predicting drug properties based on modified algorithms of artificial immune systems
Currently, due to the huge progress in the field of information technologies and computer equipment, it is important to use modern approaches of artificial intelligence in order to process extensive chemical i... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - July 16, 2020 Category: Biomedical Science Authors: Galina Samigulina and Zarina Samigulina Tags: Research Source Type: research

Quantifying the annual incidence and underestimation of seasonal influenza: A modelling approach
Seasonal influenza poses a significant public health and economic burden, associated with the outcome of infection and resulting complications. The true burden of the disease is difficult to capture due to the... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - July 10, 2020 Category: Biomedical Science Authors: Zachary McCarthy, Safia Athar, Mahnaz Alavinejad, Christopher Chow, Iain Moyles, Kyeongah Nah, Jude D. Kong, Nishant Agrawal, Ahmed Jaber, Laura Keane, Sam Liu, Myles Nahirniak, Danielle St Jean, Razvan Romanescu, Jessica Stockdale, Bruce T. Seet & hellip Tags: Research Source Type: research

Modelling HIV disease process and progression in seroconversion among South Africa women: using transition-specific parametric multi-state model
HIV infected patients may experience many intermediate events including between-event transition throughout their follow up. Through modelling these transitions, we can gain a deeper understanding of HIV disea... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - June 23, 2020 Category: Biomedical Science Authors: Zelalem G. Dessie, Temesgen Zewotir, Henry Mwambi and Delia North Tags: Research Source Type: research

Risk estimation of the SARS-CoV-2 acute respiratory disease outbreak outside China
On December 31, 2019, the World Health Organization was alerted to the occurrence of cases of pneumonia in Wuhan, Hubei Province, China, that were caused by an unknown virus, which was later identified as a co... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - June 5, 2020 Category: Biomedical Science Authors: Soyoung Kim, Sunhwa Choi, Youngsuk Ko, Moran Ki and Eunok Jung Tags: Research Source Type: research

Computational models of melanoma
Genes, proteins, or cells influence each other and consequently create patterns, which can be increasingly better observed by experimental biology and medicine. Thereby, descriptive methods of statistics and b... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 14, 2020 Category: Biomedical Science Authors: Marco Albrecht, Philippe Lucarelli, Dagmar Kulms and Thomas Sauter Tags: Review Source Type: research

Modelling the effect of a dengue vaccine on reducing the evolution of resistance against antibiotic due to misuse in dengue cases
This paper intends to check whether and how a hypothetical dengue vaccine could contribute to issue of evolution of bacteria resistance against antibiotics by reducing the number of patients that would inappro... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 13, 2020 Category: Biomedical Science Authors: Ana Kurauchi, Claudio Jose Struchiner, Annelies Wilder-Smith and Eduardo Massad Tags: Research Source Type: research

Modeling and dynamic analysis of tuberculosis in mainland China from 1998 to 2017: the effect of DOTS strategy and further control
Tuberculosis (TB) is one of the most important health topics in the world. Directly observed treatment and short course chemotherapy (DOTS) strategy combines medicine care and modern health system firmly, and ... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 4, 2020 Category: Biomedical Science Authors: Siyu Liu, Yingjie Bi and Yawen Liu Tags: Research Source Type: research

An agent-based model to investigate microbial initiation of Alzheimer ’s via the olfactory system
Alzheimer ’s disease (AD) is a degenerative brain disease. A novel agent-based modelling framework was developed in NetLogo 3D to provide fundamental insights into the potential mechanisms by which a microbe (eg. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - April 15, 2020 Category: Biomedical Science Authors: Shalini Sundar, Carly Battistoni, Ryan McNulty, Fernando Morales, Jonathan Gorky, Henry Foley and Prasad Dhurjati Tags: Research Source Type: research

Methylation-driven model for analysis of dinucleotide evolution in genomes
CpGs, the major methylation sites in vertebrate genomes, exhibit a high mutation rate from the methylated form of CpG to TpG/CpA and, therefore, influence the evolution of genome composition. However, the quan... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - April 8, 2020 Category: Biomedical Science Authors: Jian-Hong Sun, Shi-Meng Ai and Shu-Qun Liu Tags: Research Source Type: research