Editorial
(Source: The Obstetrician and Gynaecologist)
Source: The Obstetrician and Gynaecologist - July 19, 2023 Category: OBGYN Authors: Jo Morrison Tags: Editorial Source Type: research
Authors' reply re: Androgens in postmenopausal women
(Source: The Obstetrician and Gynaecologist)
Source: The Obstetrician and Gynaecologist - July 19, 2023 Category: OBGYN Authors: Kugajeevan Vigneswaran,
Haitham Hamoda Tags: Letters and emails Source Type: research
Re: Androgens in postmenopausal women
(Source: The Obstetrician and Gynaecologist)
Source: The Obstetrician and Gynaecologist - July 19, 2023 Category: OBGYN Authors: Kevan Wylie Tags: Letters and emails Source Type: research
Tuberculosis in pregnancy
AbstractKey content
Tuberculosis (TB) is an important global cause of maternal and neonatal morbidity and mortality.
With increasing migration, cases of tuberculosis in pregnancy or the puerperium are increasing in resource-rich nations with advanced health care systems.
Diagnosis may be delayed given the overlap of some of the symptoms with that of pregnancy.
Timely diagnosis is essential to initiate appropriate treatment and prevent maternal and neonatal morbidity and mortality.Learning objectives
To understand the relevant global and UK epidemiology of the disease, including recent goals set by the World Health Organiza...
Source: The Obstetrician and Gynaecologist - June 15, 2023 Category: OBGYN Authors: Ainharan Raveendran,
Anish Keepanasseril,
Ravi Kumar Balu,
Ashalatha Shetty,
Mahendran Chetty Tags: Review Source Type: research
Quantification of blood loss in obstetric haemorrhage: implications on intervention and transfusion
AbstractKey content
Postpartum haemorrhage accounts for 27% of all maternal deaths. Incorrect quantification of blood loss can lead to unnecessary interventions, such as the transfusion of blood products, which is not without risk.
During pregnancy, cardiovascular changes may explain how blood loss can occur rapidly, with pregnant women tolerating large volumes of blood loss before a change in clinical signs is seen.
Several methods are used to quantify blood loss, such as visual estimation, volumetric, gravimetric, colorimetric and photometric.
The Obstetric Bleeding Strategy for Wales (OBS Cymru) project, which standardi...
Source: The Obstetrician and Gynaecologist - June 11, 2023 Category: OBGYN Authors: Noreen Haque,
Ruth Roberts,
Bid Kumar Tags: Review Source Type: research
Hyperlipidaemia and severe hypertriglyceridaemia in pregnancy
AbstractKey content
Lipid and triglyceride levels increase in pregnancy and do not pose problems for most women. However, pregnancy-specific factors and genetic aberrations, especially mutations, may result in supraphysiological hypercholesterolaemia (HC) and severe hypertriglyceridaemia (sHTG).
Hypercholesterolaemia and severe hypertriglyceridaemia are associated with complications in pregnancy, including acute pancreatitis, hyperviscosity syndrome and pre-eclampsia.
Abnormally high levels of lipids and triglycerides also affect fetal growth and the onset of gestational diabetes.
The clinical presentation and diagnosis of...
Source: The Obstetrician and Gynaecologist - June 10, 2023 Category: OBGYN Authors: Mohammed Bashir,
Osric B Navti,
Badreldeen Ahmed,
Justin C Konje Tags: Review Source Type: research
Menopause and mental health
AbstractKey content
Studies reveal a high prevalence of mental health issues around the menopause transition.
Menopausal symptoms are influenced by personal and environmental factors.
Beneficial effects of estrogen for menopausal depression have been reported.
An integrated care model for the management of mental health symptoms is recommended.
Evidence-based management options include considering the impact of lifestyle changes, HRT and cognitive behavioural therapy.Learning objectives
To understand the assessment and management of mental health issues in menopause
To understand the role of lifestyle modifications, HRT an...
Source: The Obstetrician and Gynaecologist - June 10, 2023 Category: OBGYN Authors: Ajay Swaminathan,
Peter Lepping,
Geeta Kumar Tags: Review Source Type: research
Gastrointestinal congenital anomalies requiring surgery: diagnosis, counselling, and management
AbstractKey content
Congenital anomalies affect more than 2% of fetuses in the UK, with 70% noncardiac in origin. Around 10% are gastrointestinal anomalies such as abdominal wall defects and intestinal atresias.
Most gastrointestinal anomalies require postnatal surgical management.
Obstetricians must understand the key features of diagnosis and management of common gastrointestinal anomalies.
Clinically relevant and evidence-based information helps facilitate parental reproductive autonomy through timely and informed counselling, planning for delivery and optimising perinatal outcomes.
Management of pregnancies complicated...
Source: The Obstetrician and Gynaecologist - June 3, 2023 Category: OBGYN Authors: Stuart Mires,
Arun Raychoudhury,
Timothy Overton,
Clare Skerritt,
Kelly ‐Ann Eastwood Tags: Review Source Type: research
Spotlight on … intrapartum care
(Source: The Obstetrician and Gynaecologist)
Source: The Obstetrician and Gynaecologist - June 2, 2023 Category: OBGYN Authors: Adalina Sacco Tags: Spotlight Source Type: research
Recent trends in molecular testing and maintenance targeted therapies in ovarian cancer
AbstractKey content
Surgical cytoreduction and platinum-based chemotherapy are the mainstays of ovarian cancer treatment, but 70% of patients with advanced-stage disease will relapse after responding to first-line chemotherapy.
Recent randomised controlled trials have shown significant improvement in progression-free survival by adding maintenance therapy including either PARP inhibitors (PARPi), bevacizumab (VEGF-A inhibitor), or both.
Homologous recombination repair is a pathway to repair DNA breaks; homologous recombination deficiency (HRD) is encountered in approximately 50% of ovarian high-grade serous cancers (HGSC)....
Source: The Obstetrician and Gynaecologist - May 29, 2023 Category: OBGYN Authors: Ahmed Darwish,
Osnat Elyashiv,
Radha Graham,
Rowan E Miller Tags: Review Source Type: research
Sentinel lymph node mapping in the modern management of gynaecological malignancy
AbstractKey content
Sentinel lymph node (SLN) biopsy is an alternative to systematic lymphadenectomy in the surgical staging of gynaecological malignancy. It is recommended in the management of vulval cancer and is increasingly used in endometrial and cervical cancer.
Sentinel lymph node failed mapping algorithms require that side-specific lymphadenectomy should be performed in the case of failed mapping, and that suspicious lymph nodes are removed.
Ultrastaging protocols improve detection of lymph-node metastasis and should be used for the pathological processing of sentinel lymph nodes.Learning objectives
To understand t...
Source: The Obstetrician and Gynaecologist - May 13, 2023 Category: OBGYN Authors: Anna Collins,
Andrew Phillips Tags: Review Source Type: research
Prenatal genomic testing for ultrasound ‐detected fetal structural anomalies
Key content
In the presence of a fetal structural anomaly, fetal DNA can be obtained through invasive testing (e.g. amniocentesis and chorionic villus sampling) in order to undertake genomic testing to attempt to uncover a unifying genetic diagnosis.
There are number of traditional and more novel genomic tests available, which can identify aneuploidy, chromosomal structural variation and/or sequence variants within genes.
The cumulative diagnostic yield of such technologies is approximately 25%, 6% and up to 80% in some cohorts for QF-PCR/G-banding karyotype, chromosome microarray and exome sequencing, respectively.Lear...
Source: The Obstetrician and Gynaecologist - April 17, 2023 Category: OBGYN Authors: Kelly Reilly,
Caoimhe McKenna,
Simon McCullough,
Shane McKee,
Fionnuala Mone Tags: Review Source Type: research
Issue Information
(Source: The Obstetrician and Gynaecologist)
Source: The Obstetrician and Gynaecologist - April 17, 2023 Category: OBGYN Tags: Issue Information Source Type: research
