Semaglutide, lipid-lowering drugs, and NAFLD
Publication date: May 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 5 Author(s): Niki Katsiki, Vasilios G Athyros, Asterios Karagiannis, Dimitri P Mikhailidis (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 22, 2017 Category: Endocrinology Source Type: research

Analysis of the MAVIDOS trial – Author's reply
Publication date: May 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 5 Author(s): Nicholas C Harvey, Rebecca J Moon, Hazel M Inskip, Keith M Godfrey, Cyrus Cooper (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 22, 2017 Category: Endocrinology Source Type: research

Analysis of the MAVIDOS trial
Publication date: May 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 5 Author(s): Christopher S Kovacs (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 22, 2017 Category: Endocrinology Source Type: research

Bariatric surgery in adolescents – Author's reply
Publication date: May 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 5 Author(s): Torsten Olbers, Andrew J Beamish, Claude Marcus (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 22, 2017 Category: Endocrinology Source Type: research

Bariatric surgery in adolescents
Publication date: May 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 5 Author(s): Yu Zhang, Wenhua Tang (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 22, 2017 Category: Endocrinology Source Type: research

Insulin affordability
Publication date: May 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 5 Author(s): Robert A Hegele (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 22, 2017 Category: Endocrinology Source Type: research

Guidelines for type 2 diabetes: keeping a finger on the pulse
Publication date: Available online 19 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Anthony H Barnett, Paul O'Hare, Julian Halcox (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 20, 2017 Category: Endocrinology Source Type: research

What role for lipoprotein(a) in clinical practice?
Publication date: Available online 10 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Stephen J Nicholls, Peter J Psaltis (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 11, 2017 Category: Endocrinology Source Type: research

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis
Publication date: Available online 10 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Danish Saleheen, Philip C Haycock, Wei Zhao, Asif Rasheed, Adam Taleb, Atif Imran, Shahid Abbas, Faisal Majeed, Saba Akhtar, Nadeem Qamar, Khan Shah Zaman, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Nadeem Hayyat Mallick, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Khalid Mahmood, Naveeduddin Ahmed, Philippe Frossard, Sotirios Tsimikas, Joseph L Witztum, Santica Marcovina, Manjinder Sandhu, Daniel J Rader, John Danesh Background The lipoprotein(a) pathway is a causal factor in c...
Source: The Lancet Diabetes and Endocrinology - April 11, 2017 Category: Endocrinology Source Type: research

Urbanisation, inequality, and non-communicable disease risk
Publication date: Available online 5 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 6, 2017 Category: Endocrinology Source Type: research

Research digest: the risks of type 2 diabetes at a young age
Publication date: Available online 5 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Naveed Sattar, David Preiss (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 6, 2017 Category: Endocrinology Source Type: research

Corrections needed to 2016 ESC and AHA guidelines on heart failure
Publication date: Available online 5 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Lars Rydén, Frans Van de Werf, Paul W Armstrong, Darren K McGuire, Eberhard Standl, Eric D Peterson, Rury R Holman (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 6, 2017 Category: Endocrinology Source Type: research

Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial
Publication date: Available online 3 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Bo Ahrén, Luis Masmiquel, Harish Kumar, Mehmet Sargin, Julie Derving Karsbøl, Sanja Hald Jacobsen, Francis Chow Background Semaglutide is a novel glucagon-like peptide-1 (GLP-1) analogue, suitable for once-weekly subcutaneous administration, in development for treatment of type 2 diabetes. We assessed the efficacy and safety of semaglutide versus the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin, thiazolidinediones, or both....
Source: The Lancet Diabetes and Endocrinology - April 4, 2017 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2017; published online Jan 25. http://dx.doi.org/10.1016/S2213-8587(17)30033-5
Publication date: Available online 3 April 2017 Source:The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 4, 2017 Category: Endocrinology Source Type: research

Glycaemic control and weight loss with semaglutide in type 2 diabetes
Publication date: Available online 3 April 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Sten Madsbad, Jens J Holst (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 4, 2017 Category: Endocrinology Source Type: research

Guidelines for management of diabetic ketoacidosis: time to revise?
Publication date: Available online 31 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Ketan K Dhatariya, Guillermo E Umpierrez (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 1, 2017 Category: Endocrinology Source Type: research

Endocrinology through the ages
Publication date: Available online 31 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Sophie Watt (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - April 1, 2017 Category: Endocrinology Source Type: research

Tightening our understanding of intensive glycaemic control
Publication date: Available online 30 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): William G Herrington, David Preiss (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 31, 2017 Category: Endocrinology Source Type: research

Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials
Publication date: Available online 30 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Sophia Zoungas, Hisatomi Arima, Hertzel C Gerstein, Rury R Holman, Mark Woodward, Peter Reaven, Rodney A Hayward, Timothy Craven, Ruth L Coleman, John Chalmers Background Intensive glucose control is understood to prevent complications in adults with type 2 diabetes. We aimed to more precisely estimate the effects of more intensive glucose control, compared with less intensive glucose control, on the risk of microvascular events. Methods In this meta-analysis, we obtained de-identified individual participant data...
Source: The Lancet Diabetes and Endocrinology - March 31, 2017 Category: Endocrinology Source Type: research

Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial
Publication date: Available online 23 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Vanita R Aroda, Stephen C Bain, Bertrand Cariou, Milivoj Piletič, Ludger Rose, Mads Axelsen, Everton Rowe, J Hans DeVries Background Several pharmacological treatment options are available for type 2 diabetes; however, many patients do not achieve optimum glycaemic control and therefore new therapies are necessary. We assessed the efficacy and safety of semaglutide, a glucagon-like peptide-1 (GLP-1) analogue in clinical development, compared with insulin glargine in patients with type 2 diabetes who were inadequ...
Source: The Lancet Diabetes and Endocrinology - March 25, 2017 Category: Endocrinology Source Type: research

Transgender hormone therapy: understanding international variation in practice
Publication date: April 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 4 Author(s): Yaasir Mamoojee, Leighton J Seal, Richard Quinton (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 22, 2017 Category: Endocrinology Source Type: research

Sweet success: will sugar taxes improve health?
Publication date: April 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 4 Author(s): The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 22, 2017 Category: Endocrinology Source Type: research

What research is needed to address the co-epidemics of HIV and cardiometabolic disease in sub-Saharan Africa?
Publication date: Available online 17 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Pascal Geldsetzer, Jennifer Manne-Goehler, Till Bärnighausen, Justine Ina Davies (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 18, 2017 Category: Endocrinology Source Type: research

Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial
Publication date: Available online 18 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Jelena P Seferovic, Brian Claggett, Sara B Seidelmann, Ellen W Seely, Milton Packer, Michael R Zile, Jean L Rouleau, Karl Swedberg, Martin Lefkowitz, Victor C Shi, Akshay S Desai, John J V McMurray, Scott D Solomon Background Diabetes is an independent risk factor for heart failure progression. Sacubitril/valsartan, a combination angiotensin receptor-neprilysin inhibitor, improves morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF), compared with the angiotensin-convertin...
Source: The Lancet Diabetes and Endocrinology - March 18, 2017 Category: Endocrinology Source Type: research

Essential medicines and access to insulin
Publication date: Available online 18 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Geoff Gill, John S Yudkin, Solomon Tesfaye, Maximilian de Courten, Edwin Gale, Ayesha Motala, Kaushik Ramaiya, Nigel Unwin, Sarah Wild (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 18, 2017 Category: Endocrinology Source Type: research

Glycaemic control in heart failure: a PARADIGM shift for patients with concomitant diabetes?
Publication date: Available online 18 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Gregory Giamouzis, Javed Butler (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 18, 2017 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2017; published online Jan 23. http://dx.doi.org/10.1016/S2213-8587(17)30014-1
Publication date: Available online 11 March 2017 Source:The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 11, 2017 Category: Endocrinology Source Type: research

Does fetal exposure to vitamin D programme childhood bone mass?
Publication date: Available online 2 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Christopher S Kovacs (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 2, 2017 Category: Endocrinology Source Type: research

25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study
We examined associations using multivariable linear regression models, adjusted for several sociodemographic and lifestyle variables, and for child's height. Findings We enrolled 9901 mother-and-child pairs and obtained both mid-pregnancy maternal 25(OH)D concentrations and offspring DXA scans at age 6 years in 4815 pairs. Severe maternal 25(OH)D deficiency (<25 nmol/L) during mid-pregnancy was associated with higher offspring BMC (4·71 g, 95% CI 1·09 to 8·33; p=0·011) and larger bone area (7·54 cm2, 2·99 to 12·11; p=0·001) at age 6 years, compared with materna...
Source: The Lancet Diabetes and Endocrinology - March 2, 2017 Category: Endocrinology Source Type: research

Gestational diabetes in the first trimester: is early testing justified?
Publication date: Available online 1 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Arianne N Sweeting, Glynis P Ross, Jon Hyett, Jencia Wong (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 1, 2017 Category: Endocrinology Source Type: research

Obesity stories
Publication date: Available online 1 March 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Jules Morgan (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - March 1, 2017 Category: Endocrinology Source Type: research

The politics of health inequalities
Publication date: Available online 23 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Talha Khan Burki (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 23, 2017 Category: Endocrinology Source Type: research

Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects study
Publication date: Available online 23 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Lena M S Carlsson, Kajsa Sjöholm, Cecilia Karlsson, Peter Jacobson, Johanna C Andersson-Assarsson, Per-Arne Svensson, Ingrid Larsson, Stephan Hjorth, Martin Neovius, Magdalena Taube, Björn Carlsson, Markku Peltonen Background Bariatric surgery is associated with remission of diabetes and prevention of diabetic complications in patients with obesity and type 2 diabetes. Long-term effects of bariatric surgery on microvascular complications in patients with prediabetes are unknown. The aim of this study...
Source: The Lancet Diabetes and Endocrinology - February 23, 2017 Category: Endocrinology Source Type: research

Changing ethical and legal norms in the management of differences of sex development
Publication date: Available online 23 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Maayan Sudai (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 23, 2017 Category: Endocrinology Source Type: research

Microvascular complications after metabolic surgery
Publication date: Available online 23 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): George K Dimitriadis, Harpal S Randeva, Alexander D Miras (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 23, 2017 Category: Endocrinology Source Type: research

Challenges of monitoring global diabetes prevalence – Authors' reply
Publication date: March 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 3 Author(s): Peter H Bennett, Dianna J Magliano, K George Alberti, Paul Zimmet (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 23, 2017 Category: Endocrinology Source Type: research

Challenges of monitoring global diabetes prevalence
Publication date: March 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 3 Author(s): Majid Ezzati, Bin Zhou, Leanne Riley, Gretchen A Stevens, Kaveh Hajifathalian, Goodarz Danaei (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 23, 2017 Category: Endocrinology Source Type: research

Limitations of cholesterol lowering with PCSK9 inhibitors
Publication date: Available online 16 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Gilbert Thompson (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 17, 2017 Category: Endocrinology Source Type: research

Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study
Publication date: Available online 16 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Frederick J Raal, G Kees Hovingh, Dirk Blom, Raul D Santos, Mariko Harada-Shiba, Eric Bruckert, Patrick Couture, Handrean Soran, Gerald F Watts, Christopher Kurtz, Narimon Honarpour, Lihua Tang, Sree Kasichayanula, Scott M Wasserman, Evan A Stein Background Homozygous familial hypercholesterolaemia is a genetic disorder characterised by substantially raised LDL cholesterol, reduced LDL receptor function, xanthomas, and cardiovascular disease before age 20 years. Conventional therapy is with statins, ezetimibe,...
Source: The Lancet Diabetes and Endocrinology - February 17, 2017 Category: Endocrinology Source Type: research

Trans identity: out in the open
Publication date: Available online 14 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Jules Morgan (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 14, 2017 Category: Endocrinology Source Type: research

Research misconduct and the INTERGROWTH-21st study
Publication date: Available online 10 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Richard Horton, Sabine Kleinert, Sarah Linklater, Zoë Mullan (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 10, 2017 Category: Endocrinology Source Type: research

Research digest: prediabetes definitions and diabetes prevention
Publication date: Available online 9 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Naveed Sattar, David Preiss (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 9, 2017 Category: Endocrinology Source Type: research

The bare essentials: ensuring affordable access to insulin
Publication date: Available online 9 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): The Lancet Diabetes & Endocrinology (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 9, 2017 Category: Endocrinology Source Type: research

Strategies to improve the affordability of insulin in the USA
Publication date: Available online 9 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Jing Luo, Aaron S Kesselheim, Jeremy Greene, Kasia J Lipska (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 9, 2017 Category: Endocrinology Source Type: research

Blood pressure goals in type 2 diabetes —assessing the evidence
Publication date: Available online 4 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Peter M Nilsson, Sverre E Kjeldsen (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 4, 2017 Category: Endocrinology Source Type: research

Elimination of iodine deficiency disorders from the Americas: a public health triumph
Publication date: Available online 1 February 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Eduardo A Pretell, Elizabeth N Pearce, Sergio A Moreno, Omar Dary, Roland Kupka, Małgorzata Gizak, Jonathan Gorstein, Ruben Grajeda, Michael B Zimmermann (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - February 1, 2017 Category: Endocrinology Source Type: research

Integration of recent evidence into management of patients with atherosclerotic cardiovascular disease and type 2 diabetes
Publication date: Available online 26 January 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Eberhard Standl, Oliver Schnell, Darren K McGuire, Antonio Ceriello, Lars Rydén Cardiovascular outcome trials of antihyperglycaemic drugs and non-statin LDL-cholesterol-lowering drugs in patients with type 2 diabetes who have, or who are at high risk of, atherosclerotic cardiovascular disease have provided new evidence that has substantially affected the management of cardiovascular risk in these patients. On the basis of proven cardiovascular and renal benefit, the antihyperglycaemic drugs empagliflozin...
Source: The Lancet Diabetes and Endocrinology - January 26, 2017 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2016; 4: 943 –56
Publication date: February 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 2 (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - January 25, 2017 Category: Endocrinology Source Type: research

Correction to Lancet Diabetes Endocrinol 2017: 5: 125 –33
Publication date: February 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 2 (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - January 25, 2017 Category: Endocrinology Source Type: research

Prediabetes definitions and clinical outcomes – Authors' reply
Publication date: February 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 2 Author(s): Elizabeth Selvin, Bethany Warren, Kunihiro Matsushita, Naresh M Punjabi (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - January 25, 2017 Category: Endocrinology Source Type: research