Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
CONCLUSIONS: This study found that the IRF2BP1 gene variant was significantly associated with PEP. This genetic variant is a highly targeted PEP risk factor candidate and can be used for screening high-risk PEP groups before ERCP through future validation. (ClinicalTrials.gov no. NCT02928718).PMID:37867141 | DOI:10.3904/kjim.2022.404 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Young Hoon Choi Younggyun Lim Dong Kee Jang Dong-Won Ahn Ji Kon Ryu Woo Hyun Paik Yong-Tae Kim Ju Han Kim Sang Hyub Lee Source Type: research

Expanding the therapeutic landscape: ezetimibe as non-statin therapy for dyslipidemia
Korean J Intern Med. 2023 Oct 20. doi: 10.3904/kjim.2023.243. Online ahead of print.ABSTRACTDyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), and statins are the primary therapeutic options for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, it can be challenging to achieve optimal LDL-C goals with statin monotherapy. Ezetimibe, a cholesterol absorption inhibitor, offers a potential non-statin therapy to optimize LDL-C management. Key clinical trials, such as IMPROVE-IT and RACING, have demonstrated that the addition of ezetimibe to statin therapy leads to f...
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Jeongmin Lee Seung-Hwan Lee Source Type: research

Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
CONCLUSIONS: Our results reveal that the lung and gut microbiota of patients with NTM-PD exhibit an altered distribution and reduced richness and diversity.PMID:37867139 | DOI:10.3904/kjim.2023.097 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Ji Yeon Choi Bora Shim Youngmok Park Young Ae Kang Source Type: research

Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab
CONCLUSIONS: Systemic inflammation, reflected by increased disease activity, may be responsible for the increase in RANKL levels, which causes systemic bone loss in rituximab-treated patients with RA. Although rituximab affects inflammation, it does not seem to alter systemic bone metabolism in RA.PMID:37867140 | DOI:10.3904/kjim.2023.080 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Mie Jin Lim Kyong-Hee Jung Seong-Ryul Kwon Won Park Source Type: research

Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
CONCLUSIONS: This study found that the IRF2BP1 gene variant was significantly associated with PEP. This genetic variant is a highly targeted PEP risk factor candidate and can be used for screening high-risk PEP groups before ERCP through future validation. (ClinicalTrials.gov no. NCT02928718).PMID:37867141 | DOI:10.3904/kjim.2022.404 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Young Hoon Choi Younggyun Lim Dong Kee Jang Dong-Won Ahn Ji Kon Ryu Woo Hyun Paik Yong-Tae Kim Ju Han Kim Sang Hyub Lee Source Type: research