The Korean Journal of Internal Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations
Korean J Intern Med. 2023 Nov;38(6):787-796. doi: 10.3904/kjim.2023.345. Epub 2023 Nov 1.ABSTRACTLung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell lung cancer (NSCLC) is changing the paradigm of lung cancer treatment. Recently, ICIs are expanding their treatment area to early-stage NSCLC and ICIs have also changed their treatment strategies of such patients. And it is important to appropriately select patients with resectable early-stage lung cancer through a multidisciplinary team...
Source: The Korean Journal of Internal Medicine - November 8, 2023 Category: Internal Medicine Authors: Jae Kyeom Sim Juwhan Choi Sung Yong Lee Source Type: research

Long-acting interferon: pioneering disease modification of myeloproliferative neoplasms
Korean J Intern Med. 2023 Nov;38(6):810-817. doi: 10.3904/kjim.2023.333. Epub 2023 Nov 1.ABSTRACTMyeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells. The malignant clones produce cytokines that drive self-perpetuating inflammatory responses and tend to transform into more aggressive clones, leading to disease progression. The progression of MPNs follows a biological sequence from the early phases of malignancy, polycythemia vera, and essential thrombocythemia, to advanced myelofibrosis and leukemic transformation. To date, the treatment of MPNs has focused on preventing thrombosis by decrea...
Source: The Korean Journal of Internal Medicine - November 8, 2023 Category: Internal Medicine Authors: Seug Yun Yoon Sung-Yong Kim Source Type: research

Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate
CONCLUSION: Approximately one in 300 patients with an HH underwent surgical treatment. Multiple HHs and a growth rate of more than 4.8%/year were indications for surgical treatment. Nearly half of the HHs showed growing pattern in our study.PMID:37939665 | DOI:10.3904/kjim.2023.062 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 8, 2023 Category: Internal Medicine Authors: Young Cheol Shin Eun Ju Cho Hee Young Na Jai Young Cho Ho-Seong Han Yoon Jin Lee Haeryoung Kim Sangmi Jang Gwang Hyeon Choi Eun Sun Jang Jin-Wook Kim Sook-Hyang Jeong Source Type: research

Factors influencing occurrence of metachronous gastric cancer after endoscopic resection: a systematic review and meta-analysis
CONCLUSION: Gastric cancer patients with severe AG or presence of IM had a 2.0-fold or 7.0-fold higher risk of MGC occurrence after endoscopic resection than those without, respectively. They need more stringent follow-up to monitor MGC occurrences (CRD42023410940).PMID:37939666 | DOI:10.3904/kjim.2023.184 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 8, 2023 Category: Internal Medicine Authors: Younghee Choe Jae Myung Park Joon Sung Kim Yu Kyung Cho Byung-Wook Kim Myung-Gyu Choi Source Type: research

Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing
CONCLUSION: We suggest that the SNPs of SLC24A2 and ADARB2 might be genetic surrogate markers for complicating cardiac diseases in the scrub typhus infection. Our study show that early detection based on individual sequence variants might be feasible to predict complicating cardiac diseases in patients with scrub typhus infection, if further studies with more participants confirm these findings.PMID:37939667 | DOI:10.3904/kjim.2023.221 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 8, 2023 Category: Internal Medicine Authors: Ki-Woon Kang Kyung-Won Hong Seong-Kyu Lee Source Type: research

Exercise capacity and risk of incident atrial fibrillation in healthy adults
CONCLUSION: We demonstrated that poorer exercise capacity was associated with the development of AF in a healthy population. A prospective, systematic trial is necessary to confirm that appropriate exercise training will be beneficial in preventing the development of AF in such patients.PMID:37939668 | DOI:10.3904/kjim.2023.075 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 8, 2023 Category: Internal Medicine Authors: Ju Youn Kim Soo Jin Cho Juwon Kim Tae-Wan Chung Seung-Jung Park Kyoung-Min Park June Soo Kim Young Keun On Source Type: research

Association between knee osteoarthritis and mortality: a serial propensity score-matched cohort study
CONCLUSION: When propensity score matching controls metabolic risk factor imbalances, the association between symptomatic knee OA and higher CVD mortality was weaker compared to results of prior studies that used regression adjustment. The results may be more precise estimates of the total risk of knee OA for mortality in Koreans.PMID:37939669 | DOI:10.3904/kjim.2023.222 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 8, 2023 Category: Internal Medicine Authors: Minkyung Oh Mi-Yeong Kim Min Wook So Doo-Ho Lim Su Jin Choi Jae Ha Lee Minyoung Her Seong-Ho Kim Sunggun Lee Source Type: research

Expanding the therapeutic landscape: ezetimibe as non-statin therapy for dyslipidemia
Korean J Intern Med. 2023 Nov;38(6):797-809. doi: 10.3904/kjim.2023.243. Epub 2023 Oct 20.ABSTRACTDyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), and statins are the primary therapeutic options for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, it can be challenging to achieve optimal LDL-C goals with statin monotherapy. Ezetimibe, a cholesterol absorption inhibitor, offers a potential non-statin therapy to optimize LDL-C management. Key clinical trials, such as IMPROVE-IT and RACING, have demonstrated that the addition of ezetimibe to statin therapy lead...
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Jeongmin Lee Seung-Hwan Lee Source Type: research

Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
CONCLUSION: Our results reveal that the lung and gut microbiota of patients with NTM-PD exhibit an altered distribution and reduced richness and diversity.PMID:37867139 | DOI:10.3904/kjim.2023.097 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Ji Yeon Choi Bora Shim Youngmok Park Young Ae Kang Source Type: research

Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab
CONCLUSION: Systemic inflammation, reflected by increased disease activity, may be responsible for the increase in RANKL levels, which causes systemic bone loss in rituximab-treated patients with RA. Although rituximab affects inflammation, it does not seem to alter systemic bone metabolism in RA.PMID:37867140 | DOI:10.3904/kjim.2023.080 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Mie Jin Lim Kyong-Hee Jung Seong-Ryul Kwon Won Park Source Type: research

Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
CONCLUSION: This study found that the IRF2BP1 gene variant was significantly associated with PEP. This genetic variant is a highly targeted PEP risk factor candidate and can be used for screening high-risk PEP groups before ERCP through future validation. (ClinicalTrials.gov no. NCT02928718).PMID:37867141 | DOI:10.3904/kjim.2022.404 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Young Hoon Choi Younggyun Lim Dong Kee Jang Dong-Won Ahn Ji Kon Ryu Woo Hyun Paik Yong-Tae Kim Ju Han Kim Sang Hyub Lee Source Type: research

Expanding the therapeutic landscape: ezetimibe as non-statin therapy for dyslipidemia
Korean J Intern Med. 2023 Oct 20. doi: 10.3904/kjim.2023.243. Online ahead of print.ABSTRACTDyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), and statins are the primary therapeutic options for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, it can be challenging to achieve optimal LDL-C goals with statin monotherapy. Ezetimibe, a cholesterol absorption inhibitor, offers a potential non-statin therapy to optimize LDL-C management. Key clinical trials, such as IMPROVE-IT and RACING, have demonstrated that the addition of ezetimibe to statin therapy leads to f...
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Jeongmin Lee Seung-Hwan Lee Source Type: research

Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
CONCLUSIONS: Our results reveal that the lung and gut microbiota of patients with NTM-PD exhibit an altered distribution and reduced richness and diversity.PMID:37867139 | DOI:10.3904/kjim.2023.097 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Ji Yeon Choi Bora Shim Youngmok Park Young Ae Kang Source Type: research

Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab
CONCLUSIONS: Systemic inflammation, reflected by increased disease activity, may be responsible for the increase in RANKL levels, which causes systemic bone loss in rituximab-treated patients with RA. Although rituximab affects inflammation, it does not seem to alter systemic bone metabolism in RA.PMID:37867140 | DOI:10.3904/kjim.2023.080 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Mie Jin Lim Kyong-Hee Jung Seong-Ryul Kwon Won Park Source Type: research

Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
CONCLUSIONS: This study found that the IRF2BP1 gene variant was significantly associated with PEP. This genetic variant is a highly targeted PEP risk factor candidate and can be used for screening high-risk PEP groups before ERCP through future validation. (ClinicalTrials.gov no. NCT02928718).PMID:37867141 | DOI:10.3904/kjim.2022.404 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 22, 2023 Category: Internal Medicine Authors: Young Hoon Choi Younggyun Lim Dong Kee Jang Dong-Won Ahn Ji Kon Ryu Woo Hyun Paik Yong-Tae Kim Ju Han Kim Sang Hyub Lee Source Type: research