Editorial Comment
The clinical significance of radiation exposure from imaging remains an area of debate and the authors provide a fresh perspective. Currently we know that radiation effects are cumulative in nature and yet no dose limit exists related to medical imaging and limited data reflect actual patient radiation exposure from imaging.1 The current study contextualizes these uncertain harms in the backdrop of CTU. (Source: The Journal of Urology)
Source: The Journal of Urology - August 3, 2018 Category: Urology & Nephrology Authors: David T. Tzou, Thomas Chi Tags: Adult Urology Source Type: research
Reply by Authors
Pearce et al are looking for a platform to let the urology community know about their observations regarding long-term use of PPS (Elmiron ®) and potential ophthalmological complications, so much so that they have used a letter to the editor concerning our recent article on the FDA BRUDAC (Bone, Reproductive and Urologic Drugs Advisory Committee) criteria for interstitial cystitis/bladder pain syndrome as a pretext. While their letter has nothing at all to do with our article, we are happy that they have a chance to present their observations. (Source: The Journal of Urology)
Source: The Journal of Urology - August 3, 2018 Category: Urology & Nephrology Tags: Letter to the Editor/Errata Source Type: research
Prognostic value of concomitant carcinoma in situ in the radical cystectomy specimen: A systematic review and meta-analysis
To investigate the prognostic impact of concomitant carcinoma in situ (CIS) in radical cystectomy (RC) specimens. (Source: The Journal of Urology)
Source: The Journal of Urology - August 2, 2018 Category: Urology & Nephrology Authors: Shoji Kimura, Andrea Mari, Beat Foerster, Mohammad Abufaraj, Mihai D. Vartolomei, Judith Stangl-Kremser, Pierre I. Karakiewicz, Shin Egawa, Shahrokh F. Shariat Source Type: research
Experimental evaluation of human renal kidney stone spectra for intraoperative stone-tissue-instrument analysis using autofluorescence
This study evaluated technical, medical and physical conditions for real-time analysis using fluorescence for future development of a new laser for lithotripsy. (Source: The Journal of Urology)
Source: The Journal of Urology - August 2, 2018 Category: Urology & Nephrology Authors: Jan Sch ütz, Arkadiusz Miernik, Albrecht Brandenburg, Daniel Schlager Source Type: research
A Clinician ’s Guide to Next Generation Imaging in Patients With Advanced Prostate Cancer (Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence [RADAR] III)
The advanced prostate cancer therapeutic landscape has changed dramatically over the last several years, resulting in improved overall survival for patients with both castration-naive and castration-resistant disease. The evolution and development of novel next generation imaging (NGI) techniques will affect diagnostic and therapeutic decision-making. Clinicians must navigate when and which NGI techniques to use and how to adjust treatment strategies based upon their results, oftentimes in the absence of correlative therapeutic data. (Source: The Journal of Urology)
Source: The Journal of Urology - August 2, 2018 Category: Urology & Nephrology Authors: E. David Crawford, Phillip J. Koo, Neal Shore, Susan F. Slovin, Raoul S. Concepcion, Stephen J. Freedland, Leonard G. Gomella, Lawrence Karsh, Thomas E. Keane, Paul Maroni, David Penson, Daniel P. Petrylak, Ashley Ross, Vlad Mouraviev, Robert E. Reiter, C Source Type: research
Long-Term Surveillance of Complex Cystic Renal Masses and Heterogeneity of Bosniak 3 Lesions
We sought to better characterize the frequency of Bosniak cyst class changes, identify predictors of change and progression, determine the average growth rate of cysts and validate the safety of active surveillance. (Source: The Journal of Urology)
Source: The Journal of Urology - August 1, 2018 Category: Urology & Nephrology Authors: Deepak K. Pruthi, Qianqian Liu, Iain D.C. Kirkpatrick, Jonathan Gelfond, Darrel E. Drachenberg Tags: Adult Urology Source Type: research
Editorial Comment
In this retrospective study the NCDB was used to evaluate practice patterns in patients with SRMs less than 4 cm between 2010 and 2014. Following adjustment the authors report a greater increase in the use of RPN or radical nephrectomy compared to AS. This change was significant even in patients who were 75 years of old or older and in those with multiple comorbidities (Charlson comorbidity index 2 or greater). (Source: The Journal of Urology)
Source: The Journal of Urology - August 1, 2018 Category: Urology & Nephrology Authors: Brian Kadow, Marc C. Smaldone Tags: Adult Urology Source Type: research
Clinical utility of total length Gleason pattern 4 on biopsy in men with Grade Group 2 prostate cancer
The ideal methodology for quantifying secondary Gleason pattern 4 (GP4) in men with Grade group (GrdGrp) 2/Gleason score (GS) 3+4=7 on biopsy remains unknown. We compared various methods of GP4 quantification and evaluated their association with adverse pathology at radical prostatectomy (RP). (Source: The Journal of Urology)
Source: The Journal of Urology - August 1, 2018 Category: Urology & Nephrology Authors: Lucas W. Dean, Melissa Assel, Daniel D. Sjoberg, Andrew J. Vickers, Hikmat A. Al-Ahmadie, Ying-Bei Chen, Anuradha Gopalan, S. Joseph Sirintrapun, Satish K. Tickoo, James A. Eastham, Peter T. Scardino, Victor E. Reuter, Behfar Ehdaie, Samson W. Fine Source Type: research
Long-term Surveillance of Complex Cystic Renal Masses & Heterogeneity of Bosniak 3 Lesions
To better characterize the frequency of Bosniak cyst class changes and identify predictors of change and progression. To determine the average growth rate of cysts and validate the safety of active surveillance. (Source: The Journal of Urology)
Source: The Journal of Urology - August 1, 2018 Category: Urology & Nephrology Authors: Deepak K. Pruthi, Qianqian Liu, Iain D.C. Kirkpatrick, Jonathan Gelfond, Darrel E. Drachenberg Source Type: research
Ecological Momentary Assessment of Factors Associated with Water Intake Among Adolescents with Kidney Stone Disease
Maintaining high water intake reduces kidney stone recurrence, but is difficult to do. Strategies to reduce stone recurrence among adolescents are lacking. (Source: The Journal of Urology)
Source: The Journal of Urology - August 1, 2018 Category: Urology & Nephrology Authors: Gregory E. Tasian, Michelle Ross, Lihai Song, Janet Audrain-McGovern, Douglas Wiebe, Steven G. Warner, Brittney Henderson, Anisha Patel, Susan L. Furth Source Type: research
Continued Five-Alpha Reductase Inhibitor Use After Prostate Cancer Diagnosis and the Risk of Reclassification and Adverse Pathological Outcomes in the Canary Prostate Active Surveillance Study (PASS)
Outcomes of patients who enroll in active surveillance (AS) programs for prostate cancer (PCa) while taking five-alpha reductase inhibitors (5-ARIs) have not been well defined. We sought to determine the association of 5-ARI use with risk of reclassification in the Canary Prostate Active Surveillance Study (PASS). (Source: The Journal of Urology)
Source: The Journal of Urology - August 1, 2018 Category: Urology & Nephrology Authors: James T. Kearns, Anna V. Faino, Jeanette M. Schenk, Lisa F. Newcomb, James D. Brooks, Peter R. Carroll, Atreya Dash, William J. Ellis, Michael Fabrizio, Martin E. Gleave, Todd M. Morgan, Peter S. Nelson, Ian M. Thompson, Andrew Wagner, Yingye Zheng, Danie Source Type: research
Higher Neural Correlates in Multiple Sclerosis Patients with Neurogenic Overactive Bladder Following Treatment with Intradetrusor Injection of OnabotulinumtoxinA
OnabotulinumtoxinA (OnabotA) is a well-described treatment for Neurogenic Overactive Bladder (NOAB) and while its motor effects on detrusor muscle is extensively studied, its sensory effects are not. The aim of this study was to evaluate the impact of intradetrusor OnabotA injection on brain activity in female multiple sclerosis (MS) patients with NOAB. (Source: The Journal of Urology)
Source: The Journal of Urology - August 1, 2018 Category: Urology & Nephrology Authors: Rose Khavari, Saba N. Elias, Rashmi Pande, Katherine M. Wu, Timothy B. Boone, Christof Karmonik Source Type: research
Re: Moving Beyond an Age-Old Intervention
I agree with the author that urethroplasty is the preferred treatment for long or dense strictures. However, most patients have less complex strictures and many prefer a less invasive approach. I have had good results with direct incision or dilation of the stricture followed by a period of intermittent catheterization. Good long-term results are achieved in most patients with this approach, with high patient satisfaction. (Source: The Journal of Urology)
Source: The Journal of Urology - July 28, 2018 Category: Urology & Nephrology Authors: Sharad R. Shah Tags: Letter to the Editor/Errata Source Type: research
Editorial Comment
As surgeons our job is to intervene where the natural course of disease would lead to worsening illness, suffering and premature death, and observe patients who can be safely surveilled without intervention. Mazza et al present a retrospective series of 148 patients with muscle invasive bladder cancer who elected observation without radical cystectomy after a complete response to neoadjuvant chemotherapy. In a group of carefully selected patients from 2 high volume academic centers treated by 2 experienced surgeons the authors found overall 90% 5-year survival, which is on par with studies of patients who receive NAC with ...
Source: The Journal of Urology - July 28, 2018 Category: Urology & Nephrology Authors: Max Kates, Trinity J. Bivalacqua Tags: Adult Urology Source Type: research
Editorial Comment
In this cohort of patients with rigorous followup these outcomes are favorable. However, 48% of patients experienced recurrence in the bladder, including 11% with MIBC and 37% with high grade NMIBC. This shortfall in bladder tumor local control is concerning, particularly in this highly selected cohort at centers where there is significant experience with bladder cancer and where hundreds of cystectomies are performed per year. Moreover, these results may not be applicable to the general community. (Source: The Journal of Urology)
Source: The Journal of Urology - July 28, 2018 Category: Urology & Nephrology Authors: Ryan P. Werntz, Gary D. Steinberg Tags: Adult Urology Source Type: research
