Reply by Authors
We are familiar with the anatomical dimensions of the prostate since the senior author was the first to describe them in The Journal of Urology in 1993 (reference 13 in article). We find that real-time intraoperative 3-dimensional guided MRI pelvic floor dissection is more valuable than static preoperative studies and better facilitates safe pelvic dissection, whichever type of repair is chosen at initial closure.1 Finally, because ours is a referral center and we have seen more than 25 young patients with loss of the glans, corpora or both with penile disassembly and radical soft tissue mobilization, we avoid these 2 pr...
Source: The Journal of Urology - August 30, 2018 Category: Urology & Nephrology Tags: Pediatric Urology Source Type: research
Editorial Comment
In this study Kowalik et al found that 50% of women with OAB symptoms reported painful bladder filling and/or painful urgency. These are classic symptoms of IC/BPS (reference 8 in article). Yet a subset of patients with OAB reported bladder pain and comorbid pain conditions similar to IC/BPS. (Source: The Journal of Urology)
Source: The Journal of Urology - August 28, 2018 Category: Urology & Nephrology Authors: H. Henry Lai Tags: Adult Urology Source Type: research
Ten-year outcomes of renal tumor radiofrequency ablation
We sought to review long-term oncological outcomes of patients with renal tumors treated with radiofrequency ablation (RFA) greater than 10 years ago. (Source: The Journal of Urology)
Source: The Journal of Urology - August 28, 2018 Category: Urology & Nephrology Authors: Brett Johnson, Igor Sorokin, Jeffrey A. Cadeddu Source Type: research
International multi-center validation of an intermediate-risk subclassification of prostate cancer treated with radical treatment without hormone therapy
The NCCN guidelines recently endorsed a subclassification of intermediate-risk prostate cancer (IR-PCa) into favourable (FIR) and unfavourable (UIR) subgroups. However, this subclassification was developed in a treatment-heterogeneous cohort, hence the natural history of androgen deprivation treatment (ADT)-na ïve FIR- and UIR-PCa remains unknown. (Source: The Journal of Urology)
Source: The Journal of Urology - August 25, 2018 Category: Urology & Nephrology Authors: A. Berlin, F.Y. Moraes, N. Sanmamed, R. Glicksman, A. Koven, O. Espin-Garcia, E.T.T. Leite, J.L.F. Silva, R. Gadia, M. Nesbitt, C.N. Catton, S. Kaffenberger, S.S. Salami, T.M. Morgan, J.W.D. Hearn, W.C. Jackson, R. Mehra, P. Chung, N.E. Fleshner, Z.S. Zum Source Type: research
Editorial Comment
Metformin has been proposed to have efficacy in prostate cancer through several putative mechanisms. They include effects on insulin responsive prostate cancers via attenuation of hyperinsulinemia, inhibition of oxidative phosphorylation causing energetic stress in cancer cells and potentially delaying the development of castrate resistant prostate cancer, which hyperinsulinemia can potentiate.1 Retrospective studies have supported the hypothesis that metformin can improve outcomes in patients with prostate cancer (reference 25 in article). (Source: The Journal of Urology)
Source: The Journal of Urology - August 24, 2018 Category: Urology & Nephrology Authors: Bernhard J. Eigl, Nawaid Usmani Tags: Adult Urology Source Type: research
Editorial Comment
This report highlights several important aspects of patients with proximal hypospadias. Although these patients represent only a small portion of the overall hypospadias population, they require special care in view of the associated psychosocial and physical challenges outlined in this article. Several challenges face the reconstructive surgeon. These cases may involve an androgen receptor or converting enzyme deficiency, or a significant deficiency in the quality and quantity of penile skin, glans, urethral plate, corpus spongiosum and corporeal bodies. (Source: The Journal of Urology)
Source: The Journal of Urology - August 24, 2018 Category: Urology & Nephrology Authors: Tony Khoury Tags: Pediatric Urology Source Type: research
Editorial Comment
Imaging has demonstrated growing usefulness for the detection of prostate cancer. Previous data have shown that MRI fusion biopsy improves the identification of clinically significant prostate cancer and reduces the detection of clinically insignificant cancer compared to standard TRUS guided biopsy.1 In this article Simmons et al found that MRI targeted biopsy diagnosed 81% of cases of clinically significant cancer while reducing the diagnosis of clinically insignificant disease by 40% compared to saturation transperineal template biopsy sampling in men in the PICTURE trial requiring repeat biopsy. (Source: The Journal of Urology)
Source: The Journal of Urology - August 24, 2018 Category: Urology & Nephrology Authors: Hubert Huang, Mohummad Minhaj Siddiqui Tags: Adult Urology Source Type: research
The Journal of Urology ® Home Study Course 2018 Volume 199/200
(Source: The Journal of Urology)
Source: The Journal of Urology - August 22, 2018 Category: Urology & Nephrology Tags: CME Enrollment/Questionnaire Source Type: research
PI-RADSv2 Category on 3 Tesla Multiparametric Prostate MRI Predicts Oncologic Outcomes in Gleason 3+4 Prostate Cancer on Biopsy
3TmpMRI with PI-RADSv2 scoring is a common tool in prostate cancer (PCa) diagnosis and informs the likelihood of a cancerous lesion. We sought to investigate whether PI-RADSv2 also predicts adverse pathologic (AP) features mainly in patients with biopsy Gleason score (GS) 3+4. (Source: The Journal of Urology)
Source: The Journal of Urology - August 22, 2018 Category: Urology & Nephrology Authors: Izak Faiena, Amirali Salmasi, Neil Mendhiratta, Daniela Markovic, Preeti Ahuja, William Hsu, David A. Elashoff, Steven S. Raman, Robert E. Reiter Source Type: research
Patterns of Relapse and Implications for Post-Nephrectomy Surveillance for Patients with High-Risk Non-Clear Cell Renal Cell Carcinoma: Subgroup Analysis of the Phase 3 ECOG-ACRIN E2805 Trial
The natural history of non-clear cell renal cell carcinomas (non-ccRCC) following surgery with curative intent remains poorly defined, with post-operative surveillance informed by guidelines largely intended for clear cell RCC (ccRCC). We evaluated the patterns of relapse and potential implications for post-nephrectomy surveillance for patients with non-ccRCC enrolled in the largest randomized trial of adjuvant anti-angiogenic therapy for high-risk RCC (E2805). (Source: The Journal of Urology)
Source: The Journal of Urology - August 18, 2018 Category: Urology & Nephrology Authors: Vivek Narayan, Maneka Puligandla, Naomi B. Haas, Pearl Subramanian, Robert S. DiPaola, Robert Uzzo Source Type: research
Serum Testosterone Levels and Prostate Cancer Risk: A Single Post-Hoc Testosterone Measurement is not Informative
(Source: The Journal of Urology)
Source: The Journal of Urology - August 18, 2018 Category: Urology & Nephrology Authors: Kevin R. Loughlin Source Type: research
The Kinetics of Sperm Return and Late Failure Following Vasovasostomy or Vasoepididymostomy: A Systematic Review
Vasovasostomy (VV) and vasoepididymostomy (VE) are technically challenging microsurgical reconstructive procedures necessary for men with obstructive azoospermia at the level of the vas deferens or epididymis. Patency rates following VV or VE have been widely described in the literature. However, few reports have discussed the timing of sperm return to the ejaculate following reconstruction as well as the proportion of men that develop late failure following VV or VE. Therefore, the objective of this article is to review the rates and predictors associated with late failures and the timing of sperm returning to the ejacula...
Source: The Journal of Urology - August 18, 2018 Category: Urology & Nephrology Authors: Nicholas J. Farber, Ryan Flannigan, Peng Li, Philip S. Li, Marc Goldstein Source Type: research
Enhanced Recovery after Surgery Protocols in Pediatric Urology —How are we Doing and What Should we be Doing?
Enhanced recovery after surgery (ERAS) protocols have been used for adult colorectal surgery since the late 1990s, with significant evidence supporting improved patient outcomes including reduced hospital stay, lower complication rates, quicker return of bowel function and increased patient satisfaction.1 Since many of the changes have improved quality and outcomes for the patient, and decreased overall hospital costs, the ERAS principles have gained popularity in adult urological cancer surgery. (Source: The Journal of Urology)
Source: The Journal of Urology - August 17, 2018 Category: Urology & Nephrology Authors: Mark P. Cain Tags: Editorial Source Type: research
Re: Comparing Anticholinergic Persistence and Adherence Profiles in Overactive Bladder Patients Based on Gender, Obesity, and Major Anticholinergic Agents
L. L. Lua, P. Pathak and V. Dandolu (Source: The Journal of Urology)
Source: The Journal of Urology - August 17, 2018 Category: Urology & Nephrology Authors: Alan J. Wein Tags: Adult Urology Source Type: research
Re: De Novo Overactive Bladder following Midurethral Sling Procedures: A Systematic Review of the Literature and Meta-Analysis
V. Pergialiotis, Z. Mudiaga, D. N. Perrea and S. K. Doumouchtsis (Source: The Journal of Urology)
Source: The Journal of Urology - August 17, 2018 Category: Urology & Nephrology Authors: Alan J. Wein Tags: Adult Urology Source Type: research
