Erratum: Posterior tibial tendinopathy associated with matrix metalloproteinase 13 promoter genotype and haplotype
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 27, 2017 Category: Genetics & Stem Cells Tags: ERRATUM Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 27, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Association of human leukocyte antigen polymorphisms with occult hepatitis B virus infection in a Shaanxi Han population
ConclusionsThe results of the present study suggest that host HLA gene is an important influencing factor for OBI pathogenesis. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 18, 2017 Category: Genetics & Stem Cells Authors: Tianju Wang, Chunmei Shen, Liping Chen, Sheng Liu, Yanhong Ji Tags: RESEARCH ARTICLE Source Type: research
Association between MTHFR microRNA binding site polymorphisms and methotrexate concentrations in Chinese pediatric patients with acute lymphoblastic leukemia
ConclusionsThe rs3737966 and rs35134728 polymorphisms in MTHFR were associated with serum MTX concentrations. The findings indicated miRNAs might be involved in the post‐transcriptional regulation of MTHFR. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 9, 2017 Category: Genetics & Stem Cells Authors: Shu ‐mei Wang, Wei‐xin Zeng, Wan‐shui Wu, Lu‐lu Sun, Dan Yan Tags: RESEARCH ARTICLE Source Type: research
Association of incretin receptors genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients
ConclusionsWe reveal for the first time an association between the GIPR rs2302382 polymorphism and T2DM in Egyptians. Yet, there was no significant association of GIPR rs1800437 or GLP‐1R rs367543060 with T2DM risk. The haplotype A (rs2302382) C (rs1800437) was associated with an increased risk of T2DM. Furthermore, there was a significant increase of GIP and a significant decrease of GLP‐1 levels when diabetic patients were compared with controls. An important finding was that there was a relationship between both GIPR rs2302382 and rs1800437 variants and their cognate ligand levels. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 21, 2017 Category: Genetics & Stem Cells Authors: Sally M. Shalaby, Haidy E. Zidan, Amira Shokry, Jehan Saeed, Rehab H. El ‐Sokkary Tags: RESEARCH ARTICLE Source Type: research
Correlation analysis of the HLA ‐DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population
ConclusionsThe results of the present study indicate that the HLA‐DPB1*05:01 gene was associated with the geographical region of PV and the BTNL2 gene was significantly associated with family history and age of onset of PV. In conclusion, the HLA‐DPB1*05:01 and BTNL2 genes might be responsible for the complicacy of clinical features. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 19, 2017 Category: Genetics & Stem Cells Authors: Huimin Guo, Yong Huang, Juan Wu, Xiaodong Zheng, Lei Ye, Hequn Huang, Wenjun Wang, Qi Zhen, Jing Wu, Wenjun Qian, Hui Cheng, Xing Fan, Xuejun Zhang Tags: RESEARCH ARTICLE Source Type: research
MMP ‐3 (‐1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)‐3 and correlate with severity of COPD: a study of MMP‐3, MMP‐7 and MMP‐12 in a Tunisian population
ConclusionMMP‐3 (‐1171) 5A/6A and Lys45Glu (A/G) polymorphisms were associated with the decline of lung function among COPD patients. These results could be linked to the upregulation of MMP‐3 in serum from COPD patients carrying the ‐1171 6A and 45G homozygous genotypes. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 1, 2017 Category: Genetics & Stem Cells Authors: Sarra Bchir, Hela Nasr, Abdelhamid Garrouch, Amel Anes, Ammar Abbassi, Zouhair Tabka, Karim Chahed Tags: RESEARCH ARTICLE Source Type: research
Co ‐delivery of HIF‐1α siRNA and 5‐fluorouracil to overcome drug resistance in gastric cancer SGC‐7901 cells
ConclusionsCo‐delivery of siRNA and 5‐fluorouracil chitosan nanoparticles is an attractive strategy to overcome multidrug resistance. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 1, 2017 Category: Genetics & Stem Cells Authors: Yunna Chen, Li Sun, Dongdong Guo, Ziteng Wu, Weidong Chen Tags: RESEARCH ARTICLE Source Type: research
Susceptibility to HIV ‐1 infection is influenced by toll like receptor‐2 (−196 to −174) polymorphism in a north Indian population
ConclusionsThe present study reports for the first time that the TLR2–196 to −174 Ins/Del polymorphism is a risk factor for HIV‐1 transmission in HIV‐1 infected North Indian individuals. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2017 Category: Genetics & Stem Cells Authors: Sanjukta Vidyant, Animesh Chatterjee, Vikas Agarwal, Tapan N. Dhole Tags: RESEARCH ARTICLE Source Type: research
Multivalent methionine ‐functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF‐7/ADR
ConclusionsThe synthesized polymer vector can deliver siRNA molecules into tumor cells and then reverse drug resistance by down regulation of P‐glycoprotein mRNA expression. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2017 Category: Genetics & Stem Cells Authors: Yang Wu, Wei Zhang, Tinghan Li, Rong Ma, Dan Chen, Junying Zhang, Jianzhong Wu, Jinhai Tang Tags: RESEARCH ARTICLE Source Type: research
Sustained secretion of anti ‐tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis
ConclusionsThe results of the present study report microdermal tissues engineered to secrete active adalimumab as a proof of concept for sustained secretion of antibody from the novel ex vivo gene therapy TARGT platform. This technology may now be applied to a range of antibodies for the therapy of other diseases. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2017 Category: Genetics & Stem Cells Authors: Inbal Zafir ‐Lavie, Reem Miari, Shay Sherbo, Simi Krispel, Osnat Tal, Atar Liran, Tamar Shatil, Felix Badinter, Haim Goltsman, Nir Shapir, Itai Benhar, Garry A. Neil, Amos Panet Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Genetic Factors are Stressed Variably by Onset Age ‐based Sample Selection in Psoriasis: A Hint from MHC Region‐based Analysis
ConclusionsOnset age‐based sample variables would influence the results of genetic association study, at least in MHC region‐based genetic analysis. We would make more cautions in sample selection for genetic association study in order to prevent confounders which might be caused by onset age. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 1, 2017 Category: Genetics & Stem Cells Authors: Lei Ye, Chao Yang, Jin ‐Fa Dou, Lei‐Lei Wen, Wen‐Jun Wang, Xiao‐Dong Zheng, Xian‐Bo Zuo, Fu‐Sheng Zhou, Xing Fan, Xue‐Jun Zhang Tags: RESEARCH ARTICLE Source Type: research
Gene therapy for neuropathic pain induced by spared nerve injury with naked plasmid encoding hepatocyte growth factor
ConclusionsOur results indicate that pUDK‐HGF can reduce cytotoxicity products released from activated glial cells, which may provide a promising therapeutic strategy for treating NP. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 1, 2017 Category: Genetics & Stem Cells Authors: Hu Chunsheng, Lu Yuxin, Cheng Xiaochen, Cui Yufang, Wu Zuze, Zhang Qinglin Tags: RESEARCH ARTICLE Source Type: research
IL ‐1RN gene polymorphisms were associated with breast cancer risk in a Chinese Han population
ConclusionOur data shed new light on the association between genetic polymorphisms of IL‐1RN and BC susceptibility in the Chinese Han population. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 1, 2017 Category: Genetics & Stem Cells Authors: Tianbo Jin, Wei Cao, Xiaoxiao Zuo, Miao Li, Ya Yang, Tiansong Liang, Hongyao Yang, Xinhan Zhao, Daoke Yang Tags: RESEARCH ARTICLE Source Type: research
