The Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Urate-Lowering Drugs And Muscle Injury: A Systematic Review and Network Meta-Analysis
This study investigated the association of oral urate-lowering drugs with the risk of muscle injury by performing a network meta-analysis of randomized and non-randomized controlled trials. A systematic search of MEDLINE via PubMed, the ClinicalTrials.gov website, and the Cochrane Central Register of Controlled Trials was conducted to identify relevant studies with a primary outcome of "all muscle injuries." A random-effects model was used to perform a frequentist network meta-analysis to estimate whether there was significant heterogeneity among the studies. In total, 32 studies including 28,327 participants with 2,694 (9...
Source: The Journal of Clinical Pharmacology - October 15, 2023 Category: Drugs & Pharmacology Authors: Satoru Mitsuboshi Makoto Morizumi Kazumasa Kotake Ryohei Kaseda Ichiei Narita Source Type: research

Effect of Renal Impairment on The Pharmacokinetics of A Single Oral Dose of Danuglipron In Participants With Type 2 Diabetes
This article is protected by copyright. All rights reserved.PMID:37840155 | DOI:10.1002/jcph.2371 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - October 15, 2023 Category: Drugs & Pharmacology Authors: Daryl J Fediuk Donal N Gorman Stephanie-An Stoddard Yizhong Zhang Adam G Ogden Jennifer A Winton Aditi R Saxena Source Type: research

Prognostic Impact of Early Administration of Β-Blockers in Critically Ill Patients with Acute Myocardial Infarction
This article is protected by copyright. All rights reserved.PMID:37830391 | DOI:10.1002/jcph.2370 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - October 13, 2023 Category: Drugs & Pharmacology Authors: Chong Zhang Fei Wang Cuijun Hao Weiru Lian Tianhua Hou Jiayan Xin Bin Su Meng Ning Yingwu Liu Source Type: research

Genetic Polymorphism as a Possible Cause of Severe Post-Operative Pain
J Clin Pharmacol. 2023 Oct 10. doi: 10.1002/jcph.2367. Online ahead of print.NO ABSTRACTPMID:37816218 | DOI:10.1002/jcph.2367 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - October 10, 2023 Category: Drugs & Pharmacology Authors: Bart Govers Maja Matic Ron H N van Schaik Markus Klimek Source Type: research

Investigation of the differences in the pharmacokinetics of CYP2D6 substrates, desipramine and dextromethorphan in healthy African subjects carrying the allelic variants CYP2D6*17 and CYP2D6*29 when compared with normal metabolizers
This study investigated the differences in the pharmacokinetics (PK) of dextromethorphan and desipramine in African healthy volunteers to understand the effect of allelic variants of the human cytochrome-P450(CYP)2D6 enzyme namely, CYP2D6*1/*2 diplotypes, CYP2D6*17*17 and CYP2D6*29*29 genotypes. Overall, 28 adults were included through genotype screening into the three cohorts: CYP2D6*1/*2 (n = 12), CYP2D6*17*17 (n = 12), and CYP2D6*29*29 (n = 4). Each subject received a single oral dose of dextromethorphan 30-mg syrup on Day 1 and desipramine 50-mg tablet on Day 8. The PK parameters, area under plasma concentration-time c...
Source: The Journal of Clinical Pharmacology - October 7, 2023 Category: Drugs & Pharmacology Authors: Venugopal P Marasanapalle Collen Masimirembwa Rama Sivasubramanian Sarfaraz Sayyed Armin Weinzierl-Hinum Dheeraj Mehta Nyasha Nicole Kapungu Comfort Kanji Roslyn Thelingwani Julia Zack Source Type: research

Comparative Efficacy and Safety of Antidepressants for Patients with Chronic Back Pain: A Network Meta-Analysis
This study found antidepressants are more efficacious than placebos for treating chronic back pain, and TCAs were the most likely medications that lead to pain relief. This article is protected by copyright. All rights reserved.PMID:37794650 | DOI:10.1002/jcph.2365 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - October 5, 2023 Category: Drugs & Pharmacology Authors: Tao Ma Hongyu Qi Yuanrong Mao Ya Wang Baolin Duan Ke Ma Source Type: research