Early exposure to cow’s milk protein is associated with a reduced risk of cow’s milk allergic outcomes.
ConclusionExposure to cow’s milk protein in the first 3 months of life was associated with a reduced risk of cow’s milk allergy. These findings are from an observational study and clinical trials are warranted to further assess this association before any recommendations to infant feeding guidelines can be made. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2018 Category: Allergy & Immunology Source Type: research

The Safety of Antibiotic Skin Testing in Severe T-cell-Mediated Hypersensitivity of immunocompetent and immunocompromised hosts
Publication date: Available online 26 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jason A. Trubiano, Abby P. Douglas, Michelle Goh, Monica A. Slavin, Elizabeth J. Phillips (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2018 Category: Allergy & Immunology Source Type: research

Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation
Publication date: Available online 26 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Anne M. Fitzpatrick, Leonard B. Bacharier, Theresa W. Guilbert, Daniel J. Jackson, Stanley J. Szefler, Avraham Beigelman, Michael D. Cabana, Ronina Covar, Fernando Holguin, Robert F. Lemanske, Fernando D. Martinez, Wayne Morgan, Wanda Phipatanakul, Jacqueline A. Pongracic, Robert S. Zeiger, David T. Mauger, NIH/NHLBI AsthmaNetAbstractBackgroundRecurrent preschool wheezing is a heterogeneous disorder with significant morbidity, yet little is known about phenotypic determinants and their impact on...
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2018 Category: Allergy & Immunology Source Type: research

Long-term Outcome of Peanut Oral Immunotherapy Facilitated Initially by Omalizumab
ConclusionWhile adjunctive omalizumab allowed for faster and successful desensitization in patients with high peanut-IgE, almost half of patients discontinued OIT within 72 months because of reactions. Patients who stopped therapy had higher month 12 peanut-IgE and Arah2-IgE. It is possible that these patients might benefit from longer omalizumab administration. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2018 Category: Allergy & Immunology Source Type: research

Exploring the diagnosis and profile of cannabis allergy
ConclusionsThe most effective and practical tests to confirm CA are the SPT with a nCan s 3-rich extract and the sIgE rCan s 3. Can s 3 entails a risk of systemic reactions to plant-derived foods and cofactor-mediated reactions. However, as Can s 3 sensitization is not absolute, other cannabis allergens probably play a role. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2018 Category: Allergy & Immunology Source Type: research

Polyethylene Glycol: Not Just a Harmless Excipient
Publication date: Available online 3 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lucinda Kennard, Krzysztof Rutkowski, Rita Mirakian, Annette Wagner (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2018 Category: Allergy & Immunology Source Type: research

Sublingual Swelling due to Sublingual Immunotherapy
Publication date: Available online 3 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Junya Okumura, Naozumi Hashimoto, Yoshinori Hasegawa (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 5, 2018 Category: Allergy & Immunology Source Type: research

Rostrum: Latex Allergy Risks Live On
Publication date: Available online 21 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kim Liberatore, Kevin J. KellyReduction in the prevalence of IgE-mediated allergy to latex proteins from gloves in patients may lead to lax attention by health care personnel to avoid use of latex products in latex-allergic subjects. Recent evidence from the Pennsylvania Patient Safety Reporting System shows an alarming continuation of adverse events mostly from latex urinary catheters. We are strongly advocating that health care personnel must continue to pay close attention to avoidance of lat...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 22, 2018 Category: Allergy & Immunology Source Type: research

Is “Yellow Zone” Management Effective in Reducing Asthma Flares in Children?
Publication date: Available online 21 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Javen Wunschel, Bharat Kumar (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 22, 2018 Category: Allergy & Immunology Source Type: research

Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing
Publication date: Available online 20 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Maria J. Torres, N. Franklin Adkinson, Jean-Christoph Caubet, David A. Khan, Mona I. Kidon, Louis Mendelson, Eva Rebelo Gomes, Ticha Rerkpattanapipat, Shuchen Zhang, Eric Macy, AAAAI/WAO 2018 Symposium Penicillin and Cephalosporin Allergy Testing Working GroupAll beta-lactam use is associated with a certain rate of adverse reactions. Many of these adverse reactions result in an allergy to the beta-lactam being entered into the patient's medical record. Unfortunately, only a small minority of the...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 21, 2018 Category: Allergy & Immunology Source Type: research

Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center
CONCLUSIONOur data suggests that our FPIES OFC protocol is safe. Early administration of IVF may prevent the development of hypotension. It is difficult to stratify risk of severe or delayed reaction based on patient characteristics and more data is needed to identify those appropriate for home introduction. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 21, 2018 Category: Allergy & Immunology Source Type: research

Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort
Publication date: Available online 19 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Reza Yazdani, Hassan Abolhassani, Fatemeh Kiaee, Sima Habibi, Gholamreza Azizi, Marzieh Tavakol, Zahra Chavoshzadeh, Seyed Alireza Mahdaviani, Tooba Momen, Mohammad Gharagozlou, Masoud Movahedi, Amir Ali Hamidieh, Nasrin Behniafard, Mohammamd Nabavi, Mohammad Hassan Bemanian, Saba Arshi, Rasol Molatefi, Roya Sherkat, Afshin Shirkani, Reza AminAbstractBackgroundPredominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and ina...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 21, 2018 Category: Allergy & Immunology Source Type: research

Predictors of inhaled corticosteroid taper failure in adults with asthma
Publication date: Available online 19 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Juan Carlos Cardet, Christopher D. Codispoti, Tonya S. King, Leonard Bacharier, Tara Carr, Mario Castro, Vernon Chinchilli, Ryan Dunn, Fernando Holquin, Linda Engle, Kyle Nelson, Victor E. Ortega, Michael Peters, Sima Ramratnam, Jerry A. Krishnan, Michael E. Wechsler, Elliot Israel, NHLBI Asthmanet (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 21, 2018 Category: Allergy & Immunology Source Type: research

Initiating yellow jacket venom immunotherapy with a 100-μg dose: A challenge?
Publication date: Available online 19 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Byrthe J.P.R. Vos, Anthony E.J. Dubois, Michèle M. Rauber, Wolfgang Pfützner, Michaela Miehe, Barbara Bohle, Christian Möbs, Joanne N.G. Oude Elberink (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 21, 2018 Category: Allergy & Immunology Source Type: research

Antibiotic allergy labels in children are associated with adverse clinical outcomes
Publication date: Available online 19 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Michaela Lucas, Annabelle Arnold, Aine Sommerfield, Michelle Trevenen, Laure Braconnier, Alina Schilling, Fuad Abass, Lliana Slevin, Brittany Knezevic, Christopher Blyth, PhD. Kevin Murray, Britta von Ungern-Sternberg, Kristina RueterAbstractBackgroundSelf-reported antibiotic allergies are common among hospitalised adults and children. There is a paucity of studies investigating the impact of an antibiotic allergy label in childhood.ObjectiveTo investigate the impact of antibiotic allergy labell...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 21, 2018 Category: Allergy & Immunology Source Type: research

New-onset asthma in adults; what does the trigger history tell us?
Conclusionpatients with adult-onset asthma can be characterized by the trigger that seemingly incited their asthma. These triggers might represent underlying mechanisms and may be important to phenotype patients and predict disease outcome. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 19, 2018 Category: Allergy & Immunology Source Type: research

Self-reported anaphylaxis to packaged foods in Australia
Publication date: Available online 18 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Giovanni A. Zurzolo, Katrina J. Allen, Rachel L. Peters, Shyamali C. Dharmage, Mimi L.K. Tang, Maria Said, Michael Field, Maximilian de Courten, Michael L. Mathai, Dianne E. Campbell (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 19, 2018 Category: Allergy & Immunology Source Type: research

Quantifying beta agonist utilization: occasions or puffs?
Publication date: Available online 13 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Stanley J. Szefler, Heather Hoch, Michael Tuffli, Rahul Gondalia, Meredith A. Barrett, David Van Sickle, David A. Stempel (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 13, 2018 Category: Allergy & Immunology Source Type: research

Uncharted Waters: Challenges in the Era of Biologic Therapies for Nasal Polyposis
Publication date: Available online 11 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jayant M. Pinto, Fuad M. Baroody, Robert M. NaclerioSeveral new, promising, targeted therapies for nasal polyposis are being tested in large-scale clinical trials. These agents target pathways thought to be involved in the disease, including IgE, IL-5, IL-4/IL-13, and others. Designing these trials poses significant challenges: who and when to enroll is not completely clear, optimal dosing is not known, outcome measures are insufficiently robust, there are no validated biomarkers, trial regimens...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 12, 2018 Category: Allergy & Immunology Source Type: research

Anaphylaxis to trometamol excipient in gadolinium based contrast agents for clinical imaging.
Publication date: Available online 11 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Joanna Lukawska, Deepal Mandaliya, A.W. Edith Chan, Amy Foggitt, Therese Bidder, Jennifer Harvey, Lisa Stycharczuk, Sotirios Bisdas (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 12, 2018 Category: Allergy & Immunology Source Type: research

Reslizumab Compared with Benralizumab in Patients with Eosinophilic Asthma: A Systematic Literature Review and Network Meta-Analysis
ConclusionsThis indirect comparison suggests reslizumab may be more efficacious than benralizumab in patients with eosinophilic asthma in GINA step 4/5 with elevated blood eosinophil levels (benralizumab, ≥300/μL; reslizumab, ≥400/μL) and ≥2 exacerbations in the previous year. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 12, 2018 Category: Allergy & Immunology Source Type: research

Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
Publication date: Available online 8 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Inderpaul Singh Sehgal, Hansraj Choudhary, Sahajal Dhooria, Ashutosh Nath Aggarwal, Mandeep Garg, Arunaloke Chakrabarti, Ritesh AgarwalABSTRACTBackgroundChronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA) are presumed to represent two distinct manifestations of Aspergillus species in the lung.ObjectiveTo investigate any possible overlap of the immunological tests used for diagnosing ABPA in proven cases of CPA.MethodsIn consecutive subjects with CPA, we calcul...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 9, 2018 Category: Allergy & Immunology Source Type: research

Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing
Publication date: Available online 8 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Timothy J. Watts, David Thursfield, Rubaiyat Haque (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 9, 2018 Category: Allergy & Immunology Source Type: research

Mycoplasma-Induced Toxic Epidermal Necrolysis with Severe Mucositis
Publication date: Available online 7 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Ze-Hu Liu, Hong Shen (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 8, 2018 Category: Allergy & Immunology Source Type: research

Implementing Health Care Technology Research into Practice to Improve Adult Asthma Management
Publication date: Available online 7 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Peter J. Cvietusa, Glenn K. Goodrich, Jo Ann Shoup, David A. Steffen, Cathy Tacinas, Nicole M. Wagner, Courtney B. Anderson, Debra P. Ritzwoller, Bruce G. Bender (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 7, 2018 Category: Allergy & Immunology Source Type: research

A Patch Testing Initiative for the Investigation of Allergic Contact Dermatitis in a UK Allergy Practice: A Retrospective Study
ConclusionACD was detected in almost 50% of assessed patients and we highlight the importance of assessing relevance. Hydroperoxides of limonene and linalool are notable additions to the prevalence data. Patch testing should be incorporated into more allergy practices, although availability of training is a limiting factor. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 7, 2018 Category: Allergy & Immunology Source Type: research

Correction
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Treating chronic spontaneous urticaria in children
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Miles Weinberger (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Reply
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Moshe Ben-Shoshan, Clive Grattan (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Possible contribution of decreased phytoprostanes to diet-induced improvements in aspirin exacerbated respiratory disease
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Jeffrey D. Miller (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Indoor environmental interventions for furry pet allergens: How to decrease the degree of passive transport
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Gennaro Liccardi, Luigino Calzetta, Manlio Milanese, Mauro Maniscalco, Antonello Salzillo, Paola Rogliani (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Correction
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Cover 1
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Table of Contents
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Original Article Highlights From This Issue
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Editorial Board
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Information for Readers
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Practice Notes from the AAAAI
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Continuing Medical Education Calendar
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Eosinophils: Friends or Foes?
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Michael J. ChusidThe roles eosinophils are recognized to play in health and disease continue to evolve. Formerly, eosinophils were believed to fill a primary role in host defense against helminths, an intermediary one in the propagation of allergic conditions, and a pathologic one in clinical conditions characterized by systemic eosinophilia and eosinophilic infiltration of target organs. Eosinophils are increasingly understood to be positioned centrally within mammalian immune and ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

CME Exam: Eosinophils: Friends or Foes?
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Consultation for Elevated Blood Eosinophils: Clinical Presentations, High Value Diagnostic Tests, and Treatment Options
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Paneez Khoury, Bruce S. BochnerThe workup of a patient found to have eosinophilia should follow a thorough path with a detailed history and physical examination aimed at eliciting eosinophilic organ involvement, followed by histological confirmation whenever possible. The differential diagnosis of hypereosinophilia is extensive, but a rational approach beyond the history and physical examination including serologic, blood, and bone marrow cell analyses, genetic testing, and radiolog...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

CME Exam: Consultation for Elevated Blood Eosinophils: Clinical Presentations, High-Value Diagnostic Tests, and Treatment Options
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Eosinophilic Pneumonias
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): James Allen, Michael WertThe eosinophilic pneumonias are a heterogeneous group of diseases characterized by an increase in eosinophils in lung tissue or bronchoalveolar lavage fluid. Many, but not all, of the eosinophilic pneumonias are also associated with a peripheral blood eosinophilia. The etiologies of eosinophilic lung disease are wide ranging and include parasitic infections, medications or other toxins, autoimmune and inflammatory disease, and malignancies. Some eosinophilic...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Eosinophilic Granulomatosis with Polyangiitis: Clinical Pathology Conference and Review
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Eveline Y. Wu, Michelle L. Hernandez, J. Charles Jennette, Ronald J. FalkEosinophilic granulomatosis with polyangiitis (EGPA) (formerly Churg-Strauss syndrome) is a small vessel vasculitis associated with asthma and eosinophilia. Despite its rarity, continuous gains are being made in understanding the disease with knowledge advancements regarding its epidemiology, heterogeneous clinical manifestations, management, and outcomes. Large knowledge gaps remain, however, particularly surr...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

CME Exam: Eosinophilic Granulomatosis with Polyangiitis: Clinical Pathology Conference and Review
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Eosinophils and the Scope of Practice in Allergy/Immunology
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): Kevin J. Kelly (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Long-Term Clinical Outcomes of High-Dose Mepolizumab Treatment for Hypereosinophilic Syndrome
ConclusionsThis study confirms that mepolizumab is an effective and well-tolerated therapy for HES, but suggests that response is more likely in GC-responsive subjects with idiopathic or overlap forms of HES. A primary benefit of treatment is the reduction of comorbidity due to discontinuation or the reduction of conventional HES therapies. Although subjects who completely discontinued GC had the most benefit, high-dose mepolizumab was a safe and effective salvage therapy for severe, treatment-refractory HES. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research
ConclusionsGastrointestinal eosinophilia is present in approximately 10% of patients with EoE; the symptom-diagnosis time gap is influenced by age, race, food allergy, and atopic dermatitis; symptoms vary with race; concurrent infectious/immunologic disorders and mental health disorders are common; and the level of esophageal eosinophils is comparable in patients with and without fibrostenotic features. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research