Real-World Experience with Peanut Oral Immunotherapy: Lessons Learned From 270 Patients
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Richard L. Wasserman, Angela R. Hague, Deanna M. Pence, Robert W. Sugerman, Stacy K. Silvers, Joanna G. Rolen, Morley HerbertBackgroundPeanut allergy (PA) is a significant and increasing problem, interfering with psychological development and family life. The standard recommendation to avoid peanut products and have access to injectable epinephrine is often inadequate. Oral immunotherapy for PA has been formally studied. Clinical observations of allergen immunotherapy have repeatedly enhanced pati...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Peanut Oral Immunotherapy: Data from a Real-World Clinical Practice
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Julie Wang (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Patterns of Carriage of Prescribed Adrenaline Autoinjectors in 10- to 14-Year-Old Food-Allergic Students: A Population-Based Study
ConclusionsCarriage of AAI devices is suboptimal in young adolescents prescribed AAIs, particularly when young adolescents are independent of parental supervision. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Early Exposure to Cow's Milk Protein Is Associated with a Reduced Risk of Cow's Milk Allergic Outcomes
ConclusionsExposure to cow's milk protein in the first 3 months of life was associated with a reduced risk of cow's milk allergy. These findings are from an observational study and clinical trials are warranted to further assess this association before any recommendations to infant feeding guidelines can be made. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Differentiating Acute Food Protein–Induced Enterocolitis Syndrome From Its Mimics: A Comparison of Clinical Features and Routine Laboratory Biomarkers
ConclusionsIn the young vomiting child, lethargy, floppiness, pallor without fever, and normal CRP should alert clinicians to a possible diagnosis of FPIES. In contrast, a highly elevated CRP is not a feature of FPIES, and in such cases an alternative diagnosis must be considered. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Efficacy, Safety, and Quality of Life in a Multicenter, Randomized, Placebo-Controlled Trial of Low-Dose Peanut Oral Immunotherapy in Children with Peanut Allergy
We examined the efficacy, safety, immunologic parameters, quality of life (QOL), and burden of treatment (BOT) of low-dose peanut OIT in a multicenter, double-blind, randomized placebo-controlled trial.MethodsA total of 62 children aged 3 to 17 years with IgE-mediated, challenge-proven peanut allergy were randomized (1:1) to receive peanut OIT with a maintenance dose of 125 to 250 mg peanut protein or placebo. The primary outcome was the proportion of children tolerating 300 mg or more peanut protein at oral food challenge (OFC) after 16 months of OIT. We measured the occurrence of adverse events (AEs), immunologic changes...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Reduced Final Height and Inadequate Nutritional Intake in Cow's Milk-Allergic Young Adults
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Tali Sinai, Michael R. Goldberg, Liat Nachshon, Roni Amitzur-Levy, Tamar Yichie, Yitzhak Katz, Efrat Monsonego-Ornan, Arnon ElizurBackgroundGrowth impairment was previously described in milk-allergic children but was not examined in adults on reaching final height.ObjectivesTo investigate the dietary intake and final stature of young adults with IgE-mediated cow's milk allergy (IgE-CMA) as compared with nonallergic controls.MethodsEighty-seven patients with IgE-CMA, median age 19.5 years (interqua...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

What Are Those Neutrophils Doing in Severe Asthma Anyway?
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): William W. Busse (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Determining the Appropriate Use of Antibiotics for the Treatment of Acute Asthma
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): David A. Stempel (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Sex-Specific Asthma Phenotypes, Inflammatory Patterns, and Asthma Control in a Cluster Analysis
ConclusionsThis study identified heterogeneous characteristics between sexes. In females, the analysis showed atopy with eosinophil-predominant and obese with neutrophil-predominant inflammation. Two distinct asthma phenotypes were found in current and ex-smokers in males. Understanding asthma phenotypes and explaining the potentially biological pathways have become important. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Growing Concerns with Staphylococcus aureus and Asthma: New Territory for an Old Foe?
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Meghan F. Davis, Meredith C. McCormack, Elizabeth C. Matsui (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

A Large Single-Hospital Experience Using Drug Provocation Testing and Rapid Drug Desensitization in Hypersensitivity to Antineoplastic and Biological Agents
ConclusionsThis experience allows us to describe general management plans, as well as specific patient phenotypic patterns, predictors for reactions, and risk considerations that need a tailored approach (taking into account the 3 prominent drug categories: platins, taxanes, and biologicals). (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Identified in the Electronic Health Record Allergy Module
ConclusionsUsing free-text search of the EHR allergy module identified a large US DRESS syndrome cohort. DRESS prevalence was 2.18 per 100,000 patients. Both liver and kidney injury were frequent, and vancomycin was the most common drug culprit. DRESS cases were morbid and resource-intensive. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

The Immunological Mysteries of Tuberculosis
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Doñah K. Sabbagh, Richard Beasley, Guy B. Marks (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Ara h 2 is detectable on surfaces of commercial airplanes
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Jay J. Jin, Joshua M. Dorn, John Yunginger, Nancy L. Ott (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Food protein–induced enterocolitis-like syndrome in a population of adolescents and adults caused by seafood
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Purificación Gonzalez-Delgado, Esther Caparrós, M. Victoria Moreno, Begoña Cueva, Javier Fernández (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Stepwise single-dose oral egg challenge: a multicenter prospective study
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Noriyuki Yanagida, Sakura Sato, Kyohei Takahashi, Kiyotaka Ohtani, Shigehito Emura, Yasuko Shibukawa, Akiko Murano, Takatsugu Komata, Wako Ishida, Hidetoshi Fujita, Tomoyuki Asaumi, Ken-ichi Nagakura, Kiyotake Ogura, Motohiro Ebisawa (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

NSAID Hypersensitivity
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Mario Sánchez-Borges, Hae-Sim Park (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

CME Exam: NSAID Hypersensitivity
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Letter regarding “Conjunctivitis occurring in atopic dermatitis patients treated with dupilumab—clinical characteristics and treatment”
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Manuel Jorge Rial, Blanca Barroso, Carmen Rodríguez-Bermejo, Joaquín Sastre (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Reply
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Andreas Wollenberg, Stephan Thurau, Marjolein de Bruin-Weller (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Reply
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Juliana F.B. Garcia, Priscila Takejima, Camila Lopes Veronez, Marcelo V. Aun, Antonio A. Motta, Jorge Kalil, João Bosco Pesquero, Pedro Giavina-Bianchi (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Long term outcome of WHIM syndrome in 18 patients: high risk of lung disease and HPV-related malignancies
ConclusionThe WHIM syndrome onsets early in life and should be suspected in patients with chronic neutropenia. WHIM patients need careful monitoring and timely intervention for complications, mainly lung disease and HPV-related malignancies. We suggest that immunoglobulin replacement therapy should be promptly considered to control the frequency of bacterial infections and prevent chronic lung damage. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

A Feasibility Study of a Patient-Centered Educational Strategy for Rampant Inhaler Misuse among Minority Children with Asthma
Publication date: Available online 31 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Anna Volerman, Madeleine M. Toups, Ashley Hull, Valerie G. Press (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 1, 2019 Category: Allergy & Immunology Source Type: research

Risk factors for positive paracetamol drug provocation testing and procedure optimization
Publication date: Available online 29 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Dunya Nohra, Rik Schrijvers, Nidhal Touati, Olga Nahas, Najah Ben Fadhel, Laetitia Ferrando, Pascal Demoly, Anca-Mirela Chiriac (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 30, 2019 Category: Allergy & Immunology Source Type: research

Sensitivity of Multiple Breath Washout to Detect Mild to Moderate Asthma in Adolescence
Publication date: Available online 29 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lambang Arianto, Henrik W. Hallas, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo L. Chawes (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 30, 2019 Category: Allergy & Immunology Source Type: research

H1-antihistamine inhibition of histamine- and codeine-induced wheals does not predict response in chronic cold urticaria
Publication date: Available online 29 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Marina Gorczyza, Laia Curto-Barredo, Karoline Krause, Martin K. Church, Tomasz Hawro, Martin Metz, Ana Giménez-Arnau, Marcus Maurer (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 30, 2019 Category: Allergy & Immunology Source Type: research

Utilizing boiled milk sIgE as a predictor of baked milk tolerance in cow’s milk allergic children
Publication date: Available online 29 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Amanda Agyemang, Sarah Saf, Travis Sifers, Michelle Mishoe, Magnus P. Borres, Hugh A. Sampson, Anna Nowak-Wegrzyn (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 30, 2019 Category: Allergy & Immunology Source Type: research

Allergen recognition patterns in walnut allergy are age dependent and correlate with the severity of allergic reactions
Publication date: Available online 30 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Barbara K. Ballmer-Weber, Jonas Lidholm, Lars Lange, Mariona Pascal, Claudia Lang, Sunhild Gernert, Jaime Lozano-Blasco, Nora Gräni, Caroline Guillod, Andrea Wangorsch, Kay-Martin Hanschmann, Bo Pontoppidan, Linda Tjäder, Joan Bartra, Stefan ViethsAbstractBackgroundWalnut is an important elicitor of food allergy in children and adults with a high rate of severe reactions. Multicenter studies using a common clinical protocol and a comprehensive allergen are lacking.ObjectiveTo investigate...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 30, 2019 Category: Allergy & Immunology Source Type: research

Caregiver-reported asthma control predicts future visits, independent of guideline-based control measures
ConclusionAmong predominantly low-income minority children with asthma, caregiver-reported asthma control may provide information about the risk of future acute visit for asthma that is complementary to guideline-based control assessment. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 29, 2019 Category: Allergy & Immunology Source Type: research

Relevance of the basophil high-affinity IgE receptor in chronic urticaria: Clinical experience from a tertiary care institution
Publication date: Available online 25 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Gustavo Deza, Alvaro March-Rodríguez, Silvia Sánchez, Clara Ribas-Llauradó, Dulce Soto, Ramon M. Pujol, Ramon Gimeno, Ana M. Giménez-ArnauAbstractBackgroundThe high-affinity IgE receptor (FcεRI) expression on effector cells has been poorly characterized in patients with chronic urticaria (CU) to date.ObjectivesTo investigate the FcεRI expression on blood basophils in a large cohort of CU patients and its potential relationship with relevant features of t...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 25, 2019 Category: Allergy & Immunology Source Type: research

The burden of severe asthma in France: a case-control study using a medical claims database
Publication date: Available online 25 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Arnaud Bourdin, Caroline Fabry-Vendrand, Juliette Ostinelli, Malik Ait-Yahia, Elsa Darnal, Stéphane Bouee, Caroline Laurendeau, Isabelle Bureau, Julie Gourmelen, Christos ChouaidAbstractBackgroundSevere asthma (SA) is defined by treatment intensity. The availability of national databases allows accurate estimation of the prevalence, long term outcomes and costs of SA.ObjectiveTo provide accurate information on SA, focussing on comorbidities, mortality, health care resource consumption and a...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 25, 2019 Category: Allergy & Immunology Source Type: research

Changing Patient Mindsets About Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial
Publication date: Available online 23 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lauren C. Howe, Kari A. Leibowitz, Margaret A. Perry, Julie M. Bitler, Whitney Block, Ted J. Kaptchuk, Kari C. Nadeau, Alia J. CrumAbstractBackgroundOral immunotherapy (OIT) can lead to desensitization to food allergens, but patients can experience treatment-related symptoms of allergic reactions that cause anxiety and treatment dropout. Interventions to improve OIT for patients are needed.ObjectiveTo determine whether fostering the mindset that non-life-threatening symptoms during OIT can signal ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 23, 2019 Category: Allergy & Immunology Source Type: research

Specific antibody deficiencies in clinical practice
Publication date: Available online 23 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Ricardo U. Sorensen, David EdgarAbstractSpecific antibody deficiency (SAD) is defined as the inability to mount an antibody response to purified S. pneumoniae capsular polysaccharide antigens in presence of normal immunoglobulin concentrations and normal antibody responses to protein antigens. In this review we discuss the difficulties in using presently available testing methods to adequately define SAD. The fact that there are different forms of specific antibody deficiencies to pneumococcal sur...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 23, 2019 Category: Allergy & Immunology Source Type: research

Fixed-Dose Subcutaneous C1-Inhibitor Liquid for Prophylactic Treatment of C1-INH-HAE: SAHARA Randomized Study
Publication date: Available online 23 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): William R. Lumry, Inmaculada Martinez-Saguer, William H. Yang, Jonathan A. Bernstein, Joshua Jacobs, Dumitru Moldovan, Marc A. Riedl, Douglas T. Johnston, H.Henry Li, Yongqiang Tang, Jennifer Schranz, Peng Lu, Moshe Vardi, Henriette Farkas, SAHARA study groupAbstractBackgroundHereditary angioedema (HAE) with C1 inhibitor deficiency (C1-INH) is characterized by swelling of subcutaneous and/or submucosal tissues.ObjectiveTo evaluate efficacy/ safety of fixed-dose subcutaneous plasma-derived C1-INH (...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 23, 2019 Category: Allergy & Immunology Source Type: research

Vaccine Allergy? Skin testing and challenge at a tertiary pediatric hospital in Melbourne, Australia
Publication date: Available online 23 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Abigail Cheung, Sharon Choo, Kirsten P. PerrettAbstractBackgroundThe rate of true vaccine allergy is unknown. Children with potential IgE-mediated Adverse Events Following Immunization (AEFI) should undergo allergy investigation that may include skin testing or challenge. Previous protocols tend to be highly conservative and often suggest invasive testing for all; a practice not evidence based, technically difficult and unpleasant in children. It has more recently been suggested that skin testing ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 23, 2019 Category: Allergy & Immunology Source Type: research

Immediate Hypersensitivity to Clindamycin: Rare, But Not Impossible
Publication date: January 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 1Author(s): Krzysztof Rutkowski, Annette Wagner, Rita Mirakian, Iason Thomas (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 22, 2019 Category: Allergy & Immunology Source Type: research

Efficacy and safety of reslizumab in severe asthma patients with inadequate response to omalizumab: a multicentre, open-label, pilot study
ConclusionReslizumab is an effective and safe option for patients with severe eosinophilic asthma and a history of previous omalizumab failure. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 22, 2019 Category: Allergy & Immunology Source Type: research

A Randomized Control Trial to Reduce Food Allergy Anxiety about Casual Exposure by Holding the Allergen: TOUCH Study
Publication date: Available online 21 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Tamar Weinberger, Rachel Annunziato, Eric Riklin, Eyal Shemesh, Scott Sicherer (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 22, 2019 Category: Allergy & Immunology Source Type: research

Antibiotic Prophylaxis for Dental Treatment in Patients with Immunodeficiency
Publication date: Available online 21 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jacqueline Squire, Pamela J. Gardner, Niki M. Moutsopoulos, Jennifer W. LeidingAbstractRoutine antibacterial prophylaxis is recommended prior to dental procedures in select patient populations. Currently no guidelines are in place for routine prophylaxis prior to dental procedures in patients with primary immunodeficiency diseases (PIDD). We review risk factors and provide recommendations on routine dental care and antibacterial prophylaxis in patients with PIDD. (Source: The Journal of Allergy an...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 22, 2019 Category: Allergy & Immunology Source Type: research

Treatment Effect of Switching from Intravenous to Subcutaneous C1-inhibitor for Prevention of Hereditary Angioedema Attacks: COMPACT Subgroup Findings
Publication date: Available online 17 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Timothy Craig, William Lumry, Marco Cicardi, Bruce Zuraw, Jonathan A. Bernstein, John Anderson, Joshua Jacobs, Marc A. Riedl, Michael E. Manning, Aleena Banerji, Richard G. Gower, Teresa Caballero, Henriette Farkas, Henrike Feuersenger, Iris Jacobs, Thomas Machnig, Hilary Longhurst, COMPACT Investigators (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 19, 2019 Category: Allergy & Immunology Source Type: research

Drugs of porcine origin—A risk for patients with α-gal syndrome?
Publication date: Available online 15 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kyra Swiontek, Martine Morisset, Françoise Codreanu-Morel, Jörg Fischer, Jana Mehlich, Ulf Darsow, Nadine Petitpain, Tilo Biedermann, Markus Ollert, Bernadette Eberlein, Christiane Hilger (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 17, 2019 Category: Allergy & Immunology Source Type: research

Perceived Versus Actual Aeroallergen Sensitization in Urban Children
ConclusionChildren who perceive allergen sensitization to cat, dog, dust or grass are likely to demonstrate actual sensitization to these individual allergens. Children with no perceived sensitization to allergens are nonetheless frequently sensitized. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 15, 2019 Category: Allergy & Immunology Source Type: research

Atopic dermatitis in US adults: from population to healthcare utilization.
ConclusionAdults with AD had low rates of outpatient and high rates of urgent care, ED and hospital visits. The major predictor of outpatient utilization for AD care was AD severity. Racial/ethnic, socio-economic and/or healthcare disparities reduce outpatient utilization and increase urgent, ED and hospital utilization. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 15, 2019 Category: Allergy & Immunology Source Type: research

Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma
ConclusionsIn children with severe, therapy-resistant asthma, BAL granulocyte patterns and infectious species are associated with novel phenotypic features which can inform pathway-specific revisions in treatment. In 32% of children evaluated, BAL revealed corticosteroid-refractory eosinophilic infiltration amenable to anti-Th2 biological therapies, and in 12%, a treatable bacterial pathogen. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 15, 2019 Category: Allergy & Immunology Source Type: research

Serum IgG concentrations in adult patients experiencing virus-induced severe asthma exacerbations
Publication date: Available online 14 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Morgane Verduyn, Guillaume Botto, Julien Jaubert, Clément Lier, Thomas Flament, Laurent GuilleminaultAbstractBackgroundPatients experiencing severe asthma exacerbations have a poorer quality of life and an increase in morbidity and mortality. Viruses are frequently involved in asthma exacerbations.ObjectiveDetermining the value of measuring serum immunoglobulin G (IgG) concentrations in asthma exacerbations and their link with viral infections in patients hospitalised for asthma has been as...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 15, 2019 Category: Allergy & Immunology Source Type: research

Efficacy and safety of omalizumab (Xolair®) for cholinergic urticaria in patients unresponsive to a double dose of antihistamines: a randomized mixed double-blind and open-label placebo-controlled clinical trial
ConclusionThis randomized mixed double-blinded and open-label placebo-controlled trial showed evidence of the safety and potential efficacy of omalizumab in patients with UCOL. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 15, 2019 Category: Allergy & Immunology Source Type: research

Effectiveness and Safety of Oral Tacrolimus in Refractory Chronic Urticaria
Publication date: Available online 12 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Steve M. Dorman, Stephanie B. Regan, David A. Khan (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 12, 2019 Category: Allergy & Immunology Source Type: research

A Pilot Study of the Effect of an Educational Web Application on Asthma Control and Medication Adherence
ConclusionsThe AAP was effective in promoting adherence and helped to improve asthma control. These findings provide preliminary validation of the AAP model. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 12, 2019 Category: Allergy & Immunology Source Type: research

Now Is the Time to Use Molecular Gene Testing for the Diagnosis of Primary Immune Deficiencies
Publication date: Available online 10 January 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jennifer HeimallAbstractThe discovery of chromosomes, genes, and DNA in the early 20th century paved the way for the development of techniques to examine the role of these elements in disease pathogenesis. Since the start of the 21st century, genetic testing and particularly next-generation sequencing has allowed for a rapid rate of gene disease associations for a broad range of primary immunodeficiency patients. At the same time, biologic and small molecule–based therapies targeting specifi...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 11, 2019 Category: Allergy & Immunology Source Type: research