Treatment with the SQ house dust mite sublingual immunotherapy tablet may be initiated year-round
Publication date: Available online 1 March 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Hendrik Nolte, David I. Bernstein, Jörg Kleine-Tebbe, Peter A. Fejerskov, Qing Li, Susan Lu, Harrold S. Nelson (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 2, 2018 Category: Allergy & Immunology Source Type: research

A multicenter evaluation of diagnosis and management of omega-5 gliadin allergy (also known as wheat-dependent exercise induced anaphylaxis) in 132 adults
Conclusions Omega-5 gliadin allergy is a rare wheat allergy that presents with severe anaphylaxis. The diagnosis is frequently delayed, therefore we recommend that all adult patients presenting with anaphylaxis of unclear cause should have omega-5 gliadin specific IgE tested. A gluten-free diet or avoidance of wheat based meals in combination with exercise (if the cofactor is exercise) helps to significantly decrease the risk of future allergic reactions. However, antihistamines and an epinephrine auto-injector must always be prescribed, as a third of patients continue to have allergic reactions despite dietary advice. (So...
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 2, 2018 Category: Allergy & Immunology Source Type: research

Asthma phenotypes defined from parameters obtained during recovery from a hospital-treated exacerbation
Conclusion The clusters during recovery from an exacerbation of asthma were distinguished by airflow obstruction and a neutrophilic, eosinophilic or mixed inflammation. Eosinophilic inflammation was found in smoking and non-smoking asthmatics during an exacerbation. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 2, 2018 Category: Allergy & Immunology Source Type: research

Diagnostic Value of Tryptase in Food Allergic Reactions: A Prospective Study of 160 Adult Peanut Challenges
Conclusions Serum tryptase measurement is valuable in food allergic reactions, and correlates with symptom severity. Comparing peak reaction levels at 2 hours with baseline is essential. A rise in tryptase of 30% is associated with food allergic reactions. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 2, 2018 Category: Allergy & Immunology Source Type: research

Long-Term Follow-Up After Baked Milk  Introduction
Conclusions The majority of patients who underwent a BM challenge, including those who failed their challenge, were able to progress to direct or less-cooked forms of milk. However, adverse reactions were common, and even a successful BM challenge does not guarantee future tolerance of BM or preclude later reactions, even to previously tolerated doses. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 2, 2018 Category: Allergy & Immunology Source Type: research

Comparison of Basophil Activation Test and Skin Testing Performances in NMBA Allergy
Conclusion In our technical conditions, BAT does not replace skin testing in the assessment of NMBA allergy. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 22, 2018 Category: Allergy & Immunology Source Type: research

Liver disturbances in activated phosphoinositide 3-kinase δ syndrome
Publication date: Available online 16 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Gil Ben-Yakov, Devika Kapuria, Jamie Marko, Min Ho Cho, Stefania Pittaluga, David Erwin Kleiner, Christopher Koh, Steven Holland, Gulbu Uzel, Theo Heller (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 17, 2018 Category: Allergy & Immunology Source Type: research

Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma
Conclusions A direct relationship between the number of exacerbations in patients with severe eosinophilic asthma and decline in lung function was observed. Repeated exacerbations may be associated with accelerated loss of lung function. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 16, 2018 Category: Allergy & Immunology Source Type: research

Incidence and Risk of Oxaliplatin-Induced Hypersensitivity in Patients with Asymptomatic Prior Exposure: A Prospective Observational Study
Conclusions Previous exposure to oxaliplatin is a risk factor for earlier HSR onset and more severe and frequent HSR episodes, even if prior therapy was well tolerated. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 15, 2018 Category: Allergy & Immunology Source Type: research

In  Vitro Diagnosis of Immediate Drug Hypersensitivity During Anesthesia: A Review of the Literature
Publication date: Available online 14 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Didier G. Ebo, Margaretha Faber, Jessy Elst, Athina L. Van Gasse, Chris H. Bridts, Christel Mertens, Luc S. De Clerck, Margo M. Hagendorens, Vito Sabato Quantification of specific IgE (sIgE) antibodies constitutes an important measure to document anesthesia-related immediate hypersensitivity reactions (IHRs). However, only a few drug-specific assays are available and their predictive value is not known. In cases of non-IgE mediated IHRs, diagnosis might benefit from cellular tests such as basop...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 15, 2018 Category: Allergy & Immunology Source Type: research

Association Between Obesity and Acute Severity Among Patients Hospitalized for Asthma Exacerbation
Conclusions In this population-based study of adults hospitalized for asthma exacerbation, obesity was associated with higher acute severity. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 15, 2018 Category: Allergy & Immunology Source Type: research

Exacerbations in adults with asthma: A systematic review and external validation of prediction models
Conclusion The preservation of three predictors in models derived from variable populations and the fairly consistent predictive properties of most models in two distinct validation populations suggest the feasibility of a generalizable model predicting severe exacerbations. Nevertheless, improvement of the models is warranted as predictive performances are below the desired level. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 15, 2018 Category: Allergy & Immunology Source Type: research

Anxiety, depression, and asthma control: Changes after standardized treatment
Conclusions Under standardized asthma care and after a specific visit with the specialist, patients present significant improvement in these psychological disorders and exhibit better asthma control and functional parameters. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 15, 2018 Category: Allergy & Immunology Source Type: research

Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy
Conclusion There is a higher rate of acceptable maneuvers with spirometry compared with IOS, but IOS may be a better indicator of peripheral airway function in preschool children. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 14, 2018 Category: Allergy & Immunology Source Type: research

Patients Taking β-Blockers Do Not Require Increased Doses of Epinephrine for Anaphylaxis
Conclusions β-Blocker use may not be clinically significant with regard to the need for epinephrine dosing among emergency department patients with anaphylaxis. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 14, 2018 Category: Allergy & Immunology Source Type: research

Food-dependent exercise-induced anaphylaxis due to almond in a PR-10 –sensitized patient
Publication date: Available online 13 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): A.S. Senders, A. Ruiz Oropeza, B. Kristensen, E. Eller, H.F. Kjaer, C. Bindslev-Jensen, C.G. Mortz (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 14, 2018 Category: Allergy & Immunology Source Type: research

Chronic inducible urticarias in children
Publication date: Available online 14 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Maddalena Napolitano, Matteo Megna, Claudia Costa, Nicola Balato, Cataldo Patruno (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 14, 2018 Category: Allergy & Immunology Source Type: research

The Dietary Inflammatory Index and Current Wheeze Among Children and Adults in the United States
Conclusions Our findings suggest that a proinflammatory diet, assessed by the DII, increases the odds of current wheeze in adults and children with allergic (atopic) wheeze. These results further support testing dietary interventions as part of the management of asthma. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 14, 2018 Category: Allergy & Immunology Source Type: research

Use of pdC1-INH concentrate for long-term prophylaxis during pregnancy in hereditary angioedema with normal C1-INH
Publication date: Available online 10 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Juliana F.B. Garcia, Priscila Takejima, Camila Lopes Veronez, Marcelo V. Aun, Antonio A. Motta, Jorge Kalil, João Bosco Pesquero, Pedro Giavina-Bianchi (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 11, 2018 Category: Allergy & Immunology Source Type: research

Successful subcutaneous desensitization in a patient with allergy to ixekizumab
Publication date: Available online 10 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Ruth Barranco Jimenez, Daiana Guillen Vera, Raquel Rivera-Díaz, Susana Cortijo-Cascajares, Ruth Mielgo Ballesteros, María del Carmen Diéguez Pastor (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 11, 2018 Category: Allergy & Immunology Source Type: research

Conjunctivitis Occurring in Atopic Dermatitis Patients Treated with Dupilumab - Clinical Characteristics and Treatment
Publication date: Available online 9 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Andreas Wollenberg, Lieneke Ariens, Stephan Thurau, Chantal van Luijk, Marlene Seegräber, Marjolein de Bruin-Weller (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 10, 2018 Category: Allergy & Immunology Source Type: research

Implementation of Guidelines for Early Peanut Introduction at a Pediatric Academic Center
Publication date: Available online 9 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): David R. Stukus, Ben T. Prince, Irene Mikhail (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 10, 2018 Category: Allergy & Immunology Source Type: research

Impact of Adverse Event Solicitation on the Safety Profile of SQ House Dust Mite Sublingual Immunotherapy Tablet
Conclusions Qualitatively, the safety profile of 12 SQ-HDM was similar when AEs were solicited vs unsolicited; hence, solicitation did not alter the safety profile. Higher observed frequencies of local application site reactions with AE solicitation may be partly due to suggestive reporting bias, as observed in placebo-treated subjects. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 10, 2018 Category: Allergy & Immunology Source Type: research

Use of ICS/LABA Combinations or LAMA is Associated with a Lower Risk of Acute Exacerbation in Patients with Coexistent COPD and Asthma
Conclusions LAMA or ICS/LABA combinations use was associated with a lower risk of acute exacerbation in patients with COPD and asthma in this study. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 10, 2018 Category: Allergy & Immunology Source Type: research

Immune modulation in a patient with Morquio syndrome treated with enzyme replacement therapy
Publication date: Available online 6 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Angela Sun, Walaa Alshuaibi, Daniel Petroni, Suzanne Skoda-Smith, Michael J. Goldberg, Susan Hale (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research

Increased Dose and Duration of Statin Use is Associated with Decreased Asthma-Related Emergency Department Visits and Hospitalizations
Conclusions Our study suggests that statin use is associated with the decreased risk of asthma-related ED visits and/or hospitalizations in patients with asthma. A dose-response effect of statin use is also observed in this study. Therefore, future randomized clinical trials would be warranted to further evaluate the association. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research

A favorable response to omalizumab in a patient with cheilitis granulomatosa
Publication date: Available online 6 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Eustachio Nettis, Elisabetta Di Leo, Maria Bisaccia, Carolina Marasco, Caterina Foti, Angelo Vacca (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research

Smell loss is associated with severe and uncontrolled disease in children and adolescents with persistent allergic rhinitis
Publication date: Available online 6 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Franklin Mariño-Sanchez, Meritxell Valls-Mateus, Oliver Haag, Isam Alobid, Jean Bousquet, Joaquim Mullol (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research

Onset of action of the fixed combination intranasal azelastine-fluticasone propionate in an allergen exposure chamber
Conclusion MP-AzeFlu had a more rapid onset of action (5 minutes) and was more effective than LORA/INFP. Registration of the trial ClinicalTrials.gov Identifier: NCT03004131; Key words: allergic rhinitis, azelastine, environmental exposure chamber, fluticasone propionate, loratadine, onset of action (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research

Efficacy and safety of five-day challenge for the evaluation of non-severe amoxicillin allergy in children
Conclusion Five-day challenge is a safe and effective way to rule out nonimmediate amoxicillin allergy, and it ensures a better compliance with future penicillin use. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research

Determination of the Preferred Tongue Position for Optimal Inhaler Use
Publication date: Available online 2 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Takahiko Horiguchi, Rieko Kondo (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Male X-chromosome Mosaicism leading to Carrier Phenotype and inheritance of Chronic Granulomatous Disease
Publication date: Available online 2 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Stephanie Harris, Helen Braggins, Karin van Leeuwen, Kimberly Gilmour, Matthew S. Buckland, Dirk Roos, David M. Lowe (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Ara h 2 basophil activation test does not predict clinical reactivity to peanut
Publication date: Available online 2 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Alexandra Chapuis, Jonathan Thevenot, Frédéric Coutant, Khaled Messaoudi, Elodie Michaud, Bruno Pereira, Emmanuelle Rochette, Nelly Gourdon-Dubois, Etienne Merlin, Jean-Luc Fauquert, Bertrand Evrard, Paul Rouzaire (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Two-week intervals during omalizumab treatment may provide better symptom control in selected patients with chronic urticaria
Publication date: Available online 2 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Murat Türk, Emek Kocatürk, Kübra Cüre, İnsu Yılmaz (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

As You Eat It: Effects of prenatal nutrition on asthma
Publication date: Available online 2 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Kathleen Lee-Sarwar, Augusto A. Litonjua Asthma most frequently develops early in life, and increased recognition of the role of lifestyle and environmental factors in asthma susceptibility raises the possibility that dietary exposures during pregnancy may influence risk of asthma in offspring. This review discusses the latest evidence with regard to the effect of diet during pregnancy on childhood asthma risk, including potential mechanisms, outcomes of randomized clinical trials, and results f...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Partial RAG Deficiency in a Patient with Varicella Infection, Autoimmune Cytopenia, and Anti-Cytokine Antibodies
Publication date: Available online 2 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Vera Goda, Aniko Malik, Tibor Kalmar, Zoltan Maroti, Bhumika Patel, Boglarka Ujhaz, Krisztian Csomos, Jaime E. Hale, Karin Chen, Jacob Bleesing, Paolo Palma, Caterina Cancrini, Anne M. Comeau, Gergely Krivan, Jolan E. Walter (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Tiotropium attenuates refractory cough and capsaicin cough reflex sensitivity in patients with asthma
Conclusion Tiotropium may alleviate asthmatic cough refractory to ICS/LABA by modulating cough reflex sensitivity but not thorough bronchodilation. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Inhaled corticosteroids safety and adverse effects in patients with asthma
Publication date: Available online 3 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Enrico Heffler, Lorena Nascimento Girardi Madeira, Matteo Ferrando, Francesca Puggioni, Francesca Racca, Luca Malvezzi, Gianni Passalacqua, Giorgio Walter Canonica Asthma is a common inflammatory airway disease for which the most commonly used controller medications are inhaled corticosteroids (ICS). Asthma control is difficult to achieve in individuals with severe asthma, which comprise 5-10% of individuals with asthma, even with high doses of ICS and other anti-inflammatory drugs. In this clin...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Cross-Reactivity and Tolerability Of Cephalosporins In Patients With Ige-Mediated Hypersensitivity To Penicillins
Conclusions Cross-reactivity between penicillins and cephalosporins seems to be mainly related to side chain similarity or identity.Subjects with an IgE-mediated hypersensitivity to penicillins could be treated with cephalosporins like cefuroxime and ceftriaxone that have side chain determinants different from those of penicillins and are negative in pretreatment skin testing. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Value of a second dose of epinephrine during anaphylaxis: a patient/caregiver survey
Conclusion Our study suggests poor adherence in patients and caregivers to anaphylaxis guidelines recommending >1 EAI available at all times and implies that this can result in adverse outcomes. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Clinician Agreement, Self-efficacy, and Adherence with the Guidelines for the Diagnosis and Management of Asthma
Conclusions Agreement with and adherence to asthma guidelines was higher for specialists than primary care clinicians, but was low in both groups for several key recommendations. Self-efficacy was a good predictor of guideline adherence among primary care clinicians but not among specialists. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 3, 2018 Category: Allergy & Immunology Source Type: research

Risk Factors for Food Allergy in Early Adolescence: The SchoolNuts Study
Conclusions Early-onset eczema, Asian background, and family history of allergic disease were associated with an increased risk of food allergy, whereas dog exposure in early life reduced the risk in 10- to14-year-old adolescents. Factors predicting food allergy risk in an adolescent population-based cohort appear remarkably similar to those predicting early-onset food allergy in infancy. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

Conducting an Integrative Health Interview
Publication date: Available online 1 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Maureen George, Melissa Avila, Thomas Speranger, Heidi K. Bailey, William S. Silvers Complementary medicine incorporates the use of non–evidence-based complementary modalities into conventional (Western) medicine. Alternative medicines are approaches that are used in place of conventional medicine. Integrative medicine is the synthesis of conventional medical treatments with “evidence-based” complementary medical practices. When complementary approaches are incorporated into ma...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

The Journal of Allergy and Clinical Immunology: In  Practice 2017 Year in Review
Publication date: Available online 1 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Michael Schatz, Scott H. Sicherer, Robert S. Zeiger An impressive number of clinically impactful studies and reviews were published in The Journal of Allergy and Clinical Immunology: In Practice in 2017. As a service to our readers, the editors provide this Year in Review article to highlight and contextualize the advances published over the past year. We include information from articles on asthma, allergic rhinitis, rhinosinusitis, immunotherapy, atopic dermatitis, contact dermatitis, food all...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

Should Younger Siblings of Peanut Allergic Children Be Screened for Peanut Allergy?
Publication date: Available online 1 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Elissa M. Abrams, Edmond S. Chan, Scott H. Sicherer The role of screening younger siblings of peanut allergic children with allergy testing before peanut introduction is controversial. Although certain guidelines note some value in screening this population, it is not a direct indication in the recent National Institute of Allergy and Infectious Diseases guideline. Some studies suggest that siblings of peanut allergic children are at increased risk of peanut allergy, whereas others note that del...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

Allergy and mental health among pregnant women in the Japan Environment and Children's Study
Publication date: Available online 1 February 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Kiwako Yamamoto-Hanada, Kazue Ishitsuka, Kyongsun Pak, Mayako Saito, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Limin Yang, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

Asthma and Allergic Disorders in Uganda: A Population-Based Study Across Urban and Rural Settings
Conclusions Asthma and allergic rhinitis were twice as prevalent in urban settings. Asthma was associated with greater impairment and worse lung function outcomes. We identified a high prevalence of allergic disorders in Uganda, which can be expected to increase due to urbanization and resultant exposures throughout early development. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

Outcome of 490 Desensitizations to Chemotherapy Drugs with a Rapid One-Solution Protocol
Conclusions This 1-solution protocol for desensitization has demonstrated to be safe and useful in our study population, especially for mild-to-moderate reactions and nonplatinum drugs. If our results were reproducible in other centers and larger populations, they could contribute to simplifying protocols and making desensitization available for more patients. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

DRESS Syndrome due to benzylpenicillin with cross-reactivity to amoxicillin
Publication date: Available online 31 January 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Timothy J. Watts, Philip H. Li, Rubaiyat Haque (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 1, 2018 Category: Allergy & Immunology Source Type: research

Health-Related Quality-of-Life with Subcutaneous C1-inhibitor for Prevention of Attacks of Hereditary Angioedema
Conclusions In patients with frequent HAE attacks, a treatment strategy of routine prevention with self-administered twice-weekly C1-INH(SC) had a greater impact on improving multiple HAE-related HRQoL impairments, most notably anxiety and work productivity, compared with on-demand treatment alone (placebo prophylaxis). (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 1, 2018 Category: Allergy & Immunology Source Type: research