Prescribing vitamin B complex: Need for reassessment
Indian J Med Res. 2021 Jun;154(6):781-785. doi: 10.4103/ijmr.IJMR_1467_19.NO ABSTRACTPMID:35662082 | DOI:10.4103/ijmr.IJMR_1467_19 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Proteesh Rana Vandana Roy Source Type: research

Cancer metabolomics: A tool of clinical utility for early diagnosis of gynaecological cancers
Indian J Med Res. 2021 Jun;154(6):787-796. doi: 10.4103/ijmr.IJMR_239_19.ABSTRACTGynaecological cancers are the major cause of cancer-related deaths in Indian women. The poor prognosis and lack of symptoms in the early stages make early cancer diagnosis difficult. The absence of mandatory screening programmes and the lack of awareness pose to be a real challenge in a developing economy as India. Prompt intervention is required to enhance cancer patient survival statistics and to lessen the social and financial burden. Conventional screening and cytological techniques employed currently have helped to reduce the incidence o...
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Akshata Kishore Karekar Sucheta Prakash Dandekar Source Type: research

Tafenoquine for < em > Plasmodium vivax < /em > malaria: Concerns regarding efficacy & amp; safety
Indian J Med Res. 2021 Jun;154(6):797-805. doi: 10.4103/ijmr.IJMR_1167_19.ABSTRACTPlasmodium vivax (P. vivax) malaria is a major problem in various countries such as America, Southeast Asia, Africa and the Eastern Mediterranean. The major barrier in controlling P. vivax malaria is its ability to remain in the liver as a hypnozoite form which is responsible for relapse of P. vivax malaria; hence it is necessary to target both the blood (schizont) as well as the liver (hypnozoite) stages of P. vivax to prevent its relapse. A number of factors limit the use of primaquine (PQ), the currently available therapy for P. vivax (hyp...
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Jatin Sharma C S Gautam Harmanjit Singh Jagjit Singh Source Type: research

Smoking & amp; risk of advanced liver fibrosis among patients with primary biliary cholangitis: A systematic review & amp; meta-analysis
CONCLUSIONS: This meta-analysis found that smoking is associated with a significantly higher risk of advanced liver fibrosis among patients with PBC. Further prospective studies are still required to determine whether this association is causal.PMID:35662085 | DOI:10.4103/ijmr.IJMR_639_19 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Karn Wijarnpreecha Monia Werlang Panadeekarn Panjawatanan Surakit Pungpapong Frank J Lukens Denise M Harnois Patompong Ungprasert Source Type: research

Clinicopathological study of annexin A5 & amp; apelin in pre-eclamptic placentae with emphasis on foetal outcome
CONCLUSIONS: The results of the present study suggest that both ANXA5 and apelin levels are reduced in pre-eclamptic placentae. Hence, it is recommended to further explore the impact of these markers on pregnancy outcomes by undertaking randomized controlled trials.PMID:35662086 | DOI:10.4103/ijmr.IJMR_433_21 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Senjuti Dasgupta Priyanka Maity Uma Banerjee Partha Mukhopadhyay Saswata Saha Biplab Das Source Type: research

Quality of life assessment & amp; out-of-pocket expenditure in multiple myeloma: An observational study
CONCLUSIONS: Regular assessment of QoL in the clinical management of multiple myeloma patients has the potential of improving treatment outcomes. Measures to reduce out-of-pocket expenditure may improve treatment compliance.PMID:35662087 | DOI:10.4103/ijmr.IJMR_4028_20 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Anisha Mathew Habib Hasan Farooqui Lalit Kumar Source Type: research

Inhibitors of Gq signalling down-regulate β-catenin expression & amp; function in human colon cancer cells
CONCLUSIONS: The results of this study further support the positive role of Gq signalling in regulating β-catenin expression and function and may provide a new means of preventing β-catenin-mediated carcinogenesis by blocking heterotrimeric G proteins.PMID:35662088 | DOI:10.4103/ijmr.IJMR_1370_19 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Nasim Forghani S Mahmoud A Najafi Source Type: research

High soluble interleukin-2 receptor values in Indian paediatric & amp; adult controls - Need for population-specific threshold in the diagnosis of haemophagocytic lymphohistiocytosis
CONCLUSIONS: Paediatric controls in India showed higher sIL2R levels than most studies conducted in other countries, except for some reports in Chinese and Russian populations. Age-appropriate reference values of sIL2R in a specific population may be considered to determine elevated sIL2R as a marker of HLH.PMID:35662089 | DOI:10.4103/ijmr.IJMR_684_19 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Veronique Dinand Anupam Sachdeva Sakshi Sharma Alpana Prasad Deepanjali Pant Anil Sachdev Nirmal Kumar Ganguly Source Type: research

Plasminogen activator inhibitor-1 promoter sequence variations in idiopathic osteonecrosis of head of femur
CONCLUSIONS: Our findings demonstrate that the minor alleles of promoter region sequences of the PAI-1 gene do not contribute to an increase in ONFH predisposition. However, this is a preliminary study and its findings should be considered as suggestive for studies to be done in a larger sample size.PMID:35662090 | DOI:10.4103/ijmr.IJMR_496_19 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Srishty Raman Rima Dada Tapas Chandra Nag Chandra Shekhar Yadav Source Type: research

Effects of continuous-combined oral drospirenone- estradiol on blood pressure, body weight & amp; lipid profile in early menopausal women
CONCLUSIONS: Continuous long-term therapy with DRSP 2 mg/E2 1 mg significantly lowered 24 h systolic and diastolic BPs and reduced the risk of cardiovascular disease in early menopausal women with stage 1 hypertension. Timely initiated menopausal hormone therapy can have beneficial effects on BP and can reduce the incidence of cardiovascular disease in menopausal women.PMID:35662091 | DOI:10.4103/ijmr.IJMR_478_20 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Aleksandar Đogo Branko Do žić Svetlana Vujovi ć Dragana Srebro Ivan Do žić Source Type: research

Coronin-1 levels in patients with tuberculosis
CONCLUSIONS: Coronin 1a appears to play an important role in the TB disease pathophysiology and agents developed against coronin may have a role in the treatment of TB. Further studies are required to assess if coronin-1a levels are elevated in non-tubercular infective a etiologies and whether these can be a potential drug target in patients with TB.PMID:35662092 | DOI:10.4103/ijmr.IJMR_4343_20 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Sanjeev Sinha Gaurav Gupta Sagnik Biswas Kartik Gupta P P Singh Rahul Jain S K Sharma Bimal K Das Source Type: research

A novel reassortant avian influenza H4N6 virus isolated from an environmental sample during a surveillance in Maharashtra, India
CONCLUSIONS: This is the first report of the isolation and characterization of an LPAI H4N6 virus from an environmental sample from India. The present study showed that the H4N6 virus is a novel reassortant and divergent as compared with the reported H4N6 viruses from poultry in India, indicating independent introduction. This highlights the role of wild and migratory birds in the transmission of AI viruses and necessity of such studies at the human-animal interface.PMID:35662093 | DOI:10.4103/ijmr.IJMR_1514_20 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Shailesh D Pawar Sachin S Keng Sadhana S Kode Deeksha S Tare Dinesh K Singh Jayati Mullick Source Type: research

Detection & amp; analysis of inflammatory cytokines in tears of patients with lacrimal duct obstruction
CONCLUSIONS: Specific pro-inflammatory cytokines were increased in tears of patients with LDOD compared with those in the controls. The specific cytokine profiles observed in the tears of individuals with different LDOD subtypes may be associated with the unique aetiopathogenesis of these conditions.PMID:35662094 | DOI:10.4103/ijmr.IJMR_1435_19 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Dan Wang Nan Xiang Wei Kun Hu Ban Luo Xiang Tian Xiao Yin Zhao Bin Li Rong Liu Source Type: research

Health-related quality of life in chronic obstructive pulmonary disease
Indian J Med Res. 2021 Jun;154(6):895. doi: 10.4103/ijmr.ijmr_2653_21.NO ABSTRACTPMID:35662095 | DOI:10.4103/ijmr.ijmr_2653_21 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Deependra Kumar Rai Source Type: research

Authors' response
Indian J Med Res. 2021 Jun;154(6):896-897. doi: 10.4103/0971-5916.346065.NO ABSTRACTPMID:35662096 | DOI:10.4103/0971-5916.346065 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - June 6, 2022 Category: Biomedical Science Authors: Sidharth Kharbanda R Anand Source Type: research