Pharmacoeconomics of medicines used for geriatric individuals in a tertiary care hospital in Delhi
CONCLUSIONS: Comorbidities, prolonged hospitalization, polypharmacy, inappropriate medicines and parenteral medicines being prescribed contribute to increased expenditure on medicines in geriatric inpatients. In view of the rising number of geriatric inpatients, there is a need to frame a drug policy for them along with surveillance of expenditure on prescribed medicines. This needs to be treated as a priority.PMID:38577855 | DOI:10.4103/ijmr.ijmr_2507_21 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Vikram Jit Singh Vandana Roy Shubha Singhal M K Daga Source Type: research

Geographic information system-aided evaluation of epidemiological trends of dengue serotypes in West Bengal, India
CONCLUSIONS: Co-circulation of all the four dengue serotypes was observed in this study, but only one serotype became prevalent during an outbreak. Representation of NS1-positive cases and serotype distribution in GIS mapping clearly showed serotypic shift in co-circulation. The findings of this study suggest the need for stringent surveillance in dengue-endemic areas to limit the impact of dengue and implement better vector-control strategies.PMID:38577856 | DOI:10.4103/ijmr.ijmr_1055_23 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Upasana Baskey Priya Verma Palash Mondal Supradip Dutta Aritra Biswas Sagnik Bakshi Raina Das Sudipta Bhaduri Dipankar Maji Shanta Dutta Provash Chandra Sadhukhan Source Type: research

Emerging role of exosomes as a liquid biopsy tool for diagnosis, prognosis & amp; monitoring treatment response of communicable & amp; non-communicable diseases
Indian J Med Res. 2024 Feb 1;159(2):163-180. doi: 10.4103/ijmr.ijmr_2344_22. Epub 2024 Apr 4.ABSTRACTFrom an initial thought of being used as a cellular garbage bin to a promising target for liquid biopsies, the role of exosomes has drastically evolved in just a few years of their discovery in 1983. Exosomes are naturally secreted nano-sized vesicles, abundant in all types of body fluids and can be isolated intact even from the stored biological samples. Being stable carriers of genetic material (cellular DNA, mRNA and miRNA) and having specific cargo (signature content of originating cells), exosomes play a crucial role i...
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Rajbala Yadav Ajay Vir Singh Shweta Kushwaha Devendra Singh Chauhan Source Type: research

Long-term clinical outcomes of combined modality therapy for advanced-stage Hodgkin lymphoma in the PET era: A retrospective study
CONCLUSIONS: Individuals with advanced-stage HL treated with anthracycline-based chemotherapy (anthracycline-based chemotherapy with doxorubicin, bleomycin, vinblastine and dacarbazine regimen) and CRT had excellent long-term outcomes. As isolated infield failures are uncommon, selective consolidation with conformal RT to high-risk sites improves final disease outcomes.PMID:38577858 | DOI:10.4103/ijmr.ijmr_3459_21 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Swati Chugh Goutam Panda Smruti Mokal Hasmukh Jain Bhausaheb Bagal Nehal Khanna Sridhar Epari Sachin Punatar Lingaraj Nayak Anant Gokarn Naveen Khattry Manju Sengar Siddhartha Laskar Jayant S Goda Source Type: research

Urinary lipoarabinomannan in individuals with sputum-negative pulmonary tuberculosis
CONCLUSIONS: The findings of this study suggest that individuals with smear-negative PTB and a urinary LAM value of >0.615 ng/ml were most likely to have microbiological confirmed TB while those with a LAM value <0.615 ng/ml >0.478 ng/ml are less likely and those with a value <0.478 ng/ml are unlikely to have microbiological confirmed TB.PMID:38577859 | DOI:10.4103/ijmr.ijmr_2074_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: P Ajantha Man Mohan Puri Devika Tayal U Khalid Source Type: research

Outcome of individuals with alcoholic cirrhosis hospitalized with first decompensation and their predictors
CONCLUSIONS: There is significant heterogeneity in the type of decompensation in individuals with alcoholic cirrhosis. We observed significantly high mortality rate among alcoholic participants hospitalized with initial decompensation; deaths occurring in more than one-third of study participants within 90 days.PMID:38577860 | DOI:10.4103/ijmr.ijmr_1690_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Suprabhat Giri Sushrut Ingawale Sidharth Harindanath Mohit Jain Pranav Garg Harish Darak Sanjay Kumar Aditya Kale Akash Shukla Source Type: research

Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research

Pharmacoeconomics of medicines used for geriatric individuals in a tertiary care hospital in Delhi
CONCLUSIONS: Comorbidities, prolonged hospitalization, polypharmacy, inappropriate medicines and parenteral medicines being prescribed contribute to increased expenditure on medicines in geriatric inpatients. In view of the rising number of geriatric inpatients, there is a need to frame a drug policy for them along with surveillance of expenditure on prescribed medicines. This needs to be treated as a priority.PMID:38577855 | DOI:10.4103/ijmr.ijmr_2507_21 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Vikram Jit Singh Vandana Roy Shubha Singhal M K Daga Source Type: research

Geographic information system-aided evaluation of epidemiological trends of dengue serotypes in West Bengal, India
CONCLUSIONS: Co-circulation of all the four dengue serotypes was observed in this study, but only one serotype became prevalent during an outbreak. Representation of NS1-positive cases and serotype distribution in GIS mapping clearly showed serotypic shift in co-circulation. The findings of this study suggest the need for stringent surveillance in dengue-endemic areas to limit the impact of dengue and implement better vector-control strategies.PMID:38577856 | DOI:10.4103/ijmr.ijmr_1055_23 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Upasana Baskey Priya Verma Palash Mondal Supradip Dutta Aritra Biswas Sagnik Bakshi Raina Das Sudipta Bhaduri Dipankar Maji Shanta Dutta Provash Chandra Sadhukhan Source Type: research

Emerging role of exosomes as a liquid biopsy tool for diagnosis, prognosis & amp; monitoring treatment response of communicable & amp; non-communicable diseases
Indian J Med Res. 2024 Feb 1;159(2):163-180. doi: 10.4103/ijmr.ijmr_2344_22. Epub 2024 Apr 4.ABSTRACTFrom an initial thought of being used as a cellular garbage bin to a promising target for liquid biopsies, the role of exosomes has drastically evolved in just a few years of their discovery in 1983. Exosomes are naturally secreted nano-sized vesicles, abundant in all types of body fluids and can be isolated intact even from the stored biological samples. Being stable carriers of genetic material (cellular DNA, mRNA and miRNA) and having specific cargo (signature content of originating cells), exosomes play a crucial role i...
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Rajbala Yadav Ajay Vir Singh Shweta Kushwaha Devendra Singh Chauhan Source Type: research

Long-term clinical outcomes of combined modality therapy for advanced-stage Hodgkin lymphoma in the PET era: A retrospective study
CONCLUSIONS: Individuals with advanced-stage HL treated with anthracycline-based chemotherapy (anthracycline-based chemotherapy with doxorubicin, bleomycin, vinblastine and dacarbazine regimen) and CRT had excellent long-term outcomes. As isolated infield failures are uncommon, selective consolidation with conformal RT to high-risk sites improves final disease outcomes.PMID:38577858 | DOI:10.4103/ijmr.ijmr_3459_21 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Swati Chugh Goutam Panda Smruti Mokal Hasmukh Jain Bhausaheb Bagal Nehal Khanna Sridhar Epari Sachin Punatar Lingaraj Nayak Anant Gokarn Naveen Khattry Manju Sengar Siddhartha Laskar Jayant S Goda Source Type: research

Urinary lipoarabinomannan in individuals with sputum-negative pulmonary tuberculosis
CONCLUSIONS: The findings of this study suggest that individuals with smear-negative PTB and a urinary LAM value of >0.615 ng/ml were most likely to have microbiological confirmed TB while those with a LAM value <0.615 ng/ml >0.478 ng/ml are less likely and those with a value <0.478 ng/ml are unlikely to have microbiological confirmed TB.PMID:38577859 | DOI:10.4103/ijmr.ijmr_2074_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: P Ajantha Man Mohan Puri Devika Tayal U Khalid Source Type: research

Outcome of individuals with alcoholic cirrhosis hospitalized with first decompensation and their predictors
CONCLUSIONS: There is significant heterogeneity in the type of decompensation in individuals with alcoholic cirrhosis. We observed significantly high mortality rate among alcoholic participants hospitalized with initial decompensation; deaths occurring in more than one-third of study participants within 90 days.PMID:38577860 | DOI:10.4103/ijmr.ijmr_1690_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Suprabhat Giri Sushrut Ingawale Sidharth Harindanath Mohit Jain Pranav Garg Harish Darak Sanjay Kumar Aditya Kale Akash Shukla Source Type: research

Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches
Indian J Med Res. 2024 Feb 1;159(2):121-129. doi: 10.4103/ijmr.ijmr_2383_22. Epub 2024 Apr 4.ABSTRACTLeprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M. leprae...
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Purna Dwivedi Mukul Sharma Afzal Ansari Pushpendra Singh Source Type: research

Pharmacoeconomics of medicines used for geriatric individuals in a tertiary care hospital in Delhi
CONCLUSIONS: Comorbidities, prolonged hospitalization, polypharmacy, inappropriate medicines and parenteral medicines being prescribed contribute to increased expenditure on medicines in geriatric inpatients. In view of the rising number of geriatric inpatients, there is a need to frame a drug policy for them along with surveillance of expenditure on prescribed medicines. This needs to be treated as a priority.PMID:38577855 | DOI:10.4103/ijmr.ijmr_2507_21 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Vikram Jit Singh Vandana Roy Shubha Singhal M K Daga Source Type: research