Treatment response and progression to end stage renal disease in adolescents and young adults with lupus nephritis: A follow up study in an Egyptian cohort
ConclusionPrevention and aggressive management of hypertension, proteinuria and renal flares is expected to prevent progression to ESRD in lupus nephritis in adolescent and young adult SLE patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - January 11, 2020 Category: Rheumatology Source Type: research
Pregnancy outcome in a cohort of Egyptian women with rheumatoid arthritis
ConclusionPregnant RA patients have higher frequency of abortion, delivery by CS, preeclampsia and LBW of newborns; especially those having higher disease activity and/ortreated with potentially harmful medications. It is crucial to educate female RA patients about these risks and they should be considered as high-risk pregnancy and followed accordingly. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 14, 2019 Category: Rheumatology Source Type: research
Potential role of brain biomarkers in primary knee osteoarthritis patients using magnetic resonance spectroscopy
Conclusions: This work confirms the importance of mACC in central sensitization of pain and highlights a promising role of the inflammatory neurotransmitter GABA and myo-inositol:Glx ratio as mechanistic biomarkers of chronic KOA pain. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 11, 2019 Category: Rheumatology Source Type: research
Hughes-Stovin syndrome without venous involvement – Unusual presentation of a rare disease: Case report and review of the literature
ConclusionHSS is a rare type of vasculitis, which can present with arterial, venous and/or intracardiac thrombosis even without other systemic manifestations. HSS can present without venous involvement. HSS require aggressive immune suppressive treatment, however anticoagulation and surgery can be attempted when indicated. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - October 26, 2019 Category: Rheumatology Source Type: research
Nailfold capillaroscopic changes in Egyptian patients with psoriatic arthritis in comparison to rheumatoid arthritis
ConclusionThe nailfold capillaroscopy in RA patients had no specific changes, While in PsA patients showed low density, dilated, tortuous and disorganized capillaries and hemorrhages. So, Nailfold capillaroscopy can be used in the differentiation between both diseases. NFC abnormalities may be related to the disease activity. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - October 24, 2019 Category: Rheumatology Source Type: research
Editorial Board
Publication date: October 2019Source: The Egyptian Rheumatologist, Volume 41, Issue 4Author(s): (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - October 24, 2019 Category: Rheumatology Source Type: research
Soluble CCN2/connective tissue growth factor levels in Egyptian systemic sclerosis patients: Possible association with cutaneous and pulmonary fibrosis
ConclusionThe work indicates the importance of CCN2 in cutaneous and pulmonary fibrosis in patients with SSc especially those with diffuse subtype. An additional prospective large scale, a longitudinal study should be carried out to support these findings and to reveal the mechanistic connections between CCN-2 levels and SSc disease manifestations. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - October 22, 2019 Category: Rheumatology Source Type: research
Neutrophil/lymphocyte and platelet/lymphocyte ratios are useful predictors comparable to serum IL6 for disease activity and damage in naive and relapsing patients with lupus nephritis
ConclusionNLR and PLR appear to be potentially useful cheap parameters of activity, relapse and severity in SLE patients with nephritis. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - September 15, 2019 Category: Rheumatology Source Type: research
Significance of calgranulins (S100A8, S100A9 and S100A12), ferritin and toll-like receptor 4 in juvenile idiopathic arthritis children
ConclusionsS100A8, S100A9 and ferritin were upregulated in sera of JIA patients. Their significance as predicting biomarkers of disease outcome was augmented, especially in CRP- and RF-seropositive, low JADAS27 and persistent oligoarticular JIA patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - September 1, 2019 Category: Rheumatology Source Type: research
Therapeutic potential of perineural injection for temporomandibular joint pain, dysfunction and musculoskeletal ultrasound findings in rheumatoid arthritis patients
ConclusionThere is a potential significant effect of PIT on improving TMJ pain and function in RA patients. The unchanged MSUS findings make its role in tissue regeneration questionable. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - September 1, 2019 Category: Rheumatology Source Type: research
Potential anti-inflammatory action of resveratrol and piperine in adjuvant-induced arthritis: Effect on pro-inflammatory cytokines and oxidative stress biomarkers
ConclusionCo-administration of PIP enhanced the anti-inflammatory efficacy of RSV in the arthritic-induced rats. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - August 30, 2019 Category: Rheumatology Source Type: research
Short term effect of non-steroidal anti-inflammatory drugs on clinical and magnetic resonance imaging of the sacroiliac joints progression in axial spondyloarthritis patients
ConclusionIn Egyptian cohort of patients with axSpA, intake of maximally tolerated dose of NSAID could improve the health-related quality of life, disease activity scores, and sacroiliac joint inflammation on MRI. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - August 23, 2019 Category: Rheumatology Source Type: research
New promising avenue for the simvastatin combination with residronate, strontium ranelate and raloxifene in experimentally-induced osteoporosis
ConclusionSimvastatin combined regimens have promising synergistic effects on bone microarchitecture with cardiovascular protective effects which might be considered by clinicians as valid preventive and therapeutic strategy in patients with osteoporosis with or highly susceptible to cardiovascular disease. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - July 25, 2019 Category: Rheumatology Source Type: research
Micro RNA 499 gene expression and interleukin 17 in Egyptian patients with Behçet’s disease
ConclusionMicro RNA-499 relative expression and IL17 levels were significantly higher in BD patients compared to the controls. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - July 23, 2019 Category: Rheumatology Source Type: research
Dysregulation of microRNA146a-5p expression in systemic lupus erythematosus females: Diagnostic potential and association with ocular manifestations
ConclusionThese findings suggest that miR-146a-5p could be a potential diagnostic biomarker in SLE and may implicate a functional role in the pathophysiology of the ocular manifestations in the disease. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - July 20, 2019 Category: Rheumatology Source Type: research
