Role of syndecan-1 (CD138) in Egyptian systemic lupus erythematosus patients with lupus nephritis: Relation to disease activity
ConclusionSerum syndecan-1 is significantly high in active LN patients and can be a useful tool for diagnosis of active nephritis. It correlates with disease activity, consumed complement and proteinuria. It was significantly related to the presence of musculoskeletal manifestations and serositis. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - January 29, 2019 Category: Rheumatology Source Type: research
Hyponatremia in systemic lupus erythematosus patients: Relation to disease activity and fatigue
ConclusionHyponatremia in SLE patients is associated with higher disease activity and more perceived fatigue. Hyponatremia could reflect severe inflammation and could be considered as one of the predisposing factors of fatigue. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - January 18, 2019 Category: Rheumatology Source Type: research
Risk factors for osteonecrosis severity among Egyptian systemic lupus erythematosus patients: Magnetic resonance imaging (MRI) staging
ConclusionNephritis, serositis, GI involvement, arthritis, steroids are key predictors for advanced ONFH while HCQ was protective. Risk factors for bilateral ONFH were serositis, nephritis, increased damage-index and VAS-pain. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - January 8, 2019 Category: Rheumatology Source Type: research
Sonographic synovitis in primary knee osteoarthritis patients and its relation to biomarkers of inflammation and oxidative stress
ConclusionsAlthough the serum levels of both inflammatory and oxidative stress biomarkers were significantly higher in OA patients compared to the control, there was no correlation with the sonographic findings of synovitis. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 21, 2018 Category: Rheumatology Source Type: research
Unilateral versus bilateral primary knee osteoarthritis: Relation to the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), C-reactive protein and radiological assessment in Egyptian patients
ConclusionsPain on weight bearing in females and bending activities especially going downstairs (in males) appears early with primary KOA. Bilateral involvement is more painful with more radiographic severity. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 21, 2018 Category: Rheumatology Source Type: research
Arterial aneurysms in Behçet’s disease patients: Frequency, clinical characteristics and long-term outcome
ConclusionArterial aneurysms are common in Egyptian BD patients mostly males. Increased awareness of the rheumatologists and including appropriate imaging techniques for early detection of AA in BD are mandatory. Early detection and prompt treatment with immunosuppressives may improve the disease outcome. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 21, 2018 Category: Rheumatology Source Type: research
Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) syndrome in an elderly Spanish patient: Ruling-out polymyalgia rheumatica and management
ConclusionRS3PE could be diagnosed even without polyarthritis and successfully treated by low dose steroids after excluding any related malignancy. Excluding PMR is important to avoid exposing the patient to unwanted higher steroid doses. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 20, 2018 Category: Rheumatology Source Type: research
Neuropathic pain in Egyptian patients with primary knee osteoarthritis: Relationship with functional status and radiological severity
ConclusionA relevant proportion of KOA patients have NP and is remarkably related to the disease duration. Functional capacity is adversely affected in these patients. However, no relation was found between DN4 questionnaire and the radiological severity. Once detected, suitable treatment options for NP should be included in the management of primary KOA. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 19, 2018 Category: Rheumatology Source Type: research
Hazards of pulse steroid use in a cohort of Egyptian lupus nephritis patients
ConclusionRepeated “pulse” steroid was associated with higher renal damage and deleterious effect on central nervous system and bone. The abuse of “pulse” steroid therapy should be avoided. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 15, 2018 Category: Rheumatology Source Type: research
Serum pentraxin 3 levels in rheumatoid arthritis patients and its association with disease activity
ConclusionPTX3 can be considered as a marker of a positive acute phase response and may serve as a potential novel biomarker for detecting RA activity. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 27, 2018 Category: Rheumatology Source Type: research
Diagnostic potential of metastasis-associated-lung-adenocarcinoma-transcript-1 (MALAT-1) and TNFα and hnRNPL related immunoregulatory long non-coding RNA (THRIL) in systemic lupus erythematosus patients: Relation to disease activity
ConclusionMALAT-1 and THRIL may be potential diagnostic biomarkers for SLE and only MALAT-1 may be valuable in detecting disease activity. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 23, 2018 Category: Rheumatology Source Type: research
Diagnostic potential of ultrasound in systemic lupus erythematosus patients with joint involvement: Relation to anticyclic citrullinated peptide (anti-CCP), disease activity and functional status
Conclusion: Erosive arthritis can be detected in SLE patients with arthritis and have an impact on disease activity and functional status. Anti-CCP can also be detected in SLE and is associated with erosive arthritis. MSUS findings including; synovitis, tenosynovitis and PD signals also have an impact on disease activity and functional ability in SLE patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 23, 2018 Category: Rheumatology Source Type: research
Influence of +299G>A and +62G˃A resistin gene promoter variants on cardiovascular risk in Egyptian women with systemic lupus erythematosus
ConclusionResistin +299G/A gene polymorphisms especially the AA genotype and A allele may play an important role in pathogenesis and activity of SLE as well as susceptibility to develop CVD in Egyptian population. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 21, 2018 Category: Rheumatology Source Type: research
Increased serum and synovial levels of midkine are associated with radiological progression in primary knee osteoarthritis patients
ConclusionOsteoarthritis patients have significantly elevated serum and synovial levels of midkine that were correlated with functional status assessed with WOMAC index and obviously associated with radiological progression on MSUS suggesting that it could be a useful marker to reflect OA severity and implies a possible role in the disease pathogenesis. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 16, 2018 Category: Rheumatology Source Type: research
Screening for latent tuberculosis infection prior to biologic therapy in patients with chronic immune-mediated inflammatory diseases (IMID): Interferon-gamma release assay (IGRA) versus tuberculin skin test (TST)
ConclusionsTST and IGRA have a low agreement. Both tests should be included in the strategy to diagnose LTBI prior to biologic therapy in IMID patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 16, 2018 Category: Rheumatology Source Type: research
