Medical management of pleural infection: Why not saline intrapleural lavage?
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 29, 2022 Category: Respiratory Medicine Authors: Valentine Mismetti, Marios E. Froudarakis Tags: EDITORIAL Source Type: research

Challenges of vaccination and herd immunity in COVID ‐19 and management strategies
A. Vaccination induces production of protective antibodies to block the receptor binding domain (RBD) of spike protein from binding to the host angiotensin-converting enzyme-2 (ACE-2) receptor; B. Mass vaccination in population establishes immune barrier, while no vaccination or few vaccination is at risk of COVID-19 spreading. AbstractCoronavirus disease 2019 (COVID-19), the highly contagious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide with millions of cases and more than 5 million deaths to date. SARS-CoV-2 has caused serious damage all over the world with ma...
Source: The Clinical Respiratory Journal - September 29, 2022 Category: Respiratory Medicine Authors: Jun She, Dongni Hou, Cuicui Chen, Jing Bi, Yuanlin Song Tags: REVIEW ARTICLE Source Type: research

A simple and reliable adult uncuffed endotracheal tube for combined forceps and cryoprobe biopsy during bronchoscopy
ConclusionThis study suggests that UCETT under spontaneous respiration can provide satisfactory airway support and a shorter recovery time in stable patients; thus, it may be an option to assist forceps and cryoprobe biopsy. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 16, 2022 Category: Respiratory Medicine Authors: Meimei Tao, Xinxia Wang, Qian Sun, Hui Li, Hang Zou, Guangfa Zhu Tags: ORIGINAL ARTICLE Source Type: research

The potential role of interleukin (IL) ‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis
ConclusionIL-25/IL-33/TSLP contributes to non-allergic lung fibrosis by mediating persistent abnormal epithelial-mesenchymal crosstalk. IL-25/IL-33/TSLP may serve the promising novel target for the treatment of IPF. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 9, 2022 Category: Respiratory Medicine Authors: Xuefeng Xu, Huaping Dai, Jinglan Zhang Tags: REVIEW ARTICLE Source Type: research

Advantages and challenges of metagenomic sequencing for the diagnosis of pulmonary infectious diseases
ConclusionMetagenomic sequencing improves efficiency to identify pathogens compared with traditional diagnostic methods and can be applied in clinical diagnosis. However, the technology of metagenomic sequencing still needs to be improved. Also, clinicians should learn more about when to use metagenomic sequencing and how to interpret its results. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 7, 2022 Category: Respiratory Medicine Authors: Yan Chen, Li ‐Chao Fan, Yan‐Hua Chai, Jin‐Fu Xu Tags: MINI REVIEW Source Type: research

Lung function in Lolland ‐Falster Health Study (LOFUS)
ConclusionPrevalence of airway obstruction in this rural population was comparable to previous estimates from urban Danish population studies. The choice of cut-off impacts the estimated prevalence, and using the FEV1/FVC cut-off may overestimate prevalence. However, many participants with known respiratory disease had normal spirometry in this health study. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 3, 2022 Category: Respiratory Medicine Authors: Katja Kemp Jacobsen, Randi Jepsen, Uffe Bodtger, Knud Rasmussen, Gry St ‐Martin Tags: ORIGINAL ARTICLE Source Type: research

Headway and the remaining hurdles of mesenchymal stem cells therapy for bronchopulmonary dysplasia
ConclusionWith BPD existing as a constant threat and there being no permanent solutions, the idea of regenerative medicine such as MSC may prove to be a breakthrough strategy when it comes to treating BPD. The success in clinical trials led to the formulation of prospective MSC-derived products such as PNEUMOSTEM ®, and there is the possibility of a stem cell medication and permanent treatment for BPD in the near future. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 3, 2022 Category: Respiratory Medicine Authors: Eireen Tang, Mariam Zaidi, Wen ‐Huey Lim, Vijayendran Govindasamy, Kong‐Yong Then, Khong‐Lek Then, Anjan Kumar Das, Soon‐Keng Cheong Tags: REVIEW ARTICLE Source Type: research

Respiratory support for patients with COVID ‐19: A national survey of respiratory departments in England
ConclusionsThe number of beds capable of managing patients requiring CPAP increased significantly. We found deviations from previous standards of care, which likely reflects the pressure faced by hospitals in managing patients with COVID-19. The regional variation in equipment shortages suggests moving resources between regions may have been beneficial. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 2, 2022 Category: Respiratory Medicine Authors: Sam Bartlett ‐Pestell, Annakan V. Navaratnam, Ini Adelaja, Martin Allen Tags: BRIEF REPORT Source Type: research

Issue Information
No abstract is available for this article. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 2, 2022 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Prognosis of hospital ‐acquired pneumonia/ventilator‐associated pneumonia with Stenotrophomonas maltophilia versus Klebsiella pneumoniae in intensive care unit: A retrospective cohort study
ConclusionSM-HAP/VAP and KP-HAP/VAP patients in ICU might have a similar prognosis in mortality, the total duration of the artificial airway and ventilator use, the total length of ICU stay, and hospital stay. The risk factors of SM-HAP/VAP versus KP-HAP/VAP might be the artificial airway, ventilator use, gastric tube placement, acid suppressant and antibiotics (especially carbapenem). (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 1, 2022 Category: Respiratory Medicine Authors: Shuping Chen, Dongdong Zou Tags: ORIGINAL ARTICLE Source Type: research

Factors associated with failure of using high flow nasal cannula in children
ConclusionHFNC is feasible to use for children with respiratory distress; however, patients with congenital heart disease, using HFNC with FiO2 >  0.6, lobar infiltration on chest X-ray should be closely monitored. Heart rate and respiratory rate are important parameters in addition to clinical assessment for evaluating HFNC failure in children. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - August 31, 2022 Category: Respiratory Medicine Authors: Kanokkarn Sunkonkit, Supakanya Kungsuwan, Sukanlaya Seetaboot, Sanit Reungrongrat Tags: ORIGINAL ARTICLE Source Type: research

Response to inhaled ceftazidime in patients with non ‐cystic fibrosis bronchiectasis and chronic bronchial infection unrelated to Pseudomonas aeruginosa
ConclusionThe results suggest that inhaled ceftazidime in NCFB unrelated to PA is a plausible alternative to the standard therapies used in clinical practice. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - August 29, 2022 Category: Respiratory Medicine Authors: Vanessa Riveiro, Ana Casal, Jos é M. Álvarez‐Dobaño, Tamara Lourido, Pedro Suárez‐Artime, Carlota Rodríguez‐García, Lucía Ferreiro, María E. Toubes, Luis Valdés Tags: BRIEF REPORT Source Type: research

Issue Information
No abstract is available for this article. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - August 15, 2022 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research

Is conventional transbronchial lung biopsy out: The evaluation of clinical value in diffuse parenchymal lung disease
Conclusion that conventional TBLB served as a key determinant or provided supplementary information in the final diagnosis of non-infectious diffuse parenchymal lung diseases (DPLDs). TBLB decision-making should therefore be based on clinical and radiological data. AbstractIntroductionTransbronchial lung biopsy (TBLB) is a relatively safe technique routinely employed by pulmonologists for the diagnosis of diffuse parenchymal lung disease (DPLD). Cryobiopsy is associated with higher diagnostic yield and a favorable risk/benefit ratio. Nevertheless, TBLB remains the representative method for definite diagnosis in developing ...
Source: The Clinical Respiratory Journal - August 12, 2022 Category: Respiratory Medicine Authors: Lefei Zhou, Feng Wang, Xiaoguang Xu, Lili Xu, Zhen Wang, Zhaohui Tong Tags: ORIGINAL ARTICLE Source Type: research

Evaluating changes in pulse transit time drop index in patients with obstructive sleep apnea before and during CPAP therapy
Here, we evaluated changes in pulse transmission time (PTT) drop index before and during CPAP therapy in patients with obstructive sleep apnea. PTT drop index significantly decreased after CPAP therapy. PTT drop index was strongly correlated to AHI, RDI, ODI, arousal index, and PLM index. AbstractAirflow limitation in patients with obstructive sleep apnea (OSA) leads to arousal, increased sympathetic nervous system activity, and elevated blood pressure, which causes a decrease in pulse transit time (PTT). The present study aims to evaluate the effect of CPAP therapy on PTT in patients with moderate to severe OSA. This was ...
Source: The Clinical Respiratory Journal - August 9, 2022 Category: Respiratory Medicine Authors: Elham Kalantari, Forough Kalantari, Maryam Edalatifard, Besharat Rahimi Tags: ORIGINAL ARTICLE Source Type: research